![](https://scdn.x-mol.com/css/images/icon-new-link.png)
样式: 排序: IF: - GO 导出 标记为已读
-
Factors associated with skeletal muscle mass in middle‐aged men living with HIV J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-17 Yide Xu, Dongdong Wang, Pei Chen, Bufeng Qi, Xiaoting Li, Chunfeng Xie, Jieshu Wu, Lin Li, Gu Gao, Shanshan Geng, Dandan Yang
BackgroundDespite extensive research on muscle loss in people living with HIV (PLWH), the prevalence and contributing factors specifically among middle‐aged men remain unclear. This study aimed to determine the prevalence of low muscle mass within this demographic and to identify associated factors.MethodsA total of 378 men living with HIV were enrolled in the study. They were classified into low muscle
-
Roles of programmed death‐1 and muscle innate lymphoid cell‐derived interleukin 13 in sepsis‐induced intensive care unit‐acquired weakness J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-17 Yuichi Akama, Eun Jeong Park, Naoko Satoh‐Takayama, Atsushi Ito, Eiji Kawamoto, Arong Gaowa, Eri Matsuo, Satoshi Oikawa, Masafumi Saito, Shigeaki Inoue, Takayuki Akimoto, Kei Suzuki, Motomu Shimaoka
BackgroundIntensive care unit‐acquired weakness (ICU‐AW) is a syndrome characterized by a long‐term muscle weakness often observed in sepsis‐surviving patients during the chronic phase. Although ICU‐AW is independently associated with increased mortality, effective therapies have yet to be established. Programmed death‐1 (PD‐1) inhibitors have attracted attention as potential treatments for reversing
-
Association between metabolic dysfunction‐associated steatotic liver disease and myosteatosis measured by computed tomography J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-16 Myung Jin Kim, Yun Kyung Cho, Eun Hee Kim, Min Jung Lee, Woo Je Lee, Hong‐Kyu Kim, Chang Hee Jung
BackgroundIn 2023, the concept of metabolic dysfunction‐associated steatotic liver disease (MASLD) was introduced as an alternative to non‐alcoholic fatty liver disease (NAFLD). We aimed to assess the quantity and quality of skeletal muscle using each of these diagnostic classifications.MethodsThis cross‐sectional study included 18 154 participants (11 551 [63.6%] men and 6603 [36.4%] women, mean age
-
Proteomic profiling of human plasma extracellular vesicles identifies PF4 and C1R as novel biomarker in sarcopenia J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-16 Paula Aparicio, David Navarrete‐Villanueva, Alba Gómez‐Cabello, Tresa López‐Royo, Enrique Santamaría, Joaquín Fernández‐Irigoyen, Karina Ausín, Manuel Arruebo, Victor Sebastian, Germán Vicente‐Rodríguez, Rosario Osta, Raquel Manzano
BackgroundSarcopenia, the gradual and generalized loss of muscle mass and function with ageing, is one of the major health problems in older adults, given its high prevalence and substantial socioeconomic implications. Despite the extensive efforts to reach consensus on definition and diagnostic tests and cut‐offs for sarcopenia, there is an urgent and unmet need for non‐invasive, specific and sensitive
-
Skeletal muscle p53‐depletion uncovers a mechanism of fuel usage suppression that enables efficient energy conservation J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-16 Georgia Lenihan‐Geels, Francisco Garcia Carrizo, Marina Leer, Sabrina Gohlke, Moritz Oster, Sophie Pöhle‐Kronawitter, Christiane Ott, Alexandra Chadt, Isabel N. Reinisch, Markus Galhuber, Chen Li, Wenke Jonas, Markus Jähnert, Susanne Klaus, Hadi Al‐Hasani, Tilman Grune, Annette Schürmann, Tobias Madl, Andreas Prokesch, Michael Schupp, Tim J. Schulz
BackgroundThe ability of skeletal muscle to respond adequately to changes in nutrient availability, known as metabolic flexibility, is essential for the maintenance of metabolic health and loss of flexibility contributes to the development of diabetes and obesity. The tumour suppressor protein, p53, has been linked to the control of energy metabolism. We assessed its role in the acute control of nutrient
-
Association between myosteatosis and impaired glucose metabolism: A deep learning whole‐body magnetic resonance imaging population phenotyping approach J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-16 Matthias Jung, Hanna Rieder, Marco Reisert, Susanne Rospleszcz, Johanna Nattenmueller, Annette Peters, Christopher L. Schlett, Fabian Bamberg, Jakob Weiss
BackgroundThere is increasing evidence that myosteatosis, which is currently not assessed in clinical routine, plays an important role in risk estimation in individuals with impaired glucose metabolism, as it is associated with the progression of insulin resistance. With advances in artificial intelligence, automated and accurate algorithms have become feasible to fill this gap.MethodsIn this retrospective
-
Mitochondrial bioenergetics are not associated with myofibrillar protein synthesis rates J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-15 Andrew M. Holwerda, Marlou L. Dirks, Pierre‐Andre Barbeau, Joy Goessens, Annemie Gijsen, Luc J.C. van Loon, Graham P. Holloway
