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Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis Nature (IF 50.5) Pub Date : 2025-04-16
Malgorzata Gozdecka, Monika Dudek, Sean Wen, Muxin Gu, Richard J. Stopforth, Justyna Rak, Aristi Damaskou, Guinevere L. Grice, Matthew A. McLoughlin, Laura Bond, Rachael Wilson, George Giotopoulos, Vijaya Mahalingam Shanmugiah, Rula Bany Bakar, Eliza Yankova, Jonathan L. Cooper, Nisha Narayan, Sarah J. Horton, Ryan Asby, Dean C. Pask, Annalisa Mupo, Graham Duddy, Ludovica Marando, Theodoros GeorgomanolisSomatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To identify DNMT3A-R882-mutant-specific vulnerabilities, we conducted a genome-wide CRISPR screen on primary
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The phased pan-genome of tetraploid European potato Nature (IF 50.5) Pub Date : 2025-04-16
Hequan Sun, Sergio Tusso, Craig I. Dent, Manish Goel, Raúl Y. Wijfjes, Lisa C. Baus, Xiao Dong, José A. Campoy, Ana Kurdadze, Birgit Walkemeier, Christine Sänger, Bruno Huettel, Ronald C. B. Hutten, Herman J. van Eck, Klaus J. Dehmer, Korbinian Schneeberger -
Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs Nature (IF 50.5) Pub Date : 2025-04-16
Mohsen Hosseini, Veronique Voisin, Ali Chegini, Angelica Varesi, Severine Cathelin, Dhanoop Manikoth Ayyathan, Alex C. H. Liu, Yitong Yang, Vivian Wang, Abdula Maher, Eric Grignano, Julie A. Reisz, Angelo D’Alessandro, Kira Young, Yiyan Wu, Martina Fiumara, Samuele Ferrari, Luigi Naldini, Federico Gaiti, Shraddha Pai, Grace Egan, Aaron D. Schimmer, Gary D. Bader, John E. Dick, Stephanie Z. Xie, Jennifer -
Electric-field-induced domain walls in wurtzite ferroelectrics Nature (IF 50.5) Pub Date : 2025-04-16
Ding Wang, Danhao Wang, Mahlet Molla, Yujie Liu, Samuel Yang, Shuaishuai Yuan, Jiangnan Liu, Mingtao Hu, Yuanpeng Wu, Tao Ma, Kai Sun, Hong Guo, Emmanouil Kioupakis, Zetian Mi -
Multi-zonal liver organoids from human pluripotent stem cells Nature (IF 50.5) Pub Date : 2025-04-16
Hasan Al Reza, Connie Santangelo, Kentaro Iwasawa, Abid Al Reza, Sachiko Sekiya, Kathryn Glaser, Alexander Bondoc, Jonathan Merola, Takanori Takebe -
A pangenome reference of wild and cultivated rice Nature (IF 50.5) Pub Date : 2025-04-16
Dongling Guo, Yan Li, Hengyun Lu, Yan Zhao, Nori Kurata, Xinghua Wei, Ahong Wang, Yongchun Wang, Qilin Zhan, Danlin Fan, Congcong Zhou, Yiqi Lu, Qilin Tian, Qijun Weng, Qi Feng, Tao Huang, Lei Zhang, Zhoulin Gu, Changsheng Wang, Ziqun Wang, Zixuan Wang, Xuehui Huang, Qiang Zhao, Bin Han -
Structure of the ATP-driven methyl-coenzyme M reductase activation complex Nature (IF 50.5) Pub Date : 2025-04-16
Fidel Ramírez-Amador, Sophia Paul, Anuj Kumar, Christian Lorent, Sebastian Keller, Stefan Bohn, Thinh Nguyen, Stefano Lometto, Dennis Vlegels, Jörg Kahnt, Darja Deobald, Frank Abendroth, Olalla Vázquez, Georg Hochberg, Silvan Scheller, Sven T. Stripp, Jan Michael Schuller -
