Dry eye disease (DED) is characterized by a dysfunctional tear film in which the corneal epithelium and its abundant nerves are affected by ocular desiccation and inflammation. Although adaptive immunity and specifically CD4 + T cells play a role in DED pathogenesis, the exact contribution of these cells to corneal epithelial and neural damage remains undetermined. To address this, we explored the

Understanding the processes that link genotype to phenotype is a central challenge in biology. Despite progress in discovering genes associated with ecologically relevant traits, a poor understanding of the processes and functions via which molecules mediate evolutionary differences leaves us critically far from linking proximate and ultimate causes of evolution. This knowledge gap is particularly

Desert ants are known to rely heavily on vision while venturing for food and returning to the nest. During these foraging trips, ants memorize and recognize their visual surroundings, which enables them to recapitulate individually learned routes in a fast and effective manner. The compound eyes are crucial for such visual navigation; however, it remains unclear how information from both eyes are integrated

Mutualisms are mediated by adaptive traits of interacting organisms and play a central role in the ecology and evolution of species. Thousands of plant species possess tiny structures called “domatia” that house mites which protect plants from pests, yet these traits remain woefully understudied. Here, we release a worldwide database of species with mite domatia and provide an evaluation of the phylogenetic

Group VIA calcium-independent phospholipase A 2 (iPLA 2 ) is a member of the PLA 2 superfamily that exhibits calcium-independent activity in contrast to the other two major types, secreted phospholipase A 2 (sPLA 2 ) and cytosolic phospholipase A 2 (cPLA 2 ), which both require calcium for their enzymatic activity. Adenosine triphosphate (ATP) has been reported to allosterically activate iPLA 2 , and

Natural visual scenes are dominated by spatiotemporal image dynamics, but how the visual system integrates “movie” information over time is unclear. We characterized optic tectal neuronal receptive fields using sparse noise stimuli and reverse correlation analysis. Neurons recognized movies of ~200-600 ms durations with defined start and stop stimuli. Movie durations from start to stop responses were

Viruses with broad tissue distribution and cell tropism successfully replicate in various nutrient environments in the body. Several viruses reprogram metabolism for viral replication. However, many studies focus on metabolic reprogramming in nutrient-rich conditions that do not recapitulate physiological environments in the body. Here, we investigated how viruses may replicate when a metabolite thought

Experimental autoimmune encephalomyelitis (EAE) is the most widely used rodent model for multiple sclerosis. Interferon-γ (IFN-γ) and regulatory T cells (Tregs) are individually well known to play beneficial roles in amelioration of EAE. However, little is known about the relationship between IFN-γ and Tregs during the disease. Here, we show that IFN-γ polarizes Tregs into T helper 1 (Th1)-type Tregs

Sustained androgen receptor (AR) signaling during relapse is a central driver of metastatic castration-resistant prostate cancer (mCRPC). Current AR antagonists, such as enzalutamide, fail to provide long-term benefit for the mCRPC patients who have dramatic increases in AR expression. Here, we report AR antagonists with efficacy in AR-overexpressing models. These molecules bind to the ligand-binding

Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory skin disease with a poorly understood immunopathogenesis. Here, we report that HS lesional skin is characterized by the expansion of innate lymphocytes and T cells expressing CD2, an essential activation receptor and adhesion molecule. Lymphocytes expressing elevated CD2 predominated with unique spatial distribution throughout the

We ask the question of how angular momentum is conserved in electroweak interaction processes. To introduce the problem with a minimum of mathematics, we first raise the same issue in elastic scattering of a circularly polarized photon by an atom, where the scattered photon has a different spin direction than the original photon, and note its presence in scattering of a fully relativistic spin-1/2

The H3K27M oncogenic histone (oncohistone) mutation drives ~80% of incurable childhood brain tumors known as diffuse midline gliomas (DMGs). The major molecular feature of H3K27M mutant DMGs is a global loss of H3K27 trimethylation (H3K27me3), a phenotype conserved in Caenorhabditis elegans ( C. elegans ). Here, we perform unbiased genome-wide suppressor screens in C. elegans expressing H3K27M and

The human lens is composed of a monolayer of lens epithelial cells (LECs) and elongated fibers that align tightly but are separated by the plasma membrane. The integrity of the lens plasma membrane is crucial for maintaining lens cellular structure, homeostasis, and transparency. Glutathione peroxidase 4 (GPX4), a selenoenzyme, plays a critical role in protecting against lipid peroxidation. This study

