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Organophosphate Ester Flame Retardants and Plasticizers in Relation to Fetal Growth in the LIFECODES Fetal Growth Study. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-07-05 Paige A Bommarito,Danielle R Stevens,Barrett M Welch,Maria Ospina,Antonia M Calafat,John D Meeker,David E Cantonwine,Thomas F McElrath,Kelly K Ferguson
BACKGROUND Organophosphate esters (OPEs), used ubiquitously as flame retardants and plasticizers in consumer products, are suspected of having developmental toxicity. OBJECTIVES Our study aimed to estimate associations between prenatal exposure to OPEs and fetal growth, including both ultrasound (head circumference, abdominal circumference, femur length, and estimated fetal weight) and delivery [birth
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Combined Exposures and Mixtures Research: An Enduring NIEHS Priority. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-07-05 Danielle J Carlin,Cynthia V Rider
BACKGROUND The National Institute of Environmental Health Sciences (NIEHS) continues to prioritize research to better understand the health effects resulting from exposure to mixtures of chemical and nonchemical stressors. Mixtures research activities over the last decade were informed by expert input during the development and deliberations of the 2011 NIEHS Workshop "Advancing Research on Mixtures:
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The Role of Biodiversity in the Development of Asthma and Allergic Sensitization: A State-of-the-Science Review. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-06-27 Inês Paciência,Needhi Sharma,Timo T Hugg,Aino K Rantala,Behzad Heibati,Wael K Al-Delaimy,Maritta S Jaakkola,Jouni J K Jaakkola
BACKGROUND Changes in land use and climate change have been reported to reduce biodiversity of both the environment and human microbiota. These reductions in biodiversity may lead to inadequate and unbalanced stimulation of immunoregulatory circuits and, ultimately, to clinical diseases, such as asthma and allergies. OBJECTIVE We summarized available empirical evidence on the role of inner (gut, skin
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Association of Gaseous Ambient Air Pollution and Dementia-Related Neuroimaging Markers in the ARIC Cohort, Comparing Exposure Estimation Methods and Confounding by Study Site. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-06-26 Katie M Lynch,Erin E Bennett,Qi Ying,Eun Sug Park,Xiaohui Xu,Richard L Smith,James D Stewart,Duanping Liao,Joel D Kaufman,Eric A Whitsel,Melinda C Power
BACKGROUND Evidence linking gaseous air pollution to late-life brain health is mixed. OBJECTIVE We explored associations between exposure to gaseous pollutants and brain magnetic resonance imaging (MRI) markers among Atherosclerosis Risk in Communities (ARIC) Study participants, with attention to the influence of exposure estimation method and confounding by site. METHODS We considered data from 1
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Microplastics and Metabolism: Physiological Responses in Mice Following Ingestion. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-06-26 Wendee Nicole
Mice exposed orally to microspheres showed changes in lipid and other metabolic pathways, and the particles were detected in tissues throughout the body. Changes were greater after exposure to mixed microplastics compared with polystyrene alone.
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PERHLs of Wisdom: Environmental Reproductive Health Literacy and Phthalates. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-06-25 Wendee Nicole
Most tools that measure environmental health literacy are broad in nature. Researchers have now developed a tool specific to phthalate awareness and behaviors as they relate to reproductive health.