BackgroundMitochondria represent key organelles influencing cellular homeostasis and have been implicated in the signalling events regulating protein synthesis.MethodsWe examined whether mitochondrial bioenergetics (oxidative phosphorylation and reactive oxygen species (H2O2) emission, ROS) measured in vitro in permeabilized muscle fibres represent regulatory factors for integrated daily muscle protein
-
A multi‐omics approach to overeating and inactivity‐induced muscle atrophy in db/db mice J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-13 Takuro Okamura, Masahide Hamaguchi, Genki Kobayashi, Takahiro Ichikawa, Yuka Hasegawa, Tomoki Miyoshi, Takafumi Senmaru, Naoko Nakanishi, Ryoichi Sasano, Michiaki Fukui
BackgroundOvereating and inactivity are associated with type 2 diabetes. This study aimed to investigate its pathological basis using integrated omics and db/db/mice, a model representing this condition.MethodsThe study involved housing 8‐week‐old db/m and db/db mice for 8 weeks. Various analyses were conducted, including gene expression in skeletal muscle and small intestine using next‐generation
-
Tumour‐induced alterations in single‐nucleus transcriptome of atrophying muscles indicate enhanced protein degradation and reduced oxidative metabolism J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-13 Samet Agca, Aylin Domaniku‐Waraich, Sevval Nur Bilgic, Melis Sucuoglu, Meric Dag, Sukru Anil Dogan, Serkan Kir
BackgroundTumour‐induced skeletal muscle wasting in the context of cancer cachexia is a condition with profound implications for patient survival. The loss of muscle mass is a significant clinical obstacle and is linked to reduced tolerance to chemotherapy and increased frailty. Understanding the molecular mechanisms driving muscle atrophy is crucial for the design of new therapeutics.MethodsLewis
-
Differential impacts of fat and muscle mass on cardiovascular and non‐cardiovascular mortality in individuals with type 2 diabetes J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-13 Jie Guo, Yuxia Wei, Emerald G. Heiland, Anna Marseglia
BackgroundThe distribution of fat and muscle mass in different regions of the body can reflect different pathways to mortality in individuals with diabetes. Therefore, we investigated the associations between whole‐body and regional body fat and muscle mass with cardiovascular disease (CVD) and non‐CVD mortality in type 2 diabetes (T2D).MethodsWithin the National Health and Nutrition Examination Survey
-
Bidirectional transitions of sarcopenia states in older adults: The longitudinal evidence from CHARLS J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-13 Ya‐Xi Luo, Xiao‐Han Zhou, Tian Heng, Ling‐Ling Yang, Ying‐Hai Zhu, Peng Hu, Xiu‐Qing Yao
BackgroundSarcopenia, the age‐related loss of muscle mass and function, brings multiple adverse outcomes including disability and death. Several sarcopenia consensuses have newly introduced the premorbid concept of possible sarcopenia and recommended early lifestyle interventions. Bidirectional transitions of premorbid states have been revealed in several chronic diseases yet not clarified in sarcopenia
-
A new computed tomography‐based approach to quantify swallowing muscle volume by measuring tongue muscle area in a single slice J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-13 Javier Hurtado‐Oliva, Aniek T. Zwart, Jeroen Vister, Anouk van der Hoorn, Roel J.H.M. Steenbakkers, Inge Wegner, Gyorgy B. Halmos
BackgroundMeasuring the swallowing muscle mass with volume measurements is complex and time intensive; therefore, it is not used in clinical practice. However, it can be clinically relevant, for instance, in the case of sarcopenic dysphagia. The aim of the study was to develop a feasible and clinically applicable method to measure swallowing muscle mass.MethodsData from 10 head and neck cancer patients
-
Curcumin‐activated Wnt5a pathway mediates Ca2+ channel opening to affect myoblast differentiation and skeletal muscle regeneration J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-10 Mao‐yuan Wang, Jia‐ming Yang, Yi Wu, Hai Li, Yan‐biao Zhong, Yun Luo, Rui‐lian Xie
BackgroundSkeletal muscle injury is one of the most common sports injuries; if not properly treated or not effective rehabilitation treatment after injury, it can be transformed into chronic cumulative injury. Curcumin, an herbal ingredient, has been found to promote skeletal muscle injury repair and regeneration. The Wnt5a pathway is related to the expression of myogenic regulatory factors, and Ca2+
-
KLF13 restrains Dll4‐muscular Notch2 axis to improve the muscle atrophy J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-08 Shu Yang, Lijiao Xiong, Guangyan Yang, Jiaqing Xiang, Lixing Li, Lin Kang, Zhen Liang
BackgroundMuscle atrophy can cause muscle dysfunction and weakness. Krüppel‐like factor 13 (KLF13), a central regulator of cellular energy metabolism, is highly expressed in skeletal muscles and implicated in the pathogenesis of several diseases. This study investigated the role of KLF13 in muscle atrophy, which could be a novel therapeutic target.MethodsThe effects of gene knockdown and pharmacological
-
