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In This Issue Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-20
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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Schlank orchestrates insect developmental transition by switching H3K27 acetylation to trimethylation in the prothoracic gland Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Dongqin Yuan, Xing Zhang, Yan Yang, Ling Wei, Hao Li, Tujing Zhao, Mengge Guo, Zheng Li, Zhu Huang, Min Wang, Zongcai Dai, Peixin Li, Qingyou Xia, Wenliang Qian, Daojun Cheng
Insect developmental transitions are precisely coordinated by ecdysone and juvenile hormone (JH). We previously revealed that accumulated H3K27 trimethylation (H3K27me3) at the locus encoding JH signal transducer Hairy is involved in the larval–pupal transition in insects, but the underlying mechanism remains to be fully defined. Here, we show in Drosophila and Bombyx that Rpd3-mediated H3K27 deacetylation
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The evolution of autonomy from two cooperative specialists in fluctuating environments Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Xiaoli Chen, Miaoxiao Wang, Laipeng Luo, Xiaonan Liu, Liyun An, Yong Nie, Xiao-Lei Wu
From microbes to humans, organisms perform numerous tasks for their survival, including food acquisition, migration, and reproduction. A complex biological task can be performed by either an autonomous organism or by cooperation among several specialized organisms. However, it remains unclear how autonomy and cooperation evolutionarily switch. Specifically, it remains unclear whether and how cooperative
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The microbiota-dependent tryptophan metabolite alleviates high-fat diet–induced insulin resistance through the hepatic AhR/TSC2/mTORC1 axis Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Wei Du, Shanshan Jiang, Shengxiang Yin, Rongjiang Wang, Chunling Zhang, Bin-Cheng Yin, Jialin Li, Li Li, Nan Qi, Ying Zhou, Bang-Ce Ye
Type 2 diabetes (T2D) is potentially linked to disordered tryptophan metabolism that attributes to the intricate interplay among diet, gut microbiota, and host physiology. However, underlying mechanisms are substantially unknown. Comparing the gut microbiome and metabolome differences in mice fed a normal diet (ND) and high-fat diet (HFD), we uncover that the gut microbiota–dependent tryptophan metabolite
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Atomic resolution map of the solvent interactions driving SOD1 unfolding in CAPRIN1 condensates Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Rashik Ahmed, Mingyang Liang, Rhea P. Hudson, Atul K. Rangadurai, Shuya Kate Huang, Julie D. Forman-Kay, Lewis E. Kay
Biomolecules can be sequestered into membrane-less compartments, referred to as biomolecular condensates. Experimental and computational methods have helped define the physical-chemical properties of condensates. Less is known about how the high macromolecule concentrations in condensed phases contribute “solvent” interactions that can remodel the free-energy landscape of other condensate-resident
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Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor immunity Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Fumiaki Mukohara, Kazuma Iwata, Takamasa Ishino, Takashi Inozume, Joji Nagasaki, Youki Ueda, Ken Suzawa, Toshihide Ueno, Hideki Ikeda, Katsushige Kawase, Yuka Saeki, Shusuke Kawashima, Kazuo Yamashita, Yu Kawahara, Yasuhiro Nakamura, Akiko Honobe-Tabuchi, Hiroko Watanabe, Hiromichi Dansako, Tatsuyoshi Kawamura, Yutaka Suzuki, Hiroaki Honda, Hiroyuki Mano, Shinichi Toyooka, Masahito Kawazu, Yosuke Togashi
Immune checkpoint inhibitors (ICIs) exert clinical efficacy against various types of cancers by reinvigorating exhausted CD8 + T cells that can expand and directly attack cancer cells (cancer-specific T cells) among tumor-infiltrating lymphocytes (TILs). Although some reports have identified somatic mutations in TILs, their effect on antitumor immunity remains unclear. In this study, we successfully
