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Lipopolysaccharide‐Induced Lysosomal Cell Death Through Reactive Oxygen Species in Rat Liver Cell Clone 9 Environ. Toxicol. (IF 4.4) Pub Date : 2024-07-19 Chien‐Sheng Hsu, Shu‐Hao Chang, Rei‐Cheng Yang, Cheng‐Han Lee, Ming‐Sheng Lee, Jun‐Kai Kao, Jeng‐Jer Shieh
In sepsis, bacterial components, particularly lipopolysaccharide (LPS), trigger organ injuries such as liver dysfunction. Although sepsis induces hepatocyte damage, the mechanisms underlying sepsis‐related hepatic failure remain unclear. In this study, we demonstrated that the LPS‐treated rat hepatocyte cell line Clone 9 not only induced reactive oxygen species (ROS) generation and apoptosis but also
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Tetrahydrocurcumin Attenuates Polymyxin B Sulfate‐Induced HK‐2 Cells Apoptosis by Inhibiting Endoplasmic Reticulum Stress‐Mediated PERK/eIF2α/ATF4/CHOP Signaling Pathway Axis Environ. Toxicol. (IF 4.4) Pub Date : 2024-07-18 Junjie Chen, Weibin Fan, Jing Fan, Jiao Xie, Yan Wang, Yinhui Wang, Nengming Lin, Bin Lin
The clinical application of polymyxin B (PMB) is limited by its nephrotoxic effects, making the reduction of PMB‐induced nephrotoxicity has become a pressing concern for clinicians. Tetrahydrocurcumin (THC), known for its beneficial characteristics in biological functions, presents an attractive option for intervention therapy to mitigate PMB‐induced nephrotoxicity. However, the underlying mechanism
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Exposure to Trimethyltin Chloride Induces Pyroptosis and Immune Dysfunction in Grass Carp CIK Cells by Activating the NF‐κB Pathway Through Oxidative Stress Environ. Toxicol. (IF 4.4) Pub Date : 2024-07-15 Xiaotong Ni, Haozheng Hong, Haotian Xu, Meng Qi, Shiwen Xu
Trimethyltin chloride (TMT) is a highly toxic organotin pollutant frequently found in aquatic environments, posing a significant threat to the ecological system. The kidney plays a vital role in the body's detoxification processes, and TMT present in the environment tends to accumulate in the kidneys. However, it remained unclear whether exposure to different doses of TMT could induce pyroptosis and
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Histone Methyltransferase SUV39H2 Supports Nasopharyngeal Carcinoma Cell Metastasis by Regulation of SIRT1 Environ. Toxicol. (IF 4.4) Pub Date : 2024-07-12 Jianqiang You, Haixiang Xue, Changjiang Chao, Zhixuan Zhang, Xiaoye Tan, Xiaoye Wang, Haifeng Li
Nasopharyngeal carcinoma (NPC) is a malignant tumor with high metastatic features originating from the nasopharynx. However, the underlying mechanism of Suppressor of variegation 3–9 homolog 2 (SUV39H2) in NPC remains poorly understood. RT‐qPCR was carried out to examine SUV39H2 and SIRT1 expression in NPC tissues and cells. Kaplan–Meier method was utilized to evaluate the association between SUV39H2
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Ecotoxicological Research on the Toxic Impact of Zinc Oxide and Silver Nanoparticles on Oreochromis mossambicus Environ. Toxicol. (IF 4.4) Pub Date : 2024-07-10 Ashokkumar Sibiya, Jeyaraj Jeyavani, Dharmaraj Ramesh, Sundaresan Bhavaniramya, Baskaralingam Vaseeharan
Silver nanoparticles (AgNPs) and Zinc oxide nanoparticles (ZnONPs) have been widely used and are eventually been discharged into the natural aquatic ecosystem. The current study examined and correlated the toxicity of AgNPs and ZnONPs on the Mozambique tilapia, Oreochromis mossambicus. Lethal concentration (LC50) was determined with four different concentrations (0.05, 0.10, 0.15, and 0.20 mg/L) of
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Silver Nanoparticles Loaded With Oleuropein Alleviates LPS‐Induced Acute Lung Injury by Modulating the TLR4/P2X7 Receptor‐Mediated Inflammation and Apoptosis in Rats Environ. Toxicol. (IF 4.4) Pub Date : 2024-07-09 Seda Yakut, Volkan Gelen, Hülya Kara, Seçkin Özkanlar, Ali Yeşildağ
Toll‐like receptor 4 (TLR‐4) ligands were initially shown to be the source of lipopolysaccharide (LPS), a gram‐negative bacterium's cell wall immunostimulatory component. Oxidative stress, apoptosis, and inflammation are all potential effects of LPS treatment on the lungs. By triggering oxidative stress and inflammation, these negative effects could be avoided. Robust flavonoid oleuropein (OLE) exhibits
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Long noncoding RNA VPS9D1‐AS1 promotes the progression of endometrial cancer via regulation of the miR‐187‐3p/S100A4 axis Environ. Toxicol. (IF 4.4) Pub Date : 2024-07-02 Wei Ren, Ling Ouyang
VPS9D1‐AS1 functions as an oncogene in many cancers. However, its role and potential mechanism in the progression of endometrial cancer (EC) are not fully understood. VPS9D1‐AS1 levels in EC and adjacent normal tissues were investigated using the TCGA‐UCEC cohort and 24 paired clinical samples. The roles of VPS9D1‐AS1 and miR‐187‐3p in cell cycle, proliferation, and apoptosis were evaluated by loss‐
