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Assessing Best Practices in Natural Gas Production and Emerging CO2 Capture Techniques to Minimize the Carbon Footprint of Electricity Generation Environ. Sci. Technol. (IF 10.8) Pub Date : 2024-11-16 Ryan Cownden, Mathieu Lucquiaud
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Solar-Driven Thin Air Gap Membrane Distillation with a Slippery Condensing Surface Environ. Sci. Technol. (IF 10.8) Pub Date : 2024-11-16 Hongxia Li, Aikifa Raza, Noora Ali AlMarzooqi, Meera AlMehrzi, Alaa Shaheen, Faisal AlMarzooqi, TieJun Zhang
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Quantifying the Cooling Effect of Urban Greening Driven by Ecological Restoration Projects in China Environ. Sci. Technol. (IF 10.8) Pub Date : 2024-11-16 Dong Xu, Tingting Bai, Lin Yang, Yuyu Zhou, Bin Chen, Haifeng Xu, Yongze Song, Yuan Yuan, Yuanzheng Cui, Meng Lin, Ziqian Xia, Min Chen, Zhenci Xu, Peng Zhao, Guihua Dong, Lei Zhang, Jiacheng Zhao, Wanben Wu, Wei Wang, Zhao Liu, Jie Cheng, Philippe Ciais
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Transforming Aviation’s Impact on the Climate: Rethinking the Research Strategy Environ. Sci. Technol. (IF 10.8) Pub Date : 2024-11-15 Steffen Kallbekken, Marianne T. Lund, David G. Victor
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Soil Emissions of Reactive Oxidized Nitrogen Reduce the Effectiveness of Anthropogenic Source Control in China Environ. Sci. Technol. (IF 10.8) Pub Date : 2024-11-15 Yurun Wang, Yanan Wang, Qinyi Li, Yue Tan, Mingxue Li, Yingnan Zhang, Cheng He, Tao Wang
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Source variations of atmospheric particles in response to control measures in northern China during 2022 winter olympics and paralympics: Evidence from microscopic analysis Environ. Int. (IF 10.3) Pub Date : 2024-11-16 Wenjun Li, Jian Gao, Yuanguan Gao, Hong Li, Yizhen Chen, Jinying Li, Haisheng Li
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Understanding prenatal household exposures to per- and polyfluorylalkyl substances using paired Biological and dust measurements with sociodemographic and housing variables Environ. Int. (IF 10.3) Pub Date : 2024-11-16 Dylan James Wallis, Kelsey E. Miller, Nicole M. DeLuca, Kent Thomas, Chris Fuller, James McCord, Elaine A. Cohen Hubal, Jeffrey M. Minucci
Per- and poly-fluoroalkyl substances (PFAS) are chemicals of concern—they are ubiquitous, persistent, with known and suspected health impacts. Well studied, primary sources of exposure to PFAS are drinking water and food. The presence of PFAS in human tissue of general populations suggests other important exposure sources/pathways. House dust measurements suggest widespread presence of PFAS in residences
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Communicating risk in the face of data gaps: Toxic metals in tampons Environ. Int. (IF 10.3) Pub Date : 2024-11-16 Jenni A. Shearston, Kristen Upson, Milo Gordon, Vivian Do, Olgica Balac, Khue Nguyen, Beizhan Yan, Marianthi-Anna Kioumourtzoglou, Kathrin Schilling
A recent correspondence (Öberg, 2024) about our manuscript, Tampons as a source of exposure to metal(loid)s (Shearston et al., 2024), highlights the importance of data for complete risk assessment and public health communication when data gaps exist. Our study, which measured the concentration of 16 metals in tampons, detected the toxic metals lead (Pb), arsenic (As), and cadmium (Cd). Our study was
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Exploring environmental modifiers of LRRK2-associated Parkinson’s disease penetrance: An exposomics and metagenomics pilot study on household dust Environ. Int. (IF 10.3) Pub Date : 2024-11-16 Begoña Talavera Andújar, Sandro L. Pereira, Susheel Bhanu Busi, Tatiana Usnich, Max Borsche, Sibel Ertan, Peter Bauer, Arndt Rolfs, Soraya Hezzaz, Jenny Ghelfi, Norbert Brüggemann, Paul Antony, Paul Wilmes, Christine Klein, Anne Grünewald, Emma L. Schymanski
