We developed a novel method utilizing surface-enhanced Raman spectroscopy (SERS) with calcium ion-modified silver nanoparticles as the enhancing substrate. This approach enables label-free detection of the dissolution rate of bisphosphonates. This technique is fast, sensitive, and highly reproducible, significantly advancing drug quality control. Experimental results demonstrated detection limits for etidronate, alendronate, and risedronate as low as 1 ng/mL. Notably, this method accurately identifies characteristic drug peaks without interference from excipients, allowing for precise quantitative detection. In summary, our SERS-based method offers a simple, efficient, and reliable approach for the qualitative and quantitative quality control of bisphosphonate drugs.

中文翻译：

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一种使用表面增强拉曼光谱高效检测双膦酸盐药物溶出速率的新型无标记方法


我们开发了一种利用表面增强拉曼光谱 （SERS） 的新方法，以钙离子修饰的银纳米颗粒作为增强底物。这种方法可以对双膦酸盐的溶出速率进行无标记检测。该技术快速、灵敏且可重复性高，显著推进了药物质量控制。实验结果表明，依替膦酸盐、阿仑膦酸盐和利塞膦酸盐的检出限低至 1 ng/mL。值得注意的是，该方法可准确识别特征性药物峰，而不受赋形剂的干扰，可实现精确的定量检测。总之，我们基于 SERS 的方法为双膦酸盐类药物的定性和定量质量控制提供了一种简单、高效和可靠的方法。