A critical host response against viral infections entails the activation of innate immune signaling that culminates in the production of antiviral proteins. DNA viruses are sensed by the cytosolic pattern recognition receptor cyclic GMP–AMP synthase (cGAS), which initiates a signaling pathway that results in production of proinflammatory cytokines such as Interferon-β (IFN-β) and activation of the

Oxygen vacancies and their correlation with the nanomagnetism and electronic structure are crucial for applications in dilute magnetic semiconductors design applications. Here, we report on cobalt single atom-incorporated titanium dioxide (TiO 2 ) monodispersed nanoparticles synthesized using a thermodynamic redistribution strategy. Using advanced synchrotron-based X-ray techniques and simulations

In the late spring to summer season of 2023, Canada witnessed unprecedented wildfires, with an extensive burning area and smoke spreading as far as the East Coast of the United States and Europe. Here, using multisource data analysis and climate model simulations, we show that an abnormally warm North Atlantic, as well as an abnormally low Barents Sea ice concentration (SIC), are likely key climate

Antibiotic resistance is a global public health threat. Many factors contribute to this issue, with human antibiotic consumption being significant among them. Analyzing trends and patterns in consumption can aid in developing policies to mitigate the burden of antimicrobial resistance and global disparities in access to antibiotics. Using pharmaceutical sales data licensed from IQVIA, we estimate national-level

Human evolution is intricately linked with culture, which permeates almost all facets of human life from health and reproduction, to the environments in which we live. Nevertheless, our understanding of the ways in which stably transmitted, evolutionarily relevant human cultural traits might interact with the human genome is incomplete, and methods to detect such interactions are limited. Here, we

The Civil War was the deadliest conflict in US history. However, incomplete records have made it difficult to estimate the exact death toll both nationally, and especially, at the state level. In this article, we leverage the recently released full count of individual census returns and a sample of linked records across multiple censuses to provide i) the most precise national estimate of excess mortality

Primates are known for their exceptional ability to recognize faces. However, we still have much to learn about how their brains process faces when they are partially hidden. When we cover parts of a face, it affects how our brains respond, even though we still perceive the face as a whole. This suggests that complex brain networks are at work in understanding partially hidden faces. To explore this

Since their domestication, horses have accompanied mankind, and humans have constantly shaped horses according to their needs through stallion-centered breeding. Consequently, the male-specific portion of the Y chromosome (MSY) is extremely uniform in modern horse breeds. The majority of stallions worldwide carry MSY haplotypes (HT) attributed to an only ~1,500-y-old, so-called, “Crown” haplogroup

Nest predation rates critically influence avian biodiversity and evolution. In the north temperate zone, increased nest failure along edges of forest fragments is hypothesized to play a major role in the disappearance of bird species from disturbed landscapes. However, we lack comprehensive syntheses from tropical latitudes, where biodiversity is highest and increasingly threatened by habitat fragmentation

The loss of phosphorous (P) from the land to aquatic systems has polluted waters and threatened food production worldwide. Systematic trend analysis of P, a nonrenewable resource, has been challenging, primarily due to sparse and inconsistent historical data. Here, we leveraged intensive hydrometeorological data and the recent renaissance of deep learning approaches to fill data gaps and reconstruct

NLR family, apoptosis inhibitory proteins (NAIPs) detect bacterial flagellin and structurally related components of bacterial type III secretion systems (T3SS), and recruit NLR family CARD domain containing protein 4 (NLRC4) and caspase-1 into an inflammasome complex that induces pyroptosis. NAIP/NLRC4 inflammasome assembly is initiated by the binding of a single NAIP to its cognate ligand, but a subset

The last two decades have seen great advances in the study of social learning (learning from others), in part due to efforts to identify it in the wild as the basis of behavioral traditions. Theoretical frameworks suggest that both the dynamics of social tolerance and transmission biases (or social learning strategies) influence the pathways of information diffusion in social groups. Bearded capuchins

Cultural practices perceived to be adaptive—from clearing land for food production to medical innovations—can disseminate quickly through human populations. However, these same practices often have unintended maladaptive effects. A particularly consequential effect is the emergence of diseases. In numerous instances, a cultural change is followed by the appearance of a new pathogen. Here, we develop

Variability within species is key for adaptability and biological evolution. To understand individualities in the context of animal movement, we focused on one of the most remarkable migrations—the journey of the endangered European eel from their birthplace in the Sargasso Sea to freshwater environments. Laboratory observations unveiled a continuum of diverse phenotypes of migrating eels: Some displayed