An ultrasensitive method for detection of cell-free RNA Nature (IF 50.5) Pub Date : 2025-04-16
Monica C. Nesselbush, Bogdan A. Luca, Young-Jun Jeon, Isabel Jabara, Catherine B. Meador, Andrea Garofalo, Michael S. Binkley, Angela B. Hui, Iris van ‘t Erve, Nova Xu, William Y. Shi, Kevin J. Liu, Takeshi Sugio, Noah Kastelowitz, Emily G. Hamilton, Chih Long Liu, Mari Olsen, Rene F. Bonilla, Yi Peng Wang, Alice Jiang, Brianna Lau, Jordan Eichholz, Mandeep Banwait, Joseph Schroers-Martin, Jan Boegeholz -
Observation of the axion quasiparticle in 2D MnBi2Te4 Nature (IF 50.5) Pub Date : 2025-04-16
Jian-Xiang Qiu, Barun Ghosh, Jan Schütte-Engel, Tiema Qian, Michael Smith, Yueh-Ting Yao, Junyeong Ahn, Yu-Fei Liu, Anyuan Gao, Christian Tzschaschel, Houchen Li, Ioannis Petrides, Damien Bérubé, Thao Dinh, Tianye Huang, Olivia Liebman, Emily M. Been, Joanna M. Blawat, Kenji Watanabe, Takashi Taniguchi, Kin Chung Fong, Hsin Lin, Peter P. Orth, Prineha Narang, Claudia Felser, Tay-Rong Chang, Ross McDonald -
Subnanosecond flash memory enabled by 2D-enhanced hot-carrier injection Nature (IF 50.5) Pub Date : 2025-04-16
Yutong Xiang, Chong Wang, Chunsen Liu, Tanjun Wang, Yongbo Jiang, Yang Wang, Shuiyuan Wang, Peng Zhou -
A sharp volatile-rich cap to the Yellowstone magmatic system Nature (IF 50.5) Pub Date : 2025-04-16
Chenglong Duan, Wenkai Song, Brandon Schmandt, Jamie Farrell, David Lumley, Tobias Fischer, Lindsay Lowe Worthington, Fan-Chi Lin -
Driven bright solitons on a mid-infrared laser chip Nature (IF 50.5) Pub Date : 2025-04-16
Dmitry Kazakov, Theodore P. Letsou, Marco Piccardo, Lorenzo L. Columbo, Massimo Brambilla, Franco Prati, Sandro Dal Cin, Maximilian Beiser, Nikola Opačak, Pawan Ratra, Michael Pushkarsky, David Caffey, Timothy Day, Luigi A. Lugiato, Benedikt Schwarz, Federico Capasso -
Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease Nature (IF 50.5) Pub Date : 2025-04-16
Nobukatsu Sawamoto, Daisuke Doi, Etsuro Nakanishi, Masanori Sawamura, Takayuki Kikuchi, Hodaka Yamakado, Yosuke Taruno, Atsushi Shima, Yasutaka Fushimi, Tomohisa Okada, Tetsuhiro Kikuchi, Asuka Morizane, Satoe Hiramatsu, Takayuki Anazawa, Takero Shindo, Kentaro Ueno, Satoshi Morita, Yoshiki Arakawa, Yuji Nakamoto, Susumu Miyamoto, Ryosuke Takahashi, Jun Takahashi -
Chromosome end protection by RAP1-mediated inhibition of DNA-PK Nature (IF 50.5) Pub Date : 2025-04-16
Patrik Eickhoff, Ceylan Sonmez, Charlotte E. L. Fisher, Oviya Inian, Theodoros I. Roumeliotis, Angela dello Stritto, Jörg Mansfeld, Jyoti S. Choudhary, Sebastian Guettler, Francisca Lottersberger, Max E. Douglas -
The growing memristor industry Nature (IF 50.5) Pub Date : 2025-04-16
Mario Lanza, Sebastian Pazos, Fernando Aguirre, Abu Sebastian, Manuel Le Gallo, Syed M. Alam, Sumio Ikegawa, J. Joshua Yang, Elisa Vianello, Meng-Fan Chang, Gabriel Molas, Ishai Naveh, Daniele Ielmini, Ming Liu, Juan B. Roldan -
Antiferromagnetic quantum anomalous Hall effect under spin flips and flops Nature (IF 50.5) Pub Date : 2025-04-16
