-
Copper-Catalyzed Reductive Hydroamination of Alkenes and 1,3-Dienes with Nitroarenes J. Org. Chem. (IF 3.3) Pub Date : 2025-04-24
Zi-Heng Zhang, Shuang-Shuang Ma, Yuan-Yuan Jiang, Jin-Qing Lin, Bao-Hua Xu -
Mechanosynthesis of β-Naphthol Derivatives via Triflic Anhydride-Mediated Reaction of Arylacetic Acids with Arylalkynes J. Org. Chem. (IF 3.3) Pub Date : 2025-04-24
Xu-Ling Xia, Liang Li, Jun-Shen Chen, Li-Feng Guo, Guan-Wu Wang -
PhICl2/KSeCN Mediated Synthesis of Selenopheno[3,2-b]indoles and 3-Selenocyanato-2-benzoselenophene Indoles from 1,3-Diynes via Double Electrophilic Cyclization J. Org. Chem. (IF 3.3) Pub Date : 2025-04-23
Jianing Zhang, Fengxia Sun, Xiangyu Zhan, Yunfei Du -
Synthesis of Thienoacenes via Cascade Copper-Catalyzed C–S Coupling and Thienannulation Reactions and Their Thermoelectric Properties J. Org. Chem. (IF 3.3) Pub Date : 2025-04-23
Jiaxuan Dong, Yifan Lv, Yiyang Li, Kexin Xu, Xinrui Cui, Cun-Yue Guo, Baolin Li -
Cross-Dimerization Giving Silyl-Substituted Conjugated Hexatrienes: An Approach to 1,6-Diarylhexa-1,3,5-trienes J. Org. Chem. (IF 3.3) Pub Date : 2025-04-23
Fuma Sakamoto, Eri Arata, Ryo Saito, Sayori Kiyota, Nobuyuki Komine, Masafumi Hirano -
The Importance of Atomic Charges for Predicting Site-Selective Ir-, Ru-, and Rh-Catalyzed C–H Borylations J. Org. Chem. (IF 3.3) Pub Date : 2025-04-23
Shannon M. Stephens, Kyle M. Lambert -
Nucleophile-Controlled Regiodivergent Domino Reactions of Enetriones with γ-Bromocrotonates: Access to 1,3-Dienic Esters and Tetrasubstituted Pyrans J. Org. Chem. (IF 3.3) Pub Date : 2025-04-23
Dan Xiong, Sen Zhang, Zhiyue Li, Hui Yao, Linxuan Li, Nianyu Huang, Nengzhong Wang -
Synthesis of 3-Amino-β-lactams through Selective Imination of 3-Oxo-β-lactams J. Org. Chem. (IF 3.3) Pub Date : 2025-04-23
Sari Deketelaere, Emma Vandenheede, Nicola Piens, Lore Cools, Lieselotte Crul, Lotte Demeurisse, Karen Mollet, Christian V. Stevens, Matthias D’hooghe -
Photocatalytic Approach Toward the Synthesis of Amides via S–C Cleavage: A Mild Approach J. Org. Chem. (IF 3.3) Pub Date : 2025-04-23
Shikha Pandey, Sandeep Kumar, Vishal Singh, Vandana Srivastava, Sundaram Singh -
Scalable Multistep One-Pot Synthesis of Natural and Modified Nucleoside Triphosphates J. Org. Chem. (IF 3.3) Pub Date : 2025-04-23
Sergei Negria, Yinglong Jia, Noah A. Setterholm, Bhawna Barpuzary, John C. Chaput -
N-Heterocyclic Carbene-Catalyzed [4 + 2] Annulation of Enolizable Thioesters for the Synthesis of 2-Pyrones J. Org. Chem. (IF 3.3) Pub Date : 2025-04-23
Jinfeng Zhang, Chen Zhu, Xu Cao, Hui Jin, Lixin Zhang -
Visible-Light-Induced 4CzIPN-Catalyzed Alkylamination of Alkenes via Cyclobutanone Oxime Esters and Anilines J. Org. Chem. (IF 3.3) Pub Date : 2025-04-22
Jiang-Hong Liu, Ze-Yu Tian, Zhen-Ye Wu, Tian-Le Huang, Li Hai, Li Guo, Yong Wu, Zhongzhen Yang -
