BackgroundHigh-quality estimates of the epidemiology of the autism spectrum and the health needs of autistic people are necessary for service planners and resource allocators. Here we present the global prevalence and health burden of autism spectrum disorder from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 following improvements to the epidemiological data and burden

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BackgroundThe comparative benefits and harms of available interventions for ADHD in adults remain unclear. We aimed to address these important knowledge gaps. MethodsIn this systematic review and component network meta-analysis (NMA), we searched multiple databases for published and unpublished randomised controlled trials (RCTs) investigating pharmacological and non-pharmacological interventions for

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Although studies of psychedelic-assisted psychotherapy are accumulating, there is no consensus regarding best practice of the psychotherapeutic component. In this systematic review, we summarised the quality of reporting on psychological interventions in research about psychedelic treatments. The design followed PRISMA guidelines and was preregistered in PROSPERO (CRD42022319221). We searched MEDLINE

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Zavlis O, Luyten P, Pilling S, Fonagy P. Pressing need for clinical trial research on dimensional personality disorder. Lancet Psychiatry 2024; published online Nov 21. https://doi.org/10.1016/s2215-0366(24)00365-1. In this Correspondence, the second sentence of the first paragraph should read, “However, national health guidelines (such as those from the UK's National Institute of Clinical Excellence)

BackgroundAdolescent mental health appears to be in crisis, yet few studies have comprehensively charted the course of common mental disorders (CMDs; depression and anxiety) across this key life stage. We aimed to describe the course of CMD symptoms in adolescence by summarising annual prevalence, cumulative incidence, and course for depression and anxiety, both separately and as comorbid CMDs, by

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BackgroundPsychotherapy outcomes are typically measured in terms of symptom relief. However, this method might overlook important changes from clients' perspectives when they are asked to report on them. A more client-centred approach might bring a deeper understanding of psychotherapy outcomes. We aimed to evaluate the outcomes identified by clients within qualitative psychotherapy research. MethodsThe

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BackgroundPsychological interventions are increasingly discussed as a method to prevent major depressive disorder (MDD) in adults who already experience subthreshold depressive symptoms. In this individual participant data meta-analysis, we quantify the effect of preventive interventions against control on MDD onset in this population, and explore effect modifiers. MethodsIn this systematic review

BackgroundThe association between lithium use and chronic kidney disease, and the effect of comorbidities on this association are poorly understood. Our aim was to examine the risk of developing stage 3 or higher chronic kidney disease among people receiving lithium therapy. MethodsThis was a retrospective, population-based cohort study of all adults (aged ≥18 years) in Iceland treated with lithium

BackgroundAccess to effective treatment for major depressive disorder remains limited and difficult to track across place and time. We analysed the available data on minimally adequate treatment (MAT) for major depressive disorder globally with the aim of providing a useful metric against which to monitor national responses to the growing public health burden imposed by major depressive disorder. MethodsMAT

Santomauro DF, Vos T, Whiteford HA, Chisholm D, Saxena S, Ferrari AJ. Service coverage for major depressive disorder: estimated rates of minimally adequate treatment for 204 countries and territories in 2021. Lancet Psychiatry 2024; 11: 1012–21—In figures 1 and 3 of this Article, the colours for some locations have been updated and statements added to the legends regarding WHO standards for geographical

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The understanding and treatment of psychiatric disorders present unique challenges due to these conditions' multifaceted nature, comprising dynamic interactions between biological, psychological, social, and environmental factors. Traditional reductionistic approaches often simplify these conditions into linear cause-and-effect relationships, overlooking the complexity and interconnectedness inherent

Antipsychotic polypharmacy remains a clinical reality, despite an increased risk of adverse events and little evidence of additional efficacy compared with antipsychotic monotherapy. In this systematic review and meta-analysis, we aimed to provide a comprehensive assessment of antipsychotic polypharmacy prevalence, trends, and correlates across mental disorders.

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Psychological distress is common among mothers in low-income and middle-income countries, limiting their capacity to care for themselves and their children. This study aimed to test the feasibility and acceptability of an adapted psychosocial intervention for distressed mothers in low-resource settings.

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Pinchuk I, Leventhal B L, Ladyk-Bryzghalova A, et al. The Lancet Psychiatry Commission on mental health in Ukraine. Lancet Psychiatry 2024; 11: 910–33—In this Commission, the affiliation for author Marisa Casanova Dias MD MSc is incorrect. The correct affiliation is National Centre for Mental Health, Cardiff University, Cardiff, UK. This correction has been made to the online version as of Nov 4.

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Herrera-Ferrá K, Muñoz JM, Becerril A, et al. The regulation of neurotechnology: the neurorights bill in Mexico. Lancet Psychiatry 2024; published online Oct 8, 2024. https://doi.org/10.1016/S2215-0366(24)00286-4—In this Comment, the spelling of author Jesús Alejandro Alonso Olamendi's name was incorrect. This correction has been made to the online version as of Oct 17, 2024, and will be made to the

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Pinchuk I, Leventhal B L, Ladyk-Bryzghalova A, et al. The Lancet Psychiatry Commission on mental health in Ukraine. Lancet Psychiatry 2024; 11: 910–33—In this Commission, the value of the total health-care expenditure of US$ 13·5 per capita given in sentence five in paragraph two of Part 5: Resourcing the future of mental health section is incorrect. The number should be $6·75 per capita. The name

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Research, mainly conducted in Europe and North America, has shown an inequitable burden of internalising mental health problems among adolescents from poorer households. We investigated whether these mental health inequalities differ across a diverse range of countries and multiple measures of economic circumstances.

Cognitive deficits are a key source of disability in individuals with major depressive disorder (MDD) and worsen with disease progression. Despite their clinical relevance, the underlying mechanisms of cognitive deficits remain poorly elucidated, hampering effective treatment strategies. Emerging evidence suggests that alterations in white matter microstructure might contribute to cognitive dysfunction

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