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Reshaping the gut microbiota: A novel oppinion of Eucommiae cortex polysaccharide alleviate learning and memory impairments in Alzheimer’s disease J. Adv. Res. (IF 11.4) Pub Date : 2025-04-17
Yongkang Zhao, Wenxing Zhao, Xuejun Chai, Penghao Sun, Junlang Huang, Xinrui Guo, Lulu Zhang, Duoduo Ren, Chenju Yi, Xiaoyan Zhu, Shanting Zhao -
Medical gas plasma modifies Nrf2 signaling in diabetic wound healing J. Adv. Res. (IF 11.4) Pub Date : 2025-04-16
Anke Schmidt, Lea Miebach, Can Bagli, Liane Kantz, Steffen Emmert, Thomas von Woedtke, Sander Bekeschus -
Pulsed electromagnetic fields treatment ameliorates cardiac function after myocardial infarction in mice and pigs J. Adv. Res. (IF 11.4) Pub Date : 2025-04-16
Shiqi Wang, Gaiqin Pei, Jiayu Shen, Zhi Fang, Tingyu Chen, Lu Wang, Hongxin Cheng, Hanbin Li, Hongliang Pei, Qipu Feng, Qingwen Fan, Chengqi He, Chenying Fu, Yingqiang Guo, Quan Wei -
Gastrodin enhances stress resilience through promoting Wnt/β-Catenin-Dependent neurogenesis J. Adv. Res. (IF 11.4) Pub Date : 2025-04-13
Haili Zhang, Zhihuang Zhao, Pei Liu, Meidan Wang, Yu-e Liu, Hui He, Yangyan Ge, Tao Zhou, Chenghong Xiao, Zili You, Jinqiang Zhang -
Bacteroides thetaiotaomicron: A symbiotic ally against diarrhea along with modulation of gut microbial networks via tryptophan metabolism and AHR-Nrf2 signaling J. Adv. Res. (IF 11.4) Pub Date : 2025-04-13
Yuheng Luo, Cong Lan, Wen Ren, Aimin Wu, Bing Yu, Jun He, Daiwen Chen -
Comparative single-cell transcriptomic map reveals divergence in leaves between two cotton species at cell type resolution J. Adv. Res. (IF 11.4) Pub Date : 2025-04-12
Hailiang Cheng, Shang Liu, Youping Zhang, Dongyun Zuo, Qiaolian Wang, Limin Lv, Yi Yang, Lingyu Hao, Xue Zhang, Shuo Zhang, Guoli Song -
MRI-based radiomics to determine the role of thigh muscle quality in the development of knee osteoarthritis: A discovery and validation study J. Adv. Res. (IF 11.4) Pub Date : 2025-04-11
Qin Dang, Zixuan Hong, Dong Zeng, Peihua Cao, Shengfa Li, Han Cen, Xiaoshuai Wang, Zhaohua Zhu, Weiyu Han, Jian Wang, Liang Zhao, Ali Mobasheri, David J Hunter, Jianhua Ma, Jia Li, Changhai Ding -
Engineered 3D mesenchymal stem cell aggregates with multifunctional prowess for bone regeneration: Current status and future prospects J. Adv. Res. (IF 11.4) Pub Date : 2025-04-11
Linxue Zhang, Xiaojing Yuan, Rui Song, Zuoying Yuan, Yuming Zhao, Yunfan Zhang -
TMEM158 promotes ICC metastasis via inducing lactic acid mediated reduction of actin skeleton stiffness of ICC cells J. Adv. Res. (IF 11.4) Pub Date : 2025-04-11
Peng Chen, Jing Yang, Shengxi Jin, Yujie Li, Duguang Li, Cheng Zhong, Yiyin Zhang, Qiming Xia, Xiaoxiao Fan, Hui Lin -
Integrated deep eutectic system enrichment and AI-assisted high-throughput visual detection for Hg2+ in environmental samples J. Adv. Res. (IF 11.4) Pub Date : 2025-04-10
Yilin Peng, Kunze Du, Hengmao Yue, Hui Li, Haixiang Li, Meng Liu, Shenhao Shangguan, Xicheng He, Xiaoxia Li, Yanxu Chang -
