This study aimed to explore the association between gut microbiota functional profiles and skeletal muscle mass, focusing on sex-specific differences in a population under 65 years of age.

Background Advances in instrumented mouthguards (iMGs) allow for accurate quantification of single high-acceleration head impacts and cumulative head acceleration exposure in collision sports. However, relationships between these measures and risk of brain cell injury remain unclear. Aim The purpose of this study was to quantify measures of non-concussive head impact exposure and assess their association

Objective We aimed to investigate the association of cardiorespiratory fitness (CRF) with cognitive function and dementia risk, taking genetic predisposition for dementia into account. Methods Within the UK Biobank, 61 214 dementia-free participants aged 39–70 years were followed for up to 12 years. CRF score was estimated using a 6 min submaximal exercise test on a stationary bike and divided into

We recently read with great interest the paper by Yin and colleagues [1] that pharmacologically available genomic data, cis-eQTL/cis-pQTL from human blood and skeletal muscle tissue, and GWAS pooled data on sarcopenia related traits were used to analyse the potential causal relationship between drug target genes and sarcopenia. The study employed colocalization and Mendelian randomization (MR) analyses

IntroductionLong COVID‐19 illness is a severely disabling disease with shortness of breath, weakness and fatigue as leading symptoms, resulting in poor quality of life and substantial delay in return to work.No specific respiratory therapy has been validated for patients with long COVID. The intermittent hypoxia–hyperoxia training (IHHT) is a respiratory therapeutic modality to improve exercise performance

BackgroundSarcopenia is thought to be underlined by age‐associated anabolic resistance and dysregulation of intracellular signalling pathways. However, it is unclear whether these phenomena are driven by ageing per se or other confounding factors.MethodsLean and healthy young (n = 10, 22 ± 3 years, BMI; 23.4 ± 0.8 kg/m2) and old men (n = 10, 70 ± 3 years, BMI; 22.7 ± 1.3 kg/m2) performed unilateral

BackgroundBoth Alzheimer's disease (AD) and cerebral small vessel disease (CSVD) manifest in cognitive impairment and gait disorders. The precise similarities and differences in gait characteristics and underlying neuroimaging mechanisms remain unclear.MethodsA total of 399 participants were enrolled: 132 with probable AD, including 98 with mild cognitive impairment due to AD (AD‐MCI) and 34 with AD

Background:Anterior cruciate ligament (ACL) injury is one of the most severe injuries for athletes. It is important to identify risk factors because a better understanding of injury causation can help inform athletes about risk and increase their understanding of and motivation for injury prevention.Purpose:To investigate the relationship between anatomic factors and risk for future noncontact ACL

Objectives The purpose of this study was to investigate head kinematic variables in elite men’s and women’s rugby union and their ability to predict player removal for an off-field (HIA1) head injury assessment. Methods Instrumented mouthguard (iMG) data were collected for 250 men and 132 women from 1865 and 807 player-matches, respectively, and synchronised to video-coded match footage. Head peak

Background:Despite the clinical benefits over nonoperative treatment or meniscectomy, the clinical outcomes of surgical repair for medial meniscus posterior root tear (MMRT) remain suboptimal, which may be attributed to the insufficient restoration of meniscal hoop tension during surgery.Purpose:To analyze the clinical outcomes of surgical repair of MMRT based on the appearance of the meniscal tension

Background:Sleep disturbance is commonly reported by patients wearing an abduction brace after arthroscopic rotator cuff repair (ARCR). Although a sling has been proven noninferior to an abduction brace for function and repair integrity, there is no evidence-based medical support for the advantage of the sling in improving sleep quality compared with a brace.Purpose/Hypothesis:This study aimed to compare

The force–length relationship is usually obtained for isometric contractions with maximal activation, but less is known about how sarcomere length affects force during submaximal activation. During submaximal activation, length-dependent alterations in calcium sensitivity, owing to changes in cross-bridge kinetics (rate of attachment and/or detachment), result in an activation-dependent shift in optimal

Objective Low physical activity (PA) levels are associated with increased mortality. Improved measurement has resulted in stronger proven associations between PA and mortality, but this has not yet translated to improved estimates of the disease burden attributable to low PA. This study estimated how much low PA reduces life expectancy, and how much life expectancy could be improved by increasing PA

Background:The open Latarjet procedure yields excellent results as a treatment for anterior shoulder instability. The position of the bony fragment and the insertion angle of the screw (the alpha angle) are critical factors for a successful procedure. The alpha angle is considered overangulated at >25°, which is associated with poor bone fixation and healing.Purpose:To assess preoperative patient anatomic