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Circadian and environmental signal integration in a natural population of Arabidopsis Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Haruki Nishio, Dora L. Cano-Ramirez, Tomoaki Muranaka, Luíza Lane de Barros Dantas, Mie N. Honjo, Jiro Sugisaka, Hiroshi Kudoh, Antony N. Dodd
Plants sense and respond to environmental cues during 24 h fluctuations in their environment. This requires the integration of internal cues such as circadian timing with environmental cues such as light and temperature to elicit cellular responses through signal transduction. However, the integration and transduction of circadian and environmental signals by plants growing in natural environments
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Supramolecular assembly of polycation/mRNA nanoparticles and in vivo monocyte programming Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Yizong Hu, Stephany Y. Tzeng, Leonardo Cheng, Jinghan Lin, Andres Villabona-Rueda, Shuai Yu, Sixuan Li, Zachary Schneiderman, Yining Zhu, Jingyao Ma, David R. Wilson, Sydney R. Shannon, Tiarra Warren, Yuan Rui, Chenhu Qiu, Erin W. Kavanagh, Kathryn M. Luly, Yicheng Zhang, Nicole Korinetz, Franco R. D’Alessio, Tza-Huei Wang, Efrosini Kokkoli, Sashank K. Reddy, Erik Luijten, Jordan J. Green, Hai-Quan
Size-dependent phagocytosis is a well-characterized phenomenon in monocytes and macrophages. However, this size effect for preferential gene delivery to these important cell targets has not been fully exploited because commonly adopted stabilization methods for electrostatically complexed nucleic acid nanoparticles, such as PEGylation and charge repulsion, typically arrest the vehicle size below 200
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Presynaptic neurons self-tune by inversely coupling neurotransmitter release with the abundance of CaV2 voltage-gated Ca 2+ channels Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Ame Xiong, Janet E. Richmond, Hongkyun Kim
The abundance of CaV2 voltage-gated calcium channels is linked to presynaptic homeostatic plasticity (PHP), a process that recalibrates synaptic strength to maintain the stability of neural circuits. However, the molecular and cellular mechanisms governing PHP and CaV2 channels are not completely understood. Here, we uncover a previously not described form of PHP in Caenorhabditis elegans , revealing
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A synergetic cocatalyst for conversion of carbon dioxide, sunlight, and water into methanol Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Zhengwei Ye, Ke R. Yang, Bingxing Zhang, Ishtiaque Ahmed Navid, Yifan Shen, Yixin Xiao, Alexandre Pofelski, Gianluigi A. Botton, Tao Ma, Shubham Mondal, Theodore B. Norris, Victor S. Batista, Zetian Mi
The conversion of CO 2 into liquid fuels, using only sunlight and water, offers a promising path to carbon neutrality. An outstanding challenge is to achieve high efficiency and product selectivity. Here, we introduce a wireless photocatalytic architecture for conversion of CO 2 and water into methanol and oxygen. The catalytic material consists of semiconducting nanowires decorated with core–shell
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DOT1L-mediated RAP80 methylation promotes BRCA1 recruitment to elicit DNA repair Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Huangqi Tang, Ya-Fei Lu, Rongsheng Zeng, Chaohua Liu, Yuxin Shu, Yupei Wu, Jiajie Su, Longjiang Di, Jinqin Qian, Jun Zhang, Yuan Tian, Xiaopeng Lu, Xin-Hai Pei, Qian Zhu, Wei-Guo Zhu
Breast Cancer Type 1 Susceptibility Protein (BRCA1) is a tumor-suppressor protein that regulates various cellular pathways, including those that are essential for preserving genome stability. One essential mechanism involves a BRCA1-A complex that is recruited to double-strand breaks (DSBs) by RAP80 before initiating DNA damage repair (DDR). How RAP80 itself is recruited to DNA damage sites, however