Sarcopenia is associated with short‐ and long‐term mortality in patients with acute‐on‐chronic liver failure J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-05 Fan Zeng, Wei Jiang, Xiujun Chang, Fuxun Yang, Xiaoxiu Luo, Rongan Liu, Yu Lei, Jiajia Li, Chun Pan, Xiaobo Huang, Huaiqiang Sun, Yunping Lan
BackgroundWhile sarcopenia is recognized as a predictor of mortality in cirrhosis, its influence on acute‐on‐chronic liver failure (ACLF) remains uncertain. Despite multiple studies examining the impact of sarcopenia on short‐term mortality in patients with ACLF, the sample size of these studies was limited, and their outcomes were inconsistent. Therefore, this study aimed to explore the impact of
-
Targeted nutritional intervention attenuates experimental lung cancer cachexia J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-04 Wouter R. P. H. van de Worp, Jan Theys, Cecile J. A. Wolfs, Frank Verhaegen, Annemie M. W. J. Schols, Ardy van Helvoort, Ramon C. J. Langen
Cachexia, a syndrome with high prevalence in non-small cell lung cancer patients, impairs quality of life and reduces tolerance and responsiveness to cancer therapy resulting in decreased survival. Optimal nutritional care is pivotal in the treatment of cachexia and a recommended cornerstone of multimodal therapy. Here, we investigated the therapeutic effect of an intervention diet consisting of a
-
The life‐course changes in muscle mass using dual‐energy X‐ray absorptiometry: The China BCL study and the US NHANES study J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-02 Xi Wang, Liwang Gao, Jingfan Xiong, Hong Cheng, Li Liu, Hongbo Dong, Yiwen Huang, Hongmin Fan, Xia Wang, Xinying Shan, Pei Xiao, Junting Liu, Yinkun Yan, Jie Mi
BackgroundSarcopenia is an important indicator of ill health and is linked to increased mortality and a reduced quality of life. Age‐associated muscle mass indices provide a critical tool to help understand the development of sarcopenia. This study aimed to develop sex‐ and age‐specific percentiles for muscle mass indices in a Chinese population and to compare those indices with those from other ethnicities
-
Telerehabilitation improves cardiorespiratory and muscular fitness and body composition in older people with post‐COVID‐19 syndrome J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-28 Eulogio Pleguezuelos, Amin Del Carmen, Eva Moreno, Mateu Serra‐Prat, Noemí Serra‐Payá, Manuel Vicente Garnacho‐Castaño
BackgroundThe effects of post‐coronavirus disease 2019 (COVID‐19) syndrome on the cardiorespiratory and muscular fitness in older people are of utmost relevance. This study aimed to evaluate the effects of a 12‐week telerehabilitation programme on cardiorespiratory and muscular fitness and body composition in older patients with post‐COVID‐19 syndrome.MethodsOne hundred twenty older patients with post‐COVID‐19
-
Sarcopenia‐related changes in serum GLP‐1 level affect myogenic differentiation J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-27 Hsien‐Hao Huang, Yun‐Jie Wang, Hui‐Yu Jiang, Helen Wenshin Yu, Yin‐Quan Chen, Arthur Chiou, Jean‐Cheng Kuo
BackgroundSarcopenia, a group of muscle‐related disorders, leads to the gradual decline and weakening of skeletal muscle over time. Recognizing the pivotal role of gastrointestinal conditions in maintaining metabolic homeostasis within skeletal muscle, we hypothesize that the effectiveness of the myogenic programme is influenced by the levels of gastrointestinal hormones in the bloodstream, and this
-
Aerobic exercise suppresses CCN2 secretion from senescent muscle stem cells and boosts muscle regeneration in aged mice J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-26 Fan Li, Fulong Zhang, Haiwang Shi, Honglin Xia, Xiaobei Wei, Siqi Liu, Tao Wu, Yuecheng Li, Feng Shu, Mengjie Chen, Jie Li, Rui Duan
BackgroundAging negatively impacts tissue repair, particularly in skeletal muscle, where the regenerative capacity of muscle stem cells (MuSCs) diminishes with age. Although aerobic exercise is known to attenuate skeletal muscle atrophy, its specific impact on the regenerative and repair capacity of MuSCs remains unclear.MethodsMice underwent moderate‐intensity continuous training (MICT) from 9 months
-
Sarcopenia is independently associated with poor preoperative physical fitness in patients undergoing colorectal cancer surgery J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-26 Jason Rai, Edward T. Pring, Katrina Knight, Henry Tilney, Judy Gudgeon, Mark Gudgeon, Fiona Taylor, Laura E. Gould, Joel Wong, Stefano Andreani, Dinh V.C. Mai, Ioanna Drami, Phillip Lung, Thanos Athanasiou, Campbell Roxburgh, John T. Jenkins
BackgroundAccurate preoperative risk assessment for major colorectal cancer (CRC) surgery remains challenging. Body composition (BC) and cardiopulmonary exercise testing (CPET) can be used to evaluate risk. The relationship between BC and CPET in patients undergoing curative CRC surgery is unclear.MethodsConsecutive patients undergoing CPET prior to CRC surgery between 2010 and 2020 were identified
-