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Prolonged Cadmium Exposure and Osteoclastogenesis: A Mechanistic Mouse and in Vitro Study. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-06-19 Zhiyuan Liu,Jinzhi Wu,Zhe Dong,Yanshuai Wang,Gang Wang,Chengjie Chen,Huihui Wang,Yang Yang,Yongxin Sun,Maowei Yang,Jingqi Fu,Jiliang Li,Qiang Zhang,Yuanyuan Xu,Jingbo Pi
BACKGROUND Cadmium (Cd) is a highly toxic and widespread environmental oxidative stressor that causes a myriad of health problems, including osteoporosis and bone damage. Although nuclear factor erythroid 2-related factor 2 (NRF2) and its Cap 'n' Collar and basic region Leucine Zipper (CNC-bZIP) family member nuclear factor erythroid 2-related factor 1 (NRF1) coordinate various stress responses by
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Invited Perspective: New Insight into Cadmium-Related Osteoporosis Yields Hope for Prevention and Therapy. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-06-19 Lu Cai
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Association of Domestic Water Hardness with All-Cause and Cause-Specific Cancers: Evidence from 447,996 UK Biobank Participants. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-06-18 Hongxi Yang,Qi Wang,Shuquan Zhang,Jingyu Zhang,Yuan Zhang,Jiangtao Feng
BACKGROUND Accumulating evidence suggests that domestic water hardness is linked to health outcomes, but its association to all-cause and cause-specific cancers warrants investigation. OBJECTIVE The aim of this study was to investigate the association of domestic hard water with all-cause and cause-specific cancers. METHODS In the prospective cohort study, a total of 447,996 participants from UK Biobank
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Exposome-Wide Association Study of Body Mass Index Using a Novel Meta-Analytical Approach for Random Forest Models. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-06-18 Haykanush Ohanyan,Mark van de Wiel,Lützen Portengen,Alfred Wagtendonk,Nicolette R den Braver,Trynke R de Jong,Monique Verschuren,Katja van den Hurk,Karien Stronks,Eric Moll van Charante,Natasja M van Schoor,Coen D A Stehouwer,Anke Wesselius,Annemarie Koster,Margreet Ten Have,Brenda W J H Penninx,Marieke F van Wier,Irina Motoc,Albertine J Oldehinkel,Gonneke Willemsen,Dorret I Boomsma,Mariëlle A Beenackers
BACKGROUND Overweight and obesity impose a considerable individual and social burden, and the urban environments might encompass factors that contribute to obesity. Nevertheless, there is a scarcity of research that takes into account the simultaneous interaction of multiple environmental factors. OBJECTIVES Our objective was to perform an exposome-wide association study of body mass index (BMI) in
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Greenness and Hospitalization for Cardiorespiratory Diseases in Brazil. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-06-18 Reizane Maria Damasceno da Silva,Mariana Andreotti Dias,Vitória Rodrigues Ferreira Barbosa,Francisco Jablinski Castelhano,Peter James,Weeberb J Requia
BACKGROUND The potential health benefits of exposure to vegetation, or greenness, are well documented, but there are few nationwide studies in Brazil, a country facing challenges related to land-use planning, deforestation, and environmental health risks. OBJECTIVES In this study, we investigated the association between greenness and hospitalizations for cardiorespiratory diseases in Brazil. METHODS
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Development and Validation of a Novel Placental DNA Methylation Biomarker of Maternal Smoking during Pregnancy in the ECHO Program. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-06-17 Lyndsey E Shorey-Kendrick,Brett Davis,Lina Gao,Byung Park,Annette Vu,Cynthia D Morris,Carrie V Breton,Rebecca Fry,Erika Garcia,Rebecca J Schmidt,T Michael O'Shea,Robert S Tepper,Cindy T McEvoy,Eliot R Spindel,
BACKGROUND Maternal cigarette smoking during pregnancy (MSDP) is associated with numerous adverse health outcomes in infants and children with potential lifelong consequences. Negative effects of MSDP on placental DNA methylation (DNAm), placental structure, and function are well established. OBJECTIVE Our aim was to develop biomarkers of MSDP using DNAm measured in placentas (N=96), collected as part