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Correlated variability and its attentional modulation depend on anatomical connectivity Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Shraddha Shah, Jacqueline Hembrook-Short, Vanessa Mock, Farran Briggs
Visual cortical neurons show variability in their responses to repeated presentations of a stimulus and a portion of this variability is shared across neurons. Attention may enhance visual perception by reducing shared spiking variability. However, shared variability and its attentional modulation are not consistent within or across cortical areas, and depend on additional factors such as neuronal
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Lipid-associated macrophages’ promotion of fibrosis resolution during MASH regression requires TREM2 Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Souradipta Ganguly, Sara Brin Rosenthal, Kei Ishizuka, Ty D. Troutman, Theresa V. Rohm, Naser Khader, German Aleman-Muench, Yasuyo Sano, Sebastiano Archilei, Pejman Soroosh, Jerrold M. Olefsky, Ariel E. Feldstein, Tatiana Kisseleva, Rohit Loomba, Christopher K. Glass, David A. Brenner, Debanjan Dhar
While macrophage heterogeneity during metabolic dysfunction-associated steatohepatitis (MASH) has been described, the fate of these macrophages during MASH regression is poorly understood. Comparing macrophage heterogeneity during MASH progression vs regression, we identified specific macrophage subpopulations that are critical for MASH/fibrosis resolution. We elucidated the restorative pathways and
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Binding adaptability of chemical ligands to polymorphic α-synuclein amyloid fibrils Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Kaien Liu, Youqi Tao, Qinyue Zhao, Wencheng Xia, Xiang Li, Shenqing Zhang, Yuxuan Yao, Huaijiang Xiang, Chao Han, Li Tan, Bo Sun, Dan Li, Ang Li, Cong Liu
α-synuclein (α-syn) assembles into structurally distinct fibril polymorphs seen in different synucleinopathies, such as Parkinson’s disease and multiple system atrophy. Targeting these unique fibril structures using chemical ligands holds diagnostic significance for different disease subtypes. However, the molecular mechanisms governing small molecules interacting with different fibril polymorphs remain
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Wnt7b acts in concert with Wnt5a to regulate tissue elongation and planar cell polarity via noncanonical Wnt signaling Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Nicholas Xie, Andre Landin Malt, Aray Adylkhan, Natalie Rodeman, Ricardo Moraes Borges, Diane Hwang, Alice Liu, Connor Smith, Arielle Hogan, Xiaowei Lu
Intercellular signaling mediated by evolutionarily conserved planar cell polarity (PCP) proteins aligns cell polarity along the tissue plane and drives polarized cell behaviors during tissue morphogenesis. Accumulating evidence indicates that the vertebrate PCP pathway is regulated by noncanonical, β-catenin-independent Wnt signaling; however, the signaling components and mechanisms are incompletely
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Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Robin Bonomi, Ansel T. Hillmer, Eric Woodcock, Shivani Bhatt, Aleksandra Rusowicz, Gustavo A. Angarita, Richard E. Carson, Margaret T. Davis, Irina Esterlis, Nabeel Nabulsi, Yiyun Huang, John H. Krystal, Robert H. Pietrzak, Kelly P. Cosgrove
Dynamic brain immune function in individuals with posttraumatic stress disorder is rarely studied, despite evidence of peripheral immune dysfunction. Positron emission tomography brain imaging using the radiotracer [ 11 C]PBR28 was used to measure the 18-kDa translocator protein (TSPO), a microglial marker, at baseline and 3 h after administration of lipopolysaccharide (LPS), a potent immune activator
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DNA damage-induced proteasome phosphorylation controls substrate recognition and facilitates DNA repair Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Xiaomei Zhang, Tianyi Zhu, Xuemei Li, Hongxia Zhao, Shixian Lin, Jun Huang, Bing Yang, Xing Guo