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Source apportionment of ultrafine particles in urban Europe Environ. Int. (IF 10.3) Pub Date : 2024-11-15 Meritxell Garcia-Marlès, Rosa Lara, Cristina Reche, Noemí Pérez, Aurelio Tobías, Marjan Savadkoohi, David Beddows, Imre Salma, Máté Vörösmarty, Tamás Weidinger, Christoph Hueglin, Nikos Mihalopoulos, Georgios Grivas, Panayiotis Kalkavouras, Jakub Ondracek, Nadezda Zikova, Jarkko V. Niemi, Hanna E. Manninen, David C. Green, Anja H. Tremper, Xavier Querol
There is a body of evidence that ultrafine particles (UFP, those with diameters ≤ 100 nm) might have significant impacts on health. Accordingly, identifying sources of UFP is essential to develop abatement policies. This study focuses on urban Europe, and aims at identifying sources and quantifying their contributions to particle number size distribution (PNSD) using receptor modelling (Positive Matrix
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The dynamics and assembly patterns of airborne pathogen communities in the municipal food waste treatment system and its risk implications Environ. Int. (IF 10.3) Pub Date : 2024-11-15 Liangmao Zhang, Binghan Wang, Kaiyi Li, Yinglong Su, Dong Wu, Ming Zhan, Bing Xie
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Cord plasma metabolomic signatures of prenatal per- and polyfluoroalkyl substance (PFAS) exposures in the Boston birth Cohort Environ. Int. (IF 10.3) Pub Date : 2024-11-15 Zeyu Li, Mingyu Zhang, Xiumei Hong, Guoying Wang, Giehae Choi, Kari C. Nadeau, Jessie P. Buckley, Xiaobin Wang
BackgroundPrenatal per- and polyfluoroalkyl substance (PFAS) exposures are associated with adverse offspring health outcomes, yet the underlying pathological mechanisms are unclear. Cord blood metabolomics can identify potentially important pathways associated with prenatal PFAS exposures, providing mechanistic insights that may help explain the long-term health effects. MethodsThe study included 590
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Shallow Shotgun Sequencing of Healthcare Waste Reveals Plastic-Eating Bacteria with Broad-Spectrum Antibiotic Resistance Genes Environ. Pollut. (IF 7.6) Pub Date : 2024-11-16 Shing Wei Siew, Mohamad Hazwan Fikri Khairi, Norhisham Abdul Hamid, Mohd Fazli Farida Asras, Hajar Fauzan Ahmad
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Nanosilica and salicylic acid synergistically regulate cadmium toxicity in rice Environ. Pollut. (IF 7.6) Pub Date : 2024-11-16 Sajid Muhammad, Zaid Ulhassan, Raheel Munir, Muhammad Umair Yasin, Faisal Islam, Kangni Zhang, Weiqi Chen, Mehmood Jan, Muhammad Afzal, Ali Muhammad, Fakhir Hannan, Weijun Zhou
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Interaction Between Root Exudates and PFOS Mobility: Effects on Rhizosphere Microbial Health in Wetland Ecosystems Environ. Pollut. (IF 7.6) Pub Date : 2024-11-16 Bianhe Lu, Peifang Wang, Yueming Zhu, Jing Hu, Jin Qian, Yuanyuan Huang, Junwei Shen, Sijing Tang, Yin Liu
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Potential Source Contribution Function Coupled with Mass Spectrometry Detection to Identify Source of Atmospheric Polyethylene Terephthalate Environ. Pollut. (IF 7.6) Pub Date : 2024-11-16 Hanling Yang, Junjie Zhang, Zhiwanxin Li, Jian Pu, Chu Peng, Chunguang Liu, Lei Wang
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Analysis of Microplastic Contamination and Associated Human Health Risks in Clarias gariepinus and Oreochromis niloticus from Kubanni Reservoir, Zaria Nigeria Environ. Pollut. (IF 7.6) Pub Date : 2024-11-16 Maria Onma Onaji, David S. Abolude, Shuaibu Akpai Abdullahi, Lucas Del Bianco Faria, Mathias Ahii Chia
