Thiacloprid, a hazardous neonicotinoid insecticide, prevalent in daily agricultural practices, raises concerns due to the harmful effects of its residues on food items, and on unintended organisms poses a significant threat to human health. Introduced in 1990, Thiacloprid have gained popularity for its perceived effectiveness and reduced risks to non-target animals. However, emerging research in recent years reports significant toxic effects of Thiacloprid on non-target species, spanning neurotoxicity, immunotoxicity, hepatotoxicity, nephrotoxicity, and reproductive issues. Mammalian studies, particularly involving rodents, reveal cognitive impairment, hippocampal damage, and hepatic abnormalities upon Thiacloprid exposure. Reproductive toxicity and DNA damage are imminent concerns, disrupting gestational epigenetic reprogramming and suggesting persistent effects on future generations. Genotoxic effects, Embryotoxic, and observed reproductive toxicity accentuate the need for caution in the utilization of Thiacloprid. This review highlights reported toxic effects produced by Thiacloprid in recent years, challenging the initial belief in its lower toxicity for vertebrates.

中文翻译：

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对农药残留噻虫啉诱导毒性的基于证据的综合审查：揭示对人类健康的危害


噻虫啉是一种危险的新烟碱类杀虫剂，在日常农业实践中普遍存在，因其残留物对食品和非预期生物体的有害影响而引起人们的关注，对人类健康构成重大威胁。噻虫啉于 1990 年推出，因其有效性和降低非目标动物风险而广受欢迎。然而，近年来的新兴研究报告了噻虫啉对非目标物种的显着毒性作用，包括神经毒性、免疫毒性、肝毒性、肾毒性和生殖问题。哺乳动物研究，特别是涉及啮齿动物的研究表明，接触噻虫啉后会出现认知障碍、海马损伤和肝脏异常。生殖毒性和 DNA 损伤是迫在眉睫的问题，它们会破坏妊娠表观遗传重编程，并对后代产生持续影响。基因毒性作用、胚胎毒性和观察到的生殖毒性强调了使用噻虫啉时需谨慎的必要性。本综述重点介绍了近年来报告的噻虫啉产生的毒性作用，挑战了其对脊椎动物毒性较低的最初信念。