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Inflammation-driven biomimetic nano-polyphenol drug delivery system alleviates severe acute pancreatitis by inhibiting macrophage PANoptosis and pancreatic enzymes oversecretion J. Adv. Res. (IF 11.4) Pub Date : 2025-04-08
Junyong Wu, Hai Huang, Wenjie Xu, Beibei Cui, Pengcheng Sun, XinYan Hao, Shihe Jiang, Xuyang Hou, Xiaoyan Qi, Zuxing Wei, Yimiao Cheng, Yanwen Zheng, Kuijie Liu, Jun He -
Teleost GSDMEc regulates GSDMEa-mediated pyroptosis J. Adv. Res. (IF 11.4) Pub Date : 2025-04-08
Hang Xu, Meng Wu, Yujian Wang, Yaoming Jiao, Yuan Chen, Zihao Yuan, Li sun -
ARHGEF3 coordinates adipocyte hypertrophy and differentiation through dual YAP-RhoA and PPARγ activation J. Adv. Res. (IF 11.4) Pub Date : 2025-04-09
Sana Abdul Khaliq, Shi-Young Park, Syeda Maham, Yoonil Cho, Miseon Lee, Seungyoon Nam, Je Kyung Seong, Jie Chen, Cheol Soo Choi, Mee-Sup Yoon -
Blockade of calcium-activated chloride channel ANO1 ameliorates ionizing radiation-induced intestinal injury J. Adv. Res. (IF 11.4) Pub Date : 2025-04-08
Yuying Guo, Tong Yuan, Yuna Wang, Lei Xia, Junling Zhang, Saijun Fan -
Maximum of the characteristic polynomial of i.i.d. matrices Comm. Pure Appl. Math. (IF 3.1) Pub Date : 2025-04-08
Giorgio Cipolloni, Benjamin LandonWe compute the leading order asymptotic of the maximum of the characteristic polynomial for i.i.d. matrices with real or complex entries. In particular, this result is new even for real Ginibre matrices, which was left as an open problem in Lambert et al. Electron. J. Probab. 29 (2024); the complex Ginibre case was covered in Lambert, Comm. Math Phys. 378 (2020). These are the first universality results
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When glycobiology meets inflammasome activation: Insights and implications J. Adv. Res. (IF 11.4) Pub Date : 2025-04-05
Hongliang Zhang, Tengchuan Jin, Mengzhou Xue, Songquan Wu, Chunfu Zheng -
The LoMYB26/LoJAZ4-LoCOMT module regulates anther dehiscence via Jasmonic acid-mediated endothecium lignification in lily J. Adv. Res. (IF 11.4) Pub Date : 2025-04-05
Qianqian Fang, Xue Pan, Ze Wu, Junpeng Yu, Ting Li, Sujuan Xu, Man He, Nianjun Teng -
Global, regional, and national burden of neglected tropical diseases and malaria in the general population, 1990–2021: Systematic analysis of the global burden of disease study 2021 J. Adv. Res. (IF 11.4) Pub Date : 2025-04-05
Jin-Xin Zheng, Yang Liu, Shi-Yang Guan, Zhao-Yu Guo, Lei Duan, Shan Lv, Shun-Xian Zhang, Shi-Zhu Li, Xiao-Nong Zhou, Xin-Yu Feng -
The porous medium equation: Large deviations and gradient flow with degenerate and unbounded diffusion Comm. Pure Appl. Math. (IF 3.1) Pub Date : 2025-04-05
Benjamin Gess, Daniel HeydeckerThe problem of deriving a gradient flow structure for the porous medium equation which is thermodynamic, in that it arises from the large deviations of some microscopic particle system is studied. To this end, a rescaled zero‐range process with jump rate is considered, and its hydrodynamic limit and dynamical large deviations are shown in the presence of both degenerate and unbounded diffusion. The