Test–retest reliability and follow‐up of muscle magnetic resonance elastography in adults with and without muscle diseases J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-25 Bram De Wel, Lotte Huysmans, Ronald Peeters, Stefan Ghysels, Kris Byloos, Guido Putzeys, Frederik Maes, Patrick Dupont, Kristl G. Claeys
BackgroundWe investigated the potential of magnetic resonance elastography (MRE) stiffness measurements in skeletal muscles as an outcome measure, by determining its test–retest reliability, as well as its sensitivity to change in a longitudinal follow‐up study.MethodsWe assessed test–retest reliability of muscle MRE in 20 subjects with (n = 5) and without (n = 15) muscle diseases and compared this
-
Cachexia in preclinical rheumatoid arthritis: Longitudinal observational study of thigh magnetic resonance imaging from osteoarthritis initiative cohort J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-25 Kamyar Moradi, Bahram Mohajer, Ali Guermazi, C. Kent Kwoh, Clifton O. Bingham, Soheil Mohammadi, Xu Cao, Mei Wan, Frank W. Roemer, Shadpour Demehri
BackgroundPreclinical rheumatoid arthritis (Pre‐RA) is defined as the early stage before the development of clinical RA. While cachexia is a well‐known and potentially modifiable complication of RA, it is not known if such an association exists also in the Pre‐RA stage. To investigate such issue, we aimed to compare the longitudinal alterations in the muscle composition and adiposity of participants
-
The association between dynamic changes in vitamin D and frailty alterations: A prospective analysis of UK Biobank participants J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-24 Pan Zhang, Jinghui Zhong, Xinfeng Liu, Wen Sun
BackgroundFrailty is a common geriatric syndrome associated with reduced reserves and increased vulnerability to stressors among older adults. Vitamin D deficiency has been implicated in frailty, as it is essential for maintaining musculoskeletal functions. The relationship between dynamic changes in vitamin D levels and frailty over time has not been extensively studied.MethodsThis study utilized
-
Multimorbidity and the risk of malnutrition, frailty and sarcopenia in adults with cancer in the UK Biobank J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-22 Nicole Kiss, Gavin Abbott, Robin M. Daly, Linda Denehy, Lara Edbrooke, Brenton J. Baguley, Steve F. Fraser, Abbas Khosravi, Carla M. Prado
BackgroundMalnutrition, sarcopenia and frailty are distinct, albeit interrelated, conditions associated with adverse outcomes in adults with cancer, but whether they relate to multimorbidity, which affects up to 90% of people with cancer, is unknown. This study investigated the relationship between multimorbidity with malnutrition, sarcopenia and frailty in adults with cancer from the UK Biobank.MethodsThis
-
RBP4 promotes denervation‐induced muscle atrophy through STRA6‐dependent pathway J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-21 Kang‐Zhen Zhang, Jia‐Wen Li, Jin‐Shui Xu, Zheng‐Kai Shen, Yu‐Shuang Lin, Can Zhao, Xiang Lu, Yun‐Feng Rui, Wei Gao
BackgroundsFat infiltration of skeletal muscle has been recognized as a common feature of many degenerative muscle disorders. Retinol binding protein 4 (RBP4) is an adipokine that has been demonstrated to be correlated with the presence and severity of sarcopenia in the elderly. However, the exact role and the underlying mechanism of RBP4 in muscle atrophy remains unclear.MethodsDenervation‐induced
-
Dose‐dependent effect of megestrol acetate supplementation in cancer patients with anorexia–cachexia syndrome: A meta‐analysis J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-21 Sepide Talebi, Sheida Zeraattalab‐Motlagh, Maryam Barkhordar, Mohammad Vaezi, Seyed Mojtaba Ghoreishy, Abed Ghavami, Yasaman Hosseini, Nikolaj Travica, Hamed Mohammadi
There is inconsistent evidence relating to the effects of megestrol acetate (MA) supplementation on cancer patients suffering from anorexia–cachexia syndrome. This review aimed to examine the dose–response effect of MA supplementation in patients with cancer‐associated anorexia/cachexia. Relevant keywords were searched in PubMed, Scopus and ISI Web of Science from inception to June 2023 for randomized
-
Long‐term insulin resistance is associated with frailty, frailty progression, and cardiovascular disease J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-21 Zezhi Ke, Han Wen, Rihua Huang, Xinghao Xu, Kevin Yang, Wenbin Liu, Suisui Wang, Xu Zhang, Ye Guo, Xinxue Liao, Xiaodong Zhuang, Jie Zhao, Litao Pan, Lizhen Liao
BackgroundInsulin resistance and diabetes are associated with an increased risk of frailty, and frailty is associated with cardiovascular disease and premature mortality. We aim to investigate the impact of long‐term insulin resistance trajectories on future frailty and cardiovascular risk among young adults.MethodsIn total, 3168 participants with a 30‐year follow‐up period. The baseline period covered
-
Sarcopenic obesity and health outcomes: An umbrella review of systematic reviews with meta‐analysis J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-20 Nicola Veronese, Francesco Saverio Ragusa, Francesco Pegreffi, Ligia J. Dominguez, Mario Barbagallo, Michela Zanetti, Emanuele Cereda
