The manipulation of nanometric objects, encompassing both non-biological and biological objects, offers a transformative avenue for breakthroughs in diverse fields, such as chemistry, biology, chemical and biomedical engineering, materials and mechanical engineering, and various industrial applications. However, achieving accuracy, precision, and high throughput in the manipulation of nanometric objects, whether on the scale of a single nanometric entity or molecule, is a formidable challenge because of the extremely small dimensions involved. Nanofluidics has already demonstrated unique capabilities for transporting the mass of ions and small molecules at the nanoscale. We posit that chip-based nanofluidic devices provide potent strategies for the precise, accurate, and high-throughput manipulation of single nanometric entities and molecules, benefiting from their dimensions, which are comparable to those of nanometric objects. This article offers an overview of the current progress in nanofluidic manipulation of single nanometric objects. It also discusses the challenges in the development of nanofluidic manipulation technologies. Furthermore, the article explores future opportunities in the field, highlighting possible solutions to the challenges, and aims to contribute to the ongoing discourse on nanofluidic manipulation, thus propelling the field to overcome its current limitations.

中文翻译：

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单纳米物体的纳米流体调控：当前进展、挑战和未来机遇


对纳米物体（包括非生物和生物物体）的操纵为化学、生物学、化学和生物医学工程、材料和机械工程以及各种工业应用等不同领域的突破提供了一条变革性的途径。然而，由于涉及的尺寸极小，在操纵纳米物体时实现准确性、精密度和高通量，无论是在单个纳米实体还是分子的尺度上，都是一项艰巨的挑战。纳米流体已经展示了在纳米尺度上传输离子和小分子质量的独特能力。我们假设基于芯片的纳米流体器件为精确、准确和高通量操纵单个纳米实体和分子提供了有效的策略，受益于它们的尺寸，可与纳米物体相媲美。本文概述了单个纳米物体的纳米流体操作的当前进展。它还讨论了纳米流体操纵技术开发中的挑战。此外，本文探讨了该领域的未来机遇，强调了应对挑战的可能解决方案，旨在为正在进行的纳米流体操纵讨论做出贡献，从而推动该领域克服其当前的局限性。