Endocrine disrupting chemicals (EDCs) may impact children's health, with medicines as a possible exposure source. Objective: to assess the potential impact of substances in paediatric medications and essential oils on children as EDC. It is a systematic review of five databases including Medline following the PECOT approach. The review focused on publications about children exposed to medication (active ingredients or excipients of interest) and having developed clinical signs of endocrine dysfunction. Out of 946 studies identified, 28 studies were included. They revealed that parabens, lavender essential oils and anti-epileptics are the most identified pharmaceutical products. The reported outcomes relate to puberty, thyroid disorders, obesity and growth. The evidence indicates potential risks, but the overall quality of available data is limited. This systematic review exposes a lack of robust evidence linking paediatric medication exposure to EDC, predominantly relying on case reports. It cautions about potential conflicts of interest.

中文翻译：

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小药丸，大影响：儿科药物内分泌干扰作用的系统评价


内分泌干扰化学物质 （EDC） 可能会影响儿童的健康，药物可能是接触源。目的：评估儿科药物和精油中的物质对 EDC 儿童的潜在影响。这是对包括 Medline 在内的五个数据库的系统评价，遵循 PECOT 方法。本综述侧重于有关暴露于药物（感兴趣的活性成分或赋形剂）和出现内分泌功能障碍临床症状的儿童的出版物。在确定的 946 项研究中，纳入了 28 项研究。他们透露，对羟基苯甲酸酯、薰衣草精油和抗癫痫药是最知名的药品。报告的结局与青春期、甲状腺疾病、肥胖和生长有关。证据表明存在潜在风险，但可用数据的整体质量有限。本系统综述揭示了缺乏将儿科药物暴露与 EDC 联系起来的有力证据，主要依赖于病例报告。它警告潜在的利益冲突。