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Diagnostic Criteria for Cancer-Associated Cachexia: Insights from a Multicentre Cohort Study J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-02-13
Zhenyu Huo, Feifei Chong, Na Li, Siyu Luo, Liangyu Yin, Jie Liu, Mengyuan Zhang, Jing Guo, Yang Fan, Ling Zhang, Xin Lin, Hongmei Zhang, Muli Shi, Xiumei He, Zongliang Lu, Ning Tong, Wei Li, Jiuwei Cui, Zengqing Guo, Qinghua Yao, Fuxiang Zhou, Ming Liu, Zhikang Chen, Huiqing Yu, Minghua Cong, Tao Li, Zengning Li, Pingping Jia, Min Weng, Chunhua Song, Hanping Shi, Hongxia XuTo explore the association between cachexia, as defined by different diagnostic criteria, and the risk of mortality in individuals with cancer. We also examined which diagnostic criteria are more feasible and appropriate for cancer-associated cachexia in clinical practice.
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Association Analysis of the Circulating Proteome With Sarcopenia-Related Traits Reveals Potential Drug Targets for Sarcopenia J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-02-13
Simin Wen, Siqi Xu, Xizeng Zong, Shifeng Wen, Wende Xiao, Weipeng Zheng, Han Cen, Zhaohua Zhu, Jingyu Xie, Yan Zhang, Changhai Ding, Guangfeng RuanSarcopenia severely affects the physical health of the elderly. Currently, there is no specific drug available for sarcopenia. This study aims to identify pathogenic proteins and druggable targets for sarcopenia through Mendelian randomization (MR)–based analytical framework.
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Successful Medial Meniscal Repair Reduces Knee Pain 10 Years After Anterior Cruciate Ligament Reconstruction: Exploring the Consequences of Subsequent Surgery With Causal Mediation Analysis in the MOON Cohort Am. J. Sports Med. (IF 4.2) Pub Date : 2025-02-13
Andrew J. Sheean, Yuxuan Jin, Annunziato Amendola, Laura J. Huston, Robert H. Brophy, Charles L. Cox, Morgan H Jones, Christopher C. Kaeding, Michael W. Kattan, Robert A. Magnussen, Robert G. Marx, Matthew J. Matava, Eric C. McCarty, Richard D. Parker, Emily Reinke, Michelle L. Wolcott, Brian R. Wolf, Rick W. Wright, Kurt P. SpindlerBackground:Medial meniscal repair performed at the time of primary anterior cruciate ligament reconstruction (ACLR) has been shown to be significantly associated with subsequent surgery, and subsequent surgery has been associated with increased Knee injury and Osteoarthritis Outcome Score (KOOS) pain score and decreased patient satisfaction.Hypothesis/Purpose:The purpose was to determine if medial
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Radiological Risk Factors for Osteochondral Fractures in Patients With First-Time and Recurrent Patellar Instability: Data From the JUPITER Cohort Am. J. Sports Med. (IF 4.2) Pub Date : 2025-02-13
James J. McGinley, Henry B. Ellis, Bennett Propp, Matthew W. Veerkamp, Philip L. Wilson, Dennis E. Kramer, Benton E. Heyworth, Sabrina Strickland, Eric Wall, Jason Koh, Yi-Meng Yen, Matthew Halsey, Robert Magnussen, David Roberts, Jack Farr, Daniel Green, Peter Fabricant, Jacqueline Brady, Marc Tompkins, Lauren H. Redler, Adam B. Yanke, Seth L. Sherman, Shital N. Parikh, Beth E. Shubin SteinBackground:Radiological risk factors for an osteochondral fracture (OCF) associated with patellar instability are rarely studied, particularly in patients with recurrent instability.Purpose:To identify specific radiological characteristics that relate to the increased prevalence of OCFs associated with patellar instability.Study Design:Case-control study; Level of evidence, 3.Methods:Patient data (n
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Structured Treadmill Training as a Strategy to Mitigate Tumor Growth and Preserve Adipose tissue and Muscle Strength in Prostate Tumor Bearing Mice. Med. Sci. Sports Exercise (IF 4.1) Pub Date : 2025-02-13
Arthur Dieumegard,Suzanne Dufresne,Cindy Richard,Luz Orfila,Brice Martin,Laurent Rouvière,Arsênio Rodrigues Oliveira,Mikaël Croyal,Romain Mathieu,Amélie RébillardPURPOSE Exercise is widely recognized for providing numerous benefits to prostate cancer (PCa) survivors. Numerous preclinical studies have investigated the role of exercise on tumor progression, but results are often controversial, largely due to variations in experimental protocols. METHODS In this study, the comprehensive effects of exercise on PCa were evaluated with two different aerobic exercises
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ICRS-FIFA-Aspetar consensus on the management of knee cartilage injuries in football players: part 1 - appropriateness of surgery in different clinical scenarios using the RAND/UCLA appropriateness method. Br. J. Sports Med. (IF 11.6) Pub Date : 2025-02-12
Elizaveta Kon,Emmanuel Papakostas,Luca Andriolo,Andreas Serner,Andrew Massey,Peter Verdonk,Peter Angele,Claudia Arias,Camila Cohen Kaleka,Ramon Cugat,Pieter D'Hooghe,Francesco Della Villa,Cristiano Eirale,Christoph Erggelet,João Espregueira-Mendes,Christian Fink,Celeste Geertsema,Liesel Geertsema,Cassandra A Lee,Bert Mandelbaum,Norimasa Nakamura,David A Parker,Kristof Sas,Bertrand Sonnery-Cottet,WillemKnee cartilage lesions are frequent in football players, but evidence for surgical treatment is lacking. The aim of this International Cartilage Regeneration & Joint Preservation Society, Fédération Internationale de Football Association, and Aspetar (ICRS-FIFA-Aspetar) consensus was to develop specific expert-based, patient-specific practical recommendations on the appropriateness of non-surgical