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Uniqueness on average of large isoperimetric sets in noncompact manifolds with nonnegative Ricci curvature Comm. Pure Appl. Math. (IF 3.1) Pub Date : 2025-04-05
Gioacchino Antonelli, Marco Pozzetta, Daniele SemolaLet be a complete Riemannian manifold which is not isometric to , has nonnegative Ricci curvature, Euclidean volume growth, and quadratic Riemann curvature decay. We prove that there exists a set with density 1 at infinity such that for every there is a unique isoperimetric set of volume in ; moreover, its boundary is strictly volume preserving stable. The latter result cannot be improved to uniqueness
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Development of a fully human glioblastoma-in-brain-spheroid model for accelerated translational research J. Adv. Res. (IF 11.4) Pub Date : 2025-04-04
Sandra Horschitz, Ammar Jabali, Sophie Heuer, Eric Zillich, Lea Zillich, Dirk C. Hoffmann, Akshaya Senthil Kumar, David Hausmann, Daniel Dominguez Azorin, Ling Hai, Wolfgang Wick, Frank Winkler, Philipp Koch -
Screening, identification and detection of the regulated and emerging mycotoxins in edible and medicinal products by integrating diversiform liquid chromatography/mass spectrometry systems and high-throughput sequencing of contaminated fungi J. Adv. Res. (IF 11.4) Pub Date : 2025-04-03
Xiao-yan Xu, Yu Wang, Lian-xing Wang, Xue Li, Meng-yao Wang, Hong-da Wang, Fei-yang Yu, Ya-dan Zou, Miao-miao Jiang, Yue-fei Wang, Wen-zhi Yang -
Senkyunolide A interrupts TRAF6-HDAC3 interaction to epigenetically suppress c-MYC and attenuate cholestatic liver injury J. Adv. Res. (IF 11.4) Pub Date : 2025-04-03
Yajing Li, Runping Liu, Jianan Li, Feng Gao, Zhi Ma, Kaihong Xie, Fanghong Li, Bing Xu, Qi Zheng, Yajie Cai, Jiaorong Qu, Xiaoyong Xue, Kexin Jia, Xiaojiaoyang Li -
Natural, safety immunomodulatory derivatives of lactobacillus biofilms promote diabetic wound healing by metabolically regulating macrophage phenotype and alleviating local inflammation J. Adv. Res. (IF 11.4) Pub Date : 2025-04-03
Qingwei Zhou, Junjie Chi, Jintao Yang, Xiaoyu Dong, Jiali Guo, Feifei Lian, Abdullah Al Mamun, Tianling Chen, Haijuan Zhang, Jiaojiao Chen, Yibing Tao, Yunmiao Ma, Keqing Shi, Jian Xiao -
Development and validation of a deep learning model based on cascade mask regional convolutional neural network to noninvasively and accurately identify human round spermatids J. Adv. Res. (IF 11.4) Pub Date : 2025-04-02
Yujiao Sun, Shihao Shao, Jiangwei Huang, Hao Shi, Liying Yan, Yongjie Lu, Ping Liu, Yuqiang Jiang, Jie Qiao, Li Zhang -
Lipidomic signatures as predictive biomarkers for early-onset lung cancer: Identification and development of a risk prediction model J. Adv. Res. (IF 11.4) Pub Date : 2025-04-01
Fei Wang, Zeming Guo, Wei Tang, Wei Cao, Xuesi Dong, Yongjie Xu, Chenran Wang, Jiaxin Xie, Xiaoyue Shi, Zilin Luo, Yadi Zheng, Guochao Zhang, Na Ren, Nan Zhang, Donghua Wei, Lingbin Du, Fengwei Tan, Ni Li -