Zichen Lian, Yongchao Wang, Yongqian Wang, Wen-Han Dong, Yang Feng, Zehao Dong, Mangyuan Ma, Shuai Yang, Liangcai Xu, Yaoxin Li, Bohan Fu, Yuetan Li, Wanjun Jiang, Yong Xu, Chang Liu, Jinsong Zhang, Yayu Wang -
Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation Nature (IF 50.5) Pub Date : 2025-04-16
Amir Hosseini, Abhinav Dhall, Nemo Ikonen, Natalia Sikora, Sylvain Nguyen, Yuqi Shen, Maria Luisa Jurgensen Amaral, Alan Jiao, Felice Wallner, Philipp Sergeev, Yuhua Lim, Yuanqin Yang, Binje Vick, Kimihito Cojin Kawabata, Ari Melnick, Paresh Vyas, Bing Ren, Irmela Jeremias, Bethan Psaila, Caroline A. Heckman, M. Andrés Blanco, Yang Shi -
Histone H1 deamidation facilitates chromatin relaxation for DNA repair Nature (IF 50.5) Pub Date : 2025-04-16
Yuan Tian, Tingting Feng, Jun Zhang, Qingren Meng, Wenxin Zhan, Ming Tang, Chaohua Liu, Mengyan Li, Wenhui Tao, Yuxin Shu, Yu Zhang, Feng Chen, Shunichi Takeda, Qian Zhu, Xiaopeng Lu, Wei-Guo Zhu -
Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines Nature (IF 50.5) Pub Date : 2025-04-16
Paweł S. Krawczyk, Michał Mazur, Wiktoria Orzeł, Olga Gewartowska, Sebastian Jeleń, Wiktor Antczak, Karolina Kasztelan, Aleksandra Brouze, Katarzyna Matylla-Kulińska, Natalia Gumińska, Bartosz Tarkowski, Ewelina P. Owczarek, Kamila Affek, Paweł Turowski, Agnieszka Tudek, Małgorzata Sroka, Tomasz Śpiewla, Monika Kusio-Kobiałka, Aleksandra Wesołowska, Dominika Nowis, Jakub Golab, Joanna Kowalska, Jacek -
Towards multimodal foundation models in molecular cell biology Nature (IF 50.5) Pub Date : 2025-04-16
Haotian Cui, Alejandro Tejada-Lapuerta, Maria Brbić, Julio Saez-Rodriguez, Simona Cristea, Hani Goodarzi, Mohammad Lotfollahi, Fabian J. Theis, Bo Wang -
Generation of human adult hepatocyte organoids with metabolic functions Nature (IF 50.5) Pub Date : 2025-04-16
Ryo Igarashi, Mayumi Oda, Ryo Okada, Tomoki Yano, Sirirat Takahashi, Strahil Pastuhov, Mami Matano, Norio Masuda, Kazuhiro Togasaki, Yuki Ohta, Saeko Sato, Takako Hishiki, Makoto Suematsu, Manabu Itoh, Masayuki Fujii, Toshiro Sato -
Deep Visual Proteomics maps proteotoxicity in a genetic liver disease Nature (IF 50.5) Pub Date : 2025-04-16
Florian A. Rosenberger, Sophia C. Mädler, Katrine Holtz Thorhauge, Sophia Steigerwald, Malin Fromme, Mikhail Lebedev, Caroline A. M. Weiss, Marc Oeller, Maria Wahle, Andreas Metousis, Maximilian Zwiebel, Niklas A. Schmacke, Sönke Detlefsen, Peter Boor, Ondřej Fabián, Soňa Fraňková, Aleksander Krag, Pavel Strnad, Matthias Mann -
Wide-swath satellite altimetry unveils global submesoscale ocean dynamics Nature (IF 50.5) Pub Date : 2025-04-16
Matthew Archer, Jinbo Wang, Patrice Klein, Gerald Dibarboure, Lee-Lueng Fu -
Low overlap of transcription factor DNA binding and regulatory targets Nature (IF 50.5) Pub Date : 2025-04-16
Lakshmi Mahendrawada, Linda Warfield, Rafal Donczew, Steven Hahn -
Phase I trial of hES cell-derived dopaminergic neurons for Parkinson’s disease Nature (IF 50.5) Pub Date : 2025-04-16
