![](https://scdn.x-mol.com/css/images/icon-new-link.png)
样式: 排序: IF: - GO 导出 标记为已读
-
Enviromental endocrine disruptor risks in the central nervous system: Neurotoxic effects of PFOS and glyphosate Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-07-02 Gianluca Antonio Franco, Francesco Molinari, Ylenia Marino, Nicla Tranchida, Francesca Inferrera, Roberta Fusco, Rosanna Di Paola, Rosalia Crupi, Salvatore Cuzzocrea, Enrico Gugliandolo, Domenico Britti
Endocrine disruptors (EDs) pose significant risks to human and environmental health, with potential implications for neurotoxicity. This study investigates the synergistic neurotoxic effects of perfluorooctane sulfonate (PFOS) and glyphosate (GLY), two ubiquitous EDs, using SHSY5Y neuronal and C6 astrocytic cell lines. While individual exposures to PFOS and glyphosate at non-toxic concentrations did
-
Exposure to PFAS contaminated urban wetland water causes similar metabolic alterations to laboratory-based exposures in the freshwater amphipod Austrochiltonia subtenuis Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-06-24 Georgia M. Sinclair, Oliver A.H. Jones, Navneet Singh, Sara M. Long
Assessing the harm caused by pollutants in urban ecosystems remains a significant challenge. Traditional ecotoxicological endpoints are often not sensitive enough to detect the effects of toxicants at environmentally relevant concentrations (≤ng/L). A potential solution is using molecular biology methods to look at small biochemical changes caused by exposure to ng/L concentrations of contaminants
-
Silicon dioxide nanoparticles induce anxiety-like behavior in a size-specific manner via the microbiota-gut-brain axis Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-06-21 Kaiyan Gong, Xiaoli Yin, Jiahui Lu, Hong Zheng, Wenjun Wu
-
Neurotoxic and cardiotoxic effects of pyrogallol on catfish (Clarias gariepinus) Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-06-08 Mohamed Hamed, Christopher J. Martyniuk, Hamdy A.M. Soliman, Alaa G.M. Osman, Rashad E.M. Said
Pyrogallol, a botanical hydrolysable tannin, has diverse medical and industrial applications. Its impact on aquatic ecosystems and fish health has been previously studied, revealing histopathological, immunological, biochemical, and haematological alterations in African catfish (). In this study, the neurotoxic potential of pyrogallol was assessed through a 15-day exposure of catfish to concentrations
-
Occurrence of the two major regulated mycotoxins, ochratoxin A and fumonisin B1, in cereal and cereal-based products in Europe and toxicological effects: A review Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-06-04 Beatriz Arce-López, Monika Coton, Emmanuel Coton, Nolwenn Hymery
-
Thymol’s modulation of cellular macromolecules, oxidative stress, DNA damage, and NF-kB/caspase-3 signaling in the liver of imidacloprid-exposed rats Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-06-03 Fathy Elsayed Abdelgawad, Ghada I. Abd El-Rahman, Amany Behairy, Yasmina M. Abd-Elhakim, Taghred M. Saber, Mohamed M.M. Metwally, Samaa Salah Abd El-Fatah, Mariam M. Samaha, Taisir Saber, Mohamed Abdelrahman Aglan
We evaluated whether thymol (THY) (30 mg/kg b.wt) could relieve the adverse effects of the neonicotinoid insecticide imidacloprid (IMD) (22.5 mg/kg b.wt) on the liver in a 56-day oral experiment and the probable underlying mechanisms. THY significantly suppressed the IMD-associated increase in hepatic enzyme leakage. Besides, the IMD-induced dyslipidemia was considerably corrected by THY. Moreover
-
Hazard identification of endocrine-disrupting carcinogens (EDCs) in relation to cancers in humans Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-31 Neha Sharma, Vinay Kumar, Vimal S., Mridul Umesh, Preeti Sharma, Basheer Thazeem, Komalpreet Kaur, Jithin Thomas, Ritu Pasrija, Divya Utreja
-