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Onboard measurements of organic vapor emissions from river vessels under various operational conditions Environ. Pollut. (IF 7.6) Pub Date : 2024-11-16 Mengxue Tong, Yanli Zhang, Mei Li, Qi Wang, Xiao Tian, Dan Zhang, Aoqi Ge, Wei Song, Xin Xiong, Yinong You, Yongjang Xu, Yihua Huang, Xin Yang, Xinming Wang
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Bacteriological safety and quality of composted products from animal, urban or sewage sludge wastes Environ. Pollut. (IF 7.6) Pub Date : 2024-11-16 Ivone Vaz-Moreira, Angelo D’Arnese, Maurice Knoll, A. Margarida Teixeira, Joana Bastos Barbosa, Paula Teixeira, Célia M. Manaia
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Short-chain chlorinated paraffins induce liver injury in mice through mitochondrial disorders and disruption of cholesterol-bile acid pathway Environ. Pollut. (IF 7.6) Pub Date : 2024-11-15 Xianpeng Zhou, Jiang Wu, Qiang He, Beibei Wang, Xulong Xu, Xue Zhao, Minmin Gao, Biao Yan
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On-road measurement of post-catalyst ammonia emissions from gasoline and hybrid vehicles using quantum cascade laser detector Environ. Pollut. (IF 7.6) Pub Date : 2024-11-15 Ruonan Li, Chongyao Wang, Xin Wang, Jiaxin Luo, Dailin Yin, Miao Wen, Lijun Hao, Jianwei Tan, Yunshan Ge
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Omics-centric evidences of fipronil biodegradation by Rhodococcus sp. FIP_B3. Environ. Pollut. (IF 7.6) Pub Date : 2024-11-15 Anjali Jaiswal, Anand Kumar Pandey, Animesh Tripathi, Suresh Kumar Dubey
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Metagenomic approaches in bioremediation of environmental pollutants Environ. Pollut. (IF 7.6) Pub Date : 2024-11-12 Dixita Chettri, Ashwani Kumar Verma, Manisha Chirania, Anil Kumar Verma
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Molecular characterization of major oxidative potential active species in ambient PM2.5: Emissions from biomass burning and ship exhaust Environ. Pollut. (IF 7.6) Pub Date : 2024-11-13 Chunbo Xing, Yaling Zeng, Xin Yang, Antai Zhang, Jinghao Zhai, Baohua Cai, Shao Shi, Yin Zhang, Yujie Zhang, Tzung-May Fu, Lei Zhu, Huizhong Shen, Jianhuai Ye, Chen Wang
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Estimation of carbon sequestration potential and air quality impacts of biochar production from straw in China Environ. Pollut. (IF 7.6) Pub Date : 2024-11-12 Jiayu Zhang, Xiaodong Ge, Xionghui Qiu, Lei Liu, Jan Mulder, Lei Duan
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Biodegradable microplastics induce profound changes in lettuce (Lactuca sativa) defense mechanisms and to some extent deteriorate growth traits Environ. Pollut. (IF 7.6) Pub Date : 2024-11-12 Sylwia Adamczyk, Laura J. Zantis, Sam van Loon, Cornelis A.M. van Gestel, Thijs Bosker, Rachel Hurley, Luca Nizzetto, Bartosz Adamczyk, Sannakajsa Velmala
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Radiation for dummies: the female mannequins testing space-travel safety Nature (IF 50.5) Pub Date : 2024-11-15
The female figures, dubbed Helga and Zohar, took a trip round the moon to measure the levels of space radiation outside low Earth orbit.
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Major biomedical funder NIH poised for massive reform under Trump 2.0 Nature (IF 50.5) Pub Date : 2024-11-15
Sweeping changes and more research scrutiny could be on the way for the US National Institutes of Health.
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Stress can disrupt memory and lead to needless anxiety — here’s how Nature (IF 50.5) Pub Date : 2024-11-15
In mice, stress altered the way that the brain formed memories, resulting in an unnecessary fear response.
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How human brains got so big: our cells learned to handle the stress that comes with size Nature (IF 50.5) Pub Date : 2024-11-15
Understanding how human neurons cope with the energy demands of a large, active brain could open up new avenues for treating neurological disorders.