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Inhibiting Bruton's Tyrosine Kinase to Counteract Chemoresistance and Stem Cell‐Like Properties in Osteosarcoma Environ. Toxicol. (IF 4.4) Pub Date : 2024-06-26 Hsiao‐Chi Tsai, Ming‐Yu Lien, Shih‐Wei Wang, Yi‐Chin Fong, Chih‐Hsin Tang
Osteosarcoma, a highly aggressive bone cancer, often develops resistance to conventional chemotherapeutics, leading to poor prognosis and survival rates. The malignancy and chemoresistance of osteosarcoma pose significant challenges in its treatment, highlighting the critical need for novel therapeutic approaches. Bruton's tyrosine kinase (BTK) plays a pivotal role in B‐cell development and has been
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A Comparative Study on the Interaction Between Protein and PET Micro/Nanoplastics: Structural and Surface Characteristics of Particles and Impacts on Lung Carcinoma Cells (A549) and Staphylococcus aureus Environ. Toxicol. (IF 4.4) Pub Date : 2024-06-25 Asli Baysal, Hasan Saygin, Ahu Soyocak
The interaction between particles and proteins is a key factor determining the toxicity responses of particles. Therefore, this study aimed to examine the interaction between the emerging pollutant polyethylene terephthalate micro/nanoplastics from water bottles with bovine serum albumin. The physicochemical characteristics of micro/nanoplastics were investigated using nuclear magnetic resonance, x‐ray
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Live and Dead Clostridium butyricumGKB7 Diminish Osteoarthritis Pain and Progression in Preclinical Animal Model Environ. Toxicol. (IF 4.4) Pub Date : 2024-06-25 Li‐Chai Chen, Yen‐You Lin, You‐Shan Tsai, Chin‐Chu Chen, Tzu‐Ching Chang, Hsien‐Te Chen, Chin‐Jung Hsu, Chih‐Hsin Tang
Osteoarthritis (OA) is a degenerative joint disease primarily affecting the elderly. It is characterized by the progressive decline of joint cartilage and alterations in the underlying bone. Several probiotic strains have exhibited immunomodulatory and anti‐inflammatory properties. Here, we examined the functions of live and dead Clostridium butyricum GKB7 (GKB7‐L and GKB7‐D) in a preclinical anterior
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1G6‐D7 Inhibits Homologous Recombination Repair by Targeting Extracellular HSP90α to Promote Apoptosis in Non–Small Cell Lung Cancer Environ. Toxicol. (IF 4.4) Pub Date : 2024-06-20 Jiangzhou Du, Jinming Zhang, Dongyu Liu, Lin Gao, Hua Liao, Lanhe Chu, Jie Lin, Wei Li, Xiaojing Meng, Fei Zou, Shaoxi Cai, Mengchen Zou, Hangming Dong
Despite recent advances in treatment, non–small cell lung cancer (NSCLC) continues to have a high mortality rate. Currently, NSCLC pathogenesis requires further investigation, and therapeutic drugs are still under development. Homologous recombination repair (HRR) repairs severe DNA double‐strand breaks. Homologous recombination repair deficiency (HRD) occurs when HRR is impaired and causes irreparable
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Role of autonomic nervous system in BDE‐209 maternal exposure induced immunotoxicity in female offspring Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-29 Guanghua Mao, Junjie Tang, Muge Xu, Emmanuel Sunday Okeke, Fangyuan Dong, Yao Chen, Jinlin Gao, Weiwei Feng, Ting Zhao, Xiangyang Wu, Liuqing Yang
Decabrominated diphenyl ether (BDE‐209) is a typical persistent organic pollutant that can cross the placental barrier, increasing the exposure risk for offspring. Norepinephrine (NE) from nerve terminals and acetylcholine (Ach) can bind to specific receptors on immune cells, inhibit the immune function of the body then cause immunotoxicity. However, whether maternal exposure to BDE‐209 could lead
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Sodium arsenite impairs sperm quality via downregulating the ZMYND15 and ZMYND10 Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-27 Xiangli Li, Kaina Shen, Dunxuan Yuan, Xi Li, Jinrou Quan, Fangzhou Tian, Yan Yang, Li Zhang, Junling Wang
Zinc finger MYND‐type containing 15 (ZMYND15) has been documented to play important roles in spermatogenesis, and mutants contribute to recessive azoospermia, severe oligozoospermia, non‐obstructive azoospermia, teratozoospermia, even male infertility. ZMYND10 is involved in sperm motility. Whether environmental pollutants impair male fertility via regulating the expression of ZMYND15 and ZMYND10 has
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Downregulation of circ‐RAPGEF5 inhibits colorectal cancer progression by reducing the expression of polypeptide N‐acetylgalactosaminyltransferase 3 (GALNT3) Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-22 Duo Cheng, Feifei Chu, Fang Liang, Nan Zhang, Jingjing Wang, Wenli Yue
BackgroundCircular RNA (circRNA) plays a crucial role in the pathogenesis and progression of colorectal cancer (CRC). However, the current understanding of the emerging function and mechanism of circ‐RAPGEF5 in CRC remains poorly understood.MethodsWe first evaluated the expression level of circ‐RAPGEF5 in CRC tissues and cells by quantitative real‐time polymerase chain reaction (qRT‐PCR). Then, we
