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Elevated muramyl dipeptide by sialic acid-facilitated postantibiotic pathobiont expansion contributes to gut dysbiosis-induced mastitis in mice J. Adv. Res. (IF 11.4) Pub Date : 2024-10-05 Min Qiu, Cong Ye, Lijuan Bao, Keyi Wu, Yihong Zhao, Xiaotong Zhao, Ruibo Tang, Ruping Shang, Shan Shang, Chongshan Yuan, Xiaoyu Hu, Naisheng Zhang, Yunhe Fu, Jun Wang, Caijun Zhao
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Hippocampal dipeptidyl peptidase 9 bidirectionally regulates memory associated with synaptic plasticity J. Adv. Res. (IF 11.4) Pub Date : 2024-10-05 Ya-Bo Zhao, Shi-Zhe Wang, Wen-Ting Guo, Le Wang, Xun Tang, Jin-Nan Li, Lin Xu, Qi-Xin Zhou
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Columbianadin ameliorates rheumatoid arthritis by attenuating synoviocyte hyperplasia through targeted vimentin to inhibit the VAV2/Rac-1 signaling pathway J. Adv. Res. (IF 11.4) Pub Date : 2024-10-05 Yuli Han, Changqing Liu, Shujing Chen, Huihui Sun, Zhaoyu Jia, Jiaxin Shi, Lirong Wang, Kunze Du, Yanxu Chang
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Serum metabolite biomarkers for the early diagnosis and monitoring of age-related macular degeneration J. Adv. Res. (IF 11.4) Pub Date : 2024-10-05 Shengjie Li, Yichao Qiu, Yingzhu Li, Jianing Wu, Ning Yin, Jun Ren, Mingxi Shao, Jian Yu, Yunxiao Song, Xinghuai Sun, Shunxiang Gao, Wenjun Cao
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Observed decrease in Deep Western Boundary Current transport in subpolar North Atlantic Nat. Geosci. (IF 15.7) Pub Date : 2024-10-04 G. Koman, A. S. Bower, N. P. Holliday, H. H. Furey, Y. Fu, T. C. Biló
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Inhibition of phototrophic iron oxidation by nitric oxide in ferruginous environments Nat. Geosci. (IF 15.7) Pub Date : 2024-10-04 Verena Nikeleit, Adrian Mellage, Giorgio Bianchini, Lea Sauter, Steffen Buessecker, Stefanie Gotterbarm, Manuel Schad, Kurt Konhauser, Aubrey L. Zerkle, Patricia Sánchez-Baracaldo, Andreas Kappler, Casey Bryce
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Indo-Pacific regional extremes aggravated by changes in tropical weather patterns Nat. Geosci. (IF 15.7) Pub Date : 2024-10-04 Chenyu Dong, Robin Noyelle, Gabriele Messori, Adriano Gualandi, Lucas Fery, Pascal Yiou, Mathieu Vrac, Fabio D’Andrea, Suzana J. Camargo, Erika Coppola, Gianpaolo Balsamo, Chen Chen, Davide Faranda, Gianmarco Mengaldo
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Sustained greening of the Antarctic Peninsula observed from satellites Nat. Geosci. (IF 15.7) Pub Date : 2024-10-04 Thomas P. Roland, Oliver T. Bartlett, Dan J. Charman, Karen Anderson, Dominic A. Hodgson, Matthew J. Amesbury, Ilya Maclean, Peter T. Fretwell, Andrew Fleming
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Toward a CRISPR-based mouse model of Vhl -deficient clear cell kidney cancer: Initial experience and lessons learned Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-04 Laura A. Stransky, Wenhua Gao, Laura S. Schmidt, Kevin Bi, Christopher J. Ricketts, Vijyendra Ramesh, Amy James, Simone Difilippantonio, Lilia Ileva, Joseph D. Kalen, Baktiar Karim, Albert Jeon, Tamara Morgan, Andrew C. Warner, Sevilay Turan, Joanne Unite, Bao Tran, Sulbha Choudhari, Yongmei Zhao, Douglas E. Linn, Changhong Yun, Sripriya Dhandapani, Vaishali Parab, Elaine M. Pinheiro, Nicole Morris
CRISPR is revolutionizing the ability to do somatic gene editing in mice for the purpose of creating new cancer models. Inactivation of the VHL tumor suppressor gene is the signature initiating event in the most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC). Such tumors are usually driven by the excessive HIF2 activity that arises when the VHL gene product, pVHL, is defective
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Embers of autoregression show how large language models are shaped by the problem they are trained to solve Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-04 R. Thomas McCoy, Shunyu Yao, Dan Friedman, Mathew D. Hardy, Thomas L. Griffiths
