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Understanding the protective effect of social support on depression symptomatology from a longitudinal network perspective. BMJ Mental Health (IF 6.6) Pub Date : 2023-11-29 Gen Li,Yifan Li,Agnes Iok Fong Lam,Weiming Tang,Soraya Seedat,Corrado Barbui,Davide Papola,Catherine Panter-Brick,Judith van der Waerden,Richard Bryant,Ellenor Mittendorfer-Rutz,Katalin Gémes,Fredrick D Purba,Hari Setyowibowo,Irene Pinucci,Christina Palantza,Ceren Acarturk,Gülşah Kurt,Lorenzo Tarsitani,Naser Morina,Sebastian Burchert,Martina Patanè,Soledad Quero,Daniel Campos,Anja C Huizink,Daniela
BACKGROUND Higher social support protects people from developing mental disorders. Limited evidence is available on the mechanism through which social support plays this protective role. OBJECTIVE To investigate the stress-buffering process of social support on depressive symptoms using a novel longitudinal dynamic symptom network approach. METHODS A total of 4242 adult participants who completed the
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Relationship between self-stigma about alcohol dependence and severity of alcohol drinking and craving. BMJ Mental Health (IF 6.6) Pub Date : 2023-11-22 Madeline E Crozier,Mehdi Farokhnia,Susan Persky,Lorenzo Leggio,Brenda Curtis
BACKGROUND The correlates and consequences of stigma surrounding alcohol use are complex. Alcohol use disorder (AUD) is typically accompanied by self-stigma, due to numerous factors, such as shame, guilt and negative stereotypes. Few studies have empirically examined the possible association between self-stigma and alcohol-related outcomes. OBJECTIVE To investigate the relationship between self-stigma
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Genetically predicted causal associations between periodontitis and psychiatric disorders. BMJ Mental Health (IF 6.6) Pub Date : 2023-11-22 Shuangshuang Tong,Yanlin Lyu,Wentao Huang,Ruijie Zeng,Rui Jiang,Qizhou Lian,Felix W Leung,Weihong Sha,Hao Chen
BACKGROUND Psychiatric disorders have serious harm to individuals' lives with high disease burden. Observational studies reported inconsistent associations between periodontitis and some psychiatric disorders, and the causal correlations between them remain unknown. OBJECTIVE This study aims to explore the causal associations between periodontitis and psychiatric disorders. METHODS A series of two-sample
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Comparative analysis of algorithm-guided treatment and predefined duration treatment programmes for depression: exploring cost-effectiveness using routine care data. BMJ Mental Health (IF 6.6) Pub Date : 2023-11-01 Fang Li,Ellen Visser,Maarten Brilman,Sybolt O de Vries,Bob Goeree,Talitha Feenstra,Frederike Jörg
BACKGROUND More knowledge on the cost-effectiveness of various depression treatment programmes can promote efficient treatment allocation and improve the quality of depression care. OBJECTIVE This study aims to compare the real-world cost-effectiveness of an algorithm-guided programme focused on remission to a predefined duration, patient preference-centred treatment programme focused on response using
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ChatGPT and mental healthcare: balancing benefits with risks of harms. BMJ Mental Health (IF 6.6) Pub Date : 2023-11-01 Charlotte Blease,John Torous
Against the global need for increased access to mental services, health organisations are looking to technological advances to improve the delivery of care and lower costs. Since November 2022, with the public launch of OpenAI's ChatGPT, the field of generative artificial intelligence (AI) has received expanding attention. Although generative AI itself is not new, technical advances and the increased
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Explaining paranoia: cognitive and social processes in the occurrence of extreme mistrust. BMJ Mental Health (IF 6.6) Pub Date : 2023-11-01 Daniel Freeman,Bao Sheng Loe
BACKGROUND Paranoia-incorrectly thinking that others are deliberating trying to harm you-causes distress, undermines social interactions and leads to withdrawal. It presents across multiple psychiatric diagnoses. OBJECTIVE The primary aim was to determine the extent that cognitive and social processes may explain paranoia. The secondary aim was to identify explanatory factors that distinguished paranoia
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Treatments for partial remission of major depressive disorder: a systematic review and meta-analysis. BMJ Mental Health (IF 6.6) Pub Date : 2023-11-01 Joost Gülpen,Marlies E Brouwer,Gert J Geurtsen,Eva A M van Dis,Damiaan A J P Denys,Claudi L Bockting
QUESTION Partial remission of major depressive disorder (MDD) is a debilitating and distressing clinical state related to chronicity, morbidity and relapse. Although one-third of patients remit partially, evidence for treatment efficacy is unclear. We provide an overview of treatment options and their efficacy. STUDY SELECTION AND ANALYSIS Embase, PsycINFO, Medline and SCOPUS were systematically searched
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Brain capital, ecological development and sustainable environments. BMJ Mental Health (IF 6.6) Pub Date : 2023-10-13 Agustin Ibanez,Harris Eyre
The importance of improving brain and mental health and developing sustainable environments is increasingly recognised. Understanding the syndemic interactions between these processes can help address contemporary societal challenges and foster global innovation. Here, we propose a green brain capital model that integrates environmental drivers of brain health and green skills necessary for long-term