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Citrulline facilitates the glycolysis, proliferation, and metastasis of lung cancer cells by regulating RAB3C Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-21 Qingjun Meng, Yanguang Li, Zhen Sun, Junfeng Liu
Lung cancer (LC) is one of the major malignant diseases threatening human health. The study aimed to identify the effect of citrulline on the malignant phenotype of LC cells and to further disclose the potential molecular mechanism of citrulline in regulating the development of LC, providing a novel molecular biological basis for the clinical treatment of LC. The effects of citrulline on the viability
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Research on the mechanism of exosomes from different sources influencing the progression of lung cancer Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-18 Guangxian Mao, Jixian Liu
As a key regulator of intercellular communication, exosomes are essential for tumor cells. In our study, we will explore the mechanisms of exosomes from different sources on lung cancer. We isolated CD8+T cells and cancer‐associated fibroblasts (CAFs) from venous blood and tumor tissues of lung cancer patients, and isolated exosomes. MiR‐2682 was high expression in CD8+T‐derived exosomes, and lncRNA‐FOXD3‐AS1
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Low‐concentration imiquimod treatment promotes enhanced skin barrier functions through epidermal melanization reaction regulation Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-18 Tzu‐Kai Lin, Chia‐Lun Tsai, Bruce Chi‐Kang Tsai, Chia‐Hua Kuo, Tsung‐Jung Ho, Dennis Jine‐Yuan Hsieh, Wei‐Wen Kuo, Chih‐Yang Huang
The primary function of the skin is to form a mechanical, permeability, antimicrobial, and ultraviolet radiation barrier, which is essential for maintaining physiological homeostasis. Our previous studies demonstrated that cutaneous pigmentation could promote skin barrier function in addition to providing anti‐ultraviolet irradiation defense. The present study aimed to develop a new regimen that enhances
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A novel model combining genes associated with disulfidptosis and glycolysis to predict breast cancer prognosis, molecular subtypes, and treatment response Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-15 Mei‐Huan Wang, Yue‐Hua Gao, Zhen‐Dan Zhao, Hua‐Wei Zhang
Breast cancer (BC) is a heterogeneous malignancy with a dismal prognosis. Disulfidptosis is a novel type of regulated cell death that happens in the presence of glucose deficiency and is linked to the metabolic process of glycolysis. However, the mechanism of action of disulfidptosis and glycolysis‐related genes (DGRG) in BC, as well as their prognostic value in BC patients, remain unknown. After identifying
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Evaluation of cytotoxic effect of siphonochilone from African ginger: an in vitro analysis Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-14 Alba Ortigosa‐Palomo, David Fuentes‐Ríos, Francisco Quiñonero, Consolación Melguizo, Raul Ortiz, Juan M. López‐Romero, Jose Prados
Plants provide a wide array of compounds that can be explored for potential anticancer properties. Siphonochilone, a furanoterpene that represents one of the main components of the African plant Siphonochilus aethiopicus, shows numerous health benefits. However, to date, its antiproliferative properties have not been tested. The aim of this study was to analyze the cytotoxic effects of siphonochilone
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Hedyotis diffusa Willd inhibits inflammation and oxidative stress to protect against chronic prostatitis via the NRF2/ARE signaling pathway Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-13 Junfu Mo, Kang Xia, Chaokui Wu
Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a common and serious disease with unclear pathogenesis and recurrent symptoms. Hedyotis diffusa Willd (HDW) has been recognized for its potential in managing various chronic inflammatory diseases. This research aimed to interrogate the mechanism of HDW in treating CP/CPPS. Complete Freund Adjuvant (CFA) and LPS were utilized to establish
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PUM2 promoted osteoarthritis progression through PTEN‐mediated chondrocyte ferroptosis by facilitating NEDD4 mRNA degradation Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-11 Yu Meng, Li Chen, Yuxia Chai, Weili Meng, Guohui Yang, Jia Ren, Hongshuai Li, Peiyi Qi, Juwu Chen, Nan Wang
Osteoarthritis (OA) is a prevalent degenerative joint disease with a lack of effective therapeutic. Chondrocyte ferroptosis contributes to the progression of OA. PUM2 is shown to exacerbate ischemia–reperfusion‐induced neuroinflammation by promoting ferroptosis, but its role in OA remains unexplored. Here, primary mouse chondrocytes were stimulated with IL‐1β to mimic OA chondrocyte injury in vitro