The widespread adoption of large language models (LLMs) makes it important to recognize their strengths and limitations. We argue that to develop a holistic understanding of these systems, we must consider the problem that they were trained to solve: next-word prediction over Internet text. By recognizing the pressures that this task exerts, we can make predictions about the strategies that LLMs will
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Engineering substrate channeling in a bifunctional terpene synthase Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-04 Eliott S. Wenger, Kollin Schultz, Ronen Marmorstein, David W. Christianson
Fusicoccadiene synthase from Phomopsis amygdala (PaFS) is a bifunctional terpene synthase. It contains a prenyltransferase (PT) domain that generates geranylgeranyl diphosphate (GGPP) from dimethylallyl diphosphate and three equivalents of isopentenyl diphosphate, and a cyclase domain that converts GGPP into fusicoccadiene, a precursor of the diterpene glycoside Fusicoccin A. The two catalytic domains
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Increasing benefits in one-time public goods does not promote cooperation Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-04 Natalie Struwe, Esther Blanco, James M. Walker
The long tradition of research on cooperation includes a well-established finding that individuals respond to the degree of conflict between self- and collective interests (that is, the relative benefits from cooperation) in providing public goods. Existing empirical evidence builds upon settings where participants make multiple decisions or strategically consider alternative scenarios. Here, we consider
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Comprehensive stable-isotope tracing of glucose and amino acids identifies metabolic by-products and their sources in CHO cell culture Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-04 Jacqueline E. Gonzalez, Harnish Mukesh Naik, Eleanor H. Oates, Venkata Gayatri Dhara, Brian O. McConnell, Swetha Kumar, Michael J. Betenbaugh, Maciek R. Antoniewicz
Mammalian cell culture processes are widely utilized for biotherapeutics production, disease diagnostics, and biosensors, and hence, should be optimized to support robust cell growth and viability. However, toxic by-products accumulate in cultures due to inefficiencies in metabolic activities and nutrient utilization. In this study, we applied comprehensive 13 C stable-isotope tracing of amino acids
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A conserved peptide-binding pocket in HyNaC/ASIC ion channels Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-04 Audrey Magdalena Ortega-Ramírez, Simone Albani, Michèle Bachmann, Axel Schmidt, Manuela Pinoé-Schmidt, Marc Assmann, Katrin Augustinowski, Giulia Rossetti, Stefan Gründer
The only known peptide-gated ion channels—FaNaCs/WaNaCs and HyNaCs—belong to different clades of the DEG/ENaC family. FaNaCs are activated by the short neuropeptide FMRFamide, and HyNaCs by Hydra RFamides, which are not evolutionarily related to FMRFamide. The FMRFamide-binding site in FaNaCs was recently identified in a cleft atop the large extracellular domain. However, this cleft is not conserved
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Minimal motifs for habituating systems Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-04 Matthew Smart, Stanislav Y. Shvartsman, Martin Mönnigmann
Habituation—a phenomenon in which a dynamical system exhibits a diminishing response to repeated stimulations that eventually recovers when the stimulus is withheld—is universally observed in living systems from animals to unicellular organisms. Despite its prevalence, generic mechanisms for this fundamental form of learning remain poorly defined. Drawing inspiration from prior work on systems that
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Observation of Brownian elastohydrodynamic forces acting on confined soft colloids Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-04 Nicolas Fares, Maxime Lavaud, Zaicheng Zhang, Aditya Jha, Yacine Amarouchene, Thomas Salez
Confined motions in complex environments are ubiquitous in microbiology. These situations invariably involve the intricate coupling between fluid flow, soft boundaries, surface forces, and fluctuations. In the present study, such a coupling is investigated using a method combining holographic microscopy and advanced statistical inference. Specifically, the Brownian motion of soft micrometric oil droplets