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Association of Cumulative Exposure to Metabolic Score for Visceral Fat With the Risk of Cardiovascular Disease and All‐Cause Mortality: A Prospective Cohort Study J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-02-12
Qian Liu, Haozhe Cui, Fei Si, Yuntao Wu, Jing YuBackgroundPrevious studies have demonstrated that metabolic score for visceral fat (METS‐VF), a novel surrogate indicator assessing visceral fat, was associated with the risk of hypertension, diabetes mellitus, cardiovascular disease (CVD) and mortality, predicting the risks based on a single METS‐VF measurement can increase limitations of the study. Few studies have investigated the association between
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Neuroimaging Findings in Nondemented Frail Individuals: A Systematic Review J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-02-12
Hamid Harandi, Soheil Mohammadi, Ali Jahanshahi, Mahsa Dolatshahi, Sogol Alikarami, Rasa Zafari, Cyrus A. RajiBackgroundFrailty is a chronic condition characterised by the progressive decline of multiple physiological functions. There is a critical need to investigate neuroimaging findings in nondemented frail individuals to better understand the underlying mechanisms and implications of frailty on brain health. This paper is aimed at reviewing neuroimaging studies assessing brain changes in nondemented frail
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Stress-Free Voluntary Exercise Promotes Prophylactic Enhancement of Stress Resilience via the Nucleus Reuniens Affecting the Medial Prefrontal Cortex-Hippocampal Pathway. Med. Sci. Sports Exercise (IF 4.1) Pub Date : 2025-02-12
Dong-Joo Hwang,Joon-Yong ChoPURPOSE Stress is a risk factor for psychiatric illnesses. However, not all individuals exposed to stress will develop affective disorders. We examined whether pretreatment with stress-free voluntary wheel running (VWR) exercise prophylactically enhances stress resilience in rodents and how it can effectively prevent the development of depressive- and anxiety-like behaviors. METHODS Eight-week-old
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Performance and Physiological Effects of Race Pace-Based versus Heart Rate Variability-Guided Training Prescription in Runners. Med. Sci. Sports Exercise (IF 4.1) Pub Date : 2025-02-12
Luis Eduardo Ranieri,Arturo Casada,Diana Martin,Daniel Trujillo-Colmena,Alexander Gil-Arias,Mark Kenneally,Alfonso JiménezPURPOSE The aim of the present study was to compare performance and physiological effects, and inter-individual response variation in performance and its physiological determinants between heart rate-based (HR), race pace-based (RP) and heart rate variability-based (HRV) training prescription approaches in recreational distance runners. METHODS Twenty-eight participants completed a 6-week endurance
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Group-mediated exercise for chronic conditions: an urgent need for implementation and scale-up. Br. J. Sports Med. (IF 11.6) Pub Date : 2025-02-11
Tim Rees,Mark R Beauchamp,Mark Stevens,Matthew Low,Thomas W Wainwright -
Circulating Extracellular Vesicles in Alcoholic Liver Disease Affect Skeletal Muscle Homeostasis and Differentiation J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-02-11
Laura Barberi, Cristiana Porcu, Caterina Boccia, Marianna Cosentino, Carmine Nicoletti, Barbara Peruzzi, Francesca Iosi, Flavia Forconi, Giulia Bagnato, Gabriella Dobrowolny, Simone Di Cola, Lucia Lapenna, Gianluca Cera, Manuela Merli, Antonio MusaròBackgroundThe mechanisms underlying muscle alteration associated to alcoholic liver disease (ALD) are not fully understood and the physiopathologic mediators of the liver–muscle interplay remains elusive. We investigated the role of circulating extracellular vesicles (EVs) in ALD as potential mediators of muscle atrophy.MethodsWe established a mouse model of sarcopenia associated to ALD, by feeding
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Biomechanical Evaluation and Surface Analysis of Glenoid Reconstruction Using a Subtalar Joint Allograft for Significant Glenoid Bone Loss in Recurrent Shoulder Instability: A Novel Alternative Graft Option Am. J. Sports Med. (IF 4.2) Pub Date : 2025-02-11
Phob Ganokroj, Justin F.M. Hollenbeck, Marco Adriani, Ryan J. Whalen, Amelia H. Drumm, Alexander R. Garcia, Wyatt H. Buchalter, Trevor J. McBride, Marco-Christopher Rupp, Matthew T. ProvencherBackground:Glenoid and humeral head bone defects are common in chronic shoulder instability. The talus, and more specifically, the subtalar joint, has been proposed as a unique allograft from which bipolar bone loss can be addressed. However, there are few biomechanical data or joint reconstruction analyses of the glenoid using the posterior facet of a subtalar joint allograft (STA).Purpose:To compare
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Establishing Benchmarks for Case Minimum Requirements During Accreditation Council for Graduate Medical Education–Accredited Orthopaedic Sports Medicine Fellowship Training Am. J. Sports Med. (IF 4.2) Pub Date : 2025-02-11