V. Tabar, H. Sarva, A. M. Lozano, A. Fasano, S. K. Kalia, K. K. H. Yu, C. Brennan, Y. Ma, S. Peng, D. Eidelberg, M. Tomishima, S. Irion, W. Stemple, N. Abid, A. Lampron, L. Studer, C. Henchcliffe -
Negative thermal expansion and oxygen-redox electrochemistry Nature (IF 50.5) Pub Date : 2025-04-16
Bao Qiu, Yuhuan Zhou, Haoyan Liang, Minghao Zhang, Kexin Gu, Tao Zeng, Zhou Zhou, Wen Wen, Ping Miao, Lunhua He, Yinguo Xiao, Sven Burke, Zhaoping Liu, Ying Shirley Meng -
Prdm16-dependent antigen-presenting cells induce tolerance to gut antigens Nature (IF 50.5) Pub Date : 2025-04-14
Liuhui Fu, Rabi Upadhyay, Maria Pokrovskii, Francis M. Chen, Gabriela Romero-Meza, Adam Griesemer, Dan R. LittmanThe gastrointestinal tract is continuously exposed to foreign antigens in food and commensal microbes with potential to induce adaptive immune responses. Peripherally induced T regulatory (pTreg) cells are essential for mitigating inflammatory responses to these agents1–4. While RORγt+ antigen-presenting cells (RORγt-APCs) were shown to program gut microbiota-specific pTreg5–7, their definition remains
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Towards accurate differential diagnosis with large language models Nature (IF 50.5) Pub Date : 2025-04-09
Daniel McDuff, Mike Schaekermann, Tao Tu, Anil Palepu, Amy Wang, Jake Garrison, Karan Singhal, Yash Sharma, Shekoofeh Azizi, Kavita Kulkarni, Le Hou, Yong Cheng, Yun Liu, S. Sara Mahdavi, Sushant Prakash, Anupam Pathak, Christopher Semturs, Shwetak Patel, Dale R. Webster, Ewa Dominowska, Juraj Gottweis, Joelle Barral, Katherine Chou, Greg S. Corrado, Yossi Matias, Jake Sunshine, Alan Karthikesalingam -
Connectomics of predicted Sst transcriptomic types in mouse visual cortex Nature (IF 50.5) Pub Date : 2025-04-09
Clare R. Gamlin, Casey M. Schneider-Mizell, Matthew Mallory, Leila Elabbady, Nathan Gouwens, Grace Williams, Alice Mukora, Rachel Dalley, Agnes L. Bodor, Derrick Brittain, JoAnn Buchanan, Daniel J. Bumbarger, Emily Joyce, Daniel Kapner, Sam Kinn, Gayathri Mahalingam, Sharmishtaa Seshamani, Marc Takeno, Russel Torres, Wenjing Yin, Philip R. Nicovich, J. Alexander Bae, Manuel A. Castro, Sven Dorkenwald -
Ultra-broadband optical amplification using nonlinear integrated waveguides Nature (IF 50.5) Pub Date : 2025-04-09
Ping Zhao, Vijay Shekhawat, Marcello Girardi, Zonglong He, Victor Torres-Company, Peter A. Andrekson -
Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease Nature (IF 50.5) Pub Date : 2025-04-09
Kimitoshi Kimura, Ayshwarya Subramanian, Zhuoran Yin, Ahad Khalilnezhad, Yufan Wu, Danyang He, Karen O. Dixon, Udbhav Kasyap Chitta, Xiaokai Ding, Niraj Adhikari, Isabell Guzchenko, Xiaoming Zhang, Ruihan Tang, Thomas Pertel, Samuel A. Myers, Aastha Aastha, Masashi Nomura, Ghazaleh Eskandari-Sedighi, Vasundhara Singh, Lei Liu, Conner Lambden, Kilian L. Kleemann, Neha Gupta, Jen-Li Barry, Ana Durao -