Upon DNA damage, numerous proteins are targeted for ubiquitin-dependent proteasomal degradation, which is an integral part of the DNA repair program. Although details of the ubiquitination processes have been intensively studied, little is known about whether and how the 26S proteasome is regulated in the DNA damage response (DDR). Here, we show that human Rpn10/PSMD4, one of the three ubiquitin receptors
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Reducing the uncertainty in estimating soil microbial-derived carbon storage Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Han Hu, Chao Qian, Ke Xue, Rainer Georg Jörgensen, Marco Keiluweit, Chao Liang, Xuefeng Zhu, Ji Chen, Yishen Sun, Haowei Ni, Jixian Ding, Weigen Huang, Jingdong Mao, Rong-Xi Tan, Jizhong Zhou, Thomas W. Crowther, Zhi-Hua Zhou, Jiabao Zhang, Yuting Liang
Soil organic carbon (SOC) is the largest carbon pool in terrestrial ecosystems and plays a crucial role in mitigating climate change and enhancing soil productivity. Microbial-derived carbon (MDC) is the main component of the persistent SOC pool. However, current formulas used to estimate the proportional contribution of MDC are plagued by uncertainties due to limited sample sizes and the neglect of
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The Lorenz ratio as a guide to scattering contributions to transport in strongly correlated metals Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Fei Sun, Simli Mishra, Ulrike Stockert, Ramzy Daou, Naoki Kikugawa, Robin S. Perry, Elena Hassinger, Sean A. Hartnoll, Andrew P. Mackenzie, Veronika Sunko
In many physical situations in which many-body assemblies exist at temperature T , a characteristic quantum-mechanical time scale of approximately ℏ / k B T can be identified in both theory and experiment, leading to speculation that it may be the shortest meaningful time in such circumstances. This behavior can be investigated by probing the scattering rate of electrons in a broad class of materials
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Multiscale modeling shows how 2’-deoxy-ATP rescues ventricular function in heart failure Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Abigail E. Teitgen, Marcus T. Hock, Kimberly J. McCabe, Matthew C. Childers, Gary A. Huber, Bahador Marzban, Daniel A. Beard, J. Andrew McCammon, Michael Regnier, Andrew D. McCulloch
2’-deoxy-ATP (dATP) improves cardiac function by increasing the rate of crossbridge cycling and Ca 2 + transient decay. However, the mechanisms of these effects and how therapeutic responses to dATP are achieved when dATP is only a small fraction of the total ATP pool remain poorly understood. Here, we used a multiscale computational modeling approach to analyze the mechanisms by which dATP improves
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Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-22 Christian T. Meyer, Brianna N. Smith, Jing Wang, Kevin B. Teuscher, Brian C. Grieb, Gregory C. Howard, Alexander J. Silver, Shelly L. Lorey, Gordon M. Stott, William J. Moore, Taekyu Lee, Michael R. Savona, April M. Weissmiller, Qi Liu, Vito Quaranta, Stephen W. Fesik, William P. Tansey
WD40 Repeat Domain 5 (WDR5) is a highly conserved nuclear protein that recruits MYC oncoprotein transcription factors to chromatin to stimulate ribosomal protein gene expression. WDR5 is tethered to chromatin via an arginine-binding cavity known as the “WIN” site. Multiple pharmacological inhibitors of the WDR5-interaction site of WDR5 (WINi) have been described, including those with picomolar affinity
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Designing turbulence with entangled vortices Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-19 Weiyu Shen, Jie Yao, Yue Yang
Matter entanglement is a common chaotic structure found in both quantum and classical systems. For classical turbulence, viscous vortices are like sinews in fluid flows, storing and dissipating energy and accommodating strain and stress throughout a complex vortex network. However, to explain how the statistical properties of turbulence arise from elemental vortical structures remains challenging.
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Cowpea lipid transfer protein 1 regulates plant defense by inhibiting the cysteine protease of cowpea mosaic virus Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-19 Jie Ji, Shengli Du, Kun Wang, Ziyan Qi, Chunyang Zhang, Rui Wang, George Bruening, Pengwei Wang, Deqiang Duanmu, Qiuling Fan
Many virus genomes encode proteases that facilitate infection. The molecular mechanism of plant recognition of viral proteases is largely unexplored. Using the system of Vigna unguiculata and cowpea mosaic virus (CPMV), we identified a cowpea lipid transfer protein (LTP1) which interacts with CPMV-encoded 24KPro, a cysteine protease, but not with the enzymatically inactive mutant 24KPro(C166A). Biochemical
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The role of emerging elites in the formation and development of communities after the fall of the Roman Empire Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-19 Yijie Tian, István Koncz, Sarah Defant, Caterina Giostra, Deven N. Vyas, Arkadiusz Sołtysiak, Luisella Pejrani Baricco, Rafał Fetner, Cosimo Posth, Guido Brandt, Elena Bedini, Alessandra Modi, Martina Lari, Stefania Vai, Paolo Francalacci, Ricardo Fernandes, Axel Steinhof, Walter Pohl, David Caramelli, Johannes Krause, Adam Izdebski, Patrick J. Geary, Krishna R. Veeramah
Elites played a pivotal role in the formation of post-Roman Europe on both macro- and microlevels during the Early Medieval period. History and archaeology have long focused on their description and identification based on written sources or through their archaeological record. We provide a different perspective on this topic by integrating paleogenomic, archaeological, and isotopic data to gain insights
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Evolving dual-trait EPSP synthase variants using a synthetic yeast selection system Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-19 Kevin B. Reed, Wantae Kim, Hongyuan Lu, Clayton T. Larue, Shirley Guo, Sierra M. Brooks, Michael R. Montez, James W. Wagner, Y. Jessie Zhang, Hal S. Alper
The enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) functions in the shikimate pathway which is responsible for the production of aromatic amino acids and precursors of other essential secondary metabolites in all plant species. EPSPS is also the molecular target of the herbicide glyphosate. While some plant EPSPS variants have been characterized with reduced glyphosate sensitivity and have
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Even laypeople use legalese Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-19 Eric Martínez, Francis Mollica, Edward Gibson
Whereas principles of communicative efficiency and legal doctrine dictate that laws be comprehensible to the common world, empirical evidence suggests legal documents are largely incomprehensible to lawyers and laypeople alike. Here, a corpus analysis ( n = 59) million words) first replicated and extended prior work revealing laws to contain strikingly higher rates of complex syntactic structures relative
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Postprandial cardiac hypertrophy is sustained by mechanics, epigenetic, and metabolic reprogramming in pythons Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-19 Claudia Crocini, Kathleen C. Woulfe, Christopher D. Ozeroff, Stefano Perni, Joseph Cardiello, Cierra J. Walker, Cortney E. Wilson, Kristi Anseth, Mary Ann Allen, Leslie A. Leinwand
Constricting pythons, known for their ability to consume infrequent, massive meals, exhibit rapid and reversible cardiac hypertrophy following feeding. Our primary goal was to investigate how python hearts achieve this adaptive response after feeding. Isolated myofibrils increased force after feeding without changes in sarcomere ultrastructure and without increasing energy cost. Ca 2+ transients were
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Abortive and productive infection of CNS cell types following in vivo delivery of VSV Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-19 Tyler B Krause, Constance L. Cepko
Viral infection is frequently assayed by ongoing expression of viral genes. These assays fail to identify cells that have been exposed to the virus but limit or inhibit viral replication. To address this limitation, we used a dual-labeling vesicular stomatitis virus (DL-VSV), which has a deletion of the viral glycoprotein gene, to allow evaluation of primary infection outcomes. This virus encodes Cre
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How auditory neurons count temporal intervals and decode information Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-19 Rishi K. Alluri, Gary J. Rose, Jamie McDowell, Anwesha Mukhopadhyay, Christopher J. Leary, Jalina A. Graham, Gustavo A. Vasquez-Opazo
The numerical sense of animals includes identifying the numerosity of a sequence of events that occur with specific intervals, e.g., notes in a call or bar of music. Across nervous systems, the temporal patterning of spikes can code these events, but how this information is decoded (counted) remains elusive. In the anuran auditory system, temporal information of this type is decoded in the midbrain
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Is gender primacy universal? Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-19 Ashley E. Martin, Diego Guevara Beltran, Jeremy Koster, Jessica L. Tracy