Many studies support the idea that sarcopenic obesity (SO) could be considered a potential risk factor for negative health outcomes. These results have been inconsistent, and no umbrella reviews exist regarding this topic. Several databases until November 2023 were searched for systematic reviews with meta‐analysis of observational studies (cross‐sectional, case–control and prospective). For each association
-
Association of computed tomography‐derived muscle mass and quality with delayed acquisition independent walking after cardiovascular surgery J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-20 Kazuya Shimizu, Ryota Matsuzawa, Shinya Nakamura, Keita Murakawa, Hideo Kawakami, Masaki Tabuchi, Motoaki Ohnaka, Masamichi Matsumori, Akira Tamaki
BackgroundIn the context of cardiovascular surgery, the foremost concern lies in delayed functional recovery, as typified by the acquisition of independent walking after surgery, among older patients with decline in skeletal muscle mass and quality. Computed tomography (CT), which is typically employed for the preoperative assessment of pathological conditions in patients undergoing cardiovascular
-
Creatinine, cystatin C, muscle mass, and mortality: Findings from a primary and replication population‐based cohort J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-20 Dion Groothof, Naser B.N. Shehab, Nicole S. Erler, Adrian Post, Daan Kremer, Harmke A. Polinder‐Bos, Ron T. Gansevoort, Henk Groen, Robert A. Pol, Reinold O.B. Gans, Stephan J.L. Bakker
BackgroundSerum creatinine is used as initial test to derive eGFR and confirmatory testing with serum cystatin C is recommended when creatinine‐based eGFR is considered less accurate due to deviant muscle mass. Low muscle mass is associated with increased risk of premature mortality. However, the associations of serum creatinine and cystatin C with muscle mass and mortality remain unclear and require
-
CD3+/CD4+ cells combined with myosteatosis predict the prognosis in patients who underwent gastric cancer surgery J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-18 Zhongze Du, Youming Xiao, Guiming Deng, Haibin Song, Yingwei Xue, Hongjiang Song
This study aimed to investigate the predictive capacity of lymphocyte subpopulations, sarcopenia and myosteatosis for clinical outcomes in patients who underwent gastric cancer surgery. Additionally, the prognostic significance of CD3+/CD4+ cells in conjunction with myosteatosis was explored.
-
Changes in pre-haemodialysis serum creatinine levels over 2 years and long-term survival in maintenance haemodialysis J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-18 Seok Hui Kang, Gui Ok Kim, Bo Yeon Kim, Eun Jung Son, Jun Young Do, Jung Eun Lee
Pre-haemodialysis (HD) serum creatinine levels are reliable and inexpensive markers of muscle mass and important predictors of survival in patients with stable chronic HD. We aimed to assess whether changes in pre-HD serum creatinine levels during a 2-year period are linked to long-term patient survival.
-
Beneficial effects of exercise, testosterone, vitamin D, calcium and protein in older men—A randomized clinical trial J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-18 Mette Midttun, Karsten Overgaard, Bo Zerahn, Maria Pedersen, Anahita Rashid, Peter Busch Østergren, Tine Kolenda Paulin, Thea Winther Pødenphanth, Linda Katharina Karlsson, Eva Rosendahl, Anne-Mette Ragle, Anders Vinther, Rune Skovgaard Rasmussen
Due to increasing older populations worldwide, injuries, disabilities and deaths caused by falls among the elderly represent a growing human and societal problem. We aimed to improve health among men of at least 70 years of age with low-normal to low testosterone and mobility problems by using testosterone undecanoate (TU) injections, progressive strength training, and oral supplements of vitamin D
-
GDF-15 is associated with sarcopenia and frailty in acutely admitted older medical patients J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-18 Rikke S. Kamper, Hanne Nygaard, Louis Praeger-Jahnsen, Anette Ekmann, Sisse Bolm Ditlev, Martin Schultz, Sofie Krarup Hansen, Pernille Hansen, Eckart Pressel, Charlotte Suetta
Growth differentiation factor-15 (GDF-15) has been associated with senescence, lower muscle strength, and physical performance in healthy older people. Still, it is not clear whether GDF-15 can be utilized as a biomarker of sarcopenia and frailty in the early stages of hospitalization. We investigated the association of plasma GDF-15 with sarcopenia and frailty in older, acutely admitted medical patients
-
Comparison of the impact of longitudinal body mass index changes on cardiac arrest risk between normal and overweight populations J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-18 Youn-Jung Kim, Min-Ju Kim, Ye-Jee Kim, Won Young Kim
Being overweight is a key modifiable risk factor for cardiovascular disease. However, the impact of longitudinal changes in body mass index (BMI) on the risk of out-of-hospital cardiac arrests (OHCA) remains unclear, especially among overweight populations.