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Association of Residential Greenness Exposure with Depression Incidence in Adults 50 Years of Age and Older: Findings from the Cohort Study on Global AGEing and Adult Health (SAGE) in China. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-06-17 Zhiqing Chen,Fan Wu,Yan Shi,Yanfei Guo,Jiahong Xu,Shuru Liang,Zhongguo Huang,Guanhao He,Jianxiong Hu,Qijiong Zhu,Siwen Yu,Shangfeng Yang,Cuiling Wu,Weiling Tang,Xiaomei Dong,Wenjun Ma,Tao Liu
BACKGROUND Depression is a social and public health problem of great concern globally. Identifying and managing the factors influencing depression are crucial for preventing and decreasing the burden of depression. OBJECTIVES Our objectives are to explore the association between residential greenness and the incidence of depression in an older Chinese population and to calculate the disease burden
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Response to "Comment on 'Determinants of PFOA Serum Half-Life after End of Exposure: A Longitudinal Study on Highly Exposed Subjects in the Veneto Region'". Environ. Health Perspect. (IF 10.1) Pub Date : 2024-06-14 Erich Batzella,Gisella Pitter,Cristina Canova,Tony Fletcher
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Effects of Developmental Lead and Phthalate Exposures on DNA Methylation in Adult Mouse Blood, Brain, and Liver: A Focus on Genomic Imprinting by Tissue and Sex. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-06-04 Rachel K Morgan,Kai Wang,Laurie K Svoboda,Christine A Rygiel,Claudia Lalancette,Raymond Cavalcante,Marisa S Bartolomei,Rexxi Prasasya,Kari Neier,Bambarendage P U Perera,Tamara R Jones,Justin A Colacino,Maureen A Sartor,Dana C Dolinoy
BACKGROUND Maternal exposure to environmental chemicals can cause adverse health effects in offspring. Mounting evidence supports that these effects are influenced, at least in part, by epigenetic modifications. It is unknown whether epigenetic changes in surrogate tissues such as the blood are reflective of similar changes in target tissues such as cortex or liver. OBJECTIVE We examined tissue- and
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Synergy under the Sun? Nanoplastics Enhance Estrogenicity of Common UV-Blocker. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-06-04 Charles Schmidt
Human cells and zebrafish coexposed to nanoplastics and the sunscreen ingredient homosalate showed more plastics in tissues, estrogenic activity, and relevant gene expression changes than they showed after either exposure alone.
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The Joint Effects of Thunderstorms and Power Outages on Respiratory-Related Emergency Visits and Modifying and Mediating Factors of This Relationship. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-06-03 Shao Lin,Quan Qi,Han Liu,Xinlei Deng,Ian Trees,Xiaojun Yuan,Mary P Gallant
BACKGROUND While limited studies have evaluated the health impacts of thunderstorms and power outages (POs) separately, few have assessed their joint effects. We aimed to investigate the individual and joint effects of both thunderstorms and POs on respiratory diseases, to identify disparities by demographics, and to examine the modifications and mediations by meteorological factors and air pollution
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Association of Psychiatric Emergency Visits and Warm Ambient Temperature during Pregnancy: A Time-Stratified Case-Crossover Study. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-06-03 Jennifer D Runkle,Margaret M Sugg,Anne Berry,Charlie Reed,Kristen Cowan,Luke Wertis,Sophie Ryan
BACKGROUND Acute exposure to high ambient temperature and heat waves during the warm season has been linked with psychiatric disorders. Emerging research has shown that pregnant people, due to physiological and psychological changes, may be more sensitive to extreme heat, and acute exposure has been linked to increased risk of pregnancy complications; however, few studies have examined psychiatric
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Nanosized Additives: Silicon Dioxide's Potential Role in Development of Food Sensitivities in Mice. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-05-30 Silke Schmidt
The anticaking agent, used in a wide variety of powdered food products, interfered with immune tolerance of ovalbumin, a model antigen; and it worsened gut inflammation in a mouse model of celiac disease.