Comprehensive insights into emerging advances in the Neurobiology of anorexia J. Adv. Res. (IF 11.4) Pub Date : 2025-04-01
Liwei Mao, Lian Wang, Zhihai Huang, Jian-Kang Chen, Lorelei Tucker, Quanguang Zhang -
Loss of life expectancy attributed to long-term ozone exposure in Chinese older adults: Cross-cohort analysis from 3 national cohorts J. Adv. Res. (IF 11.4) Pub Date : 2025-03-30
Minjin Peng, Yang Yuan, Haitong Zhe Sun, Jing Wu, Lifeng Zhu, Yi Zeng, Yunquan Zhang, Yao Yao -
Thousands-years-old deep-sea DNA viruses reveal the evolution of human pathogenic viruses J. Adv. Res. (IF 11.4) Pub Date : 2025-03-31
Tianliang He, Xinyi Zhang, Xiaobo Zhang -
Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production J. Adv. Res. (IF 11.4) Pub Date : 2025-03-31
Xiangyun Li, Zixuan Xiang, Xiaoli Wang, Haodong He, Miao Xu, Cheng Tan, Xiaohan Wu, Jixiang Zhang, Weiguo Dong -
Multifunctional nanoplatform for tumor chemodynamic and self-amplified photodynamic cascade therapy J. Adv. Res. (IF 11.4) Pub Date : 2025-03-31
Xingyu Luo, Haifeng Qi, Manqi Yan, Tong Xu, Ting Wu, Yin Ding, Wei Han -
Exploiting metabolic vulnerabilities through synergistic ferroptosis and disulfidptosis for breast cancer therapy J. Adv. Res. (IF 11.4) Pub Date : 2025-03-29
Yu Liang, Haibo Lan, Qiuyu Li, Mengdan Gao, Minyi Liu, Ziting Xu, Yang Gao, Li Zhang, Yingjia Li, Bingxia Zhao -
Online and personalised control of the Depth of hypnosis during induction using fractional order PID J. Adv. Res. (IF 11.4) Pub Date : 2025-03-29
Marcian Mihai, Isabela Birs, Erwin Hegedus, Amani Ynineb, Dana Copot, Robain De Keyser, Clara M. Ionescu, Samir Ladaci, Cristina I. Muresan, Martine Neckebroek -
The Application of artificial intelligence in periprosthetic joint infection J. Adv. Res. (IF 11.4) Pub Date : 2025-03-28
Pengcheng Li, Yan Wang, Runkai Zhao, Lin Hao, Wei Chai, Chen Jiying, Zeyu Feng, Quanbo Ji, Guoqiang Zhang -
Prediction of influenza virus infection based on deep learning and peripheral blood proteomics: A diagnostic study J. Adv. Res. (IF 11.4) Pub Date : 2025-03-28
Yumei Zhou, Pengbo Wang, Haiyun Zhang, Taihao Wang, Shuai Han, Xin Ma, Shuang Liang, Minghua Bai, Pengbei Fan, Lei Wang, Ji Wang, Qi Wang -
Corrigendum to “Hsa_circ_0001402 alleviates vascular neointimal hyperplasia through a miR-183-5p-dependent regulation of vascular smooth muscle cell proliferation, migration, and autophagy” [Journal of Advanced Research, Volume 60, June (2024) Pages 93–110] J. Adv. Res. (IF 11.4) Pub Date : 2025-03-25
Jia-Jie Lin, Rui Chen, Li-Yun Yang, Miao Gong, Mei-Yang Du, Shi-Qing Mu, Ze-An Jiang, Huan-Huan Li, Yang Yang, Xing-Hui Wang, Si-Fan Wang, Ke-Xin Liu, Shan-Hu Cao, Zhao-Yi Wang, An-Qi Zhao, Shu-Yan Yang, Cheng Li, Shao-Guang SunThe authors regret the oversight in Figs. 6 and S6. While subsequently organizing the experimental data for this article, they unexpectedly found that some images in these two figures were presented incorrectly.