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Functional mechanism of hypoxia‐like conditions mediating resistance to ferroptosis in cervical cancer cells by regulating KDM4A SUMOylation and the SLC7A11/GPX4 pathway Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-10 Jing Xiong, Puxiang Chen, Ling He, Xiaoshan Chai, Yongjing Zhang, Shujuan Sun
The discovery of ferroptosis has unveiled new perspectives for cervical cancer (CC) management. We elucidated the functional mechanism of hypoxia‐like conditions in CC cell ferroptosis resistance. CC cells were subjected to normoxia or hypoxia‐like conditions, followed by erastin treatment to induce ferroptosis. The assessment of cell viability/ferroptosis resistance was performed by MTT assay/Fe2+
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Picein alleviates oxidative stress and promotes bone regeneration in osteoporotic bone defect by inhibiting ferroptosis via Nrf2/HO‐1/GPX4 pathway Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-10 Lei Huang, Jiayi Wang, Jieqin Yu, Mengxuan Bian, Xingdong Xiang, Guanjie Han, Weisin Chen, Ning Wang, Jun Ge, Shunyi Lu, Jian Zhang
Osteoporosis (OP) can result in slower bone regeneration than the normal condition due to abnormal oxidative stress and high levels of reactive oxygen species (ROS), a condition detrimental for bone formation, making the OP‐related bone healing a significant clinical challenge. As the osteogenic differentiation ability of bone marrow mesenchymal stem cells (BMSCs) is closely related to bone regeneration;
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Unraveling the immunogenic cell death pathways in gastric adenocarcinoma: A multi‐omics study Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-08 Renjun Gu, Zilu Chen, Mengyue Dong, Ziyun Li, Min Wang, Hao Liu, Xinyu Shen, Yan Huang, Jin Feng, Kun Mei
BackgroundGastric cancer (GC) is a prevalent malignant tumor of the gastrointestinal (GI) system. However, the lack of reliable biomarkers has made its diagnosis, prognosis, and treatment challenging. Immunogenic cell death (ICD) is a type of programmed cell death that is strongly related to the immune system. However, its function in GC requires further investigation.MethodWe used multi‐omics and
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Deoxyshikonin triggers apoptosis in cervical cancer cells through p38 MAPK‐mediated caspase activation Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-08 Chung‐Yuan Lee, Pei‐Ni Chen, Shao‐Hsuan Kao, Heng‐Hsiung Wu, Yi‐Hsuan Hsiao, Tzu‐Yu Huang, Po‐Hui Wang, Shun‐Fa Yang
Deoxyshikonin (DSK) is a biological component derived from Lithospermum erythrorhizon. Although DSK possesses potential anticancer activities, whether DSK exerts anticancer effects on cervical cancer cells is incompletely explored. This study was aimed to investigate the anticancer activity of DSK against cervical cancer cells and its molecular mechanisms. Cell viability was evaluated by MTT assay
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Influence of administration timing of San‐Huang‐Xie‐Xin‐Tang treatment on attenuating Salmonella enterica serovar Typhimurium infection Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-08 Chiung‐Hung Chang, Shu‐Chiu Wang, Chia‐Ying Lee, Chiu‐Hsian Su, Yen‐Ju Lai, Wei‐De Lin, Yuan‐Man Hsu
Salmonella infections are a serious global health concern, particularly in developing countries, and are further exacerbated by the emergence of antibiotic resistance. San‐Huang‐Xie‐Xin‐Tang (SHXXT), a traditional herbal medicine with potent anti‐inflammatory properties, has recently gained attention as an alternative treatment. Our study emphasizes on the importance of precise timing in accordance
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Environmentally relevant levels of Cd and Mo coexposure induces ferroptosis and excess ferritinophagy through AMPK/mTOR axis in duck myocardium Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-08 Bingyan Huang, Gaohui Nie, Xueyan Dai, Ting Cui, Wenjing Pu, Caiying Zhang
Cadmium (Cd) and excess molybdenum (Mo) are multiorgan toxic, but the detrimental impacts of Cd and/or Mo on poultry have not been fully clarified. Thence, a 16‐week sub‐chronic toxic experiment was executed with ducks to assess the toxicity of Cd and/or Mo. Our data substantiated that Cd and Mo coexposure evidently reduced GSH‐Px, GSH, T‐SOD, and CAT activities and elevated H2O2 and MDA concentrations
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Subacute cadmium exposure changes different metabolic functions, leading to type 1 and 2 diabetes mellitus features in female rats Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-07 Charles S. da Costa, Thiago F. de Oliveira, Flavia C. F. Dos Santos, Alessandra S. Padilha, Maiara Krause, Maria Tereza W. D. Carneiro, Leandro Miranda‐Alves, Jones B. Graceli