Background:Treatment for osteochondritis dissecans (OCD) of the humeral capitellum has been predominantly guided by fragment stability and articular cartilage integrity. Nonoperative management is recommended for stable lesions, whereas surgical intervention is indicated for unstable lesions and those that fail nonoperative care. Several surgical options may be considered, although limited information

Background:Shoulder stabilization surgery has evolved over time, and bony augmentation procedures on the glenoid side are being performed more often. The Latarjet procedure modifies subscapularis anatomy because the conjoined tendon divides the subscapularis muscle fibers through a split/takedown, which has structural and functional implications. Arthroscopic anatomic glenoid reconstruction (AAGR)

Background:Latissimus dorsi tendon transfer (LDTT) leads to good clinical outcomes and recovery of function. A previous study have evaluated the outcomes of LDTT at a minimum 10-year follow-up and found durable improvements in shoulder function and pain relief but observed that shoulders with fatty infiltration of the teres minor muscle and insufficiency of the subscapularis muscle tended to have inferior

Background:Previous studies have examined the relationship between patient resilience and functional outcome scores after anterior cruciate ligament reconstruction (ACLR). However, past studies have failed to explore the longitudinal relationship between preoperative resilience and functional outcomes 2 years after ACLR.Purpose:To evaluate the relationship between preoperative patient resilience and

Background It is unknown whether there are differences in maximal oxygen uptake (\({V}\)O2max) response when prescribing intensity relative to traditional (TRAD) anchors or to physiological thresholds (THR). Objectives The present meta-analysis sought to compare: (a) mean change in \({V}\)O2max, (b) proportion of individuals increasing \({V}\)O2max beyond a minimum important difference (MID) and (c)

Objective The purpose of this review was to assess the joint relationship of cardiorespiratory fitness (CRF) and Body Mass Index (BMI) on both cardiovascular disease (CVD) and all-cause mortality risk. Design A systematic review and meta-analysis was conducted. Pooled HR and 95% CI were calculated using a three-level restricted maximum likelihood estimation random-effects model with robust variance

Objective To systematically review the association between hip adduction and abduction strength, and adduction-to-abduction strength ratio in healthy athletes with the occurrence of future groin pain and time-loss groin injuries. Design Systematic review with meta-analysis. Data sources PubMed, Web of Science, SPORTDiscus, PEDro, Embase, and Scopus. Eligibility criteria Studies included had to (1)

BackgroundRandomized controlled trials have reported no effect of moderate‐to‐vigorous physical activity (MVPA) on reducing blood pressure (BP) in youth, probably due to short trial durations. This study examined the longitudinal effect of sedentary time (ST), light PA (LPA) and MVPA on BP in 11‐year‐old children followed up for 13 years to determine the confounding and mediating role of body composition

BackgroundThe association between brain and sarcopenia has not been clarified. We aim to investigate the causal association between brain structure, function, gene expression and sarcopenia‐related traits.MethodsAll participants were Europeans. GWAS data of Brain Imaging Data Structure (BIDs) was from the UK Biobank. Gene expression in 13 brain regions was acquired from the GTEx Consortium. The sarcopenia‐related

Objective To determine the association between survey-based self-reported problematic low energy availability indicators (LEA-I) and race performance and intra-event medical encounters during the Boston Marathon. Methods 1030 runners who were registered for the 2022 Boston Marathon completed an electronic survey (1–4 weeks pre-race) assessing LEA-I, training and medical history. De-identified survey

BackgroundThe relationship between sarcopenia and the prognosis of patients with tumours who received radio‐ and/or chemotherapy still needs to be determined. In this study, we aim to investigate the relationship between sarcopenia and adverse effects and mortality in patients with tumours that received radio‐ and/or chemotherapy, stratified by study design, tumour category, the method sarcopenia assessed

BackgroundIt has been shown that in patients with liver cirrhosis, sarcopenia is a predictor of acute decompensation (AD), acute‐on‐chronic liver failure (ACLF) and death. However, computer tomography (CT), as a suggested standard method for diagnosing sarcopenia, is resource intensive and involves radiation exposure. Therefore, in this study, we evaluate the muscle thickness of quadriceps femoris

BackgroundCancer cachexia significantly contributes to morbidity and mortality in patients with non‐small‐cell lung cancer (NSCLC). Inflammatory pathways mediated by interleukin‐6 (IL‐6) play a crucial role in the development of cancer cachexia. This study aimed to investigate the use of tocilizumab in the management of NSCLC with coexisting IL‐6‐elevated cachexia.MethodsIn this retrospective study

Objective Women remain at increased risk for some sports injuries, such as anterior cruciate ligament rupture and concussion. This study applied a gendered environmental approach to identify modifiable features of women’s sport environments that may contribute to the gendered patterning of sports injuries. Our objectives were to identify features of gendered environments that mattered in athletes’