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Cognitive Benefits of Reducing Indoor Particulate Matter Exposure During Sleep: New Evidence from a Randomized, Double-blind Crossover Trial Environ. Sci. Technol. (IF 10.8) Pub Date : 2024-11-15 Di Yang, Wenlou Zhang, Luyi Li, Shan Liu, Wanzhou Wang, Yetong Zhao, Xuezhao Ji, Qisijing Liu, Shaowei Wu, Xinbiao Guo, Furong Deng
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Organophosphate Insecticide Malathion Induces Alzheimer’s Disease-Like Cognitive Impairment in Mice: Evidence of the Microbiota-Gut-Brain Axis Environ. Sci. Technol. (IF 10.8) Pub Date : 2024-11-15 Jingna Cui, Shouchun Xiao, Yue Cao, Yaru Zhang, Jiaxing Yang, Li Zheng, Fanrong Zhao, Xueke Liu, Donghui Liu, Zhiqiang Zhou, Peng Wang
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Computational Study on the Octahedral Surfaces of Magnetite Nanoparticles and Their Solvent Interaction Environ. Sci. Technol. (IF 10.8) Pub Date : 2024-11-14 Anita S. Katheras, Konstantinos Karalis, Matthias Krack, Andreas C. Scheinost, Sergey V. Churakov
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Freeze–Thaw Cycle Events Enable the Deep Disintegration of Biochar: Release of Dissolved Black Carbon and Its Structural-Dependent Carbon Sequestration Capacity Environ. Sci. Technol. (IF 10.8) Pub Date : 2024-11-14 Lang Zhu, Na Chen, Xianglei Zhang, Luyao Ren, Rui Zou, Jia Xie, Zhiqiang Wang, Huiqiang Yang, Zelin Hao, Jianjun Qin, Hanzhong Jia
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Lithological Controls on Soil Aggregates and Minerals Regulate Microbial Carbon Use Efficiency and Necromass Stability Environ. Sci. Technol. (IF 10.8) Pub Date : 2024-11-14 Peilei Hu, Wei Zhang, Andrew T. Nottingham, Dan Xiao, Yakov Kuzyakov, Lin Xu, Hongsong Chen, Jun Xiao, Pengpeng Duan, Tiangang Tang, Jie Zhao, Kelin Wang
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Pulsed laser deposition of delafossite oxide thin films on YSZ (001) substrates as solar water splitting photocathodes Environ. Sci.: Nano (IF 5.8) Pub Date : 2024-11-15 Chenyu Zhou, Atiya Banerjee, Esteban Luis Fornero, Zhaoyi Xi, Xiao Tong, Eli Stavitski, Xiaohui Qu, Sara E. Mason, Dario J. Stacchiola, Mingzhao Liu
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Highly selective capture of palladium from acidic solution by sulfur-functionalized porous carbon microsphere: Performance and mechanism Environ. Sci.: Nano (IF 5.8) Pub Date : 2024-11-15 Mingyue Wang, Ruiwen Liang, lanchao Kou, Xiukun Cao, Dezhi Chen
Efficient recovery of palladium (Pd) from waste sources is of paramount importance due to its limited natural reserves and potential environmental hazards. Herein, a carbon sorbent, namely sulfur-functionalized porous carbon microsphere (SPCM), was used to selectively capture Pd(II) from acidic solution. SPCM exhibited high efficiency for the adsorption separation of Pd(II) from 0.5 M to 6 M HNO3 solution
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Suppressed Non-Radiative Loss and Efficient Hole Transfer at Small Highest Occupied Molecular Orbital Offset Enables 19.73% Efficiency Binary Organic Solar Cells with Small Efficiency-Cost Gap Energy Environ. Sci. (IF 32.4) Pub Date : 2024-11-15 Xiaolei Kong, Nana Yang, Xixi Zhang, Jinyuan Zhang, Zhenyu Li, Xinrui Li, Yilei Wu, Rui Sun, Jing Li, Aoxiang Li, Jie Min, Guang Yang, Chenkai Sun
Suppressing energy/voltage loss and realizing efficient charge transfer at small frontier molecular orbital offsets between donor and acceptor is viable to simultaneously improve open-circuit voltage (Voc) and short-circuit current (Jsc), and thus power conversion efficiency (PCE) of organic solar cells (OSCs). Here, two A-DA’D-A type acceptors, PEH-F and TEH-F, are designed and synthesized with different
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Improving upon rechargeable battery technologies: On the role of high-entropy effects Energy Environ. Sci. (IF 32.4) Pub Date : 2024-11-15 Zihao Zhou, Yuan Ma, Torsten Brezesinski, Ben Breitung, Yuping Wu, Yanjiao Ma
In recent years, high-entropy methods have garnered significant attention in the field of energy-storage applications, particularly in rechargeable batteries. Specifically, they can impart materials with unique structures and customized properties, thereby showcasing new attributes and application potential. In this review, we describe the various influences that the high-entropy concept exert on electrochemical