-
The role of different physical function tests for the prediction of fracture risk in older women J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-18 Giulia Gregori, Lisa Johansson, Kristian F. Axelsson, Raju Jaiswal, Henrik Litsne, Berit A. M. Larsson, Mattias Lorentzon
Physical function is an important risk factor for fracture. Previous studies found that different physical tests (e.g., one-leg standing [OLS] and timed up and go [TUG]) predict fracture risk. This study aimed to determine which physical function test is the most optimal independent predictor of fracture risk, together with clinical risk factors (CRFs) used in fracture risk assessment (FRAX) and bone
-
Swallowing muscle mass contributes to post-stroke dysphagia in ischemic stroke patients undergoing mechanical thrombectomy J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-18 João Pinho, Tareq Meyer, Beate Schumann-Werner, Johanna Becker, Simone Tauber, Omid Nikoubashman, Martin Wiesmann, Jörg B. Schulz, Cornelius J. Werner, Arno Reich
Neurogenic dysphagia is a frequent complication of stroke and is associated with aspiration pneumonia and poor outcomes. Although ischaemic lesion location and size are major determinants of the presence and severity of post-stroke dysphagia, little is known about the contribution of other acute stroke-unrelated factors. We aimed to analyse the impact of swallowing and non-swallowing muscles measurements
-
Physical frailty, genetic predisposition, and the risks of severe non-alcoholic fatty liver disease and cirrhosis: a cohort study J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-18 Honghao Yang, Fengrong Ou, Qing Chang, Jinguo Jiang, Yashu Liu, Chao Ji, Liangkai Chen, Yang Xia, Yuhong Zhao
Frailty, defined as a phenotype of decreased physiological reserves and diminished ability to respond to stressors, has been linked to the development of chronic diseases. Epidemiological evidence connecting frailty to non-alcoholic fatty liver disease (NAFLD) and cirrhosis risks remain sparse. We aimed to assess the longitudinal associations of frailty with the risks of severe NAFLD and cirrhosis
-
Effects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi-centre factorial randomized trial J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-18 Justin C. Brown, Guillaume Spielmann, Shengping Yang, Stephanie L. E. Compton, Lee W. Jones, Melinda L. Irwin, Jennifer A. Ligibel, Jeffrey A. Meyerhardt
Physical activity and metformin pharmacotherapy are associated with improved clinical outcomes in breast and colorectal cancer survivors. Myokines are cytokines secreted from skeletal muscle that may mediate these associations.
-
Free essential amino acid feeding improves endurance during resistance training via DRP1-dependent mitochondrial remodelling J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-16 Jiwoong Jang, Yeongmin Kim, Taejeong Song, Sanghee Park, Hee-Joo Kim, Jin-ho Koh, Yoonil Cho, Shi-Young Park, Sakthivel Sadayappan, Hyo-Bum Kwak, Robert R. Wolfe, Il-Young Kim, Cheol Soo Choi
Loss of muscle strength and endurance with aging or in various conditions negatively affects quality of life. Resistance exercise training (RET) is the most powerful means to improve muscle mass and strength, but it does not generally lead to improvements in endurance capacity. Free essential amino acids (EAAs) act as precursors and stimuli for synthesis of both mitochondrial and myofibrillar proteins
-
Short-term mortality prediction in acute pulmonary embolism: Radiomics values of skeletal muscle and intramuscular adipose tissue J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-10 Iram Shahzadi, Alex Zwanenburg, Lynn Johann Frohwein, Dominik Schramm, Hans Jonas Meyer, Mattes Hinnerichs, Christoph Moenninghoff, Julius Henning Niehoff, Jan Robert Kroeger, Jan Borggrefe, Alexey Surov
Acute pulmonary embolism (APE) is a potentially life-threatening disorder, emphasizing the importance of accurate risk stratification and survival prognosis. The exploration of imaging biomarkers that can reflect patient survival holds the potential to further enhance the stratification of APE patients, enabling personalized treatment and early intervention. Therefore, in this study, we develop computed
-
Association between preoperative phase angle and all-cause mortality after cardiovascular surgery: A retrospective cohort study J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-10 Kenichi Shibata, Masataka Kameshima, Takuji Adachi, Hisako Kito, Chikako Tanaka, Taisei Sano, Mizuki Tanaka, Yoriyasu Suzuki, Mototsugu Tamaki, Hideki Kitamura
The importance of preoperative physical function assessment for post-operative intervention has been reported in older patients undergoing cardiovascular surgery. Phase angle (PhA), measured using bioelectrical impedance analysis, is an indicator of cellular health and integrity and is reported as a prognostic factor in several chronic diseases; however, its association with the long-term prognosis
-
Physical frailty, genetic predisposition, and incident arrhythmias J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-09 Yucong Zhang, Man Liu, Jiajun Li, Lei Ruan, Xiaofen Wu, Cuntai Zhang, Liangkai Chen
Cross-sectional evidence suggests a possible link between frailty and atrial fibrillation (AF). It remains unclear whether frailty and incident arrhythmias are longitudinally associated. This study aimed to determine whether the frailty phenotype is longitudinally associated with incident arrhythmias, especially AF.