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Sex-specific proteomic signatures improve cardiovascular risk prediction for the general population without cardiovascular disease or diabetes J. Adv. Res. (IF 11.4) Pub Date : 2025-03-26
Ruijie Xie, Tomislav Vlaski, Sha Sha, Hermann Brenner, Ben Schöttker -
Fasting influences the muscle quality of fish during transportation by regulating the balance between energy metabolism and ammonia nitrogen stress J. Adv. Res. (IF 11.4) Pub Date : 2025-03-26
Ling Peng, Juan You, Ru Liu, Yong Long, Guili Song, Soottawat Benjakul, Shanbai Xiong, Ziaur Rahman, Qiling Huang, Sheng Chen, Tao Yin -
Carbon dot superoxide dismutase nanozyme enhances reactive oxygen species scavenging in diabetic skin wound repair J. Adv. Res. (IF 11.4) Pub Date : 2025-03-26
Zhu Yan, Yufei Zhang, Qin Chen, Jing Li, Xiaoying Ning, Fan Bai, Yaqi Wang, Xiaoming Liu, Yale Liu, Mingzhen Zhang, Cui Liu, Yumin Xia -
Chromosome-level genome provides novel insights into the starch metabolism regulation and evolutionary history of Tetraselmis helgolandica J. Adv. Res. (IF 11.4) Pub Date : 2025-03-25
Zuodong Zhou, Jiawei E, Qianwen Shi, Wenjun Zhang, Liyun Sun, Jianhua Fan -
Prognostic value of tryptophan catabolism-base scores in acute myocardial infarction patients J. Adv. Res. (IF 11.4) Pub Date : 2025-03-25
Ye Wang, Pengyan Wu, Zhanchao Chen, Zhaoying Li, Yini Wang, Miao Yan, Yiying Zhang, Shanjie Wang, Shaohong Fang, Bo Yu -
Plant extracellular vesicles as emerging neuroprotective agents for central nervous system disorders J. Adv. Res. (IF 11.4) Pub Date : 2025-03-24
Yuanyuan Yu, Zhifeng Xu, Le Xu, Dan Lu, Yamei Tang, Hongcheng Mai -
MdHMGB15-MdXERICO-MdNRP module mediates salt tolerance of apple by regulating the expression of salt stress-related genes J. Adv. Res. (IF 11.4) Pub Date : 2025-03-24
Ran-Xin Liu, Shan-Shan Li, Qian-Yu Yue, Hong-Liang Li, Jie Lu, Wan-Cong Li, Yue-Ning Wang, Jia-Xing Liu, Xin-Long Guo, Xiang Wu, Ying-Xue Lv, Xiao-Fei Wang, Chun-Xiang You -
Blood metabolites mediate causal inference studies on the effect of gut microbiota on the risk of vascular calcification J. Adv. Res. (IF 11.4) Pub Date : 2025-03-24
Aoran Huang, Jianshuai Ma, Huijin Zhu, Yanli Qi, Yang Jin, Mingxuan Zhang, Li Yin, Minhong Luo, Sifan Chen, Chen Xie, Hui Huang -
Inosine monophosphate overcomes the coexisting resistance of mcr-1 and blaNDM-1 in Escherichia coli J. Adv. Res. (IF 11.4) Pub Date : 2025-03-24
Liang Zhao, Jian Xu, Saiwa Liu, Jingjing Du, Xixi Jia, Zhinan Wang, Lirui Ge, Kexin Cui, Yu Ga, Xiaowei Li, Xi Xia -
Exploring the role of endogenous and exogenous silicon in reducing arsenic accumulation in rice: A multi-scale hydroponic to field study J. Adv. Res. (IF 11.4) Pub Date : 2025-03-24
Yuepeng Yin, Mengfan Jia, Ping Li, Kaiwen Zhu, Min Nie, Xin Tang, Liqin He, Ting Li, Zhihong Guo, Zhigao Zhou, Lirong Li, Taolin Zhang, Xingxiang Wang, Changfeng Ding -
Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DEAD-box helicase 5–activating transcription factor 1–protein phosphatase 2 regulatory subunit 5A signaling J. Adv. Res. (IF 11.4) Pub Date : 2025-03-23
Di Fan, Yi Zhong, Yin Dong, Meng Du, Kai Huang, Xiaoguang Li -
