Arsenic, a ubiquitous environmental toxicant, has been acknowledged as a significant issue for public health due to its widespread pollution of drinking water and food supplies. The present review aimed to study the toxicity associated with the cardiac system. Prolonged exposure to arsenic has been associated with several harmful health outcomes, especially cardiotoxicity. Arsenic-induced cardiotoxicity encompasses a range of cardiovascular abnormalities, including cardiac arrhythmias, ischemic heart disease, and cardiomyopathy. To tackle this toxicity, understanding the molecular markers, epigenetic predictors, and targets involved in arsenic-induced cardiotoxicity is essential for creating preventative and therapeutic approaches. For preventive measures against this heavy metal poisoning of groundwater, it is crucial to regularly monitor water quality, re-evaluate scientific findings, and educate the public about the possible risks. This review thoroughly summarised what is currently known in this field, highlighting the key molecular markers, epigenetic modifications, and potential therapeutic targets associated with arsenic-induced cardiotoxicity.

中文翻译：

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砷诱导的心脏毒性：一种分子标志物、表观遗传预测因子和靶标的方法


砷是一种无处不在的环境毒物，由于其对饮用水和食品供应的广泛污染，它被认为是公共卫生的一个重要问题。本综述旨在研究与心脏系统相关的毒性。长期接触砷与多种有害的健康后果有关，尤其是心脏毒性。砷引起的心脏毒性包括一系列心血管异常，包括心律失常、缺血性心脏病和心肌病。为了解决这种毒性，了解砷诱导的心脏毒性所涉及的分子标志物、表观遗传预测因子和靶标对于创建预防和治疗方法至关重要。为了预防措施防止地下水中的重金属中毒，定期监测水质、重新评估科学发现并教育公众了解可能的风险至关重要。本综述全面总结了该领域目前已知的情况，强调了与砷诱导的心脏毒性相关的关键分子标志物、表观遗传修饰和潜在的治疗靶点。