Jason Silvestre, Harris S. Slone, John D. KellyBackground:Accrediting bodies and professional societies for surgical education are increasingly recognizing the need for case minimum requirements to enhance standardized training.Purpose:To determine case volume benchmarks for operative training during Accreditation Council for Graduate Medical Education (ACGME)–accredited orthopaedic sports medicine fellowships in the United States.Study Design:Cross-sectional
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Dry Needling in Sports and Sport Recovery: A Systematic Review with an Evidence Gap Map Sports Med. (IF 9.3) Pub Date : 2025-02-10
Adrian Kużdżał, Robert Trybulski, Jarosław Muracki, Sebastian Klich, Filipe Manuel Clemente, Adam KawczyńskiBackground Dry needling is an increasingly popular technique used in sports and regenerative medicine contexts. However, there is no comprehensive overview of investigations of dry needling in sports and sport recovery. Objectives The objectives were to perform a systematic review of dry needling in sports athletes with an evidence gap map, to identify current gaps in the literature, and to provide
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Recommendations and regulations for sport events in the heat: ReFORM summary of the International Olympic Committee's consensus statement. Br. J. Sports Med. (IF 11.6) Pub Date : 2025-02-10
Anne-Charlotte Dupont,Camille Tooth,Franck Brocherie,Sebastien Racinais,Janne Bouten -
Outcomes of Open Arthrotomy and Arthroscopic Surgery for Primary Synovial Chondromatosis of the Hip: A Comparative Study With Propensity Score Matching Am. J. Sports Med. (IF 4.2) Pub Date : 2025-02-10
Han Soul Kim, Cha Hyeong Ok, Jae Suk Chang, Ji Wan Kim, Chul-Ho KimBackground:Despite the widespread use of arthroscopic surgery for hip synovial chondromatosis, its postoperative outcomes remain uncertain. A head-to-head comparison between open arthrotomy and arthroscopic surgery is lacking.Purpose:To compare the treatment outcomes of open arthrotomy, particularly with surgical dislocation, and arthroscopic surgery for hip synovial chondromatosis.Study Design:Cohort
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Chronic Structural Adaptations of the Shoulder and Elbow Are Correlated in Professional Baseball Pitchers Am. J. Sports Med. (IF 4.2) Pub Date : 2025-02-10
Ryan W. Paul, Alim Osman, Levon N. Nazarian, Michael G. Ciccotti, Steven B. Cohen, Brandon J. Erickson, Paul Buchheit, Joseph Rauch, Daryl C. Osbahr, Stephen J. ThomasBackground:Pitchers with deficits in total shoulder rotation range of motion (ROM) are 2.6 times more likely to experience an elbow injury. Despite the effects of shoulder ROM on elbow injury, it is currently unclear whether specific tissue adaptations of the shoulder relate to the tissue adaptations of the elbow in baseball pitchers.Purpose/Hypothesis:The purpose was to evaluate the relationship between
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Effects of Heating on Tendon Mechanical Properties and Performance during Stretch-Shortening Cycle Exercises. Med. Sci. Sports Exercise (IF 4.1) Pub Date : 2025-02-10
Shuhei Sasajima,Keitaro KuboPURPOSE The purpose of this study was to investigate the effects of heating on Achilles tendon mechanical properties (elongation, elastic energy, and hysteresis) and performance during stretch-shortening cycle exercise (pre-stretch augmentation and efficiency). METHODS Fifteen males participated in this study. Before and after heating (30 min) and non-heating (control) conditions, the mechanical properties
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Body Composition, Not Body Mass Index, Is Associated with Clinical Outcomes Following ACL Reconstruction. Med. Sci. Sports Exercise (IF 4.1) Pub Date : 2025-02-10
Ashley N Buck,Sam R Moore,Abbie E Smith-Ryan,Todd A Schwartz,Amanda E Nelson,Hope Davis-Wilson,J Troy Blackburn,Brian PietrosimonePURPOSE Determine the associations of body mass index (BMI) and body composition (lean and fat mass) with i) patient-reported outcomes, ii) quadriceps strength, and iii) physical performance in anterior cruciate ligament reconstruction (ACLR) patients. METHODS Thirty-four individuals participated (56% female; 22 ± 4 years; % body fat: 22.9 ± 6.7%). Dual energy x-ray absorptiometry was used to measure
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Physical Work in Humid Heat Impairs Postural Balance during Simulated Construction Tasks at Height. Med. Sci. Sports Exercise (IF 4.1) Pub Date : 2025-02-10
Beverly Wei Lin Tan,Sharifah Badriyah Alhadad,Gerald Zheng Yang Tan,Pearl Tan Min Sze,Bruno Lemke,Jason Kai Wei LeePURPOSE Occupational heat strain can impair construction workers' motor and cognitive functions, potentially leading to accidents, injuries and lowered productivity. We examined the effects of physical work under various warm and humid tropical conditions on performance in virtual reality (VR)-based construction tasks. METHODS Eighteen healthy men (age: 29 ± 5 years) completed three randomised, counterbalanced
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Impact of exercise on musculoskeletal pain and disability in the postpartum period: a systematic review and meta-analysis. Br. J. Sports Med. (IF 11.6) Pub Date : 2025-02-08
