Particulate matter with aerodynamic diameter ≤ 2.5 μm (PM2.5) at high concentrations in dental clinics poses significant health risks to healthcare professionals. However, the morphology and chemical composition of PM2.5 in specific environments are not yet fully elucidated. In this study, we investigated the concentration, morphology, chemical composition, and health assessment of PM2.5 collected

Cuproptosis is a newly identified form of cell death that relies on copper (Cu) ionophores to transport Cu into cancer cells. As a perennial herb, Patrinia scabiosaefolia Fisch (PS) has garnered significant attention owing to its analgesic, anti‐inflammatory, antibacterial, and antitumor properties. Previous research has shown that the extract from PS (DEPS) can inhibit the growth of leukemia cell

Glyphosate has been widely used in agricultural production as a highly effective, low‐toxic, broad‐spectrum organophosphorus herbicide. However, there has been controversy about whether it is toxic to the nervous system. In order to explore this issue in depth, the present study analyzed the molecular mechanism of action of glyphosate from four perspectives, namely, gene regulation, protein expression

Titanium dioxide nanoparticles (TiO2‐NPs) have been ever increasingly exposed to people through all possible routes, while studies focusing on their potential cardiovascular risks are relatively lacking, especially the underlying biological mechanisms that are not yet elucidated. In this study, the ferroptotic effect of TiO2‐NPs (30 nm) at environmentally relevant concentrations (0, 3, 12, and 48 μg/mL)

Although chlorpyrifos poses considerable risks to the environment and human health, it is still used in many countries. This pesticide has various toxic effects on humans, including neurotoxicity, reproductive toxicity, genotoxicity, and organ damage caused by oxidative stress and DNA damage. However, its specific toxicity to the immune system remains unclear. In this study, we explored the intrinsic

RETRACTION: T. Pu, Y. Jin, C. Tang, J. Fu, C. Zhang, B. Su, and A. Cao, “,” Environmental Toxicology 39, no. (2024): 1055–1071, https://doi.org/10.1002/tox.23969.The above article, published online on 11 September 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, Paul Tchounwou; and Wiley Periodicals LLC. Following

RETRACTION: S. Wang, X. Gu, D. Xu, B. Liu, K. Qin, and X. Yuan, “,” Environmental Toxicology 39, no. (2024): 2285–2303, https://doi.org/10.1002/tox.24110.The above article, published online on 26 December 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, Christyn Bailey; and Wiley Periodicals LLC. Following an investigation

RETRACTION: J. Li, S. Chen, J. Wu, X. Liu, H. Liu, Y. Liu, and Z. Zhu, “,” Environmental Toxicology 39, no. (2024): 751–767, https://doi.org/10.1002/tox.23974.The above article, published online on 26 September 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, Paul Tchounwou; and Wiley Periodicals LLC. Following an

Growing evidence suggests an association between various immune cell phenotypes and the development of asthma. However, it is still not entirely clear whether specific immune cell phenotypes might causally contribute to the risk of asthma. Despite further studies required to validate this claim, our study delves deeper into explaining this relationship and paving the way toward new therapeutic approaches

Colorectal cancer (CRC) has become one of the most arduous challenges in contemporary cancer treatment. In nanomedicine, biomedical methodologies and nanomaterials are combined to develop novel and effective treatments for illnesses, infections, and cancer. The characteristics of nanotechnology are promising for addressing the urgent problems of modern cancer therapeutics, such as tumor recurrence

RETRACTION: S. Li, Q. Guo, R. Guo, and H. Xu, “,” Environmental Toxicology 39, no. (2024): 669–679, https://doi.org/10.1002/tox.23939.The above article, published online on 24 August 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, Paul Tchounwou; and Wiley Periodicals LLC. Following an investigation by the publisher

RETRACTION: Q. Wu, C. Qu, L. Xin, F. Yang, and L. Xu, “,” Environmental Toxicology 39, no. (2024): 768–782, https://doi.org/10.1002/tox.23987.The above article, published online on 29 September 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, Paul Tchounwou; and Wiley Periodicals LLC. Following an investigation by

Parabens are chemicals used as preservatives in food, personal care products, and pharmaceuticals. Detectable paraben levels are found in water, air, and soil, making human and animal exposure unavoidable. This study evaluated the effects of methylparaben, propylparaben, and their mixture on the prostate and gonads of male and female gerbils. Gerbils aged 90 days were assigned to the groups: (M) 10

The exposome is considered an assessment of environmental exposure and associated biological responses over an individual's lifetime. Endocrine disruptors chemicals (EDCs), an important component of such exposures, exert adverse effects on human health. The kidneys are targets for EDCs because of their characteristic of bioaccumulation. Therefore, we aimed to evaluate cellular and tissue changes in

