The cumulative toxicity of volatile organic compounds (VOCs) cause many medical diseases. We analyzed the evidence of association between VOCs and risk of metabolic syndrome in the Korean population using 1771 participants from the 2023 National Health and Nutrition Examination Survey. The creatinine-corrected urinary concentrations of BMA, 2-MHA, PGA, SPMA, 3-HPMA, BPMA and DHBMA were higher in the metabolic syndrome group than in the non-metabolic syndrome group. Urine N-Acetyl-S-(phenyl)-L-cysteine (SPMA) levels were significantly associated with metabolic syndrome after adjusting for confounders (odds ratio: 1.71). 2-MHA (OR 1.29, P=0.035) and SPMA (OR 2.84, P<0.001) were associated with the risk of elevated FBG impairment and SPMA (OR 1.57) was positively connected with the high blood pressure (P=0.016). In conclusion, the findings indicated significant association between the metabolic syndrome and a number of VOCs. Among them, there was a substantial positive correlation between the urinary SPMA levels and metabolic syndrome.

中文翻译：

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挥发性有机化合物暴露与代谢综合征的关系


挥发性有机化合物 （VOC） 的累积毒性会导致许多医学疾病。我们使用 2023 年全国健康和营养检查调查的 1771 名参与者分析了 VOCs 与韩国人群代谢综合征风险之间关联的证据。代谢综合征组肌酐校正尿 BMA 、 2-MHA 、 PGA 、 SPMA 、 3-HPMA 、 BPMA 和 DHBMA 浓度高于非代谢综合征组。调整混杂因素后，尿液 N-乙酰基-S-（苯基）-L-半胱氨酸 （SPMA） 水平与代谢综合征显著相关 （比值比： 1.71）。2-MHA （OR 1.29， P=0.035） 和 SPMA （OR 2.84， P<0.001） 与 FBG 损伤升高风险相关，SPMA （OR 1.57） 与高血压呈正相关 （P=0.016）。总之，研究结果表明代谢综合征与许多 VOCs 之间存在显着关联。其中，尿 SPMA 水平与代谢综合征呈显著正相关。