Stephanie-May Ruchat,Nicole Beamish,Sophie Pellerin,Muhammad Usman,Sinead Dufour,Sarah Meyer,Allison Sivak,Margie H DavenportOBJECTIVE To examine the impact of exercise on musculoskeletal pain (low back pain (LBP), pelvic girdle pain (PGP), lumbopelvic pain (LBPP) and bodily pain) and kinesiophobia during the postpartum period. DESIGN Systematic review with random effects meta-analysis. STUDY ELIGIBILITY CRITERIA Online databases were searched from database inception to 12 January 2024. Studies of all designs (except case
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Prehospital care of suspected spine-injured lacrosse athletes: a systematic search, evidence review, and consensus recommendations. Br. J. Sports Med. (IF 11.6) Pub Date : 2025-02-08
Thomas G Bowman,Richard J Boergers,Shane V Caswell,Darryl Conway,William J Mills,Margot Putukian,Mandy Merritt,Jason D Vescovi,Edward Strapp,Kellie Loehr,Jennifer Monnin,Rebecca Vozzo,Robert Hatch,Caroline Wesley Siler,Samantha E Scarneo-MillerLacrosse has experienced significant growth in popularity worldwide and will return to the Summer Olympic Games in 2028. While there are published consensus recommendations for prehospital care of athletes with suspected spine injuries, there are currently no recommendations specific to lacrosse athletes with and without circulation, airway, or breathing (CAB) compromise. The document aims to determine
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The Effect of Concavity Restoration on Glenohumeral Stability in a Glenoid Bone Loss Model: Comparing Distal Tibial Allograft Reconstruction to Classic Latarjet Am. J. Sports Med. (IF 4.2) Pub Date : 2025-02-08
Matthew S. Fury, Carl M. Cirino, Amirhossein Jahandar, Ryan C. Rauck, Lawrence V. Gulotta, David M. Dines, Joshua S. Dines, Theodore A. Blaine, Michael C. Fu, Russell F. Warren, Andreas Kontaxis, Samuel A. TaylorBackground:Distal tibial allograft (DTA) reconstruction for glenoid bone loss (GBL) has gained popularity. While recent studies have demonstrated that glenoid concavity is an important factor in native glenohumeral stability, there remains a paucity of data regarding concavity restoration during reconstructive procedures for GBL and its biomechanical effect.Purpose:To compare the restoration of anterior
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Revision Anterior Cruciate Ligament Reconstruction: Surgeon-Reported Causes of Failure From the Norwegian Knee Ligament Register Am. J. Sports Med. (IF 4.2) Pub Date : 2025-02-08
Søren Vindfeld, Andreas Persson, Line Lindanger, Anne Marie Fenstad, Håvard Visnes, Eivind InderhaugBackground:Failed anterior cruciate ligament reconstruction (ACLR) leads to reduced quality of life and sometimes the need for repeat surgery. The reason for failure can be multifactorial and difficult to determine. Reports on failure leading to revision are few with limited generalizability. Also, no studies have investigated the reasons for early (<2 years) versus late (≥2 years) revision.Purpose:To
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Air quality, respiratory health and performance in athletes: a summary of the IOC consensus subgroup narrative review on 'Acute Respiratory Illness in Athletes'. Br. J. Sports Med. (IF 11.6) Pub Date : 2025-02-07
Valerie Bougault,Christopher Carlsten,Paolo Emilio Adami,Nicola Sewry,Wolfgang Schobersberger,Torbjørn Soligard,Lars Engebretsen,Richard Budgett,Martin Schwellnus,Ken FitchWith the WHO stating that nearly 99% of the global population is exposed to air pollution levels that increase the risk of chronic diseases, the question of exercising in polluted environments is relevant to the health of athletes. Major sporting events held under conditions of poor air quality (AQ) have highlighted the lack of answers to concerns raised by organisers and athletes about the associated
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All the right moves: physical activity promotion for people with musculoskeletal pain. Br. J. Sports Med. (IF 11.6) Pub Date : 2025-02-07
Matt Fernandez,Katie de Luca,Robert Stanton,Stephanie Alley,Fabio Serpiello,Corneel Vandelanotte -
Blood flow restriction: methods and apparatus still matter. Br. J. Sports Med. (IF 11.6) Pub Date : 2025-02-07
Luke Hughes,Nicholas Rolnick,Alexander Franz,Johnny Owens,Patrick Michael Swain,Christoph Centner,Jeremy P Loenneke,Stuart Anthony Warmington -
Response to Comment on "Does Swimming Exercise Impair Bone Health? A Systematic Review and Meta-Analysis Comparing the Evidence in Humans and Rodent Models". Sports Med. (IF 9.3) Pub Date : 2025-02-07
Hélder Fonseca,Laura Freitas,Giorjines Boppre -
Primary Anterior Cruciate Ligament Reconstruction in Level 1 Athletes: Factors Associated With Return to Play, Reinjury, and Knee Function at 5 Years of Follow-up Am. J. Sports Med. (IF 4.2) Pub Date : 2025-02-07
Timothy McAleese, Neil Welch, Enda King, Davood Roshan, Niamh Keane, Kieran A. Moran, Mark Jackson, Daniel Withers, Ray Moran, Brian M. DevittBackground:Favorable outcomes after anterior cruciate ligament (ACL) reconstruction (ACLR) are often gauged by successful return to play (RTP), a low incidence of subsequent ACL injury, and positive patient-reported outcomes. Level 1 sports place the highest demands on the knee by requiring frequent pivoting, changes in direction, and jumping.Purpose:To analyze the outcomes of primary ACLR in level