This research aimed to assess the potential of irigenin to attenuate blue light (BL)‐induced apoptosis in human adult retinal pigment epithelial (hARPE‐19) cells loaded with N‐retinylidene‐N‐retinylethanolamine (A2E, DA50062). Furthermore, the study investigated the associated molecular mechanisms. Cell viability was assessed using the MTT assay, and flow cytometry was employed to evaluate reactive

Female fertility has been demonstrated to be directly correlated with cadmium, a heavy metal contaminant that is widely present in the environment. N‐acetyl cysteine (NAC), a powerful antioxidant, has been shown to have therapeutic effects for a number of ailments. NAC's potential to prevent ovarian toxicity caused by Cd is still unknown. Therefore, the objective of the current study was to evaluate

The global rise in obesity is closely associated with the increasing prevalence of nonalcoholic fatty liver disease (NAFLD) and metabolic syndromes, posing significant health challenges. This study explored the ameliorative effects of Ophiocordyceps sinensis mycelia (TCM‐NA01 formula: 1.4 mg adenosine and 55.2 mg polysaccharide/capsule) on hepatosteatosis development in a high‐fat diet (HFD)‐fed mice

Microplastics (MPs) have emerged as novel environmental pollutant. Their ubiquity in natural environments and the global dissemination of plastic particles through food and drink have led to the oral ingestion of these particles by all kinds of living organism. In this investigation, male mice were subjected to exposure to 2 μm virgin PS‐MPs for 6 weeks. To accomplish this, 36 adult male NMRI mice

Benzo[a]pyrene (B[a]P) is a carcinogenic contaminant widely present in the environment. Recently, increasing studies have paid attention to the developmental neurotoxicity of B[a]P in offspring in their early life stages; however, the underlying molecular mechanisms have not been clearly elucidated. In this study, we aimed to evaluate the effects of prenatal B[a]P exposure on neurobehavior of pups

RETRACTION: C. Zhao, Y. Guo, Y. Chen, G. Shang, D. Song, J. Wang, J. Yang, and H. Zhang, “Zinc Finger Protein207 Orchestrates Glioma Migration Through Regulation of Epithelial‐Mesenchymal Transition,” Environmental Toxicology (EarlyView): https://doi.org/10.1002/tox.24271.The above article, published online on 9 April 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted

D‐tetramethrin is a common insecticide that is important for the control of mosquito‐transmitted diseases such as malaria and dengue and, due to its widespread use, it is frequently detected in environmental systems. However, there is currently very little information on the influence of D‐tetramethrin on non‐target organisms. In this study, zebrafish embryos were exposed to various concentrations

RETRACTON: H. Chen, S. Hou, H. Zhang, B. Zhou, H. Xi, X. Li, Z. Lufeng, and Q. Guo, “MiR‐375 Impairs Breast Cancer Cell Stemness by Targeting the KLF5/G6PD Signaling Axis,” Environmental Toxicology (EarlyView): https://doi.org/10.1002/tox.24204.The above article, published online on 12 March 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the

RETRACTION: Y. Ma and W. Zhu, “Development of Gene Panel for Predicting Recurrence in Early‐Stage Cervical Cancer Patients,” Environmental Toxicology (EarlyView): https://doi.org/10.1002/tox.24270.The above article, published online on 2 April 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, Christyn Bailey; and Wiley

RETRACTION: J. Lv, Z. Wang, and H. Liu, “Erianin Suppressed Lung Cancer Stemness and Chemotherapeutic Sensitivity via Triggering Ferroptosis,” Environmental Toxicology 39, no. 2 (2024): 479‐486, https://doi.org/10.1002/tox.23832.The above article, published online on 20 May 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief

RETRACTION: L. Daren, Y. Dan, W. Jinhong, and L. Chao, “NIK‐Mediated Reactivation of SIX2 Enhanced the CSC‐like Traits of Hepatocellular Carcinoma Cells Through Suppressing Ubiquitin–Proteasome System,” Environmental Toxicology 39, no. 2 (2024): 583‐591, https://doi.org/10.1002/tox.23892.The above article, published online on 17 July 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/),

RETRACTION: H. Song, J. Qiu, and K. Hua, “USP14 Promotes the Proliferation of Cervical Cancer via Upregulating β‐Catenin,” Environmental Toxicology 39, no. 2 (2024): 1031‐1043, https://doi.org/10.1002/tox.23990.The above article, published online on 9 December 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, Christyn

RETRACTION: J. Huang, H. Deng, S. Xiao, Y. Lin, Z. Yu, X. Xu, L. Peng, H. Chao, and T. Zeng, “CAB39 Modulates Epithelial–Mesenchymal Transition Through NF‐κB Signaling Activation, Enhancing Invasion, and Metastasis in Bladder Cancer,” Environmental Toxicology 39, no. 10 (2024): 4791‐4802, https://doi.org/10.1002/tox.24333.The above article, published online on 22 August 2024, in Wiley Online Library

