The consumption of hormone-derived medicines, such as levonorgestrel (LNG), is increasing worldwide, and its discharge into the environment reaches non-target organisms. In our previous study, we exposed the parental generation of zebrafish to environmentally relevant concentrations of LNG during the developmental phase. Subsequently, they had grown in a tank with clean water until adulthood. Now, we allowed this parental generation to reproduce to obtain F1 progeny unexposed to LGN, in order to analyze the transgenerational effects of parental LNG exposure on the survival and hatching of unexposed F1 embryos and the stress and behavior of F1 larvae. Here, we found decreased survival rates with higher LNG concentrations, providing a transgenerational effect. This highlights the environmental impact of exposure to LNG, causing damage at the individual and population level and affecting the next generation at the beginning of development, impacting qualities in the survival of the species.

中文翻译：

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左炔诺孕酮避孕药对斑马鱼后代的跨代影响


左炔诺孕酮 (LNG) 等激素衍生药物的消费量在全球范围内不断增加，其排放到环境中的物质会接触到非目标生物体。在我们之前的研究中，我们将斑马鱼的亲代在发育阶段暴露于环境相关浓度的液化天然气中。随后，它们在装有清水的水箱中生长直至成年。现在，我们让这个亲代繁殖以获得未暴露于LGN的F1后代，以分析亲代LNG暴露对未暴露的F1胚胎的存活和孵化以及F1幼虫的应激和行为的跨代影响。在这里，我们发现液化天然气浓度越高，存活率就越低，从而产生了跨代效应。这凸显了接触液化天然气对环境的影响，对个人和群体造成损害，并在发展之初影响下一代，影响物种的生存质量。