Active energy compression of a laser-plasma electron beam Nature (IF 50.5) Pub Date : 2025-04-09
P. Winkler, M. Trunk, L. Hübner, A. Martinez de la Ossa, S. Jalas, M. Kirchen, I. Agapov, S. A. Antipov, R. Brinkmann, T. Eichner, A. Ferran Pousa, T. Hülsenbusch, G. Palmer, M. Schnepp, K. Schubert, M. Thévenet, P. A. Walker, C. Werle, W. P. Leemans, A. R. Maier -
Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM Nature (IF 50.5) Pub Date : 2025-04-09
David P. Klebl, Sean N. McMillan, Cristina Risi, Eva Forgacs, Betty Virok, Jennifer L. Atherton, Sarah A. Harris, Michele Stofella, Donald A. Winkelmann, Frank Sobott, Vitold E. Galkin, Peter J. Knight, Stephen P. Muench, Charlotte A. Scarff, Howard D. White -
Foundation model of neural activity predicts response to new stimulus types Nature (IF 50.5) Pub Date : 2025-04-09
Eric Y. Wang, Paul G. Fahey, Zhuokun Ding, Stelios Papadopoulos, Kayla Ponder, Marissa A. Weis, Andersen Chang, Taliah Muhammad, Saumil Patel, Zhiwei Ding, Dat Tran, Jiakun Fu, Casey M. Schneider-Mizell, R. Clay Reid, Forrest Collman, Nuno Maçarico da Costa, Katrin Franke, Alexander S. Ecker, Jacob Reimer, Xaq Pitkow, Fabian H. Sinz, Andreas S. Tolias -
Leaf absorption contributes to accumulation of microplastics in plants Nature (IF 50.5) Pub Date : 2025-04-09
Ye Li, Junjie Zhang, Li Xu, Ruoqi Li, Rui Zhang, Mengxi Li, Chunmei Ran, Ziyu Rao, Xing Wei, Mingli Chen, Lu Wang, Zhiwanxin Li, Yining Xue, Chu Peng, Chunguang Liu, Hongwen Sun, Baoshan Xing, Lei Wang -
Phenotypic complexities of rare heterozygous neurexin-1 deletions Nature (IF 50.5) Pub Date : 2025-04-09
Michael B. Fernando, Yu Fan, Yanchun Zhang, Alex Tokolyi, Aleta N. Murphy, Sarah Kammourh, P. J. Michael Deans, Sadaf Ghorbani, Ryan Onatzevitch, Adriana Pero, Christopher Padilla, Sarah E. Williams, Erin K. Flaherty, Iya A. Prytkova, Lei Cao, David A. Knowles, Gang Fang, Paul A. Slesinger, Kristen J. Brennand -
Human assembloid model of the ascending neural sensory pathway Nature (IF 50.5) Pub Date : 2025-04-09
Ji-il Kim, Kent Imaizumi, Ovidiu Jurjuț, Kevin W. Kelley, Dong Wang, Mayuri Vijay Thete, Zuzana Hudacova, Neal D. Amin, Rebecca J. Levy, Grégory Scherrer, Sergiu P. Pașca -
Perisomatic ultrastructure efficiently classifies cells in mouse cortex Nature (IF 50.5) Pub Date : 2025-04-09
Leila Elabbady, Sharmishtaa Seshamani, Shang Mu, Gayathri Mahalingam, Casey M. Schneider-Mizell, Agnes L. Bodor, J. Alexander Bae, Derrick Brittain, JoAnn Buchanan, Daniel J. Bumbarger, Manuel A. Castro, Sven Dorkenwald, Akhilesh Halageri, Zhen Jia, Chris Jordan, Dan Kapner, Nico Kemnitz, Sam Kinn, Kisuk Lee, Kai Li, Ran Lu, Thomas Macrina, Eric Mitchell, Shanka Subhra Mondal, Barak Nehoran, Sergiy -
Comprehensive interrogation of synthetic lethality in the DNA damage response Nature (IF 50.5) Pub Date : 2025-04-09
John Fielden, Sebastian M. Siegner, Danielle N. Gallagher, Markus S. Schröder, Maria Rosaria Dello Stritto, Simon Lam, Lena Kobel, Moritz F. Schlapansky, Stephen P. Jackson, Petr Cejka, Marco Jost, Jacob E. Corn -