RETRACTION: P. Xie, S.Y. Tan, H.F. Li, H.D. Tang, and J.H. Zhou, “Transcriptomic Landscape of Endothelial Cells: Key Tumor Microenvironment Components Indicating Variable Clinical Outcomes in Pancreatic Ductal Adenocarcinoma,” Environmental Toxicology 39, no. 2 (2024): 572‐582, https://doi.org/10.1002/tox.23881.The above article, published online on 14 July 2023, in Wiley Online Library (http://onlinelibrary

RETRACTION: X. Dong, M. Zou, C. Li, H. Luo, S. Zhu, and Z. Gong, “Leptin Receptor Gln223Arg and Lys109Arg Polymorphisms May Be Associated with HBV‐Related Hepatocellular Carcinoma Risk: A System Review and Meta‐Analysis,” Environmental Toxicology 39, no. 10 (2024): 4623‐4634, https://doi.org/10.1002/tox.24286.The above article, published online on 18 April 2024, in Wiley Online Library (http://onlinelibrary

Methylmercury (MeHg) is markedly toxic to humans. Our study explores whether MeHg and high‐fat diet (HFD) can impair the intestinal barrier with microbiota dysbiosis in mice. Weanling mice were fed to HFD or standard diet for 40 days. In the last 20 days of diets, mice received either MeHg (20 mg/L) or drinking water. Proximal small intestine, cecum, and hair samples were collected. Villus length,

Adolescence and pregnancy involve elevated levels of hormones (e.g., estrogen, androgen) during which exposure to endocrine disruptors could have long‐term developmental and reproductive toxicity (DART) effects. Therefore, the use prevalence and abuse liability of electronic nicotine delivery systems (ENDS) among adolescents and youth, and during pregnancy, raises concerns about possible exposure to

Carcinomatosis is one of the leading threats to human public fitness. HNF1B is a critical transcription element in vertebrate proliferation and oncogenesis, which has been shown to play roles in reactive oxygen species (ROS) metabolism. Our previous results have identified HNF1B as a tumor suppressor that could inhibit the malignant progression of prostate cancer. Yet there is no pan‐carcinomatosis

BackgroundCervical squamous cell carcinoma (CSCC) threatens the body health of women worldwide. This study aimed to foster a new concept of prognostic indicator named cell death index (CDI).MethodsRNA‐seq and scRNA‐seq datasets were downloaded from the GEO and TCGA database as the training and validation cohorts. Programmed cell death (PCD)‐related gene signatures were obtained from published research

Sepsis remains the leading cause of multiple‐organ injury due to endotoxemia. Astaxanthin (ASTA), widely used in marine aquaculture, has an extraordinary potential for antioxidant and anti‐inflammatory activity. Purinergic receptor (e.g., P2X7R) activation is a powerful signaling in the modulation of inflammation. The effect of ASTA was investigated on the regulation of oxidative stress, inflammatory

The cardiovascular risks linked to PM2.5 include calcification in both vasculature and myocardial tissues, leading to structural changes and functional decline. Through the selection of a clinically proven endogenous agent, sodium thiosulfate (STS), capable of addressing PM2.5 related cardiac abnormalities, we not only address the absence of effective solutions to mitigate PM2.5 toxicity, but also

The epithelial‐mesenchymal transition (EMT) assists in the acquisition of invasiveness, relapse, and resistance in non‐small cell lung cancer (NSCLC) and can be caused by the signaling of transforming growth factor‐β1 (TGF‐β1) through Smad‐mediated or Smad‐independent pathways. (−)‐Epigallocatechin‐3‐gallate (EGCG), a multifunctional cancer‐preventing bioconstituent found in tea polyphenols, has been

The presence of high levels of fluoride (F) in groundwater is a major issue worldwide. Although F is essential for healthy teeth and bones, excessive exposure can cause fluorosis or F toxicity. This condition primarily affects the hard tissues due to their high F retention capacity. F accumulation alters bone formation and resorption mechanisms interfering with mineral homeostasis and eventually manifests

RETRACTION: C. Yue, W. Lian, Z. Fan, H. Li, M. Duan, L. Qin, X. Cao, and J. Peng, “,” Environmental Toxicology 39, no. (2024): 915–926, https://doi.org/10.1002/tox.24017.The above article, published online on 15 November 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, Paul B. Tchounwou; and Wiley Periodicals LLC.