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Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data. BMJ Mental Health (IF 6.6) Pub Date : 2023-10-01 Ruth H Jack,Rebecca M Joseph,Chris Hollis,Julia Hippisley-Cox,Debbie Butler,Dave Waldram,Carol Coupland
BACKGROUND There is an increasing demand for mental health services for young people, which may vary across the year. OBJECTIVE To determine whether there are seasonal patterns in primary care antidepressant prescribing and mental health issues in adolescents and young adults. METHODS This cohort study used anonymised electronic health records from general practices in England contributing to QResearch
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Relationship between severe mental illness and physical multimorbidity: a meta-analysis and call for action. BMJ Mental Health (IF 6.6) Pub Date : 2023-10-01 Damiano Pizzol,Mike Trott,Laurie Butler,Yvonne Barnett,Tamsin Ford,Sharon As Neufeld,Anya Ragnhildstveit,Christopher N Parris,Benjamin R Underwood,Guillermo Felipe López Sánchez,Matt Fossey,Carol Brayne,Emilio Fernandez-Egea,Guillaume Fond,Laurent Boyer,Jae Il Shin,Shahina Pardhan,Lee Smith
BACKGROUND People with severe mental illness (SMI) have a higher prevalence of several chronic physical health conditions, and the prevalence of physical multimorbidity is expected to rise. The aim of this study was to assess the strength of the association between SMI and physical multimorbidity. STUDY SELECTION AND ANALYSIS We systematically searched PubMed/Medline, Scopus, Embase, Web of Science
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Early parenting interventions to prevent internalising problems in children and adolescents: a global systematic review and network meta-analysis. BMJ Mental Health (IF 6.6) Pub Date : 2023-10-01 Ilaria Costantini,José A López-López,Deborah Caldwell,Amy Campbell,Veronica Hadjipanayi,Sarah J Cantrell,Tallulah Thomas,Nathan Badmann,Elise Paul,Deborah M James,Miguel Cordero,Tom Jewell,Jonathan Evans,Rebecca M Pearson
QUESTION We compared the effectiveness of different types of parenting interventions based on an a priori taxonomy, and the impact of waitlists versus treatment as usual (TAU), in reducing child internalising problems. STUDY SELECTION AND ANALYSIS We conducted a systematic review and network meta-analysis of published and unpublished randomised controlled trials (RCTs) until 1 October 2022 that investigated
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Predictors of transitioning to adult mental health services and associated costs: a cross-country comparison. BMJ Mental Health (IF 6.6) Pub Date : 2023-10-01 Rebecca Appleton,Alastair Canaway,Helena Tuomainen,Gwen Dieleman,Suzanne Gerritsen,Mathilde Overbeek,Athanasios Maras,Larissa van Bodegom,Tomislav Franić,Giovanni de Girolamo,Jason Madan,Fiona McNicholas,Diane Purper-Ouakil,Ulrike M E Schulze,Sabine Tremmery,Swaran P Singh
BACKGROUND Young people are at risk of falling through the care gap after leaving child and adolescent mental health services (CAMHS) despite an ongoing need for mental health support. Currently, little is known about the predictors of transitioning to adult mental health services (AMHS), and associated healthcare and societal costs as young people cross the transition boundary. OBJECTIVE To conduct
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Count Me In: an inclusive approach towards patient recruitment for clinical research studies in the NHS. BMJ Mental Health (IF 6.6) Pub Date : 2023-10-01 Verena Hinze,Catherine Henshall,Tanya Smith,Jemima Littlejohns,Zoe Collett,Helen Jones,Daniel Maughan,Roger Ede,Deborah Moll,Karl Marlowe,Nick Broughton,John Geddes,Andrea Cipriani
BACKGROUND Participation in clinical research is associated with better patient outcomes and higher staff retention and satisfaction rates. Nevertheless, patient recruitment to mental health studies is challenging due to a reliance on clinician or patient referrals (standard approach). To empower patients and make healthcare research more equitable, we explored a novel researcher-led approach, called
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Adjunctive agents to antipsychotics in schizophrenia: a systematic umbrella review and recommendations for amino acids, hormonal therapies and anti-inflammatory drugs. BMJ Mental Health (IF 6.6) Pub Date : 2023-10-01 Guillaume Fond,Jasmina Mallet,Mathieu Urbach,Michael Eriksen Benros,Michael Berk,Martina Billeci,Laurent Boyer,Christoph U Correll,Michele Fornaro,Jayashri Kulkarni,Marion Leboyer,Pierre-Michel Llorca,David Misdrahi,Romain Rey,Franck Schürhoff,Marco Solmi,Iris E C Sommer,Stephen M Stahl,Baptiste Pignon,Fabrice Berna
QUESTION This umbrella review and guidelines aimed to provide evidence to support the rational choice of selected adjunctive therapies for schizophrenia. STUDY SELECTION AND ANALYSIS Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and World Federation of Societies of Biological Psychiatry (WFSBP)-grading recommendations, 63 randomised control trials (RCTs)
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Racialised staff-patient relationships in inpatient mental health wards: a realist secondary qualitative analysis of patient experience data. BMJ Mental Health (IF 6.6) Pub Date : 2023-10-01 Phuong Hua,Sania Shakoor,Sarah-Jane Fenton,Mark Freestone,Scott Weich,Kamaldeep Bhui
BACKGROUND The current study is a secondary analysis of qualitative data collected as part of EURIPIDES, a study which assessed how patient experience data were used to improve the quality of care in National Health Service (NHS) mental health services. OBJECTIVE We undertook a detailed realist secondary qualitative analysis of 10 interviews in which expressions of racialisation were unexpectedly reported
