The structure of the zebrafish retina appears to be very similar to that of mammals, that is why it is used as a model for studying the eye. Indeed, the zebrafish retina can regenerate itself through mechanisms of Müller cell reprogramming. In this research, adult zebrafish were exposed to aluminum to cause damage in the retina and thus evaluate the regenerative capacity of the damaged tissue. Histological and histochemical analyses assessed the retinal structure and the neurodegenerative process, respectively. An expression analysis of PARPs was carried out to verify whether a potential oxidative DNA damage happens. In addition, some genes involved in the regeneration process (pax6a, pax2a, ngn1, and notch1a) were analyzed. The data confirmed the toxicity of aluminum which caused retinal neurodegeneration, but also highlighted the ability of zebrafish to regenerate the retinal structure, repairing the damage and confirming its use as a good model for translational studies.

中文翻译：

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中毒性损伤后斑马鱼视网膜再生


斑马鱼视网膜的结构似乎与哺乳动物非常相似，这就是为什么它被用作研究眼睛的模型。事实上，斑马鱼视网膜可以通过 Müller 细胞重编程机制进行自我再生。在这项研究中，成年斑马鱼暴露于铝中以对视网膜造成损伤，从而评估受损组织的再生能力。组织学和组织化学分析分别评估了视网膜结构和神经退行性过程。对 PARPs 进行表达分析，以验证是否发生潜在的氧化 DNA 损伤。此外，还分析了一些参与再生过程的基因 （pax6a 、 pax2a 、 ngn1 和 notch1a）。数据证实了铝的毒性导致视网膜神经变性，但也强调了斑马鱼再生视网膜结构的能力，修复损伤并证实其作为转化研究的良好模型。