Cadmium (Cd) is a heavy metal that acts as endocrine disrupting chemical (EDC). Few studies have investigated the effects of Cd exposure on metabolic dysfunctions, such as type 1 and 2 diabetes mellitus (T1DM and T2DM). Thus, we assessed whether subacute Cd exposure at occupational levels causes abnormalities in white adipose tissue (WAT), liver, pancreas, and skeletal muscle. We administered cadmium
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Repair effect of human umbilical cord mesenchymal stem cell‐derived small extracellular vesicles on ovarian injury induced by cisplatin Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-06 Bianling Xu, Wei Guo, Xiaojing He, Zijie Fu, Hongxu Chen, Jun Li, Qingya Ma, Shengjun An, Xiaodong Li
Small extracellular vesicles (sEVs) secreted by human umbilical cord have therapeutic effects on various degenerative diseases. However, the characteristics and potential functions of human umbilical cord mesenchymal stem cells (huMSCs)‐derived sEVs, especially the role of premature ovarian failure (POF), are poorly understood. Here, we isolated and characterized huMSCs and their sEVs. huMSCs highly
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Using single‐cell RNA sequencing and bulk RNA sequencing data to reveal a correlation between smoking and neutrophil activation in esophageal carcinoma patients Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-03 Yunhuan Ba, Xinyu Gu
BackgroundCigarette smoking is considered as a major risk factor for esophageal carcinoma (ESCA) patients. Neutrophil activation plays a key role in cancer development and progression. However, the relationship between cigarette smoking and neutrophils in ESCA patients remained unclear.MethodsSingle‐cell RNA sequencing (scRNA‐seq) and bulk RNA sequencing data were obtained from public databases. Uniform
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Glycyrrhizic acid attenuates the malignant biological properties of nonalcoholic fatty liver disease‐related hepatocellular carcinoma Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-03 Xueqing Huang, Dengwei You, Tianzhi An, Xuya Zhao, Tianpeng Jiang, Zhi Huang
Glycyrrhizic acid (GA) has effects on anti‐hepatic fibrosis, anti‐tumor and prevention from hepatocellular carcinoma (HCC) progression. Yet, the capacity of GA to ameliorate the advance of HCC pertinent to nonalcoholic fatty liver disease (NAFLD) remains to be clarified. We used the CCK‐8 method to detect the optimal treatment concentration and time for L‐02 cells, palmitic acid (PA)‐induced L‐02 cells
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M1 polarization induction by lead and amyloid peptides in microglial cells: Implications for neurodegeneration process Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-03 Murumulla Lokesh, Lakshmi Jaya Madhuri Bandaru, Ajumeera Rajanna, Virendra Singh Dhayal, Suresh Challa
Neurodegeneration in conditions like Alzheimer's and Parkinson's disease is influenced by genetic and environmental factors. This study explores the potential neurodegenerative effects of lead (Pb) toxicity and amyloid beta peptides (Aβp 1–40 and Aβp 25–35) by promoting M1 polarization in microglial cells. To this end, we investigated and observed that IC50 concentrations of Pb (22.8 μM) and Aβp 25–35(29
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Impact of anesthesia‐related genes on prognosis and tumor microenvironment in hepatocellular carcinoma: A comprehensive analysis Environ. Toxicol. (IF 4.4) Pub Date : 2024-05-03 Xia Xu, Lihong Hu
Hepatocellular carcinoma (HCC), renowned for its bleak prognosis and high recurrence rates, necessitates innovative strategies for prognosis assessment and therapeutic intervention. In this pursuit, we systematically investigated the influence of anesthesia‐related genes (ANARGs) on HCC outcomes. Leveraging data from The Cancer Genome Atlas (TCGA), our study scrutinized RNA sequencing data and clinical
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A prognostic model for hepatocellular carcinoma patients based on polyunsaturated fatty acid‐related genes Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-29 Yun Lin, Ruihao Li, Tong Li, Wenrong Zhao, Qianling Ye, Chunyan Dong, Yong Gao
ObjectivePolyunsaturated fatty acids (PUFAs) have attracted increasing attention for their role in liver cancer development. The objective of this study is to develop a prognosis prediction model for patients with liver cancer based on PUFA‐related metabolic gene characteristics.MethodTranscriptome data and clinical data were obtained from public databases, while gene sets related to PUFAs were acquired
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Construction and evaluation of a metabolic correlation diagnostic model for diabetes based on machine learning algorithms Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-29 Qiong Xu, Yina Zhou, Jianfen Lou, Yanhua Fu, Yunzhu Lu, Mengli Xu
BackgroundDiabetes mellitus (DM) is a prevalent chronic disease marked by significant metabolic dysfunctions. Understanding its molecular mechanisms is vital for early diagnosis and treatment strategies.MethodsWe used datasets GSE7014, GSE25724, and GSE156248 from the GEO database to build a diagnostic model for DM using Random Forest (RF) and LASSO regression models. GSE20966 served as a validation