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Empowering older adults for physical health and strength programme. Br. J. Sports Med. (IF 11.6) Pub Date : 2025-02-06
Shyh Poh Teo,Asmah Husaini,Sharimawati Sharbini -
Long‐Term Impact of Physical Activity on Mortality in Adults With Multimorbidity: A 12‐Year Cohort Longitudinal Study From the Survey on Health, Ageing and Retirement in Europe J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-02-06
Nicola Veronese, Francesco Saverio Ragusa, André Hajek, Brendon Stubbs, Lee Smith, Mario Barbagallo, Ligia Juliana Dominguez, Luigi Fontana, Pinar Soysal, Shaun Sabico, Nasser M. Al‐DaghriBackgroundWhile physical activity (PA) is known to reduce mortality in the general population, this relationship in individuals with multimorbidity (≥ 2 chronic conditions) is unclear. This longitudinal study aimed to investigate whether there is a long‐term association between PA levels and mortality rates over a 12‐year period in adults with multimorbidity.MethodsData were obtained from eight waves
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Targeting Drug Delivery System to Skeletal Muscles: A Comprehensive Review of Different Approaches J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-02-06
Xiaofang Li, Jintao Xu, Shanshan Yao, Ning Zhang, Bao‐Ting Zhang, Zong‐Kang ZhangThe skeletal muscle is one of the largest organs in the body and is responsible for the mechanical activity required for posture, movement and breathing. The effects of current pharmaceutical therapies for skeletal muscle diseases are far from satisfactory; approximately 24% of Duchenne muscular dystrophy (DMD) trials have been terminated because of unsatisfactory outcomes. The lack of a skeletal muscle‐targeting
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Multiomics Analysis Reveals Therapeutic Targets for Chronic Kidney Disease With Sarcopenia J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-02-06
Meiqiu Wang, Lianghui You, Xu He, Yingchao Peng, Ren Wang, Zhiqiang Zhang, Jiaping Shu, Pei Zhang, Xiaoyi Sun, LiLi Jia, Zhengkun Xia, Chenbo Ji, Chunlin GaoBackgroundThe presence of sarcopenia in patients with chronic kidney disease (CKD) is associated with poor prognosis. The mechanism underlying CKD‐induced muscle wasting has not yet been fully explored. This study investigates the influence of renal secretions on muscles using multiomics sequencing.MethodsThe kidney transcriptome analysis by RNA‐seq and protein profiling by tandem mass tag (TMT), serum
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A Cadaveric Study of the Sagittal Patellar Insertion of the Medial Patellofemoral Ligament in Children: Implications for Reconstruction Am. J. Sports Med. (IF 4.2) Pub Date : 2025-02-06
Amin Alayleh, Ian Hollyer, Thomas Johnstone, Bryan Khoo, Chiamaka Obilo, Kelly McFarlane, Wills Baird, Calvin Chan, Marc Tompkins, Henry Ellis, Matthew Schmitz, Yi-Meng Yen, Theodore Ganley, Seth L. Sherman, Kevin G. SheaBackground:Patellofemoral instability is a common problem, and medial patellofemoral ligament (MPFL) reconstruction is a standard treatment approach for recurrent instability. The accurate restoration of anatomy in MPFL reconstruction is essential. While coronal-plane anatomy of the MPFL patellar insertion has been previously reported, sagittal-plane anatomy has not been widely studied.Purpose:To evaluate
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Thin Flap Trochleoplasty With Medial Patellofemoral Ligament Reconstruction for Recurrent Patellofemoral Instability With High-Grade Trochlear Dysplasia: A Series of 63 Consecutive Cases Am. J. Sports Med. (IF 4.2) Pub Date : 2025-02-06
Laurie A. Hiemstra, Alexis Rousseau-Saine, Mark R. Lafave, Sarah KerslakeBackground:Trochlear dysplasia is present in 68% to 85% of patients with recurrent lateral patellofemoral instability (LPI) compared with 3% to 6% of healthy controls. Trochlear dysplasia has been associated with medial patellofemoral ligament (MPFL) graft failure and lower quality-of-life (QOL) outcome scores. The correction of trochlear dysplasia with trochleoplasty is indicated in patients with
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Combined Correction of Coronal and Rotational Deformities of the Femur With Distal Femoral Osteotomy Using Patient-Specific Instrumentation Am. J. Sports Med. (IF 4.2) Pub Date : 2025-02-06
Georgios Neopoulos, Lukas Jud, Lazaros Vlachopoulos, Sandro F. FucenteseBackground:Distal femoral osteotomy (DFO) can be used to simultaneously correct coronal and rotational deformities. Patient-specific instruments (PSIs) are known to be helpful in such complex osteotomies, but data on surgical accuracy for the combined correction of coronal and rotational deformities of the femur are missing.Purpose:To investigate the radiological results of DFO for simultaneous correction
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Clinical Outcomes of Fully Arthroscopic Versus Arthroscopically Assisted Latissimus Dorsi Transfer for Irreparable Subscapularis Tear Am. J. Sports Med. (IF 4.2) Pub Date : 2025-02-05
Bo Taek Kim, Luis Alfredo Miranda, Chang Hee Baek, Jung Gon Kim, Luis Leoncio Temoche Diaz, Gyu Rim Baek, Jean KanyBackground:Untreated chronic subscapularis (SSC) tears pose a challenging problem to treat owing to the resultant tendon retraction, atrophy, fatty infiltration, and changes in humeral head position, which complicate surgical options. Anterior latissimus dorsi (LD) transfer has shown effective results in treating these tears without glenohumeral arthritis.Purpose/Hypothesis:This study introduces and
