Achieving net zero global emissions of carbon dioxide (CO2), with declining emissions of other greenhouse gases, is widely expected to halt global warming. CO2 emissions will continue to drive warming until fully balanced by active anthropogenic CO2 removals. For practical reasons, however, many greenhouse gas accounting systems allow some “passive” CO2 uptake, such as enhanced vegetation growth due

Unravelling the volcanic history of the enigmatic lunar farside is essential for understanding the hemispheric dichotomy of the Moon1-3. Cratering chronology established for the lunar nearside has been used to suggest long-lived volcanism on the farside of the Moon3,4, but without sample verification. Here we report two newly recognized episodes of basaltic volcanism with Pb-Pb dating for basalt fragments

Despite recent advances in mammalian synthetic biology, there remains a lack of modular synthetic receptors that can robustly respond to soluble ligands and in turn activate bespoke cellular functions. Such receptors would have extensive clinical potential to regulate the activity of engineered therapeutic cells, but to date only receptors against cell surface targets have approached clinical translation1

Thiazoles and isothiazoles are privileged motifs in drug and agrochemical discovery.1,2 The synthesis of these derivatives is generally approached, designed and developed on a case-by-case basis. Sometimes, the lack of robust synthetic methods to a given target can pose significant difficulties or even thwart the preparation of specific derivatives for further study.3,4 Here, we report a conceptually

The continuous evolution of SARS-CoV-2, particularly the emergence of BA.2.86/JN.1 lineage replacing XBB, necessitates re-evaluation of vaccine compositions 1–3. Here, we provide a comprehensive analysis of the humoral immune response to XBB and JN.1 human exposure. We demonstrate the antigenic distinctiveness of XBB and JN.1 lineages in SARS-CoV-2-naive individuals, and JN.1 infection elicits superior