-
Plasma C-terminal agrin fragment concentrations across adulthood: Reference values and associations with skeletal muscle health J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-07 Jedd Pratt, Evgeniia Motanova, Ludmilla Pessanha, Marco Narici, Colin Boreham, Giuseppe De Vito
Increasing interest surrounds the utility of blood-based biomarkers for diagnosing sarcopenia. C-terminal agrin fragment (CAF), a marker of neuromuscular junction stability, is amongst the most promising candidates; however, a dearth of reference data impedes the incorporation of its use in public health settings. This study aimed to establish reference values for plasma CAF concentrations across adulthood
-
The combined effect of cardiorespiratory and muscular fitness on the incidence of metabolic syndrome before midlife J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-07 Kun-Zhe Tsai, Chen-Chih Chu, Wei-Chun Huang, Xuemei Sui, Carl J. Lavie, Gen-Min Lin
Cardiorespiratory fitness (CRF) could reduce the risk of metabolic syndrome (MetS) while the association between muscular endurance capacity (MEC) and incident MetS has rarely been investigated in young adults.
-
Total magnesium intake and risk of frailty in older women J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-06 Ellen A. Struijk, Teresa T. Fung, Heike A. Bischoff-Ferrari, Walter C. Willett, Esther Lopez-Garcia
An adequate magnesium intake might lower the risk of frailty through its role in muscle function.
-
Comment on ‘Weight-adjusted waist as an integrated index for fat, muscle and bone health in adults’ J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-05 Xiao Li
I read with interest the paper entitled ‘Weight-adjusted Waist as an Integrated Index for Fat, Muscle and Bone Health in Adults’ by Kim et al.,1 which utilizes the KNHANES (Korean National Health and Nutrition Examination Survey) to innovatively investigate the association between a novel index for assessing obesity, the weight-adjusted waist circumference index (WWI), and unhealthy body composition
-
Issue Information J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-05
No abstract is available for this article.
-
Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-05-23 Michael S. Yule, Joshua Thompson, Khachonphat Leesahatsawat, Mariana S. Sousa, Stefan D. Anker, Jann Arends, Trude R. Balstad, Leo R. Brown, Asta Bye, Olav Dajani, Marie Fallon, Marianne J. Hjermstad, Gunnhild Jakobsen, James McDonald, Josh McGovern, Eric J. Roeland, Judith Sayers, Richard J.E. Skipworth, Inger O. Ottestad, Iain Philips, Melanie R. Simpson, Tora S. Solheim, Ola Magne Vagnildhaug, Donald
Regulatory agencies require evidence that endpoints correlate with clinical benefit before they can be used to approve drugs. Biomarkers are often considered surrogate endpoints. In cancer cachexia trials, the measurement of biomarkers features frequently. The aim of this systematic review was to assess the frequency and diversity of biomarker endpoints in cancer cachexia trials. A comprehensive electronic
-
Transcriptomics reveals transient and dynamic muscle fibrosis and atrophy differences following spinal cord injury in rats J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-05-20 Hui Jean Kok, Drew B. Fletcher, Jacob C. Oster, Christine F. Conover, Elisabeth R. Barton, Joshua F. Yarrow
BackgroundThe rate and magnitude of skeletal muscle wasting after severe spinal cord injury (SCI) exceeds most other disuse conditions. Assessing the time course of molecular changes can provide insight into the progression of muscle wasting post‐SCI. The goals of this study were (1) to identify potential targets that may prevent the pathologic features of SCI in soleus muscles and (2) to establish
-
Single‐cell RNA‐seq reveals novel interaction between muscle satellite cells and fibro‐adipogenic progenitors mediated with FGF7 signalling J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-05-16 Lu Ma, Yingying Meng, Yalong An, Peiyuan Han, Chen Zhang, Yongqi Yue, Chenglong Wen, Xin'e Shi, Jianjun Jin, Gongshe Yang, Xiao Li
BackgroundMuscle satellite cells (MuSCs) exert essential roles in skeletal muscle adaptation to growth, injury and ageing, and their functions are extensively modulated by microenvironmental factors. However, the current knowledge about the interaction of MuSCs with niche cells is quite limited.MethodsA 10× single‐cell RNA sequencing (scRNA‐seq) was performed on porcine longissimus dorsi and soleus
-
Comment on ‘Prevalence of sarcopenia in patients with chronic kidney disease: a global systematic review and meta‐analysis’ J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-05-16 Xiao‐Ming Zhang, Zaigui Luo, Xiao‐Min Xie, Yunzhi Yang
We have recently had the pleasure of delving into an article titled ‘Prevalence of Sarcopenia in Patients with Chronic Kidney Disease: A Global Systematic Review and Meta-Analysis’ authored by Duarte and their esteemed colleagues.1 This meticulously conducted study amalgamated data from 140 research papers, encompassing a staggering 42 041 patients across 25 different countries. The findings revealed
-
Skeletal muscle hypertrophy rewires glucose metabolism: An experimental investigation and systematic review J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-05-14 Philipp Baumert, Sakari Mäntyselkä, Martin Schönfelder, Marie Heiber, Mika Jos Jacobs, Anandini Swaminathan, Petras Minderis, Mantas Dirmontas, Karin Kleigrewe, Chen Meng, Michael Gigl, Ildus I. Ahmetov, Tomas Venckunas, Hans Degens, Aivaras Ratkevicius, Juha J. Hulmi, Henning Wackerhage
Proliferating cancer cells shift their metabolism towards glycolysis, even in the presence of oxygen, to especially generate glycolytic intermediates as substrates for anabolic reactions. We hypothesize that a similar metabolic remodelling occurs during skeletal muscle hypertrophy.
