Obesity is a leading risk factor and a negative prognostic indicator for many cancers. In a recent issue of Science Immunology, Bagchi et al. identified that tumor-associated macrophages upregulate GPR65 in response to obesity-driven intratumor acidity resulting in reduced effector function to promote tumor growth.¹

中文翻译：

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巨噬细胞对 TME 中肥胖驱动的酸度有“意义”


肥胖是许多癌症的主要风险因素和负面预后指标。在最近一期的《科学免疫学》中，Bagchi 等人发现，肿瘤相关巨噬细胞响应肥胖驱动的肿瘤内酸性而上调 GPR65，导致促进肿瘤生长的效应功能降低。¹