Multi-photon three-dimensional (3D) nanoprinting technology, renowned for its 3D processing capability and nanoscale resolution beyond the diffraction limit, has garnered significant attention in the micro/nano-additive manufacturing field. This technology finds widespread applications in optics, biology, and mechanical engineering research. However, its broader adoption in industrial production and

This paper proposes that China, under the challenge of balancing its development and security, can aim for the Paris Agreement’s goal to limit global warming to no more than 2 °C by actively seeking carbon-peak and carbon-neutrality pathways that align with China’s national conditions, rather than following the idealized path toward the 1.5 °C target by initially relying on extensive negative-emission

This paper presents a novel self-sensing steel fiber-reinforced polymer composite bar (SFCB). The SFCB combines damage control, self-sensing, and structural reinforcement functions using distributed fiber optic sensing (DFOS) technology. By combining DFOS strains with theoretical and numerical models, a multilevel performance method for damage assessment is proposed from the perspectives of safety

With the development of offshore oil and gas resources, hydrates pose a significant challenge to flow assurance. Hydrates can form, accumulate, and settle in pipelines, causing blockages, reducing transport capacity, and leading to significant economic losses and fatalities. As oil and gas exploration moves deeper into the ocean, the issue of hydrate blockages has become more severe. It is essential

Meta-devices have significantly revitalized the study of nonlinear optical phenomena. At the nanoscale, the detrimental effects of phase mismatching between fundamental and harmonic waves can be substantially reduced. This review analyzes the theoretical frameworks of how plasmonic and dielectric materials induce nonlinear optical properties. Plasmonic and dielectric nonlinear meta-devices that can

Constipation is a prevalent gastrointestinal disorder affecting approximately 10% of the global population, significantly impacting patients’ physical and psychological health. Recent research underscores the close relationship between gut microbiota and constipation occurrence. However, consensus on the characteristic microbiota and metabolites associated with constipation remains elusive. To address

Airborne hyperspectral imaging spectrometers have been used for Earth observation over the past four decades. Despite the high sensitivity of push-broom hyperspectral imagers, they experience limited swath and wavelength coverage. In this study, we report the development of a push-broom airborne multimodular imaging spectrometer (AMMIS) that spans ultraviolet (UV), visible near-infrared (VNIR), shortwave

The prevalence of cardiovascular diseases (CVDs) has increased markedly as the world population has aged. Long non-coding RNAs (lncRNAs) have been reported as novel regulators in diverse pathophysiological conditions. Here, we performed RNA sequencing (RNA-seq) and observed that the lncRNA Zeb1os1 (zinc finger E-box binding homeobox 1, opposite strand 1), which is known as ZEB1-AS1 (zinc finger E-box

A sustainable solution to the dramatic spread of antibiotic resistance threatening public health security is the development of antibiotic-free antimicrobial substances. Inspired by natural host defense mechanisms involving amino-terminal copper–nickel binding motif (ATCUN) antimicrobial peptides (AMPs), we have designed and prepared an artificial complex (Cu@G-AMPs) incorporating single-atom Cu catalysts

Vision-based digital shadowing is a highly efficient way to monitor the health of buildings in use. However, previous studies on digital shadowing have been limited to laboratory experiments. This paper proposes a novel computer-vision-based digital shadow workflow and presents its successful application in a real engineering case. In this case, a 345.8-m supertall building experienced unexpected shaking

While spin–orbit interaction has been extensively studied, few investigations have reported on the interaction between orbital angular momenta (OAMs). In this work, we study a new type of orbit–orbit coupling between the longitudinal OAM and the transverse OAM carried by a three-dimensional (3D) spatiotemporal optical vortex (STOV) in the process of tight focusing. The 3D STOV possesses orthogonal

Bone frequently serves as a metastatic site for breast and prostate cancers. Given the potential of low-intensity vibration (LIV) to increase bone health and reduce cancer risk, this study investigated the impact of LIV on cancer cells, as well as noncancer cells such as lymphocytes and peripheral blood mononuclear cells (PBMCs). The results revealed that LIV exposure not only suppressed cancer cell

The development of high-performance optically transparent radio frequency (RF) radiators is limited by the intrinsic loss issue of transparent conductive films (TCFs). Instead of pursuing expensive endeavors to improve the TCFs’ electrical properties, this study introduces an innovative approach that leverages leaky-wave mode manipulation to mitigate the TCFs’ attenuating effect and maximize the RF