Indole-3-acetic acid induced cardiogenesis impairment in in-vivo zebrafish via oxidative stress and downregulation of cardiac morphogenic factors Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-29 S.P. Ramya Ranjan Nayak, Seenivasan Boopathi, Bader O. Almutairi, Selvaraj Arokiyaraj, M.K. Kathiravan, Jesu Arockiaraj
-
Biochar dust emission: Is it a health concern? Preliminary results for toxicity assessment Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-27 Silvana Pinelli, Stefano Rossi, Alessio Malcevschi, Michele Miragoli, Massimo Corradi, Luisella Selis, Sara Tagliaferri, Francesca Rossi, Delia Cavallo, Cinzia Lucia Ursini, Diana Poli, Paola Mozzoni
Biochar is currently garnering interest as an alternative to commercial fertilizer and as a tool to counteract global warming. However, its use is increasingly drawing attention, particularly concerning the fine dust that can be developed during its manufacture, transport, and use. This work aimed to assess the toxicity of fine particulate Biochar (
-
Weathered polyethylene microplastics induced immunomodulation in zebrafish Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-25 Thilagam Harikrishnan, Pandi Paramasivam, Anusuya Sankar, Madhavan Sakthivel, Elumalai Sanniyasi, Thiagarajan Raman, Muthukumar Thangavelu, Gopalakrishnan Singaram, Govarthanan Muthusamy
Microplastics are pollutants of emerging concern and the aquatic biota consumes microplastics (MPs), which has a range of toxicological and environmental effects on aquatic organisms that are not the intended targets. The current study looked into how weathered polyethylene (wPE) MPs affected immunological and haematological markers. In this experiment, fish of both sexes were placed in control and
-
Glyphosate contamination of drinking water and the occurrence of oxidative stress: Exposure assessment to rural Brazilian populations Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-23 Rafaella Ferreira Nascimento Nunes, Luiz Paulo Aguiar Marciano, Geovana Sousa Oliveira, Naiane Silva Cardoso, Fernanda Borges de Araújo Paula, Marcia Sarpa, Isarita Martins
Studies reported that continuous application of glyphosate can cause disturbance in aquatic/terrestrial environments. As such, the objective of this study is to discuss the risk of exposure to the herbicide in drinking water and to assess the oxidative stress in the consumers rural populations of Casimiro de Abreu/ RJ and Paraguaçu/ MG, Brazil. For this, water samples (n=69) were analysed from the
-
Occurrence of pharmaceuticals in rice (Oryza sativa L.) plant through wastewater irrigation Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-20 Khalid Sayed, Wan Hanna Melini Wan-Mohtar, Zarimah Mohd Hanafiah, Aziza Sultana Bithi, Nurulhikma Md Isa, Teh Sabariah Binti Abd Manan
-
Co-administration of resveratrol rescued lead-induced toxicity in Drosophila melanogaster Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-18 R. Abdulazeez, S.M. Highab, U.F. Onyawole, M.T. Jeje, H. Musa, D.M. Shehu, I.S. Ndams
Lead toxicity poses a significant environmental concern linked to diverse health issues. This study explores the potential mitigating effects of resveratrol on lead-induced toxicity in . Adult fruit flies, aged three days, were orally exposed to lead (60 mg/L), Succimer (10 mg), and varying concentrations of resveratrol (50, 100, and 150 mg). The investigation encompassed the assessment of selected
-
Acute exposure and biomarkers assessment in rainbow trout exposed to selected pharmaceuticals Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-17 C. André, J. Auclair, F. Gagné
Pharmaceuticals released from municipal effluents discharges pose a risk to aquatic organisms. The toxicity of 5 pharmaceuticals with distinct therapeutic actions were assessed in rainbow trout: olanzapine (antipsychotic), erythromycin (antibiotic), mycophenoate (immunosuppression), pinaverium (anti-inflammatory) and trazodone (sedative). Juveniles were exposed to these drugs for 96 h at concentrations
-
Pharmacokinetics and residues of florfenicol in Nile tilapia (Oreochromis niloticus) post-oral gavage Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-17 Avishek Bardhan, Thangapalam Jawahar Abraham, Tapas Kumar Sar, Ravindran Rajisha, Satyen Kumar Panda, Prasanna Kumar Patil