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Individualisation, personalisation and person-centredness in mental healthcare: a scoping review of concepts and linguistic network visualisation. BMJ Mental Health (IF 6.6) Pub Date : 2023-10-01 Gwendolyn Mayer,Ali Zafar,Svenja Hummel,Felix Landau,Jobst-Hendrik Schultz
BACKGROUND Targeted mental health interventions are increasingly described as individualised, personalised or person-centred approaches. However, the definitions for these terms vary significantly. Their interchangeable use prevents operationalisations and measures. OBJECTIVE This scoping review provides a synthesis of key concepts, definitions and the language used in the context of these terms in
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Trichotillomania: a perspective synthesised from neuroscience and lived experience. BMJ Mental Health (IF 6.6) Pub Date : 2023-09-01 Clare E Mackay
Trichotillomania, or hair-pulling disorder, is one of a family of disorders called body-focused repetitive behaviours (BFRBs), which also include disordered skin-picking (dermotillomania) and nail-biting (onychophagia). The disorders affect 1%-2% of the population, cause high levels of distress and have high levels of comorbidity with other psychiatric diagnoses. The key facts and figures are briefly
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Ecological monitoring of physical activity, emotions and daily life activities in schizophrenia: the DiAPAson study. BMJ Mental Health (IF 6.6) Pub Date : 2023-09-01 Cristina Zarbo,Matteo Rota,Stefano Calza,Scott E Crouter,Ulf Ekelund,Stefano Barlati,Riccardo Bussi,Massimo Clerici,Roberto Placenti,Giuseppina Paulillo,Silvia Pogliaghi,Matteo Rocchetti,Mirella Ruggeri,Fabrizio Starace,Stefano Zanolini,Manuel Zamparini,Giovanni de Girolamo,
BACKGROUND Schizophrenia spectrum disorders (SSD) compromise psychosocial functioning, including daily time use, emotional expression and physical activity (PA). OBJECTIVE We performed a cohort study aimed at investigating: (1) the differences in PA, daily activities and emotions between patients with SSD and healthy controls (HC); (2) the strength of the association between these variables and clinical
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Prevalence of sleep disorder diagnoses and sleep medication prescriptions in individuals with ADHD across the lifespan: a Swedish nationwide register-based study. BMJ Mental Health (IF 6.6) Pub Date : 2023-08-01 Rickard Ahlberg,Miguel Garcia-Argibay,Marc Taylor,Paul Lichtenstein,Brian M D'Onofrio,Agniezska Butwicka,Catherine Hill,Samuele Cortese,Henrik Larsson,Ebba Du Rietz
BACKGROUND Consistent evidence suggests a strong association between attention-deficit/hyperactivity disorder (ADHD) and subjectively reported sleep problems. However, the prevalence of clinically ascertained sleep disorder diagnoses and sleep medication prescriptions in individuals with ADHD remains unclear. OBJECTIVE To determine the rates of sleep disorder diagnoses and sleep medication prescriptions
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Depressive symptom networks in the UK general adolescent population and in those looked after by local authorities. BMJ Mental Health (IF 6.6) Pub Date : 2023-08-01 Pascal Schlechter,Tamsin Ford,Sharon A S Neufeld
BACKGROUND Despite the importance of understanding depressive symptom constellations during adolescence and specifically in looked-after children, studies often only apply sum score models to understand depression in these populations, neglecting associations among single symptoms that can be elucidated in network analysis. The few network analyses in adolescents have relied on different measures to
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Genetic liability to bipolar disorder and onset of postpartum mental disorders. BMJ Mental Health (IF 6.6) Pub Date : 2023-08-01 Trine Munk-Olsen,Arianna Di Florio,Veerle Bergink,Esben Agerbo,Kathrine Bang Madsen,Liselotte Vogdrup Petersen,Xiaoqin Liu
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Qualitative evidence regarding the experience of receiving and providing care for mental health conditions in non-specialist settings in low-income and middle-income countries: a systematic review of reviews. BMJ Mental Health (IF 6.6) Pub Date : 2023-08-01 Petra C Gronholm,Akerke Makhmud,Corrado Barbui,Elaine Brohan,Neerja Chowdhary
QUESTION This review of reviews synthesises qualitative evidence on the experiences of receiving and providing care and treatment for mental health conditions in non-specialist settings in low-income and middle-income countries (LMICs), and the factors that influence the provision and uptake of such services. STUDY SELECTION AND ANALYSIS Database searches were conducted in PubMed/MEDLINE, EMBASE, PsycINFO
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Depression, violence and socioeconomic outcomes among refugees in East Africa: evidence from a multicountry representative survey. BMJ Mental Health (IF 6.6) Pub Date : 2023-08-01 Julia R Pozuelo,Raphael Bradenbrink,Maria Flinder Stierna,Olivier Sterck
BACKGROUND Existing research on refugee mental health is heavily skewed towards refugees in high-income countries, even though most refugees (83%) are hosted in low-income and middle-income countries. This problem is further compounded by the unrepresentativeness of samples, small sample sizes and low response rates. OBJECTIVE To present representative findings on the prevalence and correlates of depression