Chemoselective Double Allylic Substitutions with Carbon Nucleophiles: Access to Tetrahydroindoles and Tetrahydrocarbazoles J. Org. Chem. (IF 3.3) Pub Date : 2025-04-22
Bocheng Chen, Lucas Pagès, Cyrille Kouklovsky, Sébastien Prévost, Aurélien de la Torre -
Thermal Cα–C6 Cyclization of Enediynes J. Org. Chem. (IF 3.3) Pub Date : 2025-04-22
Haonan Cheng, Wenbo Wang, Yun Zeng, Houjun Zhang, Xiaohua Huang, Fangxu Pu, Xiaofan Zhang, Aiguo Hu, Yun Ding -
Straightforward Access to 4-Sulfenylated Isocoumarins via Sulfoxides/MOMCl-Enabled Regioselective Cleavage and Reconfiguration of C–S Bonds J. Org. Chem. (IF 3.3) Pub Date : 2025-04-22
Linlin Xing, Shiyan Cao, Hezhuang Feng, Haixia Zheng, Haoyuan Fan, Kai Wang, Yongjun Zheng, Yong Zhang, Yunfei Du -
Visible-Light-Mediated Addition Reactions of Sulfur-Containing Reagents with α-Trifluoromethyl Alkenes J. Org. Chem. (IF 3.3) Pub Date : 2025-04-22
Yi-Rong Chen, Jia-Hui Han, Weidong Rao, Ping Song, Shu-su Shen, Daopeng Sheng, Shun-Yi Wang -
Visible-Light-Driven Tandem Cyclization of o-Hydroxyaryl Enaminones: Access to 3-(α-Arylsulfonamido)trifluoroethyl Chromones J. Org. Chem. (IF 3.3) Pub Date : 2025-04-22
Jinwei Yuan, Qiyang Liu, Xuanlin Liu, Da Wang, Meng Yan, Xianghui Meng, Ji Ma, Lingbo Qu -
Typical Electron-Withdrawing Groups Are ortho, meta-Directors Rather than meta-Directors in Electrophilic Aromatic Substitution J. Org. Chem. (IF 3.3) Pub Date : 2025-04-22
Paul R. Rablen -
Intra-/Intermolecular 1,2-Diamination of Alkenyl Oximes with O-Benzoylhydroxylamines Enabled by Copper Catalysis J. Org. Chem. (IF 3.3) Pub Date : 2025-04-21
Jiangfei Chen, Qi Xue, Shenyu Ren, Yi-Lin Liu, Yang Li, Jin-Heng Li -
N-Heterocyclic Carbene-Carbodiimide (NHC-CDI) Adducts: A Systematic Investigation of Electronic Modifications on Kinetic and Thermodynamic Properties of Adduct Association and Dissociation J. Org. Chem. (IF 3.3) Pub Date : 2025-04-20
Le Dung Pham, Briana Krupinsky, Anthony W. Schlimgen, Jessica R. Lamb -
Electrochemical Cascade Reactions of 1,2,3-Benzotriazinones with Alkynes to Assemble 3,4-Dihydroisoquinolin-1(2H)-ones J. Org. Chem. (IF 3.3) Pub Date : 2025-04-21
Sanfei Nian, Xudong Wu, Anwu Chen, Zhiming Lei, Qiuyue Song, Quan Huang, Min Liu, Shengming Lu, Jinkang Chen, Daijing Wei -
Substrate- and Reagent-Controlled Dimerization of Vinyl para-Quinone Methides J. Org. Chem. (IF 3.3) Pub Date : 2025-04-21
Ryan G. Baker, Kyle D. Reichl, Michael J. Smith, Michael Ricca, Margaret A. Mickelberg, John A. Porco, Jr. -
Strain-Releasing Hydrogenation of Donor–Acceptor Cyclopropanes and Cyclobutanes via Electrochemical Site Selective Carbonyl Reduction J. Org. Chem. (IF 3.3) Pub Date : 2025-04-21
Nakshatra Banerjee, Rakesh Kumar, Biswadeep Manna, Prabal Banerjee -
Phenyldithiafulvene-Substituted Ferrocene Derivatives as Redox-Regulated Molecular Switches J. Org. Chem. (IF 3.3) Pub Date : 2025-04-20