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Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-05-23 Danielle E McBride,Amit Bhattacharya,Heidi Sucharew,Kelly J Brunst,Mary Barnas,Cyndy Cox,Lorenna Altman,Timothy J Hilbert,Jeff Burkle,Susan Westneat,Kaitlin Vollet Martin,Patrick J Parsons,Meredith L Praamsma,Christopher D Palmer,Kurunthachalam Kannan,Donald R Smith,Robert Wright,Chitra Amarasiriwardena,Kim N Dietrich,Kim M Cecil,Erin N Haynes
BACKGROUND Manganese (Mn) plays a significant role in both human health and global industries. Epidemiological studies of exposed populations demonstrate a dose-dependent association between Mn and neuromotor effects ranging from subclinical effects to a clinically defined syndrome. However, little is known about the relationship between early life Mn biomarkers and adolescent postural balance. OBJECTIVES
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Heat Exposure and Cause-Specific Hospital Admissions in Spain: A Nationwide Cross-Sectional Study. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-05-22 Hicham Achebak,Grégoire Rey,Zhao-Yue Chen,Simon J Lloyd,Marcos Quijal-Zamorano,Raúl Fernando Méndez-Turrubiates,Joan Ballester
BACKGROUND More frequent and intense exposure to extreme heat conditions poses a serious threat to public health. However, evidence on the association between heat and specific diagnoses of morbidity is still limited. We aimed to comprehensively assess the short-term association between cause-specific hospital admissions and high temperature, including the added effect of temperature variability and
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Invited Perspective: Toward Resilience-Community-Based Approaches to Managing Combined Sewer Overflows in a Changing Climate. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-05-22 Jan C Semenza
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Single Cell Analysis of Human Colonoids Exposed to Uranium-Bearing Dust. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-05-21 Roger Atanga,Lidia L Appell,Myranda N Thompson,Fredine T Lauer,Adrian Brearley,Matthew J Campen,Eliseo F Castillo,Julie G In
BACKGROUND Uranium exposure remains an important environmental legacy and physiological health concern, with hundreds of abandoned uranium mines located in the Southwestern United States largely impacting underserved indigenous communities. The negative effects of heavy metals on barrier permeability and inhibition of intestinal epithelial healing have been described; however, transcriptomic changes
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Bridging Differences in Cohort Analyses of the Relationship between Secondhand Smoke Exposure during Pregnancy and Birth Weight: The Transportability Framework in the ECHO Program. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-05-21 Andreas M Neophytou,Jenny Aalborg,Sheryl Magzamen,Brianna F Moore,Assiamira Ferrara,Margaret R Karagas,Leonardo Trasande,Dana Dabelea
BACKGROUND Estimates for the effects of environmental exposures on health outcomes, including secondhand smoke (SHS) exposure, often present considerable variability across studies. Knowledge of the reasons behind these differences can aid our understanding of effects in specific populations as well as inform practices of combining data from multiple studies. OBJECTIVES This study aimed to assess the
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A Class Act? Regulating Organohalogen Flame Retardants in Groups versus Singly. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-05-17 Nate Seltenrich
Regulating chemicals by class based on chemical similarities may help reduce risk of regrettable substitutions while enhancing health protection. A new Commentary summarizes OFR toxicity and exposure research to inform this effort.
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Comparing Data from Three Satellites on Artificial Light at Night (ALAN): Focusing on Blue Light's Influence on Colorectal Cancer in a Case-Control Study in Spain. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-05-17 Barbara N Harding,Anna Palomar-Cros,Antonia Valentín,Ana Espinosa,Alejandro Sánchez de Miguel,Gemma Castaño-Vinyals,Marina Pollán,Beatriz Perez,Victor Moreno,Manolis Kogevinas
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Data-Driven Characterization of Genetic Variability in Disease Pathways and Pesticide-Induced Nervous System Disease in the United States Population. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-05-16 Marissa B Kosnik,Philipp Antczak,Peter Fantke
BACKGROUND Genetic susceptibility to chemicals is incompletely characterized. However, nervous system disease development following pesticide exposure can vary in a population, implying some individuals may have higher genetic susceptibility to pesticide-induced nervous system disease. OBJECTIVES We aimed to build a computational approach to characterize single-nucleotide polymorphisms (SNPs) implicated
