Methylglyoxal is considered a key indicator in evaluating wine flavor and quality, as well as an important marker for diabetic pathological syndromes. Rapid and accurate quantitative detection of methylglyoxal is essential in scenarios of wine production standards and human health monitoring. Herein, we report a visual method for detecting methylglyoxal via an NIR-excitable reversible ratiometric fluorescent hydrogel sensor, where NIR-excited upconversion nanoparticles serve as energy donors and eosin B acts as the energy acceptor, together forming an integrated ratiometric nanophotonic probe that ensures the accuracy of detection without being affected by various background fluorescence interference in different scenarios. The integrated optical probe is combined with a 3D network hydrogel to design a sensing patch that can be easily regenerated through simple treatment, exhibiting a distinct optical color response. Upon the addition of methylglyoxal, the G/R value of the sensing patch changes, enabling the real-time quantitative detection of methylglyoxal. Additionally, we combined the hydrogel sensing patch with a smartphone to create a portable sensing platform for the convenient visual detection of methylglyoxal. The probe and hydrogel sensing patch have detection limits for methylglyoxal as low as 59 and 75.4 nM, respectively. The portable sensing patch designed here provides an effective strategy for standardizing the wine production process and monitoring patient health.

中文翻译：

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通过 NIR 可激发可逆比例荧光水凝胶传感器在多场景下目视检测甲基乙二醛


甲基乙二醛被认为是评价葡萄酒风味和品质的关键指标，也是糖尿病病理综合征的重要标志物。在葡萄酒生产标准和人类健康监测的场景中，甲基乙二醛的快速准确定量检测是必不可少的。在此，我们报道了一种通过 NIR 可激发可逆比例荧光水凝胶传感器检测甲基乙二醛的视觉方法，其中 NIR 激发的上转换纳米颗粒作为能量供体，曙红 B 作为能量受体，共同形成一个集成的比例纳米光子探针，确保检测的准确性，不受不同场景下各种背景荧光干扰的影响。集成的光学探针与 3D 网络水凝胶相结合，设计出一种传感贴片，该贴片可以通过简单的处理轻松再生，表现出独特的光学颜色响应。添加甲基乙二醛后，传感贴片的 G/R 值发生变化，从而能够实时定量检测甲基乙二醛。此外，我们将水凝胶传感贴片与智能手机相结合，创建了一个便携式传感平台，用于方便地目视检测甲基乙二醛。探针和水凝胶传感贴片对甲基乙二醛的检测限分别低至 59 和 75.4 nM。这里设计的便携式传感贴片为标准化葡萄酒生产过程和监测患者健康状况提供了一种有效的策略。