Seismic imaging of a basaltic Lesser Antilles slab from ancient tectonics Nature (IF 50.5) Pub Date : 2025-04-09
Xusong Yang, Yujiang Xie, Catherine A. Rychert, Nicholas Harmon, Saskia Goes, Andreas Rietbrock, Lloyd Lynch -
Giant electrocaloric effect in high-polar-entropy perovskite oxides Nature (IF 50.5) Pub Date : 2025-04-09
Feihong Du, Tiannan Yang, Hua Hao, Shangshu Li, Chenhang Xu, Tian Yao, Zhiwu Song, Jiahe Shen, Chenyun Bai, Ruhong Luo, Donglin Han, Qiang Li, Shanyu Zheng, Yingjing Zhang, Yezhan Lin, Zhenhua Ma, Haotian Chen, Chenyu Guo, Jiawang Feng, Shengyi Zhong, Ruilin Mai, Guodong Hou, Haixin Qiu, Meng Xie, Xin Chen, Yakun Yuan, Dong Qian, Dao Xiang, Xuefeng Chen, Zhengqian Fu, Genshui Wang, Hanxing Liu, Jiangping -
A non-contact wearable device for monitoring epidermal molecular flux Nature (IF 50.5) Pub Date : 2025-04-09
Jaeho Shin, Joseph Woojin Song, Matthew Thomas Flavin, Seunghee Cho, Shupeng Li, Ansen Tan, Kyung Rok Pyun, Aaron G Huang, Huifeng Wang, Seongmin Jeong, Kenneth E. Madsen, Jacob Trueb, Mirae Kim, Katelynn Nguyen, Angela Yang, Yaching Hsu, Winnie Sung, Jiwon Lee, Sooyeol Phyo, Ji-Hoon Kim, Anthony Banks, Jan-Kai Chang, Amy S. Paller, Yonggang Huang, Guillermo A. Ameer, John A. Rogers -
Reprogramming site-specific retrotransposon activity to new DNA sites Nature (IF 50.5) Pub Date : 2025-04-09
Christopher W. Fell, Lukas Villiger, Justin Lim, Masahiro Hiraizumi, Dario Tagliaferri, Matthew T. N. Yarnall, Anderson Lee, Kaiyi Jiang, Alisan Kayabolen, Rohan N. Krajeski, Cian Schmitt-Ulms, Harsh Ramani, Sarah M. Yousef, Nathaniel Roberts, Christopher A. Vakulskas, Hiroshi Nishimasu, Omar O. Abudayyeh, Jonathan S. Gootenberg -
Hunter-gatherer sea voyages extended to remotest Mediterranean islands Nature (IF 50.5) Pub Date : 2025-04-09
Eleanor M. L. Scerri, James Blinkhorn, Huw S. Groucutt, Mathew Stewart, Ian Candy, Ethel Allué, Aitor Burguet-Coca, Andrés Currás, W. Christopher Carleton, Susanne Lindauer, Robert Spengler, Kseniia Boxleitner, Gillian Asciak, Margherita Colucci, Ritienne Gauci, Amy Hatton, Johanna Kutowsky, Andreas Maier, Mario Mata-González, Nicolette Mifsud, Khady Niang, Patrick Roberts, Joshua de Giorgio, Rochelle -
NEURD offers automated proofreading and feature extraction for connectomics Nature (IF 50.5) Pub Date : 2025-04-09
Brendan Celii, Stelios Papadopoulos, Zhuokun Ding, Paul G. Fahey, Eric Wang, Christos Papadopoulos, Alexander B. Kunin, Saumil Patel, J. Alexander Bae, Agnes L. Bodor, Derrick Brittain, JoAnn Buchanan, Daniel J. Bumbarger, Manuel A. Castro, Erick Cobos, Sven Dorkenwald, Leila Elabbady, Akhilesh Halageri, Zhen Jia, Chris Jordan, Dan Kapner, Nico Kemnitz, Sam Kinn, Kisuk Lee, Kai Li, Ran Lu, Thomas Macrina -
Complete sequencing of ape genomes Nature (IF 50.5) Pub Date : 2025-04-09