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Quantification of the Heat-Related Risk and Burden of Hospitalizations for Cause-Specific Injuries and Contribution of Human-Induced Climate Change: A Time-Stratified Case-Crossover Study in China. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-05-16 Lu Zhou,Cong Liu,Cheng He,Jian Lei,Yixiang Zhu,Ya Gao,Jianwei Xuan,Haidong Kan,Renjie Chen
BACKGROUND Although ambient temperature has been linked with injury incidence, there have been few nationwide studies to quantify the temperature-related risk and burden of cause-specific injury hospitalizations. Additionally, the impact of human-induced climate change to injury burden remains unknown. OBJECTIVES Our objectives are to examine the associations between ambient temperature and injury
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Reducing Transmission of Airborne Respiratory Pathogens: A New Beginning as the COVID-19 Emergency Ends. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-05-10 Linsey C Marr,Jonathan M Samet
BACKGROUND In response to the COVID-19 pandemic, new evidence-based strategies have emerged for reducing transmission of respiratory infections through management of indoor air. OBJECTIVES This paper reviews critical advances that could reduce the burden of disease from inhaled pathogens and describes challenges in their implementation. DISCUSSION Proven strategies include assuring sufficient ventilation
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Applications of Quantitative Microbial Risk Assessment to Respiratory Pathogens and Implications for Uptake in Policy: A State-of-the-Science Review. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-05-10 Lizhan Tang,William J Rhoads,Antonia Eichelberg,Kerry A Hamilton,Timothy R Julian
BACKGROUND Respiratory tract infections are major contributors to the global disease burden. Quantitative microbial risk assessment (QMRA) holds potential as a rapidly deployable framework to understand respiratory pathogen transmission and inform policy on infection control. OBJECTIVES The goal of this paper was to evaluate, motivate, and inform further development of the use of QMRA as a rapid tool
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Fetal and Infancy Exposure to Phenols, Parabens, and Phthalates and Anthropometric Measurements up to 36 Months, in the Longitudinal SEPAGES Cohort. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-05-10 Marion Ouidir,Aminata H Cissé,Jérémie Botton,Sarah Lyon-Caen,Cathrine Thomsen,Amrit K Sakhi,Azemira Sabaredzovic,Sam Bayat,Rémy Slama,Barbara Heude,Claire Philippat
BACKGROUND Endocrine-disrupting chemicals may play a role in adiposity development during childhood. Until now literature in this scope suffers from methodologic limitations in exposure assessment using one or few urine samples and missing assessment during the infancy period. OBJECTIVES We investigated the associations between early-life exposure to quickly metabolized chemicals and post-natal growth
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A Matter of Climate Justice: Heat and Air Pollution Combine to Worsen Effects of Homelessness. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-05-08 Kelley Christensen
Few studies on these concurrent health risks account for individuals without housing, yet they often experience greater exposure than other people-along with exacerbation of existing health issues.
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Development of an Automated Morphometric Approach to Assess Vascular Outcomes following Exposure to Environmental Chemicals in Zebrafish. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-05-03 Xiali Zhong,Junzhou Chen,Zhuyi Zhang,Qicheng Zhu,Di Ji,Weijian Ke,Congying Niu,Can Wang,Nan Zhao,Wenquan Chen,Kunkun Jia,Qian Liu,Maoyong Song,Chunqiao Liu,Yanhong Wei
BACKGROUND Disruptions in vascular formation attributable to chemical insults is a pivotal risk factor or potential etiology of developmental defects and various disease settings. Among the thousands of chemicals threatening human health, the highly concerning groups prevalent in the environment and detected in biological monitoring in the general population ought to be prioritized because of their
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Concentration-Response Functions Relating Concentration and Duration of Ambient Traffic-Related Air Pollution Exposure to Systolic Blood Pressure. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-05-03 Misha Eliasziw,Neelakshi Hudda,John L Durant,Wig Zamore,Doug Brugge
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A Delicate Balance: Water Disinfection and By-Product Immunotoxicity. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-30 Carrie Arnold
Mouse macrophages and human blood cells exposed to very high levels of three trihalophenols showed changes in RNA methylation, pointing to one mechanism by which disinfection by-products may harm health, even as disinfection protects it in other ways.