-
Behavioral profile alterations and predation susceptibility of Japanese medaka fish exposed to phenytoin, an antiepileptic drug Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-17 Ayaka Sawada, Uaciquete Dorcas, Yoshifumi Horie
Antiepileptic drugs, such as phenytoin, are often leaked into aquatic systems through sewage facilities due to their low metabolic rate. Fish, such as the Japanese medaka (), demonstrate abnormal swimming behavior such as equilibrium abnormalities, rotational behavior, and vertical swimming, when exposed to phenytoin. Therefore, it is hypothesized that predator avoidance may be hindered. This study
-
Exploring novel insights into the molecular mechanisms underlying Bisphenol A-induced toxicity: A persistent threat to human health Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-17 Israel Ahmad, Mandeep Kaur, Devansh Tyagi, Tejinder Bir Singh, Gurpreet Kaur, Shaikh Mohammad Afzal, Mohsin Jauhar
-
N-Acetyl-L-cysteine attenuates titanium dioxide nanoparticle (TiO2 NP)-induced autophagy in male germ cells Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-16 Beom-Jin Shin, Bang-Jin Kim, Eun-Ji Paeng, Jack Tyler Rifkin, Sung-Hwan Moon, Seung Hee Shin, Buom-Yong Ryu
Titanium dioxide nanoparticles (TiO NPs) are widely used in consumer products, raising concerns about their impact on human health. This study investigates the effects of TiO NPs on male germ cells while focusing on cell proliferation inhibition and underlying mechanisms. This was done by utilizing mouse GC-1 spermatogonia cells, an immortalized spermatogonia cell line. TiO NPs induced a concentration-dependent
-
Chlorpyrifos-induced suppression of the antioxidative defense system leads to cytotoxicity and genotoxicity in macrophages Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-15 Yin-Che Lu, Chen-Yu Chiang, Shih-Pin Chen, Yu-Wei Hsu, Wen-Ying Chen, Chun-Jung Chen, Yu-Hsiang Kuan, Sheng-Wen Wu
-
Histopathology and changes in the expression of metallothioneins, heat shock proteins and inducible nitric oxide synthase in Prochilodus costatus from a neotropical river contaminated by heavy metals Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-15 Alessandro Loureiro Paschoalini, Yves Moreira Ribeiro, Breno Thuller, Camila Leandro Gomes Soares, Elizete Rizzo, Nilo Bazzoli
The most recent dam rupture in Brazil released tons of mining tailings into the upper course of the Paraopeba River, affecting this river in an unprecedented way. The present study aimed to evaluate the influence of heavy metals on , an important commercial species in Brazil, four years after the dam colapse. To this end, biomarkers of heavy metals, oxidative stress, and environmental stress were analyzed
-
Gene expression profiles and protein-protein interaction networks in THP-1 cells exposed to metal-based nanomaterials Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-15 Michal Šíma, Helena Líbalová, Táňa Závodná, Kristýna Vrbová, Jiří Kléma, Pavel Rössner
-
Evaluation of genotoxic damage, production reactive oxygen and nitrogen species in Plasmodium yoelii yoelii exposed to sodium metavanadate Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-09 Brenda Casarrubias-Tabarez, Norma Rivera-Fernández, Norberto Alarcón-Herrera, Gabriela Guerrero-Palomo, Marcela Rojas-Lemus, Nelly López-Valdez, Jhony Anacleto-Santos, Adriana Gonzalez-Villalva, Martha Ustarroz-Cano, Teresa I. Fortoul
Malaria represents the greatest global health burden among all parasitic diseases, with drug resistance representing the primary obstacle to control efforts. Sodium metavanadate (NaVO) exhibits antimalarial activity against the Plasmodium (), yet its precise antimalarial mechanism remains elusive. This study aimed to assess the antimalarial potential of NaVO, evaluate its genotoxicity, and determine
-