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Four decades of Eukaryotic DNA replication: From yeast genetics to high-resolution cryo-EM structures of the replisome Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-04 Bik-Kwoon Tye
I had my eyes set on DNA replication research when I took my first molecular biology course in graduate school. My election to the National Academy of Sciences came just when I was retiring from active research. It gives me an opportunity to reflect on my personal journey in eukaryotic DNA replication research, which started as a thought experiment and culminated in witnessing the determination of
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A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-04 Mariana Duhne, Ali Mohebi, Kyoungjun Kim, Lilian Pelattini, Joshua D. Berke
Striatal acetylcholine and dopamine critically regulate movement, motivation, and reward-related learning. Pauses in cholinergic interneuron (CIN) firing are thought to coincide with dopamine pulses encoding reward prediction errors (RPE) to jointly enable synaptic plasticity. Here, we examine the firing of identified CINs during reward-guided decision-making in freely moving rats and compare this
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Synaptic weight dynamics underlying memory consolidation: Implications for learning rules, circuit organization, and circuit function Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-04 Brandon J. Bhasin, Jennifer L. Raymond, Mark S. Goldman
Systems consolidation is a common feature of learning and memory systems, in which a long-term memory initially stored in one brain region becomes persistently stored in another region. We studied the dynamics of systems consolidation in simple circuit architectures with two sites of plasticity, one in an early-learning and one in a late-learning brain area. We show that the synaptic dynamics of the
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SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-04 Mohamad Wessam Alnouri, Kenneth Anthony Roquid, Rémy Bonnavion, Haaglim Cho, Jan Heering, Jeonghyeon Kwon, Yannick Jäger, ShengPeng Wang, Stefan Günther, Nina Wettschureck, Gerd Geisslinger, Robert Gurke, Christa E. Müller, Ewgenij Proschak, Stefan Offermanns
Inflammation is a protective response to pathogens and injury. To be effective it needs to be resolved by endogenous mechanisms in order to avoid prolonged and excessive inflammation, which can become chronic. Specialized pro-resolving mediators (SPMs) are a group of lipids derived from omega-3 fatty acids, which can induce the resolution of inflammation. How SPMs exert their anti-inflammatory and
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Dysregulated miR-124-3p in endometrial epithelial cells reduces endometrial receptivity by altering polarity and adhesion Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-04 Wei Zhou, Michelle Van Sinderen, Katarzyna Rainczuk, Ellen Menkhorst, Kelli Sorby, Tiki Osianlis, Mulyoto Pangestu, Leilani Santos, Luk Rombauts, Alberto Rosello-Diez, Evdokia Dimitriadis
The endometrium undergoes substantial remodeling in each menstrual cycle to become receptive to an implanting embryo. Abnormal endometrial receptivity is one of the major causes of embryo implantation failure and infertility. MicroRNA-124-3p is elevated in both the serum and endometrial tissue of women with chronic endometritis, a condition associated with infertility. MicroRNA-124-3p also has a role
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Fire weakens land carbon sinks before 1.5 °C Nat. Geosci. (IF 15.7) Pub Date : 2024-10-03 Chantelle A. Burton, Douglas I. Kelley, Eleanor Burke, Camilla Mathison, Chris D. Jones, Richard A. Betts, Eddy Robertson, João C. M. Teixeira, Manoel Cardoso, Liana O. Anderson
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In This Issue Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-01
Proceedings of the National Academy of Sciences, Volume 121, Issue 40, October 2024.