All organisms use limited energy to grow, survive, and reproduce, necessitating energy allocation tradeoffs, but there is debate over how selection impacted metabolic budgets and tradeoffs in primates, including humans. Here, we develop a method to compare metabolic rates as quotients of observed relative to expected values for mammals corrected for size, body composition, environmental temperature

Cultural evolutionary processes can often lead to a statistical association between neutral and adaptive traits during episodes of population dispersal and the introduction of a beneficial technology in a geographic region. Here, we examine such cultural hitchhiking processes using an individual-based model that portrays the cultural interaction between a migrant and an incumbent population. Our model

The ability to follow the evolutionary trajectories of specific neuronal cell types has led to major insights into the evolution of the vertebrate brain. Here, we study how cave life in the Mexican tetra ( Astyanax mexicanus ) has affected an identified giant multisensory neuron, the Mauthner neuron (MN). Because this neuron is crucial in driving rapid escapes, the absence of predation risk in the

For many animals, color change is a critical adaptive mechanism believed to carry a substantial energetic cost. Yet, no study to date has directly measured the energy expenditure associated with this process. We examined the metabolic cost of color change in octopuses by measuring oxygen consumption in samples of excised octopus skin during periods of chromatophore expansion and contraction and then

Modern cultural evolution theory adopts a variety of concepts and methods developed in mathematical biology, in particular population genetics theory. In addition to forward-looking approaches such as two-locus models, backward-looking approaches such as coalescent theory, which describe ancestral states of the current population, have played an important role in population genetics. Here, we show

The study of cultural evolution using ideas from population biology began about 50 y ago, with the work of L.L. Cavalli-Sforza, Marcus Feldman, and ourselves. It has grown from this small beginning into a vital field with many publications and its own scientific society. In this essay, we give our perspective on the origins of the field and current unanswered questions.

We examine from whom children learn in mobile hunter-gatherers, a way of life that characterized much of human history. Recent studies on the modes of transmission in hunter-gatherers are reviewed before presenting an analysis of five modes of transmission described by Cavalli-Sforza and Feldman [L. L. Cavalli-Sforza, M. W. Feldman, Cultural Transmission and Evolution: A Quantitative Approach (1981)]

Many enveloped viruses bud from the plasma membrane that is tightly associated with a dense and thick actin cortex. This actin network represents a significant challenge for membrane deformation and scission, and how it is remodeled during the late steps of the viral cycle is largely unknown. Using superresolution microscopy, we show that HIV-1 buds in areas of the plasma membrane with low cortical

Cultural evolution applies evolutionary concepts and tools to explain the change of culture over time. Despite advances in both theoretical and empirical methods, the connections between cultural evolutionary theory and evidence are often vague, limiting progress. Theoretical models influence empirical research but rarely guide data collection and analysis in logical and transparent ways. Theoretical

One driver of the high failure rates of clinical trials for therapeutic cancer vaccines is likely the inability to sufficiently engage conventional dendritic cells (cDCs), the antigen-presenting cell (APC) subset that is specialized in priming antitumor T cells. Here, we demonstrate that, relative to vaccination with an injectable mesoporous silica rod (MPS) vaccine alone (Vax), combining MPS vaccines

Quantitative studies of cultural evolution and gene-culture coevolution (henceforth “CE” and “GCC”) emerged in the 1970s, in the aftermath of the “race and intelligence quotient (IQ)” and “human sociobiology” debates, as a counter to extreme hereditarian positions. These studies incorporated cultural transmission and its interaction with genetics in contributing to patterns of human variation. Neither

This article retraces the career of geneticist L. Luca Cavalli-Sforza, from his days as a student researcher to his tenure as a Stanford University professor, and beyond. We show how Cavalli-Sforza’s untiring curiosity, enthusiasm, and global knowledge led him to make incisive contributions to topics as diverse as bacterial genetics and human evolution, both biological and cultural. In an academic

Highsucrose diet (HSD) was reported as a causative factor for multiorgan injuries. The underlying mechanisms and therapeutic strategies remain largely uncharted. In the present study, by using a metabolomics approach, we identified the soluble epoxide hydrolase (sEH) as a therapeutic target for HSD-mediated gut barrier dysfunction. Specifically, 16-week feeding on an HSD caused gut barrier dysfunction