Fatma Takfa, Liam H. Britt, Yuming Zhao -
Mn(acac)3/Hydrazide-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Couplings of 1,2,3,4-Tetrahydroisoquinolines and Their Mechanistic Studies J. Org. Chem. (IF 3.3) Pub Date : 2025-04-20
Ga Young Kim, Sehee Park, Gayeong Park, Yeongyeong Kang, Hyungjun Kim, Jinho Kim -
Rh-Catalyzed Synthesis of Isobenzofurans via Donor/Donor-Type Metal Carbenoids and Their [4 + 2] Cycloaddition J. Org. Chem. (IF 3.3) Pub Date : 2025-04-20
Naoki Morita, Shinnosuke Yoshikawa, Eisuke Ota, Junichiro Yamaguchi -
Optimized Monomer-Based Synthesis of Poly-N-amino Peptides J. Org. Chem. (IF 3.3) Pub Date : 2025-04-20
Avraz F. Anwar, Juan R. Del Valle -
A Unified Strategy for the Synthesis of Diverse Bicyclo[2.2.2]octadiene Ligands J. Org. Chem. (IF 3.3) Pub Date : 2025-04-19
Wen-Tao Chen, Wen-Cai Luo, Jun-Ting Liang, Yu-Tao He, Ya-Jian Hu -
Synthesis of Functionalized Indolizines through 1,3-Dipolar Cycloaddition of Zwitterionic Ketenimines and Pyridinium Salts J. Org. Chem. (IF 3.3) Pub Date : 2025-04-19
Farhad Golmohammadi, Chiman Osmani, Frank Rominger, Saeed Balalaie -
Late-Stage Functionalization Strategies of 1,2,3-Triazoles: A Post-Click Approach in Organic Synthesis J. Org. Chem. (IF 3.3) Pub Date : 2025-04-18
Mangal S. Yadav, Vinay K. Pandey, Manoj K. Jaiswal, Sumit K. Singh, Anindra Sharma, Mayank Singh, Vinod K. Tiwari -
Asymmetric and Symmetric S-zig-zag-Fused BODIPYs: Synthesis and Photophysical and Oxidative Properties J. Org. Chem. (IF 3.3) Pub Date : 2025-04-18
Ruihan Yang, Lu Li, Shulin Gao, Zhehui Weng, WeiLi Li, Zhaohui Wang, Xiangguang Li, Yanhua Yang, Wei Jiang -
Palladium-Catalyzed Ring-Opening Defluorinative Hiyama Cross-Coupling of gem-Difluorocyclopropanes with Arylsilanes J. Org. Chem. (IF 3.3) Pub Date : 2025-04-18
Zhi-Shang Wang, Dong-Guo Hong, Hongfang Li, Teck-Peng Loh, Ming-Zhu Lu -
Pd-Catalyzed Synthesis of Acyclic 1,2-Dioxygenated Dienes and Their Regioselective Decarboxylative Diels–Alder Cycloaddition/Aromatization Reactions to Access Multisubstituted Phenols J. Org. Chem. (IF 3.3) Pub Date : 2025-04-18
Shuaikang Zhou, Siyi Qin, Xifang Zhang, Ying Song, Yuanfei Zhang -
Rapid and Additive-Free Synthesis of β-Sulfido Sulfonyl Fluorides through N-Methyl-2-pyrrolidinone (NMP)-Promoted Thia-Michael Addition J. Org. Chem. (IF 3.3) Pub Date : 2025-04-18
Junwei Han, Qiushuo Zheng, Xin Ding, Yuqin Wen, Nengrong Chen, Wanzhen Lin, Fa-Jie Chen -
Excellence in Industrial Organic Synthesis 2024 J. Org. Chem. (IF 3.3) Pub Date : 2025-04-18
Bernd Schaefer, Shashank Shekhar, James MurrayPublished as part of The Journal of Organic Chemistry special issue “Excellence in Industrial Organic Synthesis 2024”. In the chemical industry, alongside the discovery of new substances and their properties, the development and optimization of chemical reactions and processes play a decisive role, not least for economic reasons. (1,2) This is nothing new. The interplay between research and development