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The role of JNK signaling pathway in organ fibrosis J. Adv. Res. (IF 11.4) Pub Date : 2024-10-02 Zhouhui Yao, Yandan Lu, Pingping Wang, Ziyan Chen, Licheng Zhou, Xianan Sang, Qiao Yang, Kuilong Wang, Min Hao, Gang Cao
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Unravelling the role of WRKY transcription factors in leaf senescence: Genetic and molecular insights J. Adv. Res. (IF 11.4) Pub Date : 2024-10-01 Zishan Ahmad, Muthusamy Ramakrishnan, Chunyue Wang, Shamsur Rehman, Anwar Shahzad, Qiang Wei
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Pharmacological upregulation of macrophage-derived itaconic acid by pubescenoside C attenuated myocardial ischemia–reperfusion injury J. Adv. Res. (IF 11.4) Pub Date : 2024-09-30 Sixuan Chen, Haojie Yao, Yanmei Lou, Huihui Wang, Baoping Xie, Junxuan Wu, Xiaoxiao Qi, Ying Wang, Peng Wu, Rong Zhang, Zhongqiu Liu, Yuanyuan Cheng
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Population genomics analyses reveal the role of hybridization in the rapid invasion of fall armyworm J. Adv. Res. (IF 11.4) Pub Date : 2024-09-30 Xuan Wang, Zhenyong Du, Yuange Duan, Shanlin Liu, Jie Liu, Bingyan Li, Ling Ma, Yunfei Wu, Li Tian, Fan Song, Wanzhi Cai, Hu Li
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Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy J. Adv. Res. (IF 11.4) Pub Date : 2024-09-29 Guiqin Huang, Yawen Cai, Menghui Ren, Xiaoyu Zhang, Yu Fu, Run Cheng, Yingdi Wang, Mingxing Miao, Lingpeng Zhu, Tianhua Yan
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Gastrodin attenuates high fructose-induced sweet taste preference decrease by inhibiting hippocampal neural stem cell ferroptosis J. Adv. Res. (IF 11.4) Pub Date : 2024-09-29 Chuan-Feng Tang, Hong Ding, Ya-Qian Wu, Zi-An Miao, Zi-Xuan Wang, Wen-Xuan Wang, Ying Pan, Ling-Dong Kong
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A multi-omics approach reveals that lotus root polysaccharide iron ameliorates iron deficiency-induced testicular damage by activating PPARγ to promote steroid hormone synthesis J. Adv. Res. (IF 11.4) Pub Date : 2024-09-28 Pei-Yu Dong, Shuai Yuan, Yu-Mei Chen Yan, Yu Chen, Yue Bai, Yang Dong, Yin-Yin Li, Wei Shen, Xi-Feng Zhang
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The biology of the enigmatic corpse flower provides clues to its conservation. Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-03 Carolyn Wilke
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Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3 Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-03 Yujue Wang, Youwei Xu, Yue Wang, Jie Zhang, Lan Chen, Xinheng He, Wenjia Fan, Kai Wu, Wen Hu, Xi Cheng, Guizhu Yang, H. Eric Xu, Youwen Zhuang, Shuyang Sun
Somatostatin receptors (SSTRs) exert critical biological functions such as negatively regulating hormone release and cell proliferation, making them popular targets for developing therapeutics to treat endocrine disorders, especially neuroendocrine tumors. Although several panagonists mimicking the endogenous ligand somatostatin are available, the development of more effective and safer somatostatinergic
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Calcineurin-mediated dephosphorylation stabilizes E2F1 protein by suppressing binding of the FBXW7 ubiquitin ligase subunit Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-03 Yuki Sato, Makoto Habara, Shunsuke Hanaki, Takahiro Masaki, Haruki Tomiyasu, Yosei Miki, Masashi Sakurai, Masahiro Morimoto, Daigo Kobayashi, Tatsuo Miyamoto, Midori Shimada
The transcription factor E2F1 serves as a regulator of the cell cycle and promotes cell proliferation. It is highly expressed in cancer tissues and contributes to their malignant transformation. Degradation by the ubiquitin–proteasome system may help to prevent such overexpression of E2F1 and thereby to suppress carcinogenesis. A detailed understanding of the mechanisms underlying E2F1 degradation
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Improved deep learning prediction of antigen–antibody interactions Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-03 Mu Gao, Jeffrey Skolnick
Identifying antibodies that neutralize specific antigens is crucial for developing effective immunotherapies, but this task remains challenging for many target antigens. The rise of deep learning–based computational approaches presents a promising avenue to address this challenge. Here, we assess the performance of a deep learning approach through two benchmark tests aimed at predicting antibodies
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Flow-electrode capacitive separation of organic acid products and recovery of alkali cations after acidic CO 2 electrolysis Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-03 Yong Jiang, Gaoying Wu, Ying Pu, Yue Wang, Na Chu, Raymond Jianxiong Zeng, Xudong Zhang, Xiangdong Zhu, Peng Liang
Acidic CO 2 electrolysis, enhanced by the introduction of alkali cations, presents a strategic approach for improving carbon efficiency compared to processes conducted in neutral and alkaline environments. However, a significant challenge arises from the dissolution of both organic acids and alkali cations in a strongly acidic feed stream, resulting in a considerable energy penalty for downstream separation