The International Olympic Committee’s (IOC) consensus statement on ‘methods for recording and reporting of epidemiological data on injury and illness in sport’ recommended standardising methods to advance data collection and reporting consistency. However, additional aspects need to be considered when these methods are applied to specific sports settings. Therefore, we have developed a snow sports-specific

Endurance events are popular worldwide and have many health benefits. However, runners and Para athletes may sustain musculoskeletal injuries or experience other health consequences from endurance events. The American Medical Society for Sports Medicine (AMSSM) Runner Health Consortium aimed to generate consensus-based survey items for use in prospective research to identify risk factors for injuries

The Amsterdam 2022 International Consensus Statement on Concussion in Sport (6th International Conference on Concussion in Sport) was the first Concussion in Sport Group (CISG) consensus to consider the para athlete.1 To date, a lack of research in para sport on most aspects of concussion has prevented the development of evidence-informed consensus on any aspects of concussion care for para athletes

Objective Our aim was to define the priorities for future research in safeguarding athletes from interpersonal violence (IV) in sport through a Delphi consensus study of researchers in the field. Methods An internet-based three-round Delphi method was used as a multistage facilitation technique to arrive at a group consensus (set at ≥75% agreement). A targeted literature search was conducted to develop

BackgroundRisk factors of refracture after fragility fractures include osteoporosis, female gender and advanced age among others. We hypothesized that the assessment of functionality, muscle health and nutrition status contribute to the risk prediction for further fractures and death.MethodsWe assessed 334 patients admitted to the department of acute geriatrics for sociodemographic data, bone fragility

BackgroundSarcopenia is the gradual decrease in skeletal muscle mass, strength and function in elderly individuals. Gamma‐aminobutyric acid (GABA) is a neurotransmitter naturally produced from glutamate by the enzyme glutamic acid decarboxylase. Age‐related decline in GABA is linked to age‐related motor and sensory decline and seems to affect sarcopenia, yet no detailed study has been conducted. In

BackgroundThe diagnosis of sarcopenia relies extensively on human and equipment resources and requires individuals to personally visit medical institutions. The objective of this study was to develop a test‐free, self‐assessable approach to identify sarcopenia by utilizing artificial intelligence techniques and representative real‐world data.MethodsThis multicentre study enrolled 11 661 middle‐aged

BackgroundSarcopenia is an aging‐related condition characterized by loss of skeletal muscle mass and is an indicator of subclinical atherosclerosis. The relationship between reduced muscle mass and long‐term clinical outcomes in patients with advanced coronary artery disease who have undergone coronary artery bypass grafting (CABG) is not fully understood. This study is sought to evaluate the prognostic

Background:Detection of meniscal ramp lesions concomitant with anterior cruciate ligament (ACL) injury using conventional magnetic resonance imaging (MRI) has low sensitivity, and these lesions are currently difficult to diagnose preoperatively.Purpose/Hypothesis:The purpose of this study was to assess the accuracy of MRI in detecting the presence of meniscal ramp lesions in the 120° flexed-knee position

I am writing to express concerns and seek clarification regarding a paper published in the Journal of Cachexia, Sarcopenia and Muscle titled ‘Diagnosis of sarcopenia by evaluating skeletal muscle mass by adjusted bioimpedance analysis validated with dual-energy X-ray absorptiometry’ [1]. Our company, InBody Co. Ltd., manufacturer of the InBody device used for the above paper, has identified certain

Objective To examine the influence of postpartum exercise on maternal depression and anxiety. Design Systematic review with random effects meta-analysis and meta-regression. Data sources Online databases up to 12 January 2024, reference lists, recommended studies and hand searches. Eligibility criteria Randomised controlled trials (RCTs) and non-randomised interventions of any publication date or language

Objectives A paucity of studies assesses the intersection of physical health (injury and illness), mental health and experiences of interpersonal violence (IV, also known as harassment and abuse) in sport. The objectives of this study were to examine the (a) frequency of self-reported physical and mental health problems of elite athletes in the 12 months prior to the survey, (b) differences in physical

After a thorough analysis of the latest research findings by Keita Miura and colleagues, we affirm their conclusion that approximately one-third of untreated patients with advanced non–small cell lung cancer (NSCLC) exhibit cachexia before first-line systemic treatment, with different treatment methods having a significant impact on these patients' appetite-related quality of life, weight changes and

We write this letter in response to the article [1], ‘Association between dynapenic obesity and risk of cardiovascular disease: The Hisayama study’. The study offers valuable insights into the role of dynapenic obesity as a significant risk factor for cardiovascular disease (CVD) among Japanese community residents, particularly highlighting the importance of weight management and maintaining muscle