-
Rational Design of Supramolecular Receptors for Consistent Binding Affinities under High-Salinity Conditions J. Org. Chem. (IF 3.3) Pub Date : 2025-04-17
Borja Gómez-González, Nuno Basílio, Belén Vaz, M. Rita Paleo, F. Javier Sardina, Moisés Pérez-Lorenzo, Luis García-Río -
Scandium Triflate Catalyzed Cycloadditions of Vinyl Diazo Compounds and In Situ Formed Naphthoquinone Methides J. Org. Chem. (IF 3.3) Pub Date : 2025-04-17
Yi-Xiao Yin, Jie Zhan, Ren Liu, Pran Gopal Karmaker, Qing Zhou, Wen-Dao Chu, Quan-Zhong Liu -
Inherently Chiral Seven- and Eight-Membered Rings: Enantioselective Synthesis and Applications J. Org. Chem. (IF 3.3) Pub Date : 2025-04-17
Yu Luo, Shuang Luo, Qiang Zhu -
Calcium Impregnated Silica Gel in the Domino Reaction Involving Irreversible Aldol Addition, Dehydration, and Michael Addition J. Org. Chem. (IF 3.3) Pub Date : 2025-04-16
Jih Ru Hwu, Khagendra Prasad Bohara, Animesh Roy, Wen-Chieh Huang, Kuo-Chu Hwang, Chun-Cheng Lin, Kao Shu Chuang, Shu-Yu Lin, Shwu-Chen Tsay -
Merging Electrosynthesis and Biocatalysis to Access Sulfur-Based Chiral α-Fluorinated Carboxylic Acids J. Org. Chem. (IF 3.3) Pub Date : 2025-04-16
Parmjeet Kaur, Vikas Tyagi -
Solvent-Controlled and Highly Chemoselective Reduction of α,β-Unsaturated Ketones and Aldehydes J. Org. Chem. (IF 3.3) Pub Date : 2025-04-16
Yu-kun Zhang, Eman Fayad, Hanadi A. Katouah, Hua-Li Qin -
Iron-Catalyzed Thioarylation of Arenes Using Saccharin-Derived Reagents J. Org. Chem. (IF 3.3) Pub Date : 2025-04-16
Lachlan J. N. Waddell, Oluwajuwon A. M. Okunade, Amy C. Dodds, Michael C. H. Lok, R. Nisha Khanizeman, Andrew Sutherland -
Oxidation-State-Dependent Photochemistry of Sulfur-Bridged Aza-Anthracenes J. Org. Chem. (IF 3.3) Pub Date : 2025-04-16
Ryoga Hojo, Hikaru Noguchi, Jessica Toigo, Michael O. Wolf, Zachary M. Hudson -
Photoredox/Palladium-Catalyzed Reduction Alkylation of Imines and Ammonium Salts via Dual C–N Bond Cleavage J. Org. Chem. (IF 3.3) Pub Date : 2025-04-16
Tao Ju, Zhi-Hao Wang, Ai-Ling Lu, Jing Sun, Kun Huang, Wen Xiong, Ying Han, Chao-Guo Yan -
Synthetic Studies toward the Total Synthesis of Scabrolide A J. Org. Chem. (IF 3.3) Pub Date : 2025-04-16
Sabnam Begum, Tushar Kanti Chakraborty -
Z-Selective Synthesis of Trisubstituted Alkenes by the HWE Reaction Using Modified Still–Gennari Type Reagents J. Org. Chem. (IF 3.3) Pub Date : 2025-04-16
Ignacy Janicki -
Ortho-Hydroxy-Substituted Diaryliodonium Salts Enabled Intramolecular Aryliodonium Rearrangement in Synthesis of Ortho-Iodo Diaryl Ethers J. Org. Chem. (IF 3.3) Pub Date : 2025-04-15
Taiyou Liu, Cheng Pan, Limin Wang, Zhen-Jiang Xu, Jianwei Han -