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Payback trade-offs from the electrolyte design between energy efficiency and lifespan in zinc-ion batteries Energy Environ. Sci. (IF 32.4) Pub Date : 2024-11-15 Xuan Gao, Haobo Dong, Chang Su, Yuhang Dai, Yiyang Liu, Ivan P. Parkin, Claire J Carmalt, Guanjie He
Aqueous zinc ion batteries (AZIBs) present a transformative avenue in electrochemical energy storage technologies, leveraging zinc anodes and aqueous electrolytes for safety and cost-effectiveness. The primary challenge of mitigating zinc dendrite formation in these batteries is addressed through electrolyte strategies, focusing on reducing water activities. Despite advancements in extending cycle
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Binary all-polymer solar cells with 19.30% efficiency enabled by bromodibenzothiophene-based solid additive Energy Environ. Sci. (IF 32.4) Pub Date : 2024-11-15 Yanming Sun, Haisheng Ma, Jiali Song, Jia-Wei Qiao, Bingyu Han, Qianqian Wang, Min Hun Jee, Laju Bu, Donghui Wei, Han Young Woo, Xiao-Tao Hao
All-polymer solar cells (all-PSCs) are thought to be the most promising candidate for the practical application of organic solar cells (OSCs). However, the efficiencies of all-PSCs remains lower than those of small molecule acceptor (SMA)-based OSCs due to their unfavorable active-layer morphology. The complicated molecular interaction and aggregation behavior involved in all-polymer blends make it
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23.2% efficient low band gap perovskite solar cells with cyanogen management Energy Environ. Sci. (IF 32.4) Pub Date : 2024-11-14 Hashini Perera, Thomas Webb, Yuliang Xu, Jingwei Zhu, Yundong Zhou, Gustavo Trindade, Mateus Gallucci Masteghin, Steven P. Harvey, Sandra Jenatsch, Linjie Dai, Sanjayan Sathasivam, Tom Macdonald, Steven Hinder, Yunlong Zhao, Samuel D Stranks, Dewei Zhao, Wei Zhang, Imalka Jayawardena, Saif Ahmed Haque, S. Ravi P. Silva
Managing iodine formation is crucial for realising efficient and stable perovskite photovoltaics. Poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) is a widely adopted hole transport material, particularly for perovskite solar cells (PSCs). However, Improving the performance and stability of PEDOT:PSS based perovskite optoelectronics remains a key challenge. We show that amine-containing
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Effect of sulfidogenesis on ferrihydrite geochemistry and associated arsenic fate Environ. Pollut. (IF 7.6) Pub Date : 2024-11-15 Bowei Zhang, Jiarong Tong, Kun Gao, Chongxuan Liu
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Adverse outcome pathway of Alzheimer’s Disease-like changes resulting from autophagy flux blockade after MC-LR exposure Environ. Pollut. (IF 7.6) Pub Date : 2024-11-15 Yuhan Ma, Dihui Xu, Yibin Gan, Zining Chen, Yabing Chen, Xiaodong Han
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Distribution, sorption patterns, and outflows of riverine microplastics-affiliated linear alkylbenzenes and polycyclic aromatic hydrocarbons in a dynamic coastal zone Environ. Pollut. (IF 7.6) Pub Date : 2024-11-14 Huiping Wen, Po Wang, Lei Mai, Xiangrong Xu, Kefu Yu, Eddy Y. Zeng
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Characterization of soot and crystalline atmospheric ultrafine particles Environ. Pollut. (IF 7.6) Pub Date : 2024-11-14 Francisco Berrellez-Reyes, Benedetto Schiavo, Belem Gonzalez-Grijalva, Aracely Angulo-Molina, Diana Meza-Figueroa
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The foraging behavior of gerbils reveals the ecological significance of crude oil pollution Environ. Pollut. (IF 7.6) Pub Date : 2024-11-14 Malay Pandey, Hagar Vardi-Naim, Noga Kronfeld-Schor, Oded Berger-Tal
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Air Toxics Matter to More than Just Air Environ. Pollut. (IF 7.6) Pub Date : 2024-11-14 Kaixin Huang, Loretta A. Fernandez, Julia Varshavsky, Matthew J. Eckelman
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Poly-γ-glutamic acid chelates chromium (III) and copper (II), alleviating their toxicity in cucumber and affecting rhizosphere bacterial community assembly Environ. Pollut. (IF 7.6) Pub Date : 2024-11-14 Chaoyang Chen, Wenhui Yan, Yu Chen, Sijie Liu, Chuangjiang Nong, Liang Sun, Rui Wang, Hong Xu, Peng Lei, Yian Gu