DongAhn Yoo, Arang Rhie, Prajna Hebbar, Francesca Antonacci, Glennis A. Logsdon, Steven J. Solar, Dmitry Antipov, Brandon D. Pickett, Yana Safonova, Francesco Montinaro, Yanting Luo, Joanna Malukiewicz, Jessica M. Storer, Jiadong Lin, Abigail N. Sequeira, Riley J. Mangan, Glenn Hickey, Graciela Monfort Anez, Parithi Balachandran, Anton Bankevich, Christine R. Beck, Arjun Biddanda, Matthew Borchers -
DNA-guided transcription factor interactions extend human gene regulatory code Nature (IF 50.5) Pub Date : 2025-04-09
Zhiyuan Xie, Ilya Sokolov, Maria Osmala, Xue Yue, Grace Bower, J. Patrick Pett, Yinan Chen, Kai Wang, Ayse Derya Cavga, Alexander Popov, Sarah A. Teichmann, Ekaterina Morgunova, Evgeny Z. Kvon, Yimeng Yin, Jussi Taipale -
Goal-specific hippocampal inhibition gates learning Nature (IF 50.5) Pub Date : 2025-04-09
Nuri Jeong, Xiao Zheng, Abigail L. Paulson, Stephanie M. Prince, Victor P. Nguyen, Sherina R. Thomas, Caroline E. Gilpin, Matthew C. Goodson, Annabelle C. Singer -
Transforming ceria into 2D clusters enhances catalytic activity Nature (IF 50.5) Pub Date : 2025-04-09
Konstantin Khivantsev, Hien Pham, Mark H. Engelhard, Hristiyan A. Aleksandrov, Libor Kovarik, Mark Bowden, Xiaohong Shari Li, Jinshu Tian, Iskra Z. Koleva, Inhak Song, Wenda Hu, Xinyi Wei, Yipeng Sun, Pascaline Tran, Trent R. Graham, Dong Jiang, David P. Dean, Christian J. Breckner, Jeffrey T. Miller, Georgi N. Vayssilov, János Szanyi, Abhaya Datye, Yong Wang -
Inhibitory specificity from a connectomic census of mouse visual cortex Nature (IF 50.5) Pub Date : 2025-04-09
Casey M. Schneider-Mizell, Agnes L. Bodor, Derrick Brittain, JoAnn Buchanan, Daniel J. Bumbarger, Leila Elabbady, Clare Gamlin, Daniel Kapner, Sam Kinn, Gayathri Mahalingam, Sharmishtaa Seshamani, Shelby Suckow, Marc Takeno, Russel Torres, Wenjing Yin, Sven Dorkenwald, J. Alexander Bae, Manuel A. Castro, Akhilesh Halageri, Zhen Jia, Chris Jordan, Nico Kemnitz, Kisuk Lee, Kai Li, Ran Lu, Thomas Macrina -
Water abundance in the lunar farside mantle Nature (IF 50.5) Pub Date : 2025-04-09
Huicun He, Linxi Li, Sen Hu, Yubing Gao, Liang Gao, Zhan Zhou, Mengfan Qiu, Disheng Zhou, Huanxin Liu, Ruiying Li, Jialong Hao, Hejiu Hui, Yangting Lin -
Small molecules restore mutant mitochondrial DNA polymerase activity Nature (IF 50.5) Pub Date : 2025-04-09
Sebastian Valenzuela, Xuefeng Zhu, Bertil Macao, Mattias Stamgren, Carol Geukens, Paul S. Charifson, Gunther Kern, Emily Hoberg, Louise Jenninger, Anja V. Gruszczyk, Seoeun Lee, Katarina A. S. Johansson, Javier Miralles Fusté, Yonghong Shi, S. Jordan Kerns, Laleh Arabanian, Gabriel Martinez Botella, Sofie Ekström, Jeremy Green, Andrew M. Griffin, Carlos Pardo-Hernández, Thomas A. Keating, Barbara Küppers-Munther -
Translational genomics of osteoarthritis in 1,962,069 individuals Nature (IF 50.5) Pub Date : 2025-04-09
Konstantinos Hatzikotoulas, Lorraine Southam, Lilja Stefansdottir, Cindy G. Boer, Merry-Lynn McDonald, J. Patrick Pett, Young-Chan Park, Margo Tuerlings, Rick Mulders, Andrei Barysenka, Ana Luiza Arruda, Vinicius Tragante, Alison Rocco, Norbert Bittner, Shibo Chen, Susanne Horn, Vinodh Srinivasasainagendra, Ken To, Georgia Katsoula, Peter Kreitmaier, Amabel M. M. Tenghe, Arthur Gilly, Liubov Arbeeva -