Despite recent advances in understanding the biology of aging, the field remains fragmented due to the lack of a central organizing hypothesis. Although there are ongoing debates on whether the aging process is programmed or stochastic, it is now evident that neither perspective alone can fully explain the complexity of aging. Here, we propose the pro-aging metabolic reprogramming (PAMRP) theory, which

The trajectory of human history is characterized by a persistent battle against disease. Over time, the field of medicine has transitioned from enigmatic witch doctors and herbal remedies to a sophisticated realm of contemporary medicine that includes fundamental medical and health sciences, clinical medicine, and public health. Nevertheless, the present phase of medical advancement encounters significant

The manipulation of nanometric objects, encompassing both non-biological and biological objects, offers a transformative avenue for breakthroughs in diverse fields, such as chemistry, biology, chemical and biomedical engineering, materials and mechanical engineering, and various industrial applications. However, achieving accuracy, precision, and high throughput in the manipulation of nanometric objects

Acinetobacter baumannii (A. baumannii) is well known for its virulence and persistence, particularly in intensive care units. Therefore, new strategies and candidates to treat A. baumannii infection are urgently needed considering the emergence of drug-resistant bacteria. Polyphosphate kinase 1 (PPK1) is required for bacterial survival as it is involved in maintaining antibiotic resistance or tolerance

Construction engineering and management (CEM) has become increasingly complicated with the increasing size of engineering projects under different construction environments, motivating the digital transformation of CEM. To contribute to a better understanding of the state of the art of smart techniques for engineering projects, this paper provides a comprehensive review of multi-criteria decision-making

Obstacle detection and platoon control for mixed traffic flows, comprising human-driven vehicles (HDVs) and connected and autonomous vehicles (CAVs), face challenges from uncertain disturbances, such as sensor faults, inaccurate driver operations, and mismatched model errors. Furthermore, misleading sensing information or malicious attacks in vehicular wireless networks can jeopardize CAVs’ perception

Intestinal stem cells (ISCs) initiate intestinal epithelial regeneration and tumorigenesis, and they experience rapid refilling upon various injuries for epithelial repair as well as tumor reoccurrence. It is crucial to reveal the mechanism underlying such plasticity for intestinal health. Recent studies have found that metabolic pathways control stem cell fate in homeostasis, but the role of metabolism

Microproteomics, the profiling of protein expressions in small cell populations or individual cells, is essential for understanding complex biological systems. However, sample loss and insufficient sensitivity of analytical techniques pose severe challenges to this field. Microfluidics, particularly droplet-based microfluidics, provides an ideal approach by enabling miniaturized and integrated workflows

Pulmonary fibrosis (PF) is a lethal lung disease that predominantly affects older adults; however, whether and how aging triggers fibrosis remains unclear. To pinpoint the predominant initiating factors of PF, we first analyzed single-cell RNA sequencing (scRNA-seq) data from the lung tissues of 45 normal donors and 51 PF patients and found that aging might serve as the primary catalyst for PF development

As the global demographic shifts toward an aging population, understanding the efficiency of protein utilization in older adults becomes crucial. Our study explores the intricate relationship between protein intake and aging, with a focus on precision nutrition for older people. Through a meta-analysis, we confirm a decline in protein-utilization capacity in older individuals and examine the different

Skin aging is an increasingly prominent topic in the context of healthy aging. During the aging process, the skin’s barrier function diminishes, its water content decreases, wrinkles begin to form, and changes occur in the gut microbiota composition. However, the relationship between gut microbiota and skin aging remains unclear. In this study, we explored skin rejuvenation in aged mice through fecal

Facing the challenges of in-situ utilization of lunar regolith resources, applying an external electric field to manipulate lunar particles has become a promising method for space particle control, which mainly depends on the particle charging properties in the applied electric field. Using the surficial lunar regolith samples brought back from the Moon by the Chang’e-5 mission (CE5 LS), this work

Marine corrosion and biofouling are challenges that affect marine industrial equipment, and protecting equipment with functional coatings is a simple and effective approach. However, it is extremely difficult to combine anti-corrosion and anti-fouling properties in a single coating. In this work, we combine reduced graphene oxide (rGO)/silver nanoparticles (AgNPs) with a hydrophilic polymer in a bio-based

