Sepsis-associated acute kidney injury (AKI) is a health complication, encompassing excessive inflammatory response, oxidative stress, and tubular necrosis; leading to kidney failure and death. Sepsis treatments are nonspecific and palliative. In this study, we evaluated the effect of morin, a flavonoid with known nephroprotective capabilities, on sepsis-induced AKI by dividing eighty male mice into: normal, morin-treated, septic, and septic mice treated with morin. Half of the groups were sacrified 3 days post sepsis induction, while the rest was sacrified on the 7th day. Treating septic mice with morin resulted in the amelioration of sepsis-associated pathophysiological renal alterations and the increase of the survival and recovery rates compared with those of septic control group. These findings indicate that morin has a therapeutic effect against sepsis-associated AKI via its anti-inflammatory, antioxidant and regenerative effects. Thus, it could be used as potential pharmacological intervention for preventing renal complications of sepsis.

中文翻译：

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Morin 通过调节炎症反应、氧化应激和肾小管再生（Morin 和脓毒症诱导的急性肾损伤）来减轻脓毒症诱导的急性肾损伤


脓毒症相关急性肾损伤 （AKI） 是一种健康并发症，包括过度炎症反应、氧化应激和肾小管坏死;导致肾衰竭和死亡。脓毒症治疗是非特异性和姑息性的。在这项研究中，我们通过将 80 只雄性小鼠分为：正常小鼠、桑色素处理小鼠、脓毒症小鼠和桑色素处理的脓毒症小鼠，评估了桑色素（一种具有已知肾保护能力的类黄酮）对脓毒症诱导的 AKI 的影响。一半的组在脓毒症诱导后 3 天进行神圣化，而其余组在第 7 天进行神圣化。与脓毒症对照组相比，用桑色素治疗脓毒症小鼠可改善脓毒症相关的病理生理肾脏改变，提高存活率和恢复率。这些发现表明，桑色素通过其抗炎、抗氧化和再生作用对脓毒症相关 AKI 具有治疗作用。因此，它可以用作预防脓毒症肾脏并发症的潜在药物干预。