Associations between exposure to phthalates and liver function among women undergoing assisted reproductive technology Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-09 Yi Wang, Li Yin, Yao-Yao Du, Hong-Mei Liao, Juan Li, Wen Yao, Xiao-Qiong Yuan, Qing-Chun Guo, Tao-Ran Deng, Na Guo, Min Zhang, Qiang Zeng, Chong Liu, Yu-Feng Li
Phthalates can induce hepatotoxicity in animal studies. We aimed to assess the associations of individual and mixture of urinary phthalate metabolites with serum liver function indicators among 764 women undergoing assisted reproductive technology (ART). In linear models, we observed inverse correlations between urinary mono-benzyl phthalate and serum total protein (TP) as well as globulin (β=–0.27
-
Polycyclic aromatic hydrocarbons exposure and arterial stiffness-related plasma miRNAs: A panel study Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-08 Ziqian Zhang, Conghua Bai, Lei Zhao, Linlin Liu, Wenting Guo, Miao Liu, Huihua Yang, Xuefeng Lai, Xiaomin Zhang, Liangle Yang
-
Depressive symptoms and suicide attempts among farmers exposed to pesticides Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-07 Ruirui Zheng, Raúl Romero-del Rey, Fátima Ruiz-Moreno, Jessica Garcia-Gonzalez, Mar Requena-Mullor, A. Ángela Navarro-Mena, Antonia López-Villén, Raquel Alarcon-Rodriguez
Pesticides safeguard crop health but may diminish cholinesterase activity in farmers, potentially leading to psychiatric disorders like depression and suicide attempts. This study, with 453 participants (225 pesticide-exposed farmers, 228 non-farmers) in Almería, Spain, aimed to investigate the presence of depressive symptoms and suicide attempts, the decrease acetylcholinesterase (AChE) and butyrylcholinesterase
-
Genetic alteration profiling in middle-aged women acutely exposed during the mechanical processing of dental nanocomposites Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-06 Andrea Rossnerova, Irena Chvojkova, Fatima Elzeinova, Daniela Pelclova, Pavlina Klusackova, Vladimir Zdimal, Lucie Ondrackova, Pavel Bradna, Adela Roubickova, Zuzana Simova, Pavel Rossner Jr.
Nanoparticles (NPs) have become an important part of everyday life, including their application in dentistry. Aside from their undoubted benefits, questions regarding their risk to human health, and/or genome have arisen. However, studies concerning cytogenetic effects are completely absent. A group of women acutely exposed to an aerosol released during dental nanocomposite grinding was sampled before
-
Toxic heavy metals in a landfill environment (Vientiane, Laos): Fish species and associated health risk assessment Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-05-03 Vongdala Noudeng, Dek Vimean Pheakdey, Tran Dang Xuan
Leachates from municipal landfills introduce toxic heavy metals into water, causing bioaccumulation. This study assesses metal levels and potential human health risks associated with consuming and . Inductively coupled plasma mass spectrometry detected Cd, Cu, Cr, Ni, Pb, and Zn in both fish species. Leachate metal concentrations meet international discharge standards, Cd, Cr, and Pb in the fish exceed
-
Occupational second-hand smoke exposure: A comparative shotgun proteomics study on nasal epithelia from healthy restaurant workers Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-27 Sofia Neves, Solange Pacheco, Fátima Vaz, Peter James, Tânia Simões, Deborah Penque
Non-smokers exposed to second-hand smoke (SHS) present risk of developing tobacco smoke-associated pathologies. To investigate the airway molecular response to SHS exposure that could be used in health risk assessment, comparative shotgun proteomics was performed on nasal epithelium from a group of healthy restaurant workers, non-smokers (never and former) exposed and not exposed to SHS in the workplace
-
Phthalate esters in clothing: A review Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-25 Natalia Aldegunde-Louzao, Manuel Lolo-Aira, Carlos Herrero-Latorre