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Co-exposure of microplastics with heavy metals increases environmental pressure in the endangered and rare wildlife reserve: A case study of the zhalong wetland red-crowned crane nature reserve, northeast China Environ. Pollut. (IF 7.6) Pub Date : 2024-11-10 Lei Wang, Yuchen Wei, Bing Wang, Jufang Hu, Chuntao Zhao, Dongmei Yu, Jianping Wang, Ze Liu
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Biodegradation of commercial polyester polyurethane by a soil-borne bacterium Bacillus velezensis MB01B: Efficiency, degradation pathway, and in-situ remediation in landfill soil Environ. Pollut. (IF 7.6) Pub Date : 2024-11-12 Jie Zeng, Junruo Yao, Weiming Zhang, Miaomiao Zhang, Tan Wang, Xun Yu, Yongxuan Liu, Xiaowen Sun, Lin Li
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Insights into the sunlight-Induced photodegradation mechanisms of methamphetamine in surface water driven by NO₃⁻, HCO₃⁻ and Fe3+ Environ. Pollut. (IF 7.6) Pub Date : 2024-11-12 Lijuan Luo, Junhui Wu, Xueting Yuan, Xinyan Li, Bi Huang, Shanshan Chen, Jiewei Deng, Tiangang Luan
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Disposable face masks into aquatic media: Chemical and biological testing of the released compounds during the leaching process Environ. Pollut. (IF 7.6) Pub Date : 2024-11-12 Georgios Kalamaras, Maria Antonopoulou, Amaia Soto Beobide, Vasilios Triantafyllidis, Stefanos Dailianis
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Lunar farside volcanism 2.8 billion years ago from Chang’e-6 basalts Nature (IF 50.5) Pub Date : 2024-11-15 Qian W. L. Zhang, Mu-Han Yang, Qiu-Li Li, Yu Liu, Zong-Yu Yue, Qin Zhou, Liu-Yang Chen, Hong-Xia Ma, Sai-Hong Yang, Xu Tang, Guang-Liang Zhang, Xin Ren, Xian-Hua Li
Unravelling the volcanic history of the enigmatic lunar farside is essential for understanding the hemispheric dichotomy of the Moon1-3. Cratering chronology established for the lunar nearside has been used to suggest long-lived volcanism on the farside of the Moon3,4, but without sample verification. Here we report two newly recognized episodes of basaltic volcanism with Pb-Pb dating for basalt fragments
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Resistance to crucial malaria drug detected in severely ill kids in Africa Nature (IF 50.5) Pub Date : 2024-11-14
The development worries researchers because children are particularly vulnerable to the disease.
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Daily briefing: Big tomatoes get sweeter thanks to CRISPR editing Nature (IF 50.5) Pub Date : 2024-11-14
A genetic tweak can make big tomatoes much sweeter. Plus, how smartphone signals can help map the upper atmosphere
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Geothermal power is vying to be a major player in the world’s clean-energy future Nature (IF 50.5) Pub Date : 2024-11-14
With technical advances and enthusiasm from policymakers, advocates say the time for next-generation geothermal has come.
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Releasing a sugar brake generates sweeter tomato without yield penalty Nature (IF 50.5) Pub Date : 2024-11-13 Jinzhe Zhang, Hongjun Lyu, Jie Chen, Xue Cao, Ran Du, Liang Ma, Nan Wang, Zhiguo Zhu, Jianglei Rao, Jie Wang, Kui Zhong, Yaqing Lyu, Yanling Wang, Tao Lin, Yao Zhou, Yongfeng Zhou, Guangtao Zhu, Zhangjun Fei, Harry Klee, Sanwen Huang
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Engineered receptors for soluble cellular communication and disease sensing Nature (IF 50.5) Pub Date : 2024-11-14 Dan I. Piraner, Mohamad H. Abedi, Maria J. Duran Gonzalez, Adam Chazin-Gray, Annie Lin, Iowis Zhu, Pavithran T. Ravindran, Thomas Schlichthaerle, Buwei Huang, Tyler H. Bearchild, David Lee, Sarah Wyman, Young-wook Jun, David Baker, Kole T. Roybal
Despite recent advances in mammalian synthetic biology, there remains a lack of modular synthetic receptors that can robustly respond to soluble ligands and in turn activate bespoke cellular functions. Such receptors would have extensive clinical potential to regulate the activity of engineered therapeutic cells, but to date only receptors against cell surface targets have approached clinical translation1