Given its excellent biological properties and the matching of its elastic modulus with that of human bone tissue, medical polyetheretherketone (PEEK) is considered a desirable candidate for bone-implant materials. However, its poor osseointegrative and antibacterial properties greatly limit its clinical application. To address these concerns, a functional PEEK implant is needed. Herein, a novel photo-responsive multifunctional PEEK-based implant material (sPEEK/BP/E7) with both effective osteogenesis and good disinfection properties was constructed via the self-assembly of black phosphorus (BP) nanosheets, mussel-inspired polydopamine (PDA), and bioactive short peptide E7 on sulfonated PEEK (sPEEK). The versatile micro-/nano-structured PEEK surface provides superior hydrophilicity, a favorable osteogenic microenvironment, and excellent photothermal effects under near-infrared (NIR) irradiation. The in vitro results showed that sPEEK/BP/E7 displays enhanced cytocompatibility and osteogenicity in terms of cell adhesion, proliferation, alkaline phosphatase (ALP) activity, matrix mineralization, and osteogenesis-related gene expression, superior to those of the sPEEK and sPEEK/BP samples. In addition to osteogenesis, the multifunctional coating exhibited strong antibacterial activity against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Furthermore, it was confirmed in a rat femoral infection model that sPEEK/BP/E7 effectively resisted infection caused by S. aureus under NIR light irradiation and promoted osseointegration in vivo. Thus, this work presents a facile strategy to realize improvement of the “functional integration” of new polymer bone-implant materials and provide new ideas for their clinical application.

中文翻译：

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黑磷和 E7 官能化的磺化聚醚醚酮，具有有效的成骨性和抗菌活性


鉴于其优异的生物学特性及其弹性模量与人体骨组织的弹性模量相匹配，医用聚醚醚酮 （PEEK） 被认为是骨植入物材料的理想候选者。然而，其较差的骨整合和抗菌性能极大地限制了其临床应用。为了解决这些问题，需要功能性 PEEK 植入物。在此，通过黑磷 （BP） 纳米片、贻贝启发多巴胺 （PDA） 和磺化 PEEK 上的生物活性短肽 E7 （sPEEK） 的自组装，构建了一种新型光响应多功能基于 PEEK 的植入材料 （sPEEK/BP/E7），具有有效的成骨和良好的消毒性能。多功能的微/纳米结构 PEEK 表面在近红外 （NIR） 照射下提供卓越的亲水性、有利的成骨微环境和出色的光热效应。体外结果表明，sPEEK/BP/E7 在细胞粘附、增殖、碱性磷酸酶 （ALP） 活性、基质矿化和成骨相关基因表达方面表现出增强的细胞相容性和成骨性，优于 sPEEK 和 sPEEK/BP 样本。除了成骨外，多功能涂层对金黄色葡萄球菌 （S. aureus） 和大肠杆菌 （E. coli） 均表现出很强的抗菌活性。此外，在大鼠股骨感染模型中证实，sPEEK/BP/E7 在 NIR 光照射下有效抵抗金黄色葡萄球菌引起的感染，并促进体内骨结合。因此，这项工作提出了一种简单的策略，以实现新型聚合物骨植入物材料的“功能整合”的改进，并为其临床应用提供新思路。