Phthalate esters (PAEs) are widely used as plasticizers to enhance the flexibility and durability of different consumer products, including clothing. However, concerns have been raised about the potential adverse health effects associated with the presence of phthalates in textiles, such as endocrine disruption, reproductive toxicity and potential carcinogenicity. Based on examination of more than
-
A multi-approach analysis of the toxicity of a commercial formulation of monensin on Rhinella arenarum embryos and larvae Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-24 Julieta Peluso, Agostina Martínez Chehda, Carolina M. Aronzon
Monensin, an antibacterial commonly used in animal fattening, can enter aquatic ecosystems and harm non-target organisms. Since there are no previous studies about the effects of monensin on amphibians, the aim of the present study was to evaluate the lethal and sublethal toxicity of a commercial formulation of monensin (CFM) through standardized bioassays with embryos and larvae of the amphibian
-
Biopesticide spinosad: Unraveling ecotoxicological effects on zebrafish, Danio rerio Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-23 Inês Amaral, Sara C. Antunes, Daniela Rebelo, António Paulo Carvalho, Sara Rodrigues
-
Exposure to heavy metals, antioxidant status, and the interaction of single nucleotide polymorphisms in the genes CAT rs7943316, GSTP1 rs1695, as well as GSTM1 and GSTT1 genes, among workers in occupational settings Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-23 Sosan Andleeb Khan, Syed Muhammad Nurulain, Rashid Nazir Qureshi, Amina Zafar, Zarish Riaz, Aneela Shoukat, Zahid Muneer, Nazia Bibi, Saqlain Raza, Sabir Hussain, Syed Tahir Abbas Shah
-
Exposure to environmental pollutants and genetic variants related to oxidative stress and xenobiotic metabolism—Association with prostate cancer Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-23 Beatriz Álvarez-González, Antonio F. Hernández, Alberto Zafra-Gómez, Lucia Chica-Redecillas, Sergio Cuenca-López, Fernando Vázquez-Alonso, Luis Javier Martínez-González, María Jesús Álvarez-Cubero
-
Modulating responses of indicator genes in cellular homeostasis, immune defense and apoptotic process in the Macrophthalmus japonicus exposed to di(2-ethylhexyl) phthalate as a plastic additive Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-22 Kiyun Park, Ihn-Sil Kwak
Di(2-ethylhexyl) phthalate (DEHP), have been increasingly used as plasticizers to manufacture soft and flexible materials and ubiquitously found in water and sediments in the aquatic ecosystem. The aim of the present study was to evaluate the effect of DEHP exposure on cellular homeostasis ( and seven ), immune responses (), and apoptotic responses (, , ). DEHP exposure upregulated the expression of
-
Aluminum and ABC transporter activity Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-20 Goezde Oezen, Lisa Kraus, Eva-Maria Schentarra, Jan Stephan Bolten, Joerg Huwyler, Gert Fricker
Aluminum is the third most common element on Earth´s crust and despite its wide use in our workaday life it has been associated with several health risks after overexposure. In the present study the impact of aluminum salts upon ABC transporter activity was studied in the P-GP-expressing human blood-brain barrier cell line hCMEC/D3, in MDCKII cells overexpressing BCRP and MRP2, respectively, and in
-
Antagonistic effects of a COX1/2 inhibitor drug in human HepG2 cells exposed to an environmental carcinogen Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-18 Carla Martins, Marcos Felipe de Oliveira Galvão, Pedro M. Costa, Kristian Dreij
Understanding interactions between legacy and emerging environmental contaminants has important implications for risk assessment, especially when mutagens and carcinogens are involved, whose critical effects are chronic and therefore difficult to predict. The current work aimed to investigate potential interactions between benzo[]pyrene (B[]P), a carcinogenic polycyclic aromatic hydrocarbon and legacy
-