Functional connectomics spanning multiple areas of mouse visual cortex Nature (IF 50.5) Pub Date : 2025-04-09
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A Jurassic acanthocephalan illuminates the origin of thorny-headed worms Nature (IF 50.5) Pub Date : 2025-04-09
Cihang Luo, Luke A. Parry, Brendon E. Boudinot, Shengyu Wang, Edmund A. Jarzembowski, Haichun Zhang, Bo Wang -
Evidence of star cluster migration and merger in dwarf galaxies Nature (IF 50.5) Pub Date : 2025-04-09
Mélina Poulain, Rory Smith, Pierre-Alain Duc, Francine R. Marleau, Rebecca Habas, Patrick R. Durrell, Jérémy Fensch, Sungsoon Lim, Oliver Müller, Sanjaya Paudel, Rubén Sánchez-Janssen -
Stress dynamically modulates neuronal autophagy to gate depression onset Nature (IF 50.5) Pub Date : 2025-04-09
Liang Yang, Chen Guo, Zhiwei Zheng, Yiyan Dong, Qifeng Xie, Zijian Lv, Min Li, Yangyang Lu, Xiaonan Guo, Rongshan Deng, Yiqin Liu, Yirong Feng, Ruiqi Mu, Xuliang Zhang, Huan Ma, Zhong Chen, Zhijun Zhang, Zhaoqi Dong, Wei Yang, Xiangnan Zhang, Yihui Cui -
Universal photonic artificial intelligence acceleration Nature (IF 50.5) Pub Date : 2025-04-09
Sufi R. Ahmed, Reza Baghdadi, Mikhail Bernadskiy, Nate Bowman, Ryan Braid, Jim Carr, Chen Chen, Pietro Ciccarella, Matthew Cole, John Cooke, Kishor Desai, Carlos Dorta, Jonathan Elmhurst, Bryce Gardiner, Elliot Greenwald, Shashank Gupta, Parry Husbands, Brian Jones, Anthony Kopa, Ho John Lee, Arulselvan Madhavan, Adam Mendrela, Nicholas Moore, Lakshmi Nair, Aditya Om, Subie Patel, Rutayan Patro, Rob -
Recurrent humid phases in Arabia over the past 8 million years Nature (IF 50.5) Pub Date : 2025-04-09
Monika Markowska, Hubert B. Vonhof, Huw S. Groucutt, Paul S. Breeze, Nick Drake, Mathew Stewart, Richard Albert, Eric Andrieux, James Blinkhorn, Nicole Boivin, Alexander Budsky, Richard Clark-Wilson, Dominik Fleitmann, Axel Gerdes, Ashley N. Martin, Alfredo Martínez-García, Samuel L. Nicholson, Gilbert J. Price, Eleanor M. L. Scerri, Denis Scholz, Nils Vanwezer, Michael Weber, Abdullah M. Alsharekh -
Intersectional analysis for science and technology Nature (IF 50.5) Pub Date : 2025-04-09
Mathias Wullum Nielsen, Elena Gissi, Shirin Heidari, Richard Horton, Kari C. Nadeau, Dorothy Ngila, Safiya Umoja Noble, Hee Young Paik, Girmaw Abebe Tadesse, Eddy Y. Zeng, James Zou, Londa SchiebingerIntersectionality describes interdependent systems of inequality related to sex, gender, race, age, class and other socio-political dimensions. By focusing on the compounded effects of social categories, intersectional analysis can enhance the accuracy and experimental efficiency of science. Here we extend intersectional approaches that were predominantly developed in the humanities, social sciences
更新日期：2025-04-17
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