Exposure to pollutants like environmental cigarette smoke (CS) poses a major global health risk, affecting individuals from an early age. Therefore, this study explores how postnatal synbiotic supplementation affects allergic asthma symptoms in house-dust-mite (HDM)- challenged offspring maternally exposed to CS. In HDM-allergic offspring of CS-exposed dams, lung resistance was elevated, but synbiotic supplementation effectively reduced this resistance. Elevated eosinophil BALF counts following HDM challenge were intensified in pups maternally exposed to CS. Similarly, Th2 cell activation and serum IgE and IgG1 levels were more pronounced in HDM-allergic offspring of CS-exposed mothers. Synbiotics reduced eosinophil numbers and serum IgE and IgG1, and tended to decrease Th2 cell infiltration and activation. Synbiotics promoted beneficial gut bacteria like Bifidobacterium and Akkermansia. In conclusion, early-life synbiotic intervention mitigated allergic asthma associated with maternal air pollution exposure, highlighting the potential of synbiotics for clinical evaluation as a strategy to prevent allergy development in offspring.

中文翻译：

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Synbiotics，一种很有前途的方法，可以缓解临床前小鼠污染模型后代加剧的过敏性气道免疫反应


接触环境香烟烟雾 （CS） 等污染物会带来重大的全球健康风险，从小就影响个人。因此，本研究探讨了产后合生元补充剂如何影响母体暴露于 CS 的屋尘螨 （HDM） 攻击后代的过敏性哮喘症状。在 CS 暴露母猪的 HDM 过敏后代中，肺阻力升高，但补充合生元有效降低了这种阻力。HDM 攻击后嗜酸性粒细胞 BALF 计数升高在母体暴露于 CS 的幼崽中增强。同样，在 CS 暴露母亲的 HDM 过敏后代中，Th2 细胞活化和血清 IgE 和 IgG1 水平更为明显。合生元降低了嗜酸性粒细胞的数量和血清 IgE 和 IgG1，并倾向于减少 Th2 细胞的浸润和活化。Synbiotics 促进了有益的肠道细菌，如双歧杆菌和阿克曼氏菌。总之，早期合生元干预减轻了与孕产妇空气污染暴露相关的过敏性哮喘，突出了合生元作为预防后代过敏发展的策略进行临床评估的潜力。