Genotoxic effect of two environmentally safe doses of cadmium on the hepato-nephrocytic system of Bombus atratus forager workers Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-16 Guilherme Andrade Neto Schmitz Boeing, Michele Provase, Elisabete Tsukada, Raquel F. Salla, Fabio Camargo Abdalla
-
DNA modifications: Biomarkers for the exposome? Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-16 Carolina Möller, Jazmine Virzi, Yuan-Jhe Chang, Alexandra Keidel, Mu-Rong Chao, Chiung-Wen Hu, Marcus S. Cooke
The concept of the exposome is the encompassing of all the environmental exposures, both exogenous and endogenous, across the life course. Many, if not all, of these exposures can result in the generation of reactive species, and/or the modulation of cellular processes, that can lead to a breadth of modifications of DNA, the nature of which may be used to infer their origin. Because of their role in
-
Comprehensive analysis of prohibited substances and methods in sports: Unveiling trends, pharmacokinetics, and WADA evolution Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-16 Patrik Oleksak, Eugenie Nepovimova, Marian Valko, Saleh Alwasel, Suliman Alomar, Kamil Kuca
This review systematically compiles sports-related drugs, substances, and methodologies based on the most frequently detected findings from prohibited lists published annually by the World Anti-Doping Agency (WADA) between 2003 and 2021. Aligned with structure of the 2023 prohibited list, it covers all proscribed items and details the pharmacokinetics and pharmacodynamics of five representatives from
-
UV-aged polystyrene nanoplastics aggravate intestinal barrier damage by overproduction of ROS Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-12 Tianjiang Jia, Jin Cai, Shiyu He, Zhen Mao, Xiaodan Zhang, Aobo Geng, Hong Yang, Shuqin Jiang, Peili Huang
UV irradiation significantly alters nanoplastics (NPs) physicochemical properties, thus affecting their biological toxicity. This study is the first to assess the influence of virgin and UV-aged polystyrene NPs (v-PS NPs, a-PS NPs) on the intestinal barrier of ICR mice. We found that a-PS NPs can cause more severe intestinal barrier damage compared with v-PS NPs. The reason may be attributed to that
-
Evaluation of acute toxicity of an emerging contaminant Oxybenzone on an ecologically important aquatic macrophyte Lemna minor Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-10 Shamika Shantaram Sawant, Vidya Shree Bharti, Satya Prakash Shukla, Kundan Kumar, G. Rathi Bhuvaneswari
-
Nanoplastics aggravated TDCIPP-induced transgenerational developmental neurotoxicity in zebrafish depending on the involvement of the dopamine signaling pathway Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-09 Xin Ren, Zhibo Liu, Ruiqi Zhang, Yuting Shao, Xiaoyue Duan, Bo Sun, Xuesong Zhao
Plastics pose a hazard to the environment. Although plastics have toxicity, microplastics (MPs) and nanoplastics (NPs) are capable of interacting with the rest pollutants in the environment, so they serve as the carriers and interact with organic pollutants to modulate their toxicity, thus resulting in unpredictable ecological risks. PS-NPs and TDCIPP were used expose from 2 h post-fertilization (hpf)
-
Blood and tissue levels of persistent organic pollutants and genetic susceptibility in patients with breast cancer Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-06 İlgen Onat, Rasih Kocagöz, Merve Demirbügen Öz, Levent Yeniay, Yiğit Özer Tiftikçioğlu, Osman Zekioğlu, Gürdeniz Serin, Murat Özdemir, Ersin Gür, Halit Sinan Süzen, Hilmi Orhan
We investigated possible associations between the internal concentrations of POPs and correlations between blood and tumor tissue concentrations in patients who underwent surgery for breast cancer and breast reduction as controls. Genetic variations in CYP1A1, GSTP1, GSTM1, and GSTT1 and hOGG1 were evaluated to determine whether they represent risk factors for breast cancer. Certain POPs have been
-