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Eosinophils and risk of ulcerative colitis in European population: Evidence from Mendelian randomization study Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-29 Yijia Shao, Cong Liu, Xiuqi Wang, Wei Zhou
BackgroundObservational studies have indicated that peripheral blood eosinophil count is elevated in individuals diagnosed with ulcerative colitis (UC) and correlates with the disease activity of UC. However, this conclusion contradicts with findings from other studies. Therefore, we employed Mendelian randomization (MR) method to assess the genetic link between eosinophil count and UC.MethodThis MR
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Gallic acid‐loaded chitosan nanoparticles enhance the DNA damage and apoptotic features through inhibiting flap endonuclease‐1 in triple‐negative breast cancer cells Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-26 Monica Velaiyan, Rajasekar Muthusamy, Miguel Kativa, Asaikkutti Annamalai, Annamalai Govindhan, Parthipan Punniyakotti, Agilan Balupillai
This study investigated the fabrication of gallic acid‐loaded chitosan nanoparticles (Gal‐Chi‐NPs) that enhanced the DNA damage and apoptotic features by inhibiting FEN‐1 expressions in MDA‐MB 231 cells. Gal‐Chi‐NPs were fabricated by the ionic gelation method, and it was characterized by several studies such as dynamic light spectroscopy, Fourier‐transforms infrared spectroscopy, x‐ray diffraction
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STUB1 promotes the degradation of HSPB1 and induces ferroptosis in lung cancer cells Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-25 Aishanjiang Tieliwaerdi, Abudu Aini, Mulatijiang Amuti, Yiliyaer Aierken, Maimaitijiang Nijiati, Bo Luo
Lung cancer is a common malignancy characterized by ferroptosis, an iron‐dependent form of cell death caused by excessive lipid peroxidation. The disruption of the ubiquitination system plays a crucial role in tumor development and spread. In recent years, there has been increasing interest in utilizing ferroptosis for lung cancer treatment; however, the precise mechanism of how ubiquitination modulates
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Ototoxicity among cisplatin, carboplatin, and oxaliplatin in zebrafish model Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-25 Kuan‐Hui Li, Yi‐Yu Zhao, Hsin‐Lin Cheng, Jiann‐Jou Yang, Chen‐Yu Chien
Platinum‐based antineoplastic drugs, including cisplatin, carboplatin, and oxaliplatin, are widely used in the treatment of various cancers. Ototoxicity is a common adverse effect of platinum‐based drugs. Ototoxicity leads to irreversible hearing impairment. We hypothesize that different platinum‐based drugs exhibit varying ototoxic concentrations, time effects, and ototoxic mechanisms. We tested this
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Erratum of “PLS3 promotes papillary thyroid carcinoma progression by activating the Notch signaling pathway” Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-25
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Tricetin suppresses the cell migration and BMP‐6 expression through p38 signaling pathways in human retinal pigment epithelium cells Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-24 Hsiang‐Wen Chien, Chih‐Chun Chuang, Yi‐Hsien Hsieh, Chia‐Yi Lee, Nuo‐Yi Yu, Shun‐Fa Yang
Proliferative vitreoretinopathy (PVR) is a visual‐threatening disease, which cause from the migration of retinal pigment epithelium (RPE). Tricetin, a family of flavonoids, can inhibit the metastasis of several cancers. Herein, we aim to evaluate the possible effect of tricetin on inhibiting ARPE‐19 cells migration. The Boyden chamber assay, wound healing assay, RNA sequencing, and Western blot analysis
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Luteolin, apigenin, and chrysin inhibit lipotoxicity–induced NLRP3 inflammasome activation and autophagy damage in macrophages by suppressing endoplasmic reticulum stress Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-24 Chia‐Wen Lo, Chong‐Kuei Lii, Kuan‐Shuan Lin, Chien‐Chun Li, Kai‐Li Liu, Ya‐Chen Yang, Haw‐Wen Chen
Lipotoxicity leads to numerous metabolic disorders such as nonalcoholic steatohepatitis. Luteolin, apigenin, and chrysin are three flavones with known antioxidant and anti‐inflammatory properties, but whether they inhibit lipotoxicity‐mediated NLRP3 inflammasome activation was unclear. To address this question, we used J774A.1 macrophages and Kupffer cells stimulated with 100 μM palmitate (PA) in the
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Betaine ameliorates doxorubicin‐induced cardiomyopathy by inhibiting oxidative stress, inflammation, and fibrosis through the modulation of AMPK/Nrf2/TGF‐β expression Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-23 Sumeet Kumar Singh, Poonam Yadav, Dhaneshvaree Patel, Sampat Singh Tanwar, Abhishek Sherawat, Amit Khurana, Jasvinder Singh Bhatti, Umashanker Navik