Access to C5-Sulfonylated Tetrahydropyridazines via Photoinduced Cascade Sulfonylation-Cyclization of N-Cinnamyl Aldehyde Hydrazones J. Org. Chem. (IF 3.3) Pub Date : 2025-04-15
Changduo Pan, Miao Zeng -
Synthesis of Spirocyclic Phthalans via Ru-Catalyzed [2 + 2 + 2] Cycloaddition of 1,6-Diynes with Ex-Situ Generated Acetylene J. Org. Chem. (IF 3.3) Pub Date : 2025-04-15
Yoshihiko Yamamoto, Kenichi Yoshimura, Takeshi Yasui -
DNA-Compatible N-Formylation of Amines by Using TMSCF2Br J. Org. Chem. (IF 3.3) Pub Date : 2025-04-15
Huilin Liao, Xianfu Fang, Huihong Wang, Chang Chen, Gong Zhang, Yangfeng Li, Yizhou Li -
Synthesis of Phenanthrenes and Naphthoquinone Fused Benzoxepines via Hauser–Kraus Annulation of Sulfonylphthalide with Morita–Baylis–Hillman Adducts of Nitroalkenes J. Org. Chem. (IF 3.3) Pub Date : 2025-04-15
Chenikkayala Siva Sankara, Shweta Prakash Gaikwad, Suman Das Adhikary, Thekke V. Baiju, Rajni Kumari, Irishi N. N. Namboothiri -
Hydrogen-Bonding Assisted Catalytic 1,2-Addition Reaction of Trifluoropyruvate with 2,4-Dihydrocylopenta[b]indoles J. Org. Chem. (IF 3.3) Pub Date : 2025-04-15
Kexin Pang, Xin Li, Man Wang, Ran Song, Daoshan Yang, Jian Lv -
Dearomative Ring-Opening of N-Fused Heteroarenes: Access to Tetrasubstituted Alkenes and Ketimines J. Org. Chem. (IF 3.3) Pub Date : 2025-04-15
Qianling Wu, Xiaojing Wang, Qijian Ni -
Pd/NBE-Catalyzed One-Pot Modular Synthesis of Tetrahydro-γ-carbolines J. Org. Chem. (IF 3.3) Pub Date : 2025-04-14
Chuantao Huang, Wenlin Zhang, Ying Liu, Zhixin Zhang, Jun Gong, Xiaobo Wang, Ping Xue, Li Feng, Helin Lu -
An Unusual Friedel–Crafts Reaction and Violation of the Markovnikov Rule in the Formation of an Adamantyl Arene J. Org. Chem. (IF 3.3) Pub Date : 2025-04-14
B. Andes Hess, Jr, Lidia Smentek -
The Synthesis of a Naloxone-Related Oxidative Drug Product Degradant J. Org. Chem. (IF 3.3) Pub Date : 2025-04-14
Marie-Angélique F. S. Deschamps, John S. Carey, Joseph P. A. Harrity -
Electrochemistry of Azobenzenes and Its Potential for Energy Storage J. Org. Chem. (IF 3.3) Pub Date : 2025-04-14
Dominic Schatz, Hermann A. Wegner -
Synthesis of Viriditins A and B by Selective Coupling of Trans-1,2-Dichloroethylene J. Org. Chem. (IF 3.3) Pub Date : 2025-04-14
Feddro Gilbert Wijaya, Sopan Pralhad Khandare, Dániel Csókás, Raghunath O. Ramabhadran, Roderick W. Bates -
Synthesis and Chiroptical Properties of Biscarbazole-Embedded Diaza[7]helicenes J. Org. Chem. (IF 3.3) Pub Date : 2025-04-14
Gourav M. Upadhyay, Asim Swain, Esha H. Bhalodi, Prince Ravat, Ashutosh V. Bedekar -
Substrate-Controlled Pentafluorosulfanylation of Activated Alkenes Containing the Benzimidazole Moiety with SF5Cl J. Org. Chem. (IF 3.3) Pub Date : 2025-04-14
Xinqiang Tan, Yuezhen Li, Shijie Liu, Ziyou Hao, Yingchang Guo, Ruiping Fan, Yunhui Yan, Jianmei Yuan, Lizhen Fang, Ping-Xin Zhou, Hao Tang, Yingling Wang