Impact of endocrine-active compounds on adrenal androgen production in pigs during neonatal period Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-06 Katarzyna Knapczyk-Stwora, Aleksandra Kozlowska, Damian Jastrzabek, Malgorzata Grzesiak, Maria Slomczynska, Marek Koziorowski
This study investigated the impact of neonatal exposure to endocrine-active compounds (EACs): flutamide (antiandrogen), 4--octylphenol (an estrogenic compound), and methoxychlor (an organochlorine insecticide exhibiting estrogenic, antiestrogenic and antiandrogenic activities) on androgen production within porcine adrenal glands. The expression of genes related to androgen synthesis and the level of
-
Growth and physiological responses of submerged macrophytes to linear alkylbenzene sulfonate (LAS) Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-05 Cui-Min Han, Wen-Hua You
The potential toxic effects of linear alkylbenzene sulfonate (LAS), widely used in commercial detergents and cleaners, on submerged macrophytes remain unclear. We conducted a two-week exposure experiment to investigate LAS toxicity on five submerged macrophytes (four native and one exotic), focusing on their growth and physiological responses. The results showed that lower concentrations of LAS (<
-
Surviving in a multistressor world: Gene expression changes in earthworms exposed to heat, desiccation, and chemicals Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-04-01 Natasha Tilikj, Mercedes de la Fuente, Ana Belén Muñiz González, José-Luis Martínez-Guitarte, Marta Novo
-
Investigating the toxic mechanism of iron oxide nanoparticles-induced oxidative stress in tadpole (Duttaphrynus melanostictus): A combined biochemical and molecular study Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-03-28 Meesala Krishna Murthy, Pratima Khandayataray, Chandra Sekhar Mohanty, Rojalin Pattanayak
-
Biological responses in Danio rerio by the disinfectant SDBS in SARS-CoV-2 pandemic Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-03-28 Beatriz Sousa, Inês Domingues, Bruno Nunes
-
Concentration of trace elements in blood of Polish patients with prostate cancer Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-03-28 Joanna Maria Drozdz-Afelt, Beata Koim-Puchowska, Piotr Kaminski
The goal of the study was to analyse the concentrations of chemical elements (Fe, Ni, As, Cd, Pb, Hg, Cr, Zn) which are important for the determination of environmental toxins (e.g. resulting from smoking, exposure to harmful agents at work) in Polish patients with prostate cancer. The study covered 66 patients with diagnosed prostate cancer and 64 healthy volunteers over 50 years old. The analysis
-
Chronic Aroclor 1260 exposure alters the mouse liver proteome, selenoproteins, and metals in steatotic liver disease Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-03-27 Kellianne M. Piell, Belinda J. Petri, Jason Xu, Lu Cai, Shesh N. Rai, Ming Li, Daniel W. Wilkey, Michael L. Merchant, Matthew C. Cave, Carolyn M. Klinge
-
Glyphosate and aminomethylphosphonic acid metabolite (AMPA) modulate the phenotype of murine melanoma B16-F1 cells Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-03-26 Yvanna Carla de Souza Salgado Kiefer, Marianna Boia Ferreira, Jessica Zablocki da Luz, Francisco Filipak Neto, Ciro Alberto de Oliveira Ribeiro
-
Exposure to the antineoplastic ifosfamide alters molecular pathways related to cardiovascular function, increases heart rate, and induces hyperactivity in zebrafish (Danio rerio) Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-03-23 Cole D. English, Kira J. Kazi, Isaac Konig, Emma Ivantsova, Christopher L. Souders II, Christopher J. Martyniuk
Ifosfamide is an alkylating antineoplastic drug used in chemotherapy, but it is also detected in wastewater. Here, the objectives were to (1) determine teratogenic, cardiotoxic, and mitochondrial toxicity potential of ifosfamide exposure; (2) elucidate mechanisms of toxicity; (3) characterize exposure effects on larval behavior. Survival rate, hatch rate, and morphological deformity incidence were