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Characterizing Important Dietary Exposure Sources of Perfluoroalkyl Acids in Inuit Youth and Adults in Nunavik Using a Feature Selection Tool. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-29 Amira Aker,Vy Nguyen,Pierre Ayotte,Sylvie Ricard,Mélanie Lemire
BACKGROUND Previous studies have identified the consumption of country foods (hunted/harvested foods from the land) as the primary exposure source of perfluoroalkyl acids (PFAA) in Arctic communities. However, identifying the specific foods associated with PFAA exposures is complicated due to correlation between country foods that are commonly consumed together. METHODS We used venous blood sample
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Tibial Lead Levels and Erythropoiesis Stimulating Agent Dosing among 75 Patients with End-Stage Kidney Disease. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-29 Voravech Nissaisorakarn,Aaron Specht,John Danziger
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A Hazard-Based Framework for Identifying Safer Alternatives to Classes of Chemicals: A Case Study on Phthalates in Consumer Products. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-29 Marissa N Smith,Sascha Stump,Saskia K van Bergen,Holly G Davies,Elinor Fanning,Rae Eaton,Craig C Manahan,Amber Sergent,Ken Zarker
BACKGROUND Humans are exposed to hazardous chemicals found in consumer products. In 2019, the Pollution Prevention for Healthy People and Puget Sound Act was passed in Washington State. This law is meant to reduce hazardous chemicals in consumer products and protect human health and the environment. The law directs the Washington State Department of Ecology to assess chemicals and chemical classes
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Development of a Phthalate Environmental Reproductive Health Literacy (PERHL) Scale. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-26 Kathryn S Tomsho,Marlee R Quinn,Gary Adamkiewicz,Tamarra James-Todd
BACKGROUND Substantial evidence exists linking phthalate exposure to adverse reproductive health outcomes. Current US federal regulations of consumer product chemicals place the onus on individuals to mitigate their exposure to phthalates, with assumptions of sufficient environmental health literacy (EHL). Few validated scales for people of reproductive age exist to evaluate phthalate-specific EHL
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Exposure to Concurrent Heatwaves and Ozone Pollution and Associations with Mortality Risk: A Nationwide Study in China. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-25 Hang Du,Meilin Yan,Xin Liu,Yu Zhong,Jie Ban,Kailai Lu,Tiantian Li
BACKGROUND Concurrent extreme events are projected to occur more frequently under a changing climate. Understanding the mortality risk and burden of the concurrent heatwaves and ozone (O3) pollution may support the formulation of adaptation strategies and early warning systems for concurrent events in the context of climate change. OBJECTIVES We aimed to estimate the mortality risk and excess deaths
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Invited Perspective: Per- and Polyfluoroalkyl Substances in Drinking Water-Disparities in Community Exposures Based on Race and Socioeconomic Status. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-24 Kelly L Smalling,Paul M Bradley
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Quantifying Disparities in Per- and Polyfluoroalkyl Substances (PFAS) Levels in Drinking Water from Overburdened Communities in New Jersey, 2019-2021. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-24 Rosie Mueller,Derrick Salvatore,Phil Brown,Alissa Cordner
BACKGROUND Policymakers have become increasingly concerned regarding the widespread exposure and toxicity of per- and polyfluoroalkyl substances (PFAS). While concerns exist about unequal distribution of PFAS contamination in drinking water, research is lacking. OBJECTIVES We assess the scope of PFAS contamination in drinking water in New Jersey (NJ), the first US state to develop regulatory levels
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Suspect-Screening Analysis of Environmental Chemicals in Paired Human Cerebrospinal Fluid and Serum Samples. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-24 Long Zhang,Pan Yang,Yaqing Shu,Wei Huang,Wenwen Sun,Xiaotu Liu,Da Chen
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Wake-up Call: Rapid Increase in Human Fungal Diseases under Climate Change. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-22 Lindsey Konkel Neabore
Rising temperatures and extreme weather are setting the stage for increases in fungal diseases. As new pathogenic fungi emerge and known threats spread and evolve, scientists and decision makers are responding.
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The Associations of Prenatal Exposure to Fine Particulate Matter and Its Chemical Components with Allergic Rhinitis in Children and the Modification Effect of Polyunsaturated Fatty Acids: A Birth Cohort Study. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-17 Yujing Chen,Cuihua Guo,Ming Kei Chung,Quanying Yi,Xin Wang,Yuxuan Wang,Bibo Jiang,Yu Liu,Minyan Lan,Lizi Lin,Li Cai
BACKGROUND Polyunsaturated fatty acids (PUFAs) have been shown to protect against fine particulate matter <2.5μm in aerodynamic diameter (PM2.5)-induced hazards. However, limited evidence is available for respiratory health, particularly in pregnant women and their offspring. OBJECTIVES We aimed to investigate the association of prenatal exposure to PM2.5 and its chemical components with allergic rhinitis
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Evaluation of Lipids and Lipid-Related Transcripts in Human and Ovine Theca Cells and an in Vitro Mouse Model Exposed to the Obesogen Chemical Tributyltin. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-17 Natalia Pascuali,Yong Pu,Anita A Waye,Sarah Pearl,Denny Martin,Allison Sutton,Ariella Shikanov,Almudena Veiga-Lopez
BACKGROUND Exposure to obesogenic chemicals has been reported to result in enhanced adipogenesis, higher adipose tissue accumulation, and reduced ovarian hormonal synthesis and follicular function. We have reported that organotins [tributyltin (TBT) and triphenyltin (TPT)] dysregulate cholesterol trafficking in ovarian theca cells, but, whether organotins also exert lipogenic effects on ovarian cells
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Estimating Intervention Impact: Racial Disparities in Phthalate Exposure and Preterm Birth. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-17 Cynthia Washam
Pooling data from 16 studies, researchers estimated that, among Black and Hispanic/Latina participants, reducing disparities in phthalate exposure during pregnancy might also reduce preterm birth rates.