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Evaluation of telepsychiatry during the COVID-19 pandemic across service users, carers and clinicians: an international mixed-methods study. BMJ Mental Health (IF 6.6) Pub Date : 2023-08-01 Rebecca Sheriff,James S W Hong,Catherine Henshall,Armando D'Agostino,Simona Tomassi,Hans-Christian Stein,Giancarlo Cerveri,Chiara Cibra,Stefano Bonora,Barbara Giordano,Tanya Smith,Peter Phiri,Carolyn Asher,Kathryn Elliot,Caroline Zangani,Roger Ede,Fathi Saad,Katharine Alison Smith,Andrea Cipriani
BACKGROUND Worldwide uptake of telepsychiatry accelerated during the COVID-19 pandemic. OBJECTIVE To conduct an evaluation of the opinions, preferences and attitudes to telepsychiatry from service users, carers and clinicians in order to understand how telepsychiatry can be best used in the peri/post-COVID-19 era. METHODS This mixed-methods, multicentre, international study of telepsychiatry was set
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Correspondence on population health surveys and screening tools for depressive disorders: aims and uses by Arias de la Torre et al. BMJ Mental Health (IF 6.6) Pub Date : 2023-08-01 Felix Fischer,Dario Zocholl,Geraldine Rauch,Brooke Levis,Andrea Benedetti,Brett Thombs,Matthias Rose,Polychronis Kostoulas
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Predictors of positive patient-reported outcomes from 'Early Intervention in Psychosis': a national cross-sectional study. BMJ Mental Health (IF 6.6) Pub Date : 2023-08-01 Ryan Williams,Aimee Morris,Veenu Gupta,Ed Penington,Alexis E Cullen,Alan Quirk,Paul French,Belinda Lennox,Alex Bottle,Mike J Crawford
BACKGROUND The components of care delivered by Early Intervention in Psychosis (EIP) services vary, but the impact on patient experience is unknown. OBJECTIVE To investigate associations between components of care provided by EIP services in England and patient-reported outcomes. METHODS 2374 patients from EIP services in England were surveyed during the National Clinical Audit of Psychosis. Participants
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Understanding the causal relationships of attention-deficit/hyperactivity disorder with mental disorders and suicide attempt: a network Mendelian randomisation study. BMJ Mental Health (IF 6.6) Pub Date : 2023-07-01 Christa Meisinger,Dennis Freuer
BACKGROUND Attention-deficit/hyperactivity disorder (ADHD) is a lifespan neurodevelopmental condition resulting from complex interactions between genetic and environmental risk factors. There is evidence that ADHD is associated with other mental disorders, but it remains unclear whether and in what way a causal relationship exists. OBJECTIVE To investigate the direct and indirect causal paths between
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Development and validation of a dementia risk score in the UK Biobank and Whitehall II cohorts. BMJ Mental Health (IF 6.6) Pub Date : 2023-07-01 Melis Anatürk,Raihaan Patel,Klaus P Ebmeier,Georgios Georgiopoulos,Danielle Newby,Anya Topiwala,Ann-Marie G de Lange,James H Cole,Michelle G Jansen,Archana Singh-Manoux,Mika Kivimäki,Sana Suri
BACKGROUND Current dementia risk scores have had limited success in consistently identifying at-risk individuals across different ages and geographical locations. OBJECTIVE We aimed to develop and validate a novel dementia risk score for a midlife UK population, using two cohorts: the UK Biobank, and UK Whitehall II study. METHODS We divided the UK Biobank cohort into a training (n=176 611, 80%) and
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Associations between air pollution and mental health service use in dementia: a retrospective cohort study. BMJ Mental Health (IF 6.6) Pub Date : 2023-07-01 Amy Ronaldson,Robert Stewart,Christoph Mueller,Jayati Das-Munshi,Joanne B Newbury,Ian S Mudway,Matthew Broadbent,Helen L Fisher,Sean Beevers,David Dajnak,Matthew Hotopf,Stephani L Hatch,Ioannis Bakolis
BACKGROUND Little is known about the role of air pollution in how people with dementia use mental health services. OBJECTIVE We examined longitudinal associations between air pollution exposure and mental health service use in people with dementia. METHODS In 5024 people aged 65 years or older with dementia in South London, high resolution estimates of nitrogen dioxide (NO2) and particulate matter
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Self-Help Plus for refugees and asylum seekers: an individual participant data meta-analysis. BMJ Mental Health (IF 6.6) Pub Date : 2023-07-01 Eirini Karyotaki,Marit Sijbrandij,Marianna Purgato,Ceren Acarturk,Daniel Lakin,Della Bailey,Emily Peckham,Ersin Uygun,Federico Tedeschi,Johannes Wancata,Jura Augustinavicius,Kenneth Carswell,Maritta Välimäki,Mark van Ommeren,Markus Koesters,Mariana Popa,Marx Ronald Leku,Minna Anttila,Rachel Churchill,Ross G White,Sarah Al-Hashimi,Tella Lantta,Teresa Au,Thomas Klein,Wietse A Tol,Pim Cuijpers,Corrado
QUESTION Refugees and asylum seekers are at high risk of mental disorders due to various stressors before, during and after forceful displacement. The WHO Self-Help Plus (SH+) intervention was developed to manage psychological distress and a broad range of mental health symptoms in vulnerable populations. This study aimed to examine the effects and moderators of SH+ compared with Enhanced Care as Usual
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Prescription amphetamines in people with opioid use disorder and co-occurring psychostimulant use disorder initiating buprenorphine: an analysis of treatment retention and overdose risk. BMJ Mental Health (IF 6.6) Pub Date : 2023-07-01 Vitor Tardelli,Kevin Y Xu,Adam Bisaga,Frances R Levin,Thiago M Fidalgo,Richard A Grucza