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fMRI Activation in Sensorimotor Regions at 6 Weeks After Anterior Cruciate Ligament Reconstruction Am. J. Sports Med. (IF 4.2) Pub Date : 2025-02-05
Adam M. Culiver, Dustin R. Grooms, Jaclyn B. Caccese, Scott M. Hayes, Laura C. Schmitt, James A. OñateBackground:Brain activity during knee movements is altered throughout the sensorimotor network after anterior cruciate ligament reconstruction (ACLR). Patients at 2 to 5 years after surgery appear to require greater neural activity to perform basic knee movement patterns, but it is unclear if brain activity differences within sensorimotor regions are present early after surgery. It is also unknown
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Knee Ligament Moment Arms Scale with Epicondylar Width and might Contribute to Ligament Injuries in Females. Med. Sci. Sports Exercise (IF 4.1) Pub Date : 2025-02-05
Nynke B Rooks,Marco T Y Schneider,Thor F BesierINTRODUCTION Females are prone to knee ligament injuries compared to males. Moment arms describe the mechanical advantage of ligaments to stabilise the knee from injurious moments. Compared to males of the same stature, females have a smaller femoral epicondylar width, which we hypothesised would reduce their knee joint ligament moment arms in the frontal plane. METHODS To calculate varus-valgus ligament
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Superset Versus Traditional Resistance Training Prescriptions: A Systematic Review and Meta-analysis Exploring Acute and Chronic Effects on Mechanical, Metabolic, and Perceptual Variables Sports Med. (IF 9.3) Pub Date : 2025-02-04
Xing Zhang, Jonathon Weakley, Hansen Li, Zhaoqian Li, Amador García-RamosBackground Supersets are a time-efficient resistance training (RT) method that involve the sequencing of two exercises with little or no rest between them. However, despite their common implementation during RT, a comprehensive and quantitative review is still lacking. Objectives The primary aim of this systematic review and meta-analysis was to compare the acute and chronic effects of superset and
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'The right advice': a qualitative study examining enablers and barriers to recreational running and beliefs about knee health following knee surgery. Br. J. Sports Med. (IF 11.6) Pub Date : 2025-02-04
James L N Alexander,Allison M Ezzat,Adam G Culvenor,Danilo De Oliveira Silva,Melissa Haberfield,Jean-François Esculier,Christian J BartonOBJECTIVES To examine the experiences, knowledge and beliefs of recreational runners with a history of knee surgery regarding (i) enablers and barriers to running participation, (ii) the association of running and knee joint health, and (iii) perceived benefits and motivations for running. METHODS 17 runners (≥3 times/week, ≥10 km/week) with a history of knee surgery (7±7 years post-surgery, 9 women
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It is time to improve our research design, reporting and interpretation of sex and gender in exercise science and sports medicine research. Br. J. Sports Med. (IF 11.6) Pub Date : 2025-02-04
Amanda D Hagstrom,Joanne L Parsons,Sophia Nimphius,Matthew J Jordan,Stephanie E Coen,Robyn Norton -
Skeletal Muscle Mitochondrial and Autophagic Dysregulation Are Modifiable in Spinal Muscular Atrophy J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-02-04
Andrew I. Mikhail, Sean Y. Ng, Donald Xhuti, Magda A. Lesinski, Jennifer Chhor, Marc‐Olivier Deguise, Yves De Repentigny, Joshua P. Nederveen, Rashmi Kothary, Mark A. Tarnopolsky, Vladimir LjubicicBackgroundSpinal muscular atrophy (SMA) is a health‐ and life‐limiting neuromuscular disorder. Although varying degrees of mitochondrial abnormalities have been documented in SMA skeletal muscle, the influence of disease progression on pathways that govern organelle turnover and dynamics are poorly understood. Thus, the purpose of this study was to investigate skeletal muscle mitochondria during SMA
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Nicotinamide Phosphoribosyltransferase Acetylation Mediating Muscle Dysfunction Contributes to Sleep Apnoea in Obesity J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-02-04
Liu Zhang, Ya Ru Yan, Shi Qi Li, Ying Ni Lin, Yi Wang, Yu Qing Wang, Ning Li, Fang Ying Lu, Xian Wen Sun, Li Yue Zhang, Jian Ping Zhou, Yong Jie Ding, Qing Yun LiBackgroundObstructive sleep apnoea (OSA) occurs frequently among individuals with obesity, which is attributed to upper airway muscle dysfunction. Muscle function is regulated by the dynamic balance of the nicotinamide adenine dinucleotide (NAD+) and its reduced form (NADH), which is controlled by the enzyme nicotinamide phosphoribosyltransferase (NAMPT). Elevated NAMPT levels have been found in individuals
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Melatonin Ameliorates Age‐Related Sarcopenia via the Gut–Muscle Axis Mediated by Serum Lipopolysaccharide and Metabolites J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-02-04
Ling‐Shan Zhou, Yuan Yang, Li Mou, Xin Xia, Min Liu, Ling‐Jie Xu, Rong Liu, Jun‐Ping Liu, Hai‐Yan Zhang, Xiao‐Jun Ao, Chang‐Jiang Liu, Qian Xiao, Shi‐Xiong LiuBackgroundSarcopenia affects the quality of life and increases adverse outcomes in the elderly. However, as a potential safe and effective remedy to many age‐related disorders, little is known about the protective effect of melatonin against sarcopenia, especially the underlying mechanisms of pathophysiology related to the gut–muscle axis.MethodsThe young (4 months) and old‐aged (24 months) wild‐type
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Indications for Lateral Extra-articular Tenodesis in Anterior Cruciate Ligament Reconstruction: A Systematic Review Am. J. Sports Med. (IF 4.2) Pub Date : 2025-02-04
Jan Zabrzyński, Adam Kwapisz, Jakub Erdmann, Maria Zabrzyńska, Michał Błachowski, Jakub Ohla, Michalina Adamczyk, Maciej Sokołowski, Bartosz Majchrzak, Gazi HuriBackground:The anterior cruciate ligament (ACL) is a major sagittal plane stabilizer of the knee joint. Even if anterior laxity can be brought under control by utilizing modern surgical techniques, internal rotational instability may not always be controlled adequately. Various surgical techniques are used to prevent this coronal or rotational instability, such as lateral extra-articular tenodesis
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Knee Stability in Remnant-Preserving ACL Reconstruction: Response Am. J. Sports Med. (IF 4.2) Pub Date : 2025-02-04
Melissa L. Carpenter, Jorge Chahla -
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Knee Stability in Remnant-Preserving ACL Reconstruction: Letter to the Editor Am. J. Sports Med. (IF 4.2) Pub Date : 2025-02-04
Ruijia Wang, Lingxiao Chen -
A Prospective, Randomized Trial of the Modified Jobe Versus Docking Techniques With Gracilis Autograft for Ulnar Collateral Ligament Reconstruction in the Elbow Am. J. Sports Med. (IF 4.2) Pub Date : 2025-02-04
Michael C. Ciccotti, Austin M. Looney, Emma E. Johnson, Christopher J. Hadley, Adam Zoga, Levon Nazarian, Michael G. CiccottiBackground:Ulnar collateral ligament (UCL)reconstruction (UCLR) has transformed UCL injury from career-ending to career-interruptive. The most common surgical techniques are the modified Jobe and docking techniques.Purpose/Hypothesis:The purpose of this study was to perform a prospective, randomized comparison of the modified Jobe versus docking techniques in overhead athletes with respect to patient-reported
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Rapid Quantitative Assessment of Muscle Sodium Dynamics After Exercise Using 23Na‐MRI in Dysferlinopathy and Healthy Controls J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-02-03
Mary A. Neal, Carla F. Bolano‐Diaz, Mark Richardson, Jassi Michell‐Sodhi, Robert Muni‐Lofra, Meredith K. James, Kieren G. Hollingsworth, Heather Hilsden, Ian Wilson, Andrew M. Blamire, Volker Straub, Peter E. Thelwall, Jordi Diaz‐ManeraBackgroundDysferlin plays a key role in cell membrane repair; its absence or malfunction in patients with dysferlin‐deficient limb girdle muscular dystrophy leads to muscle fibre death. Muscle magnetic resonance (MR) imaging allows non‐invasive and repeatable measurements that can report on pathological changes observed in dysferlinopathy patients (DP). We aimed to demonstrate the feasibility of utilising
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The Effect of Exercise on Spexin and Follistatin in Elderly Individuals J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-02-03
Elif Yıldırım Ayaz, Berna Dincer, Gülser Cinbaz, Esra Karacan, Reyhan Kaygusuz Benli, Emel Mete, Hilal Bilgiç, Banu MesciBackgroundIn adipose tissue–muscle crosstalk mechanisms, the interaction of adipokines and myokines is known to be critical for maintaining the body's metabolic balance in age‐related metabolic disorders. The aim of the study investigate the effects of 12 weeks of aerobic and resistance exercise training on spexin and follistatin and their relationship with each other.MethodsThis study was a multicentre
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Prevalence and Prognostic Significance of Sarcopenia in Gynecologic Oncology: A Systematic Review and Meta‐Analysis J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-02-03
Chen Jiang, Qin Chen, Danping Yu, Qianqian Zhou, Cong Tang, Chenping QiaoBackgroundSarcopenia in gynaecologic oncology patients has garnered increasing attention, but its prevalence has not been comprehensively summarized. This study aims to integrate the prevalence of sarcopenia in this population through systematic evaluation and meta‐analysis, providing a reference for future clinical research.MethodsA computerized search of PubMed, Embase, The Cochrane Library, Web
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Fat‐Free Mass: Friend or Foe to Metabolic Health? J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-02-03
Christopher J. Oliver, Mike Climstein, Nedeljka Rosic, Anja Bosy‐Westphal, Grant Tinsley, Stephen MyersBackgroundFat mass (FM) and fat‐free mass (FFM) are body composition estimates commonly reported in research studies and clinical settings. Recently, fat‐free mass indexed to height (fat‐free mass index; FFMI) has been shown to be positively associated with impaired insulin sensitivity or insulin resistance. Consequently, hypertrophic resistance training which can increase FFM was also questioned.