To the Editor: We are writing in response to the article titled ‘Overall Mortality for Community-Dwelling Adults Over 50 Years at Risk of Malnutrition’ [1]. This study highlights the significant association between malnutrition risk and overall mortality, underscoring the importance of broader nutritional screening at the community level. We commend the authors for their valuable contribution and would

We read with great interest the recently published article by Ferrara et al. [1] in the Journal of Cachexia, Sarcopenia and Muscle. Based on whole-body [18F]FDG-PET/CT imaging, the study demonstrated the groupwise differences in the multi-organ metabolism of lung cancer patients (LCP) with and without cancer-associated cachexia (CAC), thus highlighting systemic metabolic aberrations symptomatic of

We have read a recent article [1] in J Cachexia Sarcopenia Muscle with great interest. This study aimed to determine the prevalence of low muscle mass within people living with HIV (PLWH) and to identify associated factors. By using multivariate logistic regression analysis, they identified antiretroviral medication types, specifically Zidovudine; BMI and NRI can be independent risk factors for low

BackgroundThe Asian Working Group for Cachexia (AWGC) proposed a new definition of cachexia; however, its impact on cachexia prevalence and overlaps with other conditions, such as sarcopenia and malnutrition, are unclear. We investigated these aspects and the prognostic value of cachexia based on the AWGC on mortality in older patients with heart failure (HF).MethodsThis study was a secondary analysis

Background:Nonoperative management of posterior shoulder instability is common. However, limited data are available to assess the pathomorphologic factors associated with its failure.Purpose/Hypothesis:The purpose of this study was 2-fold: (1) to determine glenohumeral pathomorphologic features predictive of nonoperative management failure of posterior instability; and (2) to determine the relationship

Background:Both high body mass index (BMI) and anterior cruciate ligament reconstruction (ACLR) independently influence knee osteoarthritis risk. Preliminary evidence shows the combination of these risk factors leads to poorer recovery and altered biomechanical outcomes after ACLR, but few studies have directly evaluated early changes in cartilage health between normal-BMI and high-BMI groups in this

Purpose: The associations between work time, leisure-time, and non-workday physical activity (PA) and sedentary behavior (SED) and 24 h ambulatory blood pressure (BP) are not well known. Therefore, the aim of this study was to evaluate the associations between domain-specific activity behavior and 24 h blood pressure.Methods: A hundred and fifty-six aging workers (mean age 62.4 [SD 1.0] years, BMI

Purpose: Developmental Coordination Disorder (DCD) is a common neurodevelopmental disorder characterized by motor impairments and subsequent physical activity (PA) deficits in middle childhood. It is not well understood when this gap in PA emerges. The purpose of the current study was to examine the longitudinal trajectories of device-assessed PA in a large cohort of children with and without DCD from

Purpose: This study compared the effects of four different resistance training (RT) programs that differed in the set configuration (cluster vs. traditional) and the blood flow condition [free-flow (FF) vs. blood flow restriction (BFR)] on strength, neuromuscular and hypertrophic adaptations.Methods: Forty-two resistance-trained males were randomly assigned into four protocols that differed in the

Purpose: To examine the relationship between menstrual cycle (MC) phase-dependent fluctuations of estrogen and progesterone and virtual cycling race performance, with a secondary aim of correlating perceived MC-related symptoms with performance.Methods: In a novel observational study design, thirty-seven female cyclists/triathletes not using any hormonal contraception completed one virtual cycling

Purpose: This study assessed the impact of a 12-week, home-based exercise training (HBET) program on health-related quality of life (HRQOL, primary outcome), cardiovascular and metabolic parameters in pediatric COVID-19 patients.Methods: In this single-center, randomized controlled trial conducted in Sao Paulo (Brazil) from October 2020 to January 2022, 32 patients (mean age 12 ± 3.3 years; median

Introduction: Carbon plates have been used to increase running shoes' longitudinal bending stiffness (LBS), but their effect during a long duration run remains unknown. Our study aimed to identify the effect of LBS on energy cost of running (Cr), biomechanics, and fatigue during a half-marathon.Methods: Thirteen well-trained male runners (half-marathon time < 1 h40) performed two half-marathons at

Purpose: Cardiac rehabilitation participation rates are low despite strong recommendations, and many chronic heart failure patients remain physically inactive. Rural living, long travel distance, costs, age, and frailty might be factors explaining this. To increase cardiac rehabilitation uptake, we designed an exercise-based randomized controlled telerehabilitation trial enabling chronic heart failure

Purpose: Ingestion of whey protein increases myofibrillar but not muscle connective protein synthesis rates. Recently, we defined a whey and collagen protein blend (5:1-ratio) to optimize post-prandial plasma amino acid availability. Here, we assessed the ability of this blend to increase myofibrillar and muscle connective protein synthesis rates at rest and during early recovery from exercise.Methods: