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D-aring to explore: New approaches to gasdermin D targeting
Cell Chemical Biology ( IF 6.6 ) Pub Date : 2024-12-19 , DOI: 10.1016/j.chembiol.2024.11.006
Lei Wang, Wen Zhou

Novel inhibitors of pyroptosis promise breakthroughs in treating inflammatory diseases and malignant tumors. In this issue of Cell Chemical Biology, Hu et al.1 identify two repurposed drugs that selectively target gasdermin D (GSDMD) oligomers, effectively suppressing pyroptosis while reducing off-target effects typical of cysteine-based inhibitors.

中文翻译:


探索 D-aring:gasdermin D 靶向的新方法



新型焦亡抑制剂有望在治疗炎症性疾病和恶性肿瘤方面取得突破。在本期《细胞化学生物学》中,胡 et al.1 确定了两种选择性靶向 gasdermin D (GSDMD) 寡聚体的重新利用的药物,有效抑制细胞焦亡,同时减少半胱氨酸基抑制剂典型的脱靶效应。
更新日期:2024-12-19
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