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Genome Wide Association Study on Muscle Stiffness Identified Novel Locus for Predisposition to Muscle Strain Injury. Med. Sci. Sports Exercise (IF 4.1) Pub Date : 2025-02-03
Eri Miyamoto-Mikami,Hirofumi Zempo,Hiroshi Kumagai,Kosuke Hirata,Mizuki Takaragawa,Toshinori Yoshihara,Mizuho Fuku,Naoki Kikuchi,Nobuhiro Kamiya,Naokazu Miyamoto,Noriyuki FukuPURPOSE We aimed to screen the entire genome for genetic variants associated with passive muscle stiffness, which has been suggested as a risk factor for muscle strain injury. METHODS This genome-wide association study (GWAS) on passive muscle stiffness included 350 physically active young Japanese individuals. Three hamstring constituents were measured using ultrasound shear wave elastography. Skeletal
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The Accumulation of Performance Fatigue and Perceptual Responses across Consecutive High-Intensity Interval and Constant-Load Cycling Sessions. Med. Sci. Sports Exercise (IF 4.1) Pub Date : 2025-02-03
Jenny Zhang,Keenan B MacDougall,Zachary J McClean,Brian R MacIntosh,Martin J MacInnis,Saied Jalal AboodardaINTRODUCTION In numerous sport and occupational settings, individuals often need to perform multiple exercise sessions in one day or across consecutive days, yet performance and perceptual responses to such exercise paradigms are unclear. PURPOSE: This study investigated performance fatigue and perceptual responses to repeated, consecutive sessions of high-intensity interval (HIIT) and constant-work
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Joint Associations of Moderate-to-Vigorous Physical Activity and Sedentary Time with Adiposity and Cardiometabolic Risk Factors in Adolescents. Med. Sci. Sports Exercise (IF 4.1) Pub Date : 2025-02-03
Mónica Suárez-Reyes,Robbie A Beyl,Peter T Katzmarzyk,Amanda E StaianoPURPOSE This study aims to explore the joint associations of moderate-to-vigorous physical activity (MVPA) and sedentary time (ST) with adiposity and cardiometabolic risk factors in adolescents. METHODS A cross-sectional study was conducted on 309 participants (10-16 years old). Measurements included accelerometer-measured MVPA and ST, anthropometrics, body composition, and cardiometabolic risk factors
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Graded Walking Energetics under Cold Strain. Med. Sci. Sports Exercise (IF 4.1) Pub Date : 2025-02-03
David P Looney,Erica A Schafer,Christopher L Chapman,J Luke Pryor,Brandon M Roberts,Jesse A Stein,Karl E Friedl,Adam W PotterINTRODUCTION Although research supports selecting steeper routes to minimize metabolic rate (Ṁ) in mountain racers, the "steeper is cheaper" strategy has yet to be confirmed for slower, more typical graded walking speeds under cold stress. PURPOSE Confirm whether "steeper is cheaper" is true for typical graded walking speeds in individuals exposed to incremental cold stress. METHODS Fourteen healthy
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Ice Slurry Mitigates Hyperventilation and Cerebral Hypoperfusion, and May Enhance Endurance Performance in the Heat. Med. Sci. Sports Exercise (IF 4.1) Pub Date : 2025-02-03
Akira Katagiri,Syuntaro Kawai,Takeshi Nishiyasu,Naoto FujiiPURPOSE Hyperthermia causes hyperventilation and associated cerebral hypoperfusion, both of which may limit endurance performance in the heat. Here, we investigated the hypothesis that pre-exercise ice slurry ingestion may mitigate hyperventilation and cerebral hypoperfusion during exercise in the heat, enhancing endurance performance. METHODS 12 healthy men ingested 7.5 g/kg body weight of ice slurry