The history of people’s movements and interactions shapes both genetic and linguistic variation. Genes and languages are transmitted separately and their distributions reflect different aspects of human history, but some demographic processes can cause them to be similarly distributed. In particular, forms of societal organization, including movements in and out of a community, may have shaped the

Although the theoretical foundations of the modern field of cultural evolution have been in place for over 50 y, laboratory experiments specifically designed to test cultural evolutionary theory have only existed for the last two decades. Here, we review the main experimental designs used in the field of cultural evolution, as well as major findings related to the generation of cultural variation,

In response to a recent challenge to the longstanding practice in modeling large-scale circulations in the atmosphere and ocean that neglects any horizontal component of Earth’s gravity-rotation force, this paper demonstrates that a coordinate transformation into geopotential coordinates has no such horizontal force. This framework should be understood as the justification for and, if warranted, the

Symmetry lies at the heart of two-dimensional (2D) bioelectronics, determining material properties at the fundamental level. Breaking the symmetry allows emergent functionalities and effects. However, symmetry modulation in 2D bioelectronics and the resultant applications have been largely overlooked. Here, we devise an oxidized architectural MXene, referred to as oxidized MXene (OXene), that couples

Climate change poses complex risks without precedent that challenge established planning and risk management tools, including property insurance. The nature and timing of transitions in markets and institutions in response to growing climate risks will shape prospects for future socioeconomic well-being. As property insurance markets in the United States face higher levels of turmoil, policymakers

Cultivation studies evaluating land-use histories and coevolutionary dynamics between humans and plants focus predominantly on domesticated species. Traditional anthropological divisions of “foragers” and “farmers” have shaped our understanding of ancient cultivation practices but have several limitations, including how people stewarded and managed nondomesticated species. To investigate the long-term

Rhodopsin, the prototypical class-A G-protein coupled receptor, is a highly sensitive receptor for light that enables phototransduction in rod photoreceptors. Rhodopsin plays not only a sensory role but also a structural role as a major component of the rod outer segment disc, comprising over 90% of the protein content of the disc membrane. Mutations in RHO which lead to structural or functional abnormalities

Erectile dysfunction (ED) is a major threat to male fertility and quality of life, and mesenchymal stromal cells (MSCs) are a promising therapeutic option. However, therapeutic outcomes are compromised by low MSC retention and survival rates in corpus cavernosum tissue. Here, we developed an innovative magnetic soft microrobot comprising an ultrasoft hydrogel microsphere embedded with a magnetic nanoparticle

Topological transport is determined by global properties of physical media where it occurs and is characterized by quantized amounts of adiabatically transported quantities. Discovered for periodic potential, it was also explored in disordered and discrete quasiperiodic systems. Here, we report on experimental observation of pumping of a light beam in a genuinely continuous incommensurate photorefractive

How do people search for information when they are given the opportunity to freely explore their options? Previous research has suggested that people focus on reducing uncertainty before making a decision, but it remains unclear how exactly they do so and whether they do so consistently. We present an analysis of over 1,000,000 information-search decisions made by over 2,500 individuals in a decis

Spin and orbital degrees of freedom are crucial in not only fundamental particles but also classical waves such as optical systems, wherein the spin–orbit interaction (SOI) of light provides new perspectives for manipulating electromagnetic waves. Elastic waves possess similar spin angular momentum (SAM) and orbital angular momentum (OAM). However, the elastic counterpart of SOI remains unexplored

Poly (ADP-ribose) glycohydrolase (PARG) is a dePARylating enzyme which promotes DNA repair by removal of poly (ADP-ribose) (PAR) from PARylated proteins. Loss or inhibition of PARG results in replication stress and sensitizes cancer cells to DNA-damaging agents. PARG inhibitors are now undergoing clinical development for patients having tumors with homologous recombination deficiency (HRD), such as

We develop a game-theoretic model of strategic interdependence and tipping in public policy choices and show that the model can be estimated by probit and logit estimators. We test its validity and applicability by using daily data on state-level COVID-19 responses in the United States. Social distancing via shelter-in-place (SIP) strategies and wearing masks emerged as the most effective nonpharmaceutical

Hepatitis E virus (HEV) infections are one of the most common causes of acute viral hepatitis, annually causing over 3 million symptomatic cases and 70,000 deaths worldwide. Historically, HEV was described as a hepatotropic virus, but has recently been associated with various extrahepatic manifestations including neurological disorders such as Guillain–Barré syndrome and neuralgic amyotrophy. However