BACKGROUND Attention-deficit and hyperactivity disorder (ADHD) is frequently diagnosed in patients with substance use disorders (SUDs), including opioids. There remains concern about the safety and efficacy of prescription amphetamines (PAs) and their impact on effectiveness of opioid use disorder (OUD) treatment with buprenorphine. OBJECTIVES To assess the effect of PAs on OUD buprenorphine treatment
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Improving mental healthcare access and experience for people from minority ethnic groups: an England-wide multisite experience-based codesign (EBCD) study. BMJ Mental Health (IF 6.6) Pub Date : 2023-07-01 Catherine Winsper,Rahul Bhattacharya,Kamaldeep Bhui,Graeme Currie,Dawn Edge,David R Ellard,Donna Franklin,Paramjit S Gill,Steve Gilbert,Robin Miller,Zahra Motala,Vanessa Pinfold,Harbinder Sandhu,Swaran P Singh,Scott Weich,Domenico Giacco
BACKGROUND Long-standing ethnic inequalities in access and mental healthcare were worsened by the COVID-19 pandemic. OBJECTIVES Stakeholders coproduced local and national implementation plans to improve mental healthcare for people from minority ethnic groups. METHODS Experience-based codesign conducted in four areas covered by National Health Service (NHS) mental health trusts: Coventry and Warwickshire
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Patients requesting and receiving euthanasia for psychiatric disorders in the Netherlands. BMJ Mental Health (IF 6.6) Pub Date : 2023-07-01 Monique Kammeraat,Geeske van Rooijen,Lisette Kuijper,Julian D Kiverstein,Damiaan A J P Denys
BACKGROUND Euthanasia and assisted suicide (EAS) for patients with psychiatric disorders occupies a prominent place in the public debate, but little is known about the psychiatric patients requesting and receiving EAS. OBJECTIVE To compare the social demographic and psychiatric profile of the patients who make a request for EAS and those who receive it. METHOD We carried out a review of records from
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Positive affect training to reduce mental health problems during the COVID-19 pandemic: a proof-of-concept randomised clinical trial. BMJ Mental Health (IF 6.6) Pub Date : 2023-06-01 Richard Bryant,Katie Dawson,Suzanna Azevedo,Srishti Yadav,Jenny Tran,Jasmine Choi-Christou,Elpiniki Andrew,Joanne Beames,Dharani Keyan
BACKGROUND The social restrictions occurring during the pandemic contributed to loss of many sources of reward, which contributes to poor mental health. OBJECTIVE This trial evaluated a brief positive affect training programme to reduce anxiety, depression and suicidality during the pandemic. METHODS In this single-blind, parallel, randomised controlled trial, adults who screened positive for COVID-19-related
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Physical injuries as triggers for self-harm: a within-individual study of nearly 250 000 injured people with a major psychiatric disorder. BMJ Mental Health (IF 6.6) Pub Date : 2023-06-01 Amir Sariaslan,Henrik Larsson,Keith Hawton,Joonas Pitkänen,Paul Lichtenstein,Pekka Martikainen,Seena Fazel
BACKGROUND Although there is robust evidence for several factors which may precipitate self-harm, the contributions of different physical injuries are largely unknown. OBJECTIVE To examine whether specific physical injuries are associated with risks of self-harm in people with psychiatric disorders. METHODS By using population and secondary care registers, we identified all people born in Finland (1955-2000)
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Population health surveys and screening tools for depressive disorders: aims and uses. BMJ Mental Health (IF 6.6) Pub Date : 2023-06-01 Jorge Arias de la Torre,Amy Ronaldson,Antoni Serrano-Blanco,Vicente Martín,Juan Ángel Bellón,Jose M Valderas,Jordi Alonso
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Assessing violence risk in first-episode psychosis: external validation, updating and net benefit of a prediction tool (OxMIV). BMJ Mental Health (IF 6.6) Pub Date : 2023-06-01 Daniel Whiting,Sue Mallett,Belinda Lennox,Seena Fazel
BACKGROUND Violence perpetration is a key outcome to prevent for an important subgroup of individuals presenting to mental health services, including early intervention in psychosis (EIP) services. Needs and risks are typically assessed without structured methods, which could facilitate consistency and accuracy. Prediction tools, such as OxMIV (Oxford Mental Illness and Violence tool), could provide
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Predicting outcomes at the individual patient level: what is the best method? BMJ Mental Health (IF 6.6) Pub Date : 2023-06-01 Qiang Liu,Edoardo Giuseppe Ostinelli,Franco De Crescenzo,Zhenpeng Li,Anneka Tomlinson,Georgia Salanti,Andrea Cipriani,Orestis Efthimiou
OBJECTIVE When developing prediction models, researchers commonly employ a single model which uses all the available data (end-to-end approach). Alternatively, a similarity-based approach has been previously proposed, in which patients with similar clinical characteristics are first grouped into clusters, then prediction models are developed within each cluster. The potential advantage of the similarity-based