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Associations of Serum Perfluoroalkyl Substances and Placental Human Chorionic Gonadotropin in Early Pregnancy, Measured in the UPSIDE Study in Rochester, New York. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-16 Hai-Wei Liang,Hannu Koistinen,Emily S Barrett,Xiaoshuang Xun,Qing Yin,Kurunthachalam Kannan,Nora K Moog,Carla Ng,Thomas G O'Connor,Rich Miller,Jennifer J Adibi
BACKGROUND Per- and polyfluoroalkyl substances (PFAS) are widely detected in pregnant women and associated with adverse outcomes related to impaired placental function. Human chorionic gonadotropin (hCG) is a dimeric glycoprotein hormone that can indicate placental toxicity. OBJECTIVES Our aim was to quantify the association of serum PFAS with placental hCG, measured as an intact molecule (hCG), as
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Multiomics Analysis of PCB126's Effect on a Mouse Chronic-Binge Alcohol Feeding Model. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-15 Tyler C Gripshover,Banrida Wahlang,Kimberly Z Head,Jianzhu Luo,Oluwanifemi E Bolatimi,Melissa L Smith,Eric C Rouchka,Julia H Chariker,Jason Xu,Lu Cai,Timothy D Cummins,Michael L Merchant,Hao Zheng,Maiying Kong,Matthew C Cave
BACKGROUND Environmental pollutants, including polychlorinated biphenyls (PCBs) have been implicated in the pathogenesis of liver disease. Our group recently demonstrated that PCB126 promoted steatosis, hepatomegaly, and modulated intermediary metabolism in a rodent model of alcohol-associated liver disease (ALD). OBJECTIVE To better understand how PCB126 promoted ALD in our previous model, the current
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Comment on "Neurotoxicity and Outcomes from Developmental Lead Exposure: Persistent or Permanent?" Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-12 Lorenz S Neuwirth,Bright U Emenike
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Response to "Comment on 'Neurotoxicity and Outcomes from Developmental Lead Exposure: Persistent or Permanent?'". Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-12 Jay S Schneider
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Women's Health Disparities: Spotlight on Nonchemical Stressors, Research Inequities. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-11 Jori Lewis
Participants in an NIEHS workshop call on researchers, clinicians, publishers, and funders to address racism, environmental disparities, and other factors affecting women's health.