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Lipopeptide antibiotics disrupt interactions of undecaprenyl phosphate with UptA Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-03 Abraham O. Oluwole, Neha V. Kalmankar, Michela Guida, Jack L. Bennett, Giovanna Poce, Jani R. Bolla, Carol V. Robinson
The peptidoglycan pathway represents one of the most successful antibacterial targets with the last critical step being the flipping of carrier lipid, undecaprenyl phosphate (C 55 -P), across the membrane to reenter the pathway. This translocation of C 55 -P is facilitated by DedA and DUF368 domain-containing family membrane proteins via unknown mechanisms. Here, we employ native mass spectrometry
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LAMTOR1 ablation impedes cGAS degradation caused by chemotherapy and promotes antitumor immunity Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-03 Juntao Bie, Yutong Li, Chen Song, Qiaoyou Weng, Long Zhao, Li Su, Zhongwei Zhao, Yingjiang Ye, Zhanlong Shen, Jiansong Ji, Jianyuan Luo
Chemotherapy resistance remains a significant obstacle that limits the long-term efficacy of cancer therapy, necessitating further investigations into the underlying mechanisms. Here, we find that DNA fragments induced by chemotherapeutic agents trigger the degradation of cGAS, a potent double-strand DNA (dsDNA) sensor, by lysosomes. Mechanically, the lysosome-localized protein LAMTOR1 is up-regulated
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Intestinal Lactobacillus murinus -derived small RNAs target porcine polyamine metabolism Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-03 Lijuan Fan, Bingnan Liu, Youxia Wang, Bin Tang, Tianqi Xu, Jian Fu, Chuanlong Wang, Yuan Liu, Liangpeng Ge, Hong Wei, Wenkai Ren
Gut microbiota plays a vital role in host metabolism; however, the influence of gut microbes on polyamine metabolism is unknown. Here, we found germ-free models possess elevated polyamine levels in the colon. Mechanistically, intestinal Lactobacillus murinus -derived small RNAs in extracellular vesicles down-regulate host polyamine metabolism by targeting the expression of enzymes in polyamine metabolism
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Memory effects of transcription regulator−DNA interactions in bacteria Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-03 Won Jung, Tai-Yen Chen, Ace George Santiago, Peng Chen
Memory effect refers to the phenomenon where past events influence a system’s current and future states or behaviors. In biology, memory effects often arise from intra- or intermolecular interactions, leading to temporally correlated behaviors. Single-molecule studies have shown that enzymes and DNA-binding proteins can exhibit time-correlated behaviors of their activity. While memory effects are well
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Enhancer landscape of lung neuroendocrine tumors reveals regulatory and developmental signatures with potential theranostic implications Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-03 Ester Davis, Shani Avniel-Polak, Shahd Abu-Kamel, Israel Antman, Tsipora Saadoun, Chava Brim, Mohammad Jumaa, Yariv Maron, Ofra Maimon, Anat Bel-Ange, Karine Atlan, Tomer Tzur, Firas Abu Akar, Ori Wald, Uzi Izhar, Merav Hecht, Simona Grozinsky-Glasberg, Yotam Drier
Well-differentiated low-grade lung neuroendocrine tumors (lung carcinoids or LNETs) are histopathologically classified as typical and atypical LNETs, but each subtype is still heterogeneous at both the molecular level and its clinical manifestation. Here, we report genome-wide profiles of primary LNETs’ cis-regulatory elements by H3K27ac ChIP-seq with matching RNA-seq profiles. Analysis of these regulatory
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Coupling of cell growth modulation to asymmetric division and cell cycle regulation in Caulobacter crescentus Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-03 Skye Glenn, Alessio Fragasso, Wei-Hsiang Lin, Alexandros Papagiannakis, Setsu Kato, Christine Jacobs-Wagner
In proliferating bacteria, growth rate is often assumed to be similar between daughter cells. However, most of our knowledge of cell growth derives from studies on symmetrically dividing bacteria. In many α-proteobacteria, asymmetric division is a normal part of the life cycle, with each division producing daughter cells with different sizes and fates. Here, we demonstrate that the functionally distinct
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Capturing a methanogenic carbon monoxide dehydrogenase/acetyl-CoA synthase complex via cryogenic electron microscopy Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-03 Alison Biester, David A. Grahame, Catherine L. Drennan
Approximately two-thirds of the estimated one-billion metric tons of methane produced annually by methanogens is derived from the cleavage of acetate. Acetate is broken down by a Ni-Fe-S-containing A-cluster within the enzyme acetyl-CoA synthase (ACS) to carbon monoxide (CO) and a methyl group (CH 3 + ). The methyl group ultimately forms the greenhouse gas methane, whereas CO is converted to the greenhouse