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New living evidence resource of human and non-human studies for early intervention and research prioritisation in anxiety, depression and psychosis. BMJ Mental Health (IF 6.6) Pub Date : 2023-06-01 Andrea Cipriani,Soraya Seedat,Lea Milligan,Georgia Salanti,Malcolm Macleod,Janna Hastings,James Thomas,Susan Michie,Toshi A Furukawa,David Gilbert,Karla Soares-Weiser,Carmen Moreno,Stefan Leucht,Matthias Egger,Parisa Mansoori,James M Barker,Spyridon Siafis,Edoardo Giuseppe Ostinelli,Robert McCutcheon,Simonne Wright,Matilda Simpson,Olufisayo Elugbadebo,Virginia Chiocchia,Thomy Tonia,Rania Elgarf,Ayse
In anxiety, depression and psychosis, there has been frustratingly slow progress in developing novel therapies that make a substantial difference in practice, as well as in predicting which treatments will work for whom and in what contexts. To intervene early in the process and deliver optimal care to patients, we need to understand the underlying mechanisms of mental health conditions, develop safe
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Effectiveness of a mental health stepped-care programme for healthcare workers with psychological distress in crisis settings: a multicentre randomised controlled trial. BMJ Mental Health (IF 6.6) Pub Date : 2023-06-01 Roberto Mediavilla,Mireia Felez-Nobrega,Kerry R McGreevy,Anna Monistrol-Mula,María-Fe Bravo-Ortiz,Carmen Bayón,Iago Giné-Vázquez,Rut Villaescusa,Ainoa Muñoz-Sanjosé,Salvatore Aguilar-Ortiz,Natasha Figueiredo,Pablo Nicaise,A-La Park,Papoula Petri-Romão,Marianna Purgato,Anke B Witteveen,James Underhill,Corrado Barbui,Richard Bryant,Raffael Kalisch,Vincent Lorant,David McDaid,Maria Melchior,Marit Sijbrandij
BACKGROUND Evidence-based mental health interventions to support healthcare workers (HCWs) in crisis settings are scarce. OBJECTIVE To evaluate the capacity of a mental health intervention in reducing anxiety and depression symptoms in HCWs, relative to enhanced care as usual (eCAU), amidst the COVID-19 pandemic. METHODS We conducted an analyst-blind, parallel, multicentre, randomised controlled trial
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Cause-specific excess mortality after first diagnosis of bipolar disorder: population-based cohort study. BMJ Mental Health (IF 6.6) Pub Date : 2023-05-01 Tapio Paljärvi,Kimmo Herttua,Heidi Taipale,Markku Lähteenvuo,Antti Tanskanen,Seena Fazel,Jari Tiihonen
BACKGROUND Bipolar disorder (BD) is associated with increased mortality, but evidence on cause-specific mortality is limited. OBJECTIVE To investigate cause-specific premature excess mortality in BD. METHODS Finnish nationwide cohort study of individuals with and without a diagnosis of BD who were aged 15-64 years during 2004-2018. Standardised mortality ratios (SMRs) with 95% CIs were calculated for
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Risk of death by suicide following self-harm presentations to healthcare: development and validation of a multivariable clinical prediction rule (OxSATS). BMJ Mental Health (IF 6.6) Pub Date : 2023-05-01 Seena Fazel,Maria D L A Vazquez-Montes,Yasmina Molero,Bo Runeson,Brian M D'Onofrio,Henrik Larsson,Paul Lichtenstein,Jane Walker,Michael Sharpe,Thomas R Fanshawe
BACKGROUND Assessment of suicide risk in individuals who have self-harmed is common in emergency departments, but is often based on tools developed for other purposes. OBJECTIVE We developed and validated a predictive model for suicide following self-harm. METHODS We used data from Swedish population-based registers. A cohort of 53 172 individuals aged 10+ years, with healthcare episodes of self-harm
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Insulin resistance, age and depression's impact on cognition in middle-aged adults from the PREVENT cohort. BMJ Mental Health (IF 6.6) Pub Date : 2023-05-01 Sarah D Bauermeister,Michael Ben Yehuda,Graham Reid,Gregory Howgego,Karen Ritchie,Tam Watermeyer,Sarah Gregory,Graciela Muniz Terrera,Ivan Koychev
BACKGROUND Alzheimer's disease (AD), type 2 diabetes mellitus (characterised by insulin resistance) and depression are significant challenges facing public health. Research has demonstrated common comorbidities among these three conditions, typically focusing on two of them at a time. OBJECTIVE The goal of this study, however, was to assess the inter-relationships between the three conditions, focusing
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Increasing the value of digital phenotyping through reducing missingness: a retrospective review and analysis of prior studies. BMJ Mental Health (IF 6.6) Pub Date : 2023-02-01 Danielle Currey,John Torous
BACKGROUND Digital phenotyping methods present a scalable tool to realise the potential of personalised medicine. But underlying this potential is the need for digital phenotyping data to represent accurate and precise health measurements. OBJECTIVE To assess the impact of population, clinical, research and technological factors on the digital phenotyping data quality as measured by rates of missing
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Crossroads of methodological choices in research synthesis: insights from two network meta-analyses on preventing relapse in schizophrenia. BMJ Mental Health (IF 6.6) Pub Date : 2023-02-01 Giovanni Ostuzzi,Johannes Schneider-Thoma,Federico Tedeschi,Stefan Leucht,Corrado Barbui
In recent years, network meta-analyses have been increasingly carried out to inform clinical guidelines and policy. This approach is under constant development, and a broad consensus on how to carry out several of its methodological and statistical steps is still lacking. Therefore, different working groups might often make different methodological choices based on their clinical and research experience