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Invited Perspective: Climate Changes the Effectiveness of Water, Sanitation, and Hygiene Interventions. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-11 Elizabeth J Carlton
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In Vivo Tissue Distribution of Polystyrene or Mixed Polymer Microspheres and Metabolomic Analysis after Oral Exposure in Mice. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-10 Marcus M Garcia,Aaron S Romero,Seth D Merkley,Jewel L Meyer-Hagen,Charles Forbes,Eliane El Hayek,David P Sciezka,Rachel Templeton,Jorge Gonzalez-Estrella,Yan Jin,Haiwei Gu,Angelica Benavidez,Russell P Hunter,Selita Lucas,Guy Herbert,Kyle Joohyung Kim,Julia Yue Cui,Rama R Gullapalli,Julie G In,Matthew J Campen,Eliseo F Castillo
BACKGROUND Global plastic use has consistently increased over the past century with several different types of plastics now being produced. Much of these plastics end up in oceans or landfills leading to a substantial accumulation of plastics in the environment. Plastic debris slowly degrades into microplastics (MPs) that can ultimately be inhaled or ingested by both animals and humans. A growing body
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The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA). Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-09 Frederick S Vom Saal,Michael Antoniou,Scott M Belcher,Ake Bergman,Ramji K Bhandari,Linda S Birnbaum,Aly Cohen,Terrence J Collins,Barbara Demeneix,Anne Marie Fine,Jodi A Flaws,Veronique Gayrard,William H Goodson,Andrea C Gore,Jerrold J Heindel,Patricia A Hunt,Taisen Iguchi,Christopher D Kassotis,Andreas Kortenkamp,Robin Mesnage,Jane Muncke,John Peterson Myers,Angel Nadal,Retha R Newbold,Vasantha Padmanabhan
BACKGROUND The European Food Safety Authority (EFSA) recommended lowering their estimated tolerable daily intake (TDI) for bisphenol A (BPA) 20,000-fold to 0.2 ng/kg body weight (BW)/day. BPA is an extensively studied high production volume endocrine disrupting chemical (EDC) associated with a vast array of diseases. Prior risk assessments of BPA by EFSA as well as the US Food and Drug Administration
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Persistent DNA Methylation Changes across the First Year of Life and Prenatal NO2 Exposure in a Canadian Prospective Birth Study. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-04 Samantha Lee,Hind Sbihi,Julia L MacIsaac,Robert Balshaw,Amirthagowri Ambalavanan,Padmaja Subbarao,Piushkumar J Mandhane,Theo J Moraes,Stuart E Turvey,Qingling Duan,Michael Brauer,Jeffrey R Brook,Michael S Kobor,Meaghan J Jones
BACKGROUND Evidence suggests that prenatal air pollution exposure alters DNA methylation (DNAm), which could go on to affect long-term health. It remains unclear whether DNAm alterations present at birth persist through early life. Identifying persistent DNAm changes would provide greater insight into the molecular mechanisms contributing to the association of prenatal air pollution exposure with atopic
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Arsenic Exposure-Related Hypertension in Bangladesh and Reduced Circulating Nitric Oxide Bioavailability. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-04 Moriom Khatun,Nazmul Haque,Abu Eabrahim Siddique,Abdus S Wahed,Md Shofikul Islam,Shuchismita Khan,Ahsanul Mahbub Jubayar,Junayed Sadi,Ehsanul Kabir,Tasnim Tabassum Shila,Zohurul Islam,Md Khalequzzaman Sarker,Hasan Ul Banna,Shakhawoat Hossain,Daigo Sumi,Zahangir Alam Saud,Aaron Barchowsky,Seiichiro Himeno,Khaled Hossain
BACKGROUND Hypertension is a major cause of death worldwide. Although arsenic exposure has been associated with the risk of hypertension, this association appears nonuniform due to inconsistent results from studies conducted in different populations. Moreover, hypertension is a complex condition with multiple underlying mechanisms and factors. One factor is impaired production and bioavailability of
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High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-03 Kimberley E Sala-Hamrick,Anagha Tapaswi,Katelyn M Polemi,Vy K Nguyen,Justin A Colacino
BACKGROUND There is a suite of chemicals, including metals, pesticides, and personal care product compounds, which are commonly detected at high levels in US Center for Disease Control's National Health and Nutrition Examination Survey (NHANES) chemical biomarker screens. Whether these chemicals influence development of breast cancer is not well understood. OBJECTIVES The objectives were to perform
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Speeding Up Time: New Urinary Peptide Clock Associates Greater Air Pollution Exposures with Faster Biological Aging. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-04-03 Silke Schmidt
A study in Belgium supports earlier findings on associations between higher air pollution exposures and markers of faster biological aging, this time by using urinary peptide levels instead of DNA-based markers.
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Thawing Permafrost Releases Industrial Contaminants into Arctic Communities. Environ. Health Perspect. (IF 10.1) Pub Date : 2024-03-27 Kelley Christensen
Long-sequestered pollutants-from both local and global sources-threaten Indigenous peoples' traditional foods and drinking water, and the search is on for ways to protect both health and way of life.