-
Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-05-13 Leo R. Brown, Mariana S. Sousa, Michael S. Yule, Vickie E. Baracos, Donald C. McMillan, Jann Arends, Trude R. Balstad, Asta Bye, Olav Dajani, Ross D. Dolan, Marie T. Fallon, Christine Greil, Marianne J. Hjermstad, Gunnhild Jakobsen, Matthew Maddocks, James McDonald, Inger O. Ottestad, Iain Phillips, Judith Sayers, Melanie R. Simpson, Ola M. Vagnildhaug, Tora S. Solheim, Barry J.A. Laird, Richard J
Significant variation exists in the outcomes used in cancer cachexia trials, including measures of body composition, which are often selected as primary or secondary endpoints. To date, there has been no review of the most commonly selected measures or their potential sensitivity to detect changes resulting from the interventions being examined. The aim of this systematic review is to assess the frequency
-
Inflammation‐associated intramyocellular lipid alterations in human pancreatic cancer cachexia J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-05-10 Min Deng, Jianhua Cao, Gregory van der Kroft, David P.J. van Dijk, Merel R. Aberle, Andrej Grgic, Ulf P. Neumann, Georg Wiltberger, Benjamin Balluff, Frank G. Schaap, Ron M.A. Heeren, Steven W.M. Olde Damink, Sander S. Rensen
BackgroundCancer cachexia is a multifactorial metabolic syndrome characterized by systemic inflammation and ongoing skeletal muscle loss resulting in weakness, poor quality of life, and decreased survival. Whereas lipid accumulation in skeletal muscle is associated with cancer cachexia as well as the prognosis of cancer patients, surprisingly little is known about the nature of the lipids that accumulate
-
Integrated multi-omics approach reveals the role of striated muscle preferentially expressed protein kinase in skeletal muscle including its relationship with myospryn complex J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-05-09 Qifei Li, Jasmine Lin, Shiyu Luo, Klaus Schmitz-Abe, Rohan Agrawal, Melissa Meng, Behzad Moghadaszadeh, Alan H. Beggs, Xiaoli Liu, Mark A. Perrella, Pankaj B. Agrawal
Autosomal-recessive mutations in SPEG (striated muscle preferentially expressed protein kinase) have been linked to centronuclear myopathy with or without dilated cardiomyopathy (CNM5). Loss of SPEG is associated with defective triad formation, abnormal excitation–contraction coupling, calcium mishandling and disruption of the focal adhesion complex in skeletal muscles. To elucidate the underlying
-
Reduced temporal muscle thickness predicts shorter survival in patients undergoing chronic subdural haematoma drainage J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-05-09 Tommi K. Korhonen, Otso Arponen, Moritz Steinruecke, Ilaria Pecorella, Harry Mee, Stefan Yordanov, Edoardo Viaroli, Mathew R. Guilfoyle, Angelos Kolias, Ivan Timofeev, Peter Hutchinson, Adel Helmy
BackgroundChronic subdural haematoma (CSDH) drainage is a common neurosurgical procedure. CSDHs cause excess mortality, which is exacerbated by frailty. Sarcopenia contributes to frailty – its key component, low muscle mass, can be assessed using cross‐sectional imaging. We aimed to examine the prognostic role of temporal muscle thickness (TMT) measured from preoperative computed tomography head scans
-
Meta‐analysis on the interrelationship between sarcopenia and mild cognitive impairment, Alzheimer's disease and other forms of dementia J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-05-08 Nadjia Amini, Mounir Ibn Hach, Laurence Lapauw, Jolan Dupont, Laura Vercauteren, Sabine Verschueren, Jos Tournoy, Evelien Gielen
Sarcopenia has been associated with adverse health outcomes, including cognitive dysfunction. However, its specific interrelationship with neurocognitive disorders such as mild cognitive impairment (MCI), Alzheimer's disease (AD) or other types of dementia has not been thoroughly explored. This meta‐analysis aims to summarize the existing evidence on this interrelationship. This systematic review was
-
Metabolomic analysis of dietary-restriction-induced attenuation of sarcopenia in prematurely aging DNA repair-deficient mice J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-04-30 Yupeng He, Wei Yang, Luojiao Huang, Marlien Admiraal-van Mever, Rawi Ramautar, Amy Harms, Yvonne Rijksen, Renata M.C. Brandt, Sander Barnhoorn, Kimberly Smit, Dick Jaarsma, Peter Lindenburg, Jan H. J. Hoeijmakers, Wilbert P. Vermeij, Thomas Hankemeier
Sarcopenia is characterized by loss of skeletal muscle mass and function, and is a major risk factor for disability and independence in the elderly. Effective medication is not available. Dietary restriction (DR) has been found to attenuate aging and aging-related diseases, including sarcopenia, but the mechanism of both DR and sarcopenia are incompletely understood.