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Digital mental health: challenges and next steps. BMJ Mental Health (IF 6.6) Pub Date : 2023-02-01 Katharine A Smith,Charlotte Blease,Maria Faurholt-Jepsen,Joseph Firth,Tom Van Daele,Carmen Moreno,Per Carlbring,Ulrich W Ebner-Priemer,Nikolaos Koutsouleris,Heleen Riper,Stephane Mouchabac,John Torous,Andrea Cipriani
Digital innovations in mental health offer great potential, but present unique challenges. Using a consensus development panel approach, an expert, international, cross-disciplinary panel met to provide a framework to conceptualise digital mental health innovations, research into mechanisms and effectiveness and approaches for clinical implementation. Key questions and outputs from the group were agreed
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Placebo response in trials with patients with anxiety, obsessive-compulsive and stress disorders across the lifespan: a three-level meta-analysis. BMJ Mental Health (IF 6.6) Pub Date : 2023-02-01 Luis Souza Motta,Natan Pereira Gosmann,Marianna de Abreu Costa,Marianna de Barros Jaeger,Júlia Frozi,Laura Tietzmann Grevet,Lucas Spanemberg,Gisele Gus Manfro,Pim Cuijpers,Daniel Samuel Pine,Giovanni Salum
QUESTION Randomised controlled trials assessing treatments for anxiety, obsessive-compulsive and stress-related disorders often present high placebo response rates in placebo groups. Understanding the placebo response is essential in accurately estimating the benefits of pharmacological agents; nevertheless, no studies have evaluated the placebo response across these disorders using a lifespan approach
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Blinding successfulness in antipsychotic trials of acute treatment for schizophrenia: a systematic review BMJ Mental Health (IF 6.6) Pub Date : 2023-02-01 Aran Tajika, Toshi A Furukawa, Kiyomi Shinohara, Shino Kikuchi, Rie Toyomoto, Yuki Furukawa, Masami Ito, Kazufumi Yoshida, Yukiko Honda, Tomohiro Takayama, Johannes Schneider-Thoma, Stefan Leucht
Blinding of randomised controlled trials (RCTs) is very important for the accurate assessment of drug efficacy. Without proper blinding, the effect of the intervention may be overestimated. Fergusson et al investigated the top journals in psychiatry from 1998 to 2001 and reported that blinding assessments were conducted in only 8 of 94 studies across psychiatric disorders.1 However, no studies on antipsychotic
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Police-led real-time surveillance system for suspected suicides in Great Britain BMJ Mental Health (IF 6.6) Pub Date : 2023-02-01 Lisa Marzano, Hilary Norman, Baljit Sohal, Keith Hawton, Richard Mann
It has become increasingly apparent that rapidly available information about the occurrence of suicides is needed, particularly to support suicide prevention efforts. Concerns about the potential impact of the COVID-19 pandemic on vulnerability to suicide highlighted the need for such early data internationally. Here, we set out the nature, current status and content of a real-time suicide monitoring
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Prevalence estimates of major depressive disorder in 27 European countries from the European Health Interview Survey: accounting for imperfect diagnostic accuracy of the PHQ-8 BMJ Mental Health (IF 6.6) Pub Date : 2023-02-01 Felix Fischer, Dario Zocholl, Geraldine Rauch, Brooke Levis, Andrea Benedetti, Brett Thombs, Matthias Rose, Polychronis Kostoulas
Background Cut-offs on self-report depression screening tools are designed to identify many more people than those who meet criteria for major depressive disorder. In a recent analysis of the European Health Interview Survey (EHIS), the percentage of participants with Patient Health Questionnaire-8 (PHQ-8) scores ≥10 was reported as major depression prevalence. Objective We used a Bayesian framework
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Exploring the efficacy of psychotherapies for depression: a multiverse meta-analysis BMJ Mental Health (IF 6.6) Pub Date : 2023-02-01 Constantin Yves Plessen, Eirini Karyotaki, Clara Miguel, Marketa Ciharova, Pim Cuijpers
Background Hundreds of randomised controlled trials and dozens of meta-analyses have examined psychotherapies for depression—yet not all points in the same direction. Are these discrepancies a result of specific meta-analytical decisions or do most analytical strategies reaching the same conclusion? Objective We aim to solve these discrepancies by conducting a multiverse meta-analysis containing all
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Decoding fMRI alcohol cue reactivity and its association with drinking behaviour BMJ Mental Health (IF 6.6) Pub Date : 2023-02-01 Haoye Tan, Martin Fungisai Gerchen, Patrick Bach, Alycia M Lee, Oliver Hummel, Wolfgang Sommer, Peter Kirsch, Falk Kiefer, Sabine Vollstädt-Klein
Background Cue reactivity, the enhanced sensitivity to conditioned cues, is associated with habitual and compulsive alcohol consumption. However, most previous studies in alcohol use disorder (AUD) compared brain activity between alcohol and neutral conditions, solely as cue-triggered neural reactivity. Objective This study aims to find the neural subprocesses during the processing of visual alcohol
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What I stand for as BMJ Mental Health editor BMJ Mental Health (IF 6.6) Pub Date : 2023-02-01 Andrea Cipriani
Welcome to BMJ Mental Health . In January 2023, Evidence-Based Mental Health ( EBMH ) has changed its name to BMJ Mental Health , after 25 years of activity (the journal was founded in 1998) and after recently becoming one of the top 10 psychiatric journals in terms of impact factor. BMJ Mental Health is now online only and entirely open access. Changing name is not just a rebranding exercise. It is