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Experimental localization of metal-binding sites reveals the role of metal ions in type II DNA topoisomerases Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-03 Beijia Wang, Shabir Najmudin, Xiao-Su Pan, Vitaliy Mykhaylyk, Christian Orr, Armin Wagner, Lata Govada, Naomi E. Chayen, L. Mark Fisher, Mark R. Sanderson
Metal ions have important roles in supporting the catalytic activity of DNA-regulating enzymes such as topoisomerases (topos). Bacterial type II topos, gyrases and topo IV, are primary drug targets for fluoroquinolones, a class of clinically relevant antibacterials requiring metal ions for efficient drug binding. While the presence of metal ions in topos has been elucidated in biochemical studies,
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Mixed equilibrium/nonequilibrium effects govern surface mobility in polymer glasses Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-03 Jianquan Xu, Asieh Ghanekarade, Li Li, Huifeng Zhu, Hailin Yuan, Jinsong Yan, David S. Simmons, Ophelia K. C. Tsui, Xinping Wang
Using angle-resolved X-ray photoelectron spectroscopy, sum-frequency generation vibrational spectroscopy, contact angle measurements, and molecular dynamics simulations, we verify that the glass transition temperature ( T g ) of polymer glass is lower near the free surface. However, the experimental T g -gradients showed a linear variation with depth ( z ) from the free surface, while the simulated
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Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein kinase 1 Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-02 Rachel L. Harold, Nikhil K. Tulsian, Rajesh Narasimamurthy, Noelle Yaitanes, Maria G. Ayala Hernandez, Hsiau-Wei Lee, Priya Crosby, Sarvind M. Tripathi, David M. Virshup, Carrie L. Partch
Casein kinase 1δ (CK1δ) controls essential biological processes including circadian rhythms and wingless-related integration site (Wnt) signaling, but how its activity is regulated is not well understood. CK1δ is inhibited by autophosphorylation of its intrinsically disordered C-terminal tail. Two CK1 splice variants, δ1 and δ2, are known to have very different effects on circadian rhythms. These variants
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The smallest electrochemical bubbles Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-02 Esteban D. Gadea, Yamila A. Perez Sirkin, Valeria Molinero, Damian A. Scherlis
Many of the relevant electrochemical processes in the context of catalysis or energy conversion and storage, entail the production of gases. This often implicates the nucleation of bubbles at the interface, with the concomitant blockage of the electroactive area leading to overpotentials and Ohmic drop. Nanoelectrodes have been envisioned as assets to revert this effect, by inhibiting bubble formation
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Does the use of unusual combinations of datasets contribute to greater scientific impact? Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-02 Yulin Yu, Daniel M. Romero
Scientific datasets play a crucial role in contemporary data-driven research, as they allow for the progress of science by facilitating the discovery of new patterns and phenomena. This mounting demand for empirical research raises important questions on how strategic data utilization in research projects can stimulate scientific advancement. In this study, we examine the hypothesis inspired by the
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Switching of electrochemical selectivity due to plasmonic field-induced dissociation Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-02 Francis M. Alcorn, Sajal Kumar Giri, Maya Chattoraj, Rachel Nixon, George C. Schatz, Prashant K. Jain
Electrochemical reactivity is known to be dictated by the structure and composition of the electrocatalyst–electrolyte interface. Here, we show that optically generated electric fields at this interface can influence electrochemical reactivity insofar as to completely switch reaction selectivity. We study an electrocatalyst composed of gold–copper alloy nanoparticles known to be active toward the reduction
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Brain–machine convergent evolution: Why finding parallels between brain and artificial systems is informative Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-02 Erez Simony, Shany Grossman, Rafael Malach
Central nervous system neurons manifest a rich diversity of selectivity profiles—whose precise role is still poorly understood. Following the striking success of artificial networks, a major debate has emerged concerning their usefulness in explaining neuronal properties. Here we propose that finding parallels between artificial and neuronal networks is informative precisely because these systems are
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Mechanosensitive fluorescence lifetime probes for investigating the dynamic mechanism of ferroptosis Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-02 Xing Liang, Yuping Zhao, Jun Yan, Qian Zhang, Tony D. James, Weiying Lin
Deciphering the dynamic mechanism of ferroptosis can provide insights into pathogenesis, which is valuable for disease diagnosis and treatment. However, due to the lack of suitable time-resolved mechanosensitive tools, researchers have been unable to determine the membrane tension and morphology of the plasma membrane and the nuclear envelope during ferroptosis. With this research, we propose a rational