-
Polystyrene microplastics with absorbed nonylphenol induce intestinal dysfunction in human Caco-2 cells Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-03-23 Fangfang Ding, Huimei Wang, Yingzhi Li, Xueping Leng, Jiaming Gao, Danfei Huang
-
Transcriptional and phenotypical alterations associated with a gradual benzo[a]pyrene-induced transition of human bronchial epithelial cells into mesenchymal-like cells Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-03-22 Martina Hýžďalová, Jiřina Procházková, Nicol Straková, Kateřina Pěnčíková, Simona Strapáčová, Jana Slováčková, Simona Kajabová, Helena Líbalová, Jan Topinka, Markéta Kabátková, Jan Vondráček, Steen Mollerup, Miroslav Machala
-
Biotoxicity responses of zebrafish in environmentally relevant concentration of di (2-ethylhexyl) phthalate Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-03-21 Xianxu Li, Shichang Hu, Nan Jiang, Xiangfeng Yao, Can Wang, Qian Wang, Zhongkang Yang, Jun Wang
As an emerging environmental contaminant, di (2-ethylhexyl) phthalate (DEHP) is widely present in the aquatic environment, however, the effects and underlying mechanisms of DEHP on the aquatic organisms are poorly understood. This study systematically investigated the ecotoxicity induced by chronic exposure to environmental relevant concentrations of DEHP (0.03 mg/L, 0.1 mg/L, and 0.3 mg/L) on zebrafish
-
Anabolic steroids induced changes at the level of protein expression: Effects of prolonged administration of testosterone and nandrolone to pigs Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-03-21 Jan Gebauer, Nikola Hodkovicova, Kristina Tosnerova, Kristyna Skoupa, Andrej Batik, Iva Bartejsova, Michaela Charvatova, Lenka Leva, Rea Jarosova, Zbysek Sladek, Martin Faldyna, Kamil Stastny
-
Beauvericin and enniatin B mycotoxins alter aquatic ecosystems: Effects on green algae Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-03-19 Ana Juan-García, Cristina Juan, Sami Taipale, Eeva-Riikka Vehniäinen
Myxotoxins can contaminate algal-based products and arrive to the food chain to consumers producing chronic toxicity effects. Here, we studied phytotoxicity of mycotoxins, beauvericin (BEA) and ennaitin B (ENN B) in four phytoplankton strains: , , and , which are all green algae. It was tested the capacity of clearing the media of BEA and ENN B at different concentrations by comparing nominal and measured
-
Plants buffer some of the effects of a pair of cadmium-exposed zebrafish on the un-exposed majority Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-03-18 Delia S. Shelton, Piyumika S. Suriyampola, Zoe M. Dinges, Stephen P. Glaholt, Joseph R. Shaw, Emília P. Martins
-
The ABCG2 protein in vitro transports the xenobiotic thiabendazole and increases the appearance of its residues in milk Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-03-16 Laura Álvarez–Fernández, Esther Blanco–Paniagua, Alicia Millán–García, Miriam Velasco-Díez, Ana I. Álvarez, Gracia Merino
Thiabendazole (TBZ) is a broad–spectrum anthelmintic and fungicide used in humans, animals, and agricultural commodities. TBZ residues are present in crops and animal products, including milk, posing a risk to food safety and public health. ABCG2 is a membrane transporter which affects bioavailability and milk secretion of xenobiotics. Therefore, the aim of this work was to characterize the role of
-
Is photoelectrocatalysis an efficient process to degrade endocrine disruptors chemicals? Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2024-03-16 M. Cifre-Herrando, G. Roselló-Márquez, J. García-Antón
Endocrine disruptors chemicals (EDCs) pose significant health risks, including cancer, behavioral disorders, and infertility. In this study, we employed the photoelectrocatalysis (PEC) technique with optimized tungsten oxide (WO) nanostructures as a photoanode to degrade three diverse EDCs: methiocarb, dimethyl phthalate, and 4-tert-butylphenol. PEC degradation tests were carried out for individual