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Symptom-specific effects of counselling for depression compared to cognitive–behavioural therapy BMJ Mental Health (IF 6.6) Pub Date : 2023-02-01 Ciarán O'Driscoll, Joshua E J Buckman, Rob Saunders, Sarah Ellard, Syed Ali Naqvi, Satwant Singh, Jon Wheatley, Stephen Pilling
Background Cognitive–behavioural therapy (CBT) and counselling for depression (CfD) are recommended first-line treatments for depression. While they approach change differently, there is little understanding of the impact those approaches have on change during treatment. Objectives This study aimed to identify whether CBT and CfD target different symptoms and explore the implications of modelling choices
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metaumbrella: the first comprehensive suite to perform data analysis in umbrella reviews with stratification of the evidence BMJ Mental Health (IF 6.6) Pub Date : 2023-02-01 Corentin J Gosling, Aleix Solanes, Paolo Fusar-Poli, Joaquim Radua
Objective Umbrella reviews are a new form of literature review that summarises the strength and/or quality of the evidence from all systematic reviews and meta-analyses conducted on a broad topic. This type of review thus provides an exhaustive examination of a vast body of information, providing the highest synthesis of knowledge. A critical strength of umbrella reviews is recalculating the meta-analytic
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Peer-provided psychological intervention for Syrian refugees: results of a randomised controlled trial on the effectiveness of Problem Management Plus BMJ Mental Health (IF 6.6) Pub Date : 2023-02-01 Anne M de Graaff, Pim Cuijpers, Jos W R Twisk, Barbara Kieft, Sam Hunaidy, Mariam Elsawy, Noer Gorgis, Theo K Bouman, Miriam J J Lommen, Ceren Acarturk, Richard Bryant, Sebastian Burchert, Katie S Dawson, Daniela C Fuhr, Pernille Hansen, Mark Jordans, Christine Knaevelsrud, David McDaid, Naser Morina, Hanspeter Moergeli, A-La Park, Bayard Roberts, Peter Ventevogel, Nana Wiedemann, Aniek Woodward, Marit
Background The mental health burden among refugees in high-income countries (HICs) is high, whereas access to mental healthcare can be limited. Objective To examine the effectiveness of a peer-provided psychological intervention (Problem Management Plus; PM+) in reducing symptoms of common mental disorders (CMDs) among Syrian refugees in the Netherlands. Methods We conducted a single-blind, randomised
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Examining the Lancet Commission risk factors for dementia using Mendelian randomisation BMJ Mental Health (IF 6.6) Pub Date : 2023-02-01 Roopal Desai, Amber John, Rob Saunders, Natalie L Marchant, Joshua E J Buckman, Georgina Charlesworth, Verena Zuber, Joshua Stott
Background Dementia incidence is increasing across the globe and currently there are no disease-modifying pharmaceutical treatments. The Lancet Commission on dementia identified 12 modifiable risk factors which explain 40% of dementia incidence. However, whether these associations are causal in nature is unclear. Objective To examine the modifiable risk factors for dementia as identified in the Lancet
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Comparison of antipsychotic dose equivalents for acute bipolar mania and schizophrenia BMJ Mental Health (IF 6.6) Pub Date : 2023-02-01 Chia-Ling Yu, Andre F Carvalho, Trevor Thompson, Tzu-Cheng Tsai, Ping-Tao Tseng, Chih-Wei Hsu, Tien-Wei Hsu, Chih-Sung Liang
Question Are antipsychotic dose equivalents between acute mania and schizophrenia the same? Study selection and analysis Six databases were systematically searched (from inception to 17 September 2022) to identify blinded randomised controlled trials (RCTs) that used a flexible-dose oral antipsychotic drug for patients with acute mania. The mean and SD of the effective dose and the pre–post changes
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Digital cognitive–behavioural therapy to reduce suicidal ideation and behaviours: a systematic review and meta-analysis of individual participant data BMJ Mental Health (IF 6.6) Pub Date : 2022-12-01 Rebekka Büscher, Marie Beisemann, Philipp Doebler, Hannah M Micklitz, Ad Kerkhof, Pim Cuijpers, Philip J Batterham, Alison L Calear, Helen Christensen, Eva De Jaegere, Matthias Domhardt, Annette Erlangsen, Ozlem Eylem van Bergeijk, Ryan Hill, Anita Lungu, Charlotte Mühlmann, Jeremy W Pettit, Gwendolyn Portzky, Lena S Steubl, Bregje A J van Spijker, Joseph Tighe, Aliza Werner-Seidler, Chelsey R Wilks
Question Digital interventions based on cognitive–behavioural therapy (iCBT) is associated with reductions in suicidal ideation. However, fine-grained analyses of effects and potential effect-moderating variables are missing. This study aimed to investigate the effectiveness of iCBT on suicidal ideation, effect moderators, effects on suicide attempts and predictors of adherence. Study selection and
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Associations between antipsychotics and risk of violent crimes and suicidal behaviour in personality disorder BMJ Mental Health (IF 6.6) Pub Date : 2022-12-01 Kimmo Herttua, Mike Crawford, Tapio Paljarvi, Seena Fazel
Background Despite uncertain benefits, people with personality disorder are commonly treated with antipsychotic medication. Objective To investigate the association between antipsychotics and violent crimes and suicidal behaviour in individuals with personality disorder. Methods We used nationwide Danish registries to identify all individuals with diagnosed personality disorder aged 18–64 years during