Doxorubicin (DOX) is a broad‐spectrum antibiotic with potent anti‐cancer activity. Nevertheless, despite having effective anti‐neoplasm activity, its use has been clinically restricted due to its life‐threatening side effects, such as cardiotoxicity. It is evident that betaine has anti‐oxidant, and anti‐inflammatory activity and has several beneficial effects, such as decreasing the amyloid‐β generation
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Cadmium aggravates liver injury by activating ferroptosis and neutrophil extracellular traps formation in Nile tilapia (Oreochromis niloticus) Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-22 Jingjing Wang, Yichun Chen, Xia Wang, Youpeng Sun, Mingzhen Jiang, Yingrong Ye, Hanpeng Wu, Yun Lu, Huabing Zhong, Yihe Wu, Ershun Zhou, Zhengtao Yang
Cadmium (Cd) is a pervasive environmental contaminant and a significant risk factor for liver injury. The present study was undertaken to evaluate the involvement of ferroptosis and neutrophil extracellular traps (NETs) in Cd‐induced liver injury in Nile tilapia (Oreochromis niloticus), and to explore its underlying mechanism. Cd‐induced liver injury was associated with increased total iron, malondialdehyde
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High expression of AlkB homolog 5 suppresses the progression of non‐small cell lung cancer by facilitating ferroptosis through m6A demethylation of SLC7A11 Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-20 Zhangzhou Huang, Gen Lin, Yaping Hong, Lihong Weng, Kai Zhu, Wu Zhuang
ObjectiveNon‐small cell lung cancer (NSCLC) is a prevailing LC characterized by poor outcomes. AlkB homolog 5 (ALKBH5) functions as a tumor suppressor in several cancers. This study delved into the role of ALKBH5 in NSCLC development.MethodsTCGA database predicted ALKBH5 expression in NSCLC patients. ALKBH5 levels in NSCLC and human bronchial epithelial cells were determined. pcDNA3.1‐ALKBH5/NC, pcDNA3
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Diallyl disulfide antagonizes DJ‐1 mediated proliferation, epithelial–mesenchymal transition, and chemoresistance in gastric cancer cells Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-20 Jian Su, Hong Xia, Hui He, Huan Tang, Juan Zhou, Yi Xun, Fang Liu, Bo Su, Qi Su
Diallyl disulfide (DADS), an organic component of allicin abstracted from garlic, possesses multi‐target antitumor activity. DJ‐1 performs a vital function in promoting AKT aberrant activation via down‐regulating phosphatase and tensin homologue (PTEN) in tumors. It is unknown the involvement of DJ‐1 in epithelial–mesenchymal transition (EMT) of gastric cancer (GC) cells. The purpose of this study
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Leptin receptor Gln223Arg and Lys109Arg polymorphisms may be associated with HBV‐related hepatocellular carcinoma risk: A system review and meta‐analysis Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-18 Xiaofeng Dong, Mengjie Zou, Chunxing Li, Honglin Luo, Shaoliang Zhu, Zheng Gong
Increasing evidence has suggested a strong association of hepatocellular carcinoma (HCC) susceptibility and Gln223Arg (rs1137101) and Lys109Arg (rs1137100) polymorphisms in leptin receptor (LEPR) genes. To provide a quantitative assessment for such correlation, we reviewed all related systems and conducted meta‐analysis for case and control researches. A literature search of Web of Science, EMBASE
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Critical role of endoplasmic reticulum stress on bisphenol A‐induced cytotoxicity in human keratinocyte HaCaT cells Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-17 Sou Hyun Kim, Dong Wan Kang, Doyoung Kwon, Young‐Suk Jung
Bisphenol A (BPA) is widely used in plastic and paper products, and its exposure can occur through skin contact or oral ingestion. The hazardous effects of BPA absorbed through the skin may be more severe; however, few studies have investigated the skin toxicity of BPA. This study investigated the effects of BPA on human epidermal keratinocyte cell lines, which is relevant for skin exposure. BPA treatment
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Deciphering the prognostic landscape of osteosarcoma: Integrating the roles of hippo pathway genes, programmed cell death, and the tumor immune microenvironment Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-16 Huayan Ma, Yuxian Zhang, Jing Li, Tiantian Xie, Zhi Zhao
Osteosarcoma is a highly aggressive cancer prevalent among adolescents and young adults, notorious for its tendency to metastasize to the lungs. This research delves into the molecular foundations of osteosarcoma by examining the role of the Hippo signaling pathway and its interaction with the tumor immune microenvironment (TME). Through analysis of transcriptomic data from the TARGET‐OS dataset and