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YkuR functions as a protein deacetylase in Streptococcus mutans Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-02 Qizhao Ma, Jing Li, Shuxing Yu, Jing Zhou, Yaqi Liu, Xinyue Wang, Dingwei Ye, Yumeng Wu, Tao Gong, Qiong Zhang, Lingyun Wang, Jing Zou, Yuqing Li
Protein acetylation is a common and reversible posttranslational modification tightly governed by protein acetyltransferases and deacetylases crucial for various biological processes in both eukaryotes and prokaryotes. Although recent studies have characterized many acetyltransferases in diverse bacterial species, only a few protein deacetylases have been identified in prokaryotes, perhaps in part
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Autonomous multicolor bioluminescence imaging in bacteria, mammalian, and plant hosts Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-02 Subhan Hadi Kusuma, Taishi Kakizuka, Mitsuru Hattori, Takeharu Nagai
Bioluminescence imaging has become a valuable tool in biological research, offering several advantages over fluorescence-based techniques, including the absence of phototoxicity and photobleaching, along with a higher signal-to-noise ratio. Common bioluminescence imaging methods often require the addition of an external chemical substrate (luciferin), which can result in a decrease in luminescence
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The Drosophila tracheal terminal cell as a model for branching morphogenesis Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-02 Tatyana Gavrilchenko, Alison G. Simpkins, Tanner Simpson, Lena A. Barrett, Pauline Hansen, Stanislav Y. Shvartsman, Jodi Schottenfeld-Roames
The terminal cells of the Drosophila larval tracheal system are perhaps the simplest delivery networks, providing an analogue for mammalian vascular growth and function in a system with many fewer components. These cells are a prime example of single-cell morphogenesis, branching significantly over time to adapt to the needs of the growing tissue they supply. While the genetic mechanisms governing
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Complexity of confined water vitrification and its glass transition temperature Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-02 Jorge H. Melillo, Daniele Cangialosi, Valerio Di Lisio, Elisa Steinrücken, Michael Vogel, Silvina Cerveny
The ability of vitrification when crossing the glass transition temperature (T g ) of confined and bulk water is crucial for myriad phenomena in diverse fields, ranging from the cryopreservation of organs and food to the development of cryoenzymatic reactions, frost damage to buildings, and atmospheric water. However, determining water’s T g remains a major challenge. Here, we elucidate the glass transition
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Ultrafast transient absorption spectra and kinetics of human blue cone visual pigment at room temperature Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-02 Arjun Krishnamoorthi, David Salom, Arum Wu, Krzysztof Palczewski, Peter M. Rentzepis
The ultrafast photochemical reaction mechanism, transient spectra, and transition kinetics of the human blue cone visual pigment have been recorded at room temperature. Ultrafast time-resolved absorption spectroscopy revealed the progressive formation and decay of several metastable photo-intermediates, corresponding to the Batho to Meta-II photo-intermediates previously observed with bovine rhodopsin
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Chemical mapping of the surface interactome of PIEZO1 identifies CADM1 as a modulator of channel inactivation Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-02 Anna K. Koster, Oleg Yarishkin, Adrienne E. Dubin, Jennifer M. Kefauver, Ryan A. Pak, Benjamin F. Cravatt, Ardem Patapoutian
The propeller-shaped blades of the PIEZO1 and PIEZO2 ion channels partition into the plasma membrane and respond to indentation or stretching of the lipid bilayer, thus converting mechanical forces into signals that can be interpreted by cells, in the form of calcium flux and changes in membrane potential. While PIEZO channels participate in diverse physiological processes, from sensing the shear stress
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Recent uplift of Chomolungma enhanced by river drainage piracy Nat. Geosci. (IF 15.7) Pub Date : 2024-09-30 Xu Han, Jin-Gen Dai, Adam G. G. Smith, Shi-Ying Xu, Bo-Rong Liu, Cheng-Shan Wang, Matthew Fox
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Signatures of criticality in efficient coding networks Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-10-01 Shervin Safavi, Matthew Chalk, Nikos K. Logothetis, Anna Levina
The critical brain hypothesis states that the brain can benefit from operating close to a second-order phase transition. While it has been shown that several computational aspects of sensory processing (e.g., sensitivity to input) can be optimal in this regime, it is still unclear whether these computational benefits of criticality can be leveraged by neural systems performing behaviorally relevant