From repellent to risk: DEET’s adverse effects on hormones and bone health in kids J. Adv. Res. (IF 11.4) Pub Date : 2025-03-21
Xinyu Zhu, Wanlu Liu, Baihao Lin, Haixia Qian, Mengya Xu, Yuyu Zheng, Yansen Bai -
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Pathogenicity of novel GLA gene missense mutations in Fabry disease and the therapeutic impact of migalastat J. Adv. Res. (IF 11.4) Pub Date : 2025-03-20
Wenkai Guo, Pengcheng Ji, Yaqing Li, Yixuan Zhang, Jingru Bi, Yuansheng Xie -
A mouse model of sepsis-associated DIC induced by Kappa-carrageenan and Lipopolysaccharides: Establishment and characteristics J. Adv. Res. (IF 11.4) Pub Date : 2025-03-19
Ping Tang, Boning Huang, Qianqing Ou, Fangle Liu, Liuqing Lin, Yuying Zheng, Huiyi Xie, Xinrong Yang, Xiubing Zhang, Zhongsheng Kuang, Yuhui Xie, Jingjing Sun, Bingqing Lin, Jun Li, Baoqin Lin -
Inhalation exposure to tire rubber particle-sourced pollutant 6PPD-quinone involving basolateral amygdala impairment in male ICR mice J. Adv. Res. (IF 11.4) Pub Date : 2025-03-19
Qu-Nan Wang, Chunzhi Wang, Yán Wāng -
Spatiotemporal translation of sperm acrosome associated proteins during early capacitation modulates sperm fertilizing ability J. Adv. Res. (IF 11.4) Pub Date : 2025-03-18
Yoo-Jin Park, Won-Ki Pang, Do-Yeal Ryu, Md Saidur Rahman, Myung-Geol Pang -
Discovery of mannose as an alternative non-nutrient-deficient regulator of lipid accumulation in microalgae J. Adv. Res. (IF 11.4) Pub Date : 2025-03-18
Pengyang Liu, Yuanhang Ai, Muzi Li, Jiacheng Shi, Ning Xiao, Xiaoyu Zhang, Hongbo Yu, Fuying Ma, Su Sun, Shangxian Xie -
Evidence for the role of soil C/N ratio in shaping plant responses to root-knot nematode infection J. Adv. Res. (IF 11.4) Pub Date : 2025-03-18
Jiafan Li, Shikai La, Mengyuan Song, Lihong Gao, Yongqiang Tian -
Minichromosome maintenance 4 plays a key role in protecting against acute kidney injury by regulating tubular epithelial cells survival and regeneration J. Adv. Res. (IF 11.4) Pub Date : 2025-03-17
Jing Huang, Feng Liu, Zhi-Feng Xu, Hui-Ling Xiang, Qian Yuan, Chun Zhang -
Mitochondrial fatty acid oxidation as the target for blocking therapy-resistance and inhibiting tumor recurrence: The proof-of-principle model demonstrated for ovarian cancer cells J. Adv. Res. (IF 11.4) Pub Date : 2025-03-17
Hui Lin, Lingfang Wang, Hanwen Chen, Yuqing Shen, Conghui Wang, Yite Xue, Zhi Zheng, Yanan Zhang, Dajing Xia, Yihua Wu, Fenfen Wang, Xiao Li, Xiaodong Cheng, ·Hui Wang, Junfen Xu, Weiguo Lu -
Adaptive bilirubin nanoscavenger alleviates pulmonary oxidative stress and inflammation for acute lung injury therapy J. Adv. Res. (IF 11.4) Pub Date : 2025-03-17
Longfa Kou, Yitianhe Xu, Shize Li, Zhinan He, Di Huang, Zhanzheng Ye, Yixuan Zhu, Yunzhi Wang, Xinyu Di, Yuqi Yan, Yinhao Lin, Wanling Zhu, Xianbao Shi, Hailin Zhang, Ruijie Chen -
Mitigating life-cycle multiple environmental burdens while increasing ecosystem economic benefit and crop productivity with regional universal nitrogen strategy J. Adv. Res. (IF 11.4) Pub Date : 2025-03-17
Zhi Yao, Xingbang Wang, Wei Zhang, Dunyi Liu, Wushuai Zhang, Xiaopeng Gao, Xinping Chen