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Single‐cell and bulk RNA‐sequencing reveal SPP1 and CXCL12 as cell‐to‐cell communication markers to predict prognosis in lung adenocarcinoma Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-16 Zengtuan Xiao, Zhe Nian, Mengzhe Zhang, Zuo Liu, Pengpeng Zhang, Zhenfa Zhang
Lung adenocarcinoma (LUAD) generally presents as an immunosuppressive microenvironment. The characteristics of cell‐to‐cell communication in the LUAD microenvironment has been unclear. In this study, the LUAD bulk RNA‐seq data and single‐cell RNA‐seq data were retrieved from public dataset. Differential expression genes (DEGs) between LUAD tumor and adjacent non‐tumor tissues were calculated by limma
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Teaghrelin protected dopaminergic neurons in MPTP‐induced Parkinson's disease animal model by promoting PINK1/Parkin‐mediated mitophagy and AMPK/SIRT1/PGC1‐α‐mediated mitochondrial biogenesis Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-16 Cian‐Fen Jhuo, Chun‐Jung Chen, Jason T.C. Tzen, Wen‐Ying Chen
Mitochondrial dysfunction, a common cellular hallmark in both familial and sporadic forms of Parkinson's disease (PD), is assumed to play a significant role in pathologic development and progression of the disease. Teaghrelin, a unique bioactive compound in some oolong tea varieties, has been demonstrated to protect SH‐SY5Y cells against 1‐methyl‐4‐phenylpyridinium induced neurotoxicity by binding
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Deciphering programmed cell death mechanisms in osteosarcoma for prognostic modeling Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-16 Jingyang Chen, Tengdi Fan, Lingxiao Pan, Hanshi Yang
Osteosarcoma (OS), known for its high recurrence and metastasis rates, poses a significant challenge in oncology. Our research investigates the role of programmed cell death (PCD) genes in OS and develops a prognostic model using advanced bioinformatics. We analyzed single‐cell sequencing data from the Gene Expression Omnibus (GEO) database to identify subpopulations, distinguish malignant from non‐malignant
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Comprehensive analysis of lung adenocarcinoma: Unveiling differential gene expression, survival‐linked genes, subtype stratification, and immune landscape implications Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-15 Yong Xi, Liu Xi, Jian Tan, Chaoqun Yu, Weiyu Shen, Bentong Yu
This study offers a detailed exploration of lung adenocarcinoma (LUAD), addressing its heterogeneity and treatment challenges through a multi‐faceted analysis that includes gene expression, genetic subtyping, pathway analysis, immune assessment, and drug sensitivity. It identifies 165 genes with significant expression differences and 46 genes associated with survival, revealing insights into oxidative
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Nephroprotective effects of coriander (Coriandrum sativum) leaves aqueous extracts in aristolochic acid‐intoxicated zebrafish embryos Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-13 Jen‐Ning Tsai, Yun‐Hsin Wang, Po‐Ju Lin, Chiung‐Fang Chang, Chiao‐Yin Sun, Yau‐Hung Chen
Coriander is a notable medicinal plant known for its diverse properties, including anti‐inflammatory, antioxidant, anticancer, analgesic, and anti‐diabetic effects. Despite its recognized health benefits, research on its nephroprotective properties is limited. This study aimed to investigate the potential nephroprotective properties of an aqueous extract derived from coriander leaves using an aristolochic
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Voacangine mitigates oxidative stress and neuroinflammation in middle cerebral artery occlusion‐induced cerebral ischemia/reperfusion injury by averting the NF‐κBp65/MAPK signaling pathways in rats Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-12 Bo Xu, Hua Wu, Wei Guo, Shaik Althaf Hussain, Tian Wang
Ischemic stroke is a leading cause of human mortality. Cerebral ischemia–reperfusion injury (CI/RI) is a primary cause of stroke. Ischemia–reperfusion (I/R) resulting in oxidative stress and inflammatory events may lead to severe neuronal impairments. Thus, anti‐oxidative and anti‐inflammatory mediators that can alleviate post‐I/R neuronal injuries are required for the treatment of CI/RI. An alkaloid
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Potato protein hydrolysate inhibits RANKL‐induced osteoclast development by inhibiting osteoclastogenic genes via the NF‐κB/MAPKs signaling pathways Environ. Toxicol. (IF 4.4) Pub Date : 2024-04-12 Yi‐Ju Chen, Yen‐Hua He, Yun‐Hsin Lo, Hong‐Siang Yang, Mosleh Mohammad Abomughaid, K. J. Senthil Kumar, Wan‐Teng Lin
In recent times, there has been growing attention towards exploring the nutritional and functional aspects of potato protein, along with its diverse applications. In the present study, we examined the anti‐osteoclast properties of potato protein hydrolysate (PP902) in vitro. Murine macrophages (RAW264.7) were differentiated into osteoclasts by receptor activator of nuclear factor‐κB ligand (RANKL)