The rail transit in sulfate-rich areas faces the combined effects of stray current and salt corrosion; however, the sulfate ion transport and concrete degradation mechanisms under such conditions are still unclear. To address this issue, novel sulfate transport and mesoscale splitting tests were designed, with a focus on considering the differences between the interfacial transition zone (ITZ) and

Given its excellent biological properties and the matching of its elastic modulus with that of human bone tissue, medical polyetheretherketone (PEEK) is considered a desirable candidate for bone-implant materials. However, its poor osseointegrative and antibacterial properties greatly limit its clinical application. To address these concerns, a functional PEEK implant is needed. Herein, a novel photo-responsive

Transport channels with ultrahigh K+ selectivity over other ions play a crucial role for living beings, but constructing ionic channels with promising K+ selectivity and permeability remains a challenge. Here, an asymmetric bilayer membrane based on MXene (Ti3C2Tx) lamellar channels consisting of a recognition layer (RL) on top of an enhancement layer (EL) exhibits an amazing Matthew effect: amplification

Sugar aminotransferases (SATs) catalyze the installation of chiral amines onto specific keto sugars, producing bioactive amino sugars. Their activity has been utilized in artificial reactions, such as using the SAT WecE to transform valienone into the valuable α-glucosidase inhibitor valienamine. However, the low thermostability and limited activity on non-natural substrates have hindered their applications

Petroleum has played a vital role as the major supplier of materials and energy during the evolution of human civilization. Given the change in demand for energy from high to low carbon and ultimately net zero carbon, the energy framework has undergone revolutionary changes. The energy attribute of petroleum will be gradually weakened, while the material and CO2 emission attributes will be gradually

The steel industry is considered an important basic sector of the national economy, and its high energy consumption and carbon emissions make it a major contributor to climate change, especially in China. The majority of crude steel in China is produced via the energy- and carbon-intensive blast furnace–basic oxygen furnace (BF–BOF) route, which greatly relies on coking coal. In recent years, China’s

This article reviews the anti-penetration principles and strengthening mechanisms of metal materials, ranging from macroscopic failure modes to microscopic structural characteristics, and further summarizes the micro–macro correlation in the anti-penetration process. Finally, it outlines the constitutive models and numerical simulation studies utilized in the field of impact and penetration. From the

Computational spectrometers utilizing disordered structures have emerged as promising solutions for meeting the imperative demand for integrated spectrometers, offering high performance and improved resilience to fabrication variations and temperature fluctuations. However, the current computational spectrometers are impractical because they rely on a brute-force random design approach for disordered

The inconsistent findings concerning the effects of vitamin D supplementation on cardiometabolic risk factors and the large heterogeneity in the published literature call for further research to identify sources of heterogeneity and potential effect modifiers. We performed a meta-analysis of randomized controlled trials (RCTs) published until March 2024 that reported estimates for the effects of vitamin

The 2280 km long Jinsha River has been blocked at least four times in the past 30 years. A landslide damming hazard chain can endanger communities and infrastructures hundreds of kilometers downstream from the damming site in alpine gorges. Past damming events have resulted in severe consequences, demanding a thorough assessment of damming threats along the entire Jinsha River. This study digitizes

Sanhan Huashi formula (SHHS), a traditional Chinese medicine (TCM), has shown significant therapeutic effects on coronavirus disease 2019 (COVID-19) in clinical settings. However, its specific mechanism and components still require further clarification. experiments with Vero-E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) demonstrated that SHHS effectively inhibited

To equip data-driven dynamic chemical process models with strong interpretability, we develop a light attention–convolution–gate recurrent unit (LACG) architecture with three sub-modules—a basic module, a brand-new light attention module, and a residue module—that are specially designed to learn the general dynamic behavior, transient disturbances, and other input factors of chemical processes, respectively

The real-time screening of biomolecules and single cells in biochips is extremely important for disease prediction and diagnosis, cellular analysis, and life science research. Barcode biochip technology, which is integrated with microfluidics, typically comprises barcode array, sample loading, and reaction unit array chips. Here, we present a review of microfluidics barcode biochip analytical approaches

Pesticide ecological safety continues to be a hot issue. The inherent biosafety and physiological functions of vanillin, a widely used natural flavor in food additives, have unlocked numerous applications in the medical field, leading to a plethora of pharmaceutically active derivatives and commercial drugs. Despite its extensive use in pharmaceutical discovery and the food industry, vanillin’s potential