Despite recent advances in understanding the biology of aging, the field remains fragmented due to the lack of a central organizing hypothesis. Although there are ongoing debates on whether the aging process is programmed or stochastic, it is now evident that neither perspective alone can fully explain the complexity of aging. Here, we propose the pro-aging metabolic reprogramming (PAMRP) theory, which integrates and unifies the genetic-program and stochastic hypotheses. This theory posits that aging is driven by degenerative metabolic reprogramming (MRP) over time, requiring the emergence of pro-aging substrates and triggers (PASs and PATs) to predispose cells to cellular and genetic reprogramming (CRP and GRP).

中文翻译：

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促衰老代谢重编程：衰老的统一理论


尽管最近在理解衰老生物学方面取得了进展，但由于缺乏中心组织假设，该领域仍然分散。尽管关于衰老过程是程序化的还是随机的争论一直在进行，但现在很明显，这两种观点都无法单独完全解释衰老的复杂性。在这里，我们提出了促衰老代谢重编程 （PAMRP） 理论，该理论整合并统一了遗传程序和随机假设。该理论假设衰老是由随着时间的推移而退行性代谢重编程 （MRP） 驱动的，需要出现促衰老底物和触发因素（PAS 和 PAT）以使细胞易患细胞和遗传重编程（CRP 和 GRP）。