Emerging evidence suggests that gender is a defining feature of personhood. Studies show that gender is the primary social category individuals use to perceive humanness and the social category most strongly related to seeing someone—or something—as human. However, the universality of gender’s primacy in social perception and its precedence over other social categories like race and age have been debated
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Splice modulation strategy applied to deep intronic variants in COL7A1 causing recessive dystrophic epidermolysis bullosa Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-19 Nathalie Pironon, Emmanuelle Bourrat, Catherine Prost, Mei Chen, David T. Woodley, Matthias Titeux, Alain Hovnanian
Recessive dystrophic epidermolysis bullosa (RDEB) is a rare and most often severe genetic disease characterized by recurrent blistering and erosions of the skin and mucous membranes after minor trauma, leading to major local and systemic complications. The disease is caused by loss-of-function variants in COL7A1 encoding type VII collagen (C7), the main component of anchoring fibrils, which form attachment
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Conserved 5-methyluridine tRNA modification modulates ribosome translocation Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-19 Joshua D. Jones, Monika K. Franco, Rachel N. Giles, Daniel E. Eyler, Mehmet Tardu, Tyler J. Smith, Laura R. Snyder, Yury S. Polikanov, Robert T. Kennedy, Rachel O. Niederer, Kristin S. Koutmou
While the centrality of posttranscriptional modifications to RNA biology has long been acknowledged, the function of the vast majority of modified sites remains to be discovered. Illustrative of this, there is not yet a discrete biological role assigned for one of the most highly conserved modifications, 5-methyluridine at position 54 in tRNAs (m 5 U54). Here, we uncover contributions of m 5 U54 to
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Functional dissection of mosquito humidity sensing reveals distinct Dry and Moist Cell contributions to blood feeding and oviposition Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-19 Ruocong Tang, Rachel Busby, Willem J. Laursen, Geoffrey T. Keane, Paul A. Garrity
Aedes aegypti mosquitoes are major vectors of dengue, chikungunya, and other arboviral diseases. Ae. aegypti ’s capacity to reproduce and to spread disease depends on the female mosquitoes’ ability to obtain blood meals and find water-filled containers in which to lay eggs (oviposit). While humidity sensation (hygrosensation) has been implicated in these behaviors, the specific hygrosensory pathways
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Global preventive feedback of powerful radio jets on galaxy formation Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-19 Renyue Cen
Firmly anchored on observational data, giant radio lobes from massive galaxies hosting supermassive black holes can exert a major negative feedback effect, by endowing the intergalactic gas with significant magnetic pressure hence retarding or preventing gas accretion onto less massive halos in the vicinity. Since massive galaxies that are largely responsible for producing the giant radio lobes, this
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On the role of small estuaries in retaining buoyant particles Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-19 Tong Bo, David K. Ralston, W. Rockwell Geyer, James C. McWilliams
Estuaries, as connectors between land and ocean, have complex interactions of river and tidal flows that affect the transport of buoyant materials like floating plastics, oil spills, organic matter, and larvae. This study investigates surface-trapped buoyant particle transport in estuaries by using idealized and realistic numerical simulations along with a theoretical model. While river discharge and
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Evidence of association between higher cardiorespiratory fitness and higher cerebral myelination in aging Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-19 Mary E. Faulkner, Zhaoyuan Gong, Murat Bilgel, John P. Laporte, Alex Guo, Jonghyun Bae, Elango Palchamy, Mary Kaileh, Christopher M. Bergeron, Jan Bergeron, Sarah Church, Jarod D’Agostino, Luigi Ferrucci, Mustapha Bouhrara
Emerging evidence suggests that altered myelination is an important pathophysiologic correlate of several neurodegenerative diseases, including Alzheimer and Parkinson’s diseases. Thus, improving myelin integrity may be an effective intervention to prevent and treat age-associated neurodegenerative pathologies. It has been suggested that cardiorespiratory fitness (CRF) may preserve and enhance cerebral
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Improving normothermic machine perfusion and blood transfusion through biocompatible blood silicification Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-19 Chuanyi Lei, Zeyu Li, Shuhao Ma, Qi Zhang, Jimin Guo, Qing Ouyang, Qi Lei, Liang Zhou, Junxian Yang, Jiangguo Lin, Romy Ettlinger, Stefan Wuttke, Xuejin Li, C. Jeffrey Brinker, Wei Zhu
The growing world population and increasing life expectancy are driving the need to improve the quality of blood transfusion, organ transplantation, and preservation. Here, to improve the ability of red blood cells (RBCs) for normothermic machine perfusion, a biocompatible blood silicification approach termed “shielding-augmenting RBC-in-nanoscale amorphous silica (SARNAS)” has been developed. The
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A siliceous arms race in pelagic plankton Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-19 