RETRACTION: Q. H. Tian, C. Tian, Y. Y. Lu, B. C. Yan, K. Zhang, and C. G. Wu, “,” Environmental Toxicology (EarlyView): https://doi.org/10.1002/tox.24166.The above article, published online on 23 February 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, Paul B. Tchounwou; and Wiley Periodicals LLC. Following an investigation

RETRACTION: J. Quan and C. Ma, “,” Environmental Toxicology 39, no. (2024): 783–793, https://doi.org/10.1002/tox.23976.The above article, published online on 2 October 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, Paul B. Tchounwou; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties

RETRACTION: L. Jie, W. Hengyue, and H. Ting, “,” Environmental Toxicology 39, no. (2024): 830–839, https://doi.org/10.1002/tox.23975The above article, published online on 4 October 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, Paul B. Tchounwou; and Wiley Periodicals LLC. Following an investigation by the publisher

Roundup is one of the most widely used glyphosate‐based harmful herbicides in the United States as well as globally, which poses a severe risk for terrestrial and aquatic organisms. In order to identify the detrimental effects of Roundup exposure in aquatic organisms, we investigated the environmentally relevant concentrations of Roundup exposure (low dose: 0.5 μg/L and high dose: 5.0 μg/L for 2 weeks)

RETRACTION: C. Yue, W. Lian, M. Duan, D. Xia, X. Cao, and J. Peng, “,” Environmental Toxicology 39, no. (2024): 1858–1873, https://doi.org/10.1002/tox.24051.The above article, published online on 22 December 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the authors; the journal Editor‐in‐Chief, Paul B. Tchounwou; and Wiley Periodicals LLC.

RETRACTION: Y. Wang, W. Han, Y. Zhong, W. Li, and Q. Liu, “,” Environmental Toxicology 39, no. (2024): 1769–1779, https://doi.org/10.1002/tox.24039.The above article, published online on 8 December 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, Paul B. Tchounwou; and Wiley Periodicals LLC. Following an investigation

RETRACTION: J. Zhang, S. He, and H. Ying, “,” Environmental Toxicology (EarlyView): https://doi.org/10.1002/tox.24222.The above article, published online on 13 March 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, Paul B. Tchounwou; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties

RETRACTION: X. Xudong, L. Heng, C. Benchao, C. Wenjie, L. Bao, and L. Gaofeng, “,” Environmental Toxicology 39, no. (2024): 2405–2416, https://doi.org/10.1002/tox.24105.The above article, published online on 4 January 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor‐in‐Chief, Paul B. Tchounwou; and Wiley Periodicals LLC. Following

The wide range of applications and the enormous production of nanomaterials have raised the possibility that humans may simultaneously contact with various nanomaterials through multiple routes. Although numerous toxicity studies have been conducted on the toxicity of nanomaterials, knowledge of the combined toxicity of nanomaterials remains limited. Herein, the combined toxic effects of the two types

Metal–organic frameworks (MOFs) have been gaining significant attention due to their potential application in medicine. Here, we investigated the effect of zeolite imidazole framework‐8 (ZIF‐8) on neuro‐behavioral parameters, histopathology, inflammation, and oxidative stress levels of rats' brain samples. Forty‐eight male Wistar rats were injected by four injections of saline or ZIF‐8 at different

The current study aimed to investigate the sub‐acute effects of oxamyl on male Albino rats following oral administration of either 0.031 or 0.31 mg/kg/day for 14 consecutive days. The findings demonstrated that oxamyl produced a significant impact on most of the examined blood profile and biomarkers, along with a significant progressive and discernible alterations in the histology of organs. According

AMP‐activated protein kinase (AMPK) is the master regulator of cellular energy which gets activated during energy stress and restores tissue homeostasis. AMPK is widely expressed in the pancreas and is involved in protein synthesis. In cerulein‐induced acute pancreatitis (AP), diminished AMPK activity in the pancreatic tissue may be associated with pancreatic inflammation and oxidative stress. Our

Obesity leads to a variety of health risks, and lead, which is ranked second in Agency for Toxic Substances and Disease Registry's priority list of harmful substances, may be more harmful to individuals that are obese. C57BL/6 mice were fed a normal diet or a high‐fat diet with or without exposure to 1 g/L lead exposure in drinking water for 8 consecutive weeks. Serum and hepatic biochemistry analysis

The roots of Coleus vettiveroides (CV) have been traditionally used in Indian medicinal systems such as Ayurveda and Siddha for its antioxidant, anti‐inflammatory, and antidiabetic effects. This study examines the antifibrotic potential of CV ethanolic root extract (CVERE) against thioacetamide (TAA)‐induced liver fibrosis in Wistar rats. TAA was administered via i.p., thrice weekly for 11 weeks to

Aluminum oxide nanoparticles (Al2O3 NPs) are widely utilized in vaccine manufacturing and other medical preparations. Melatonin has numerous effects as an antioxidant and anti‐apoptotic. The purpose of this study was to examine the beneficial impact of melatonin on Al2O3 NPs toxicity in the spinal cord. Forty male rats were divided into four groups: Group I, the negative controls (received standard