Humans are exposed to a cocktail of heavy metal toxicants at the same time in the environment rather than single metal. The kidney is often a site of early damage due to high renal contact to these pollutants. This study was done to examine the cumulative toxic effect of multiple elements prevalent in the environment. To explore the effect of subchronic exposure to heavy metal mixture male and female Swiss albino mice were randomly divided into 14 groups and given varying doses [MPL (maximum permissible limit), 1X, 5X, 10X, 50X, or 100X] of the multiple metals and metalloid mixtures via drinking water for 8 weeks. It was determined that metal treatment caused increased metal load in renal tissue. The kidney function deteriorated in response to 10X, 50X, 100X concentration of the dosing mixture was found associated to oxidative stress, glomerular damage, necrosis, cell death and further exacerbation of the inflammation.

中文翻译：

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共同暴露于多种重金属和准金属诱导小鼠抗氧化、炎症、DNA 损伤和凋亡途径的剂量依赖性调节，进展为肾功能障碍


人类同时在环境中接触到重金属毒物混合物，而不是单一金属。由于肾脏与这些污染物的高度接触，肾脏通常是早期损伤的部位。本研究旨在检查环境中普遍存在的多种元素的累积毒性作用。为了探讨亚慢性暴露于重金属混合物的影响，雄性和雌性瑞士白化小鼠被随机分为 14 组，通过饮水给予不同剂量的多种金属和准金属混合物 [MPL （最大允许限度）、1X、5X、10X、50X 或 100X] 8 周。确定金属处理导致肾组织中金属负荷增加。发现 10X、50X、100X 浓度的给药混合物导致肾功能恶化，与氧化应激、肾小球损伤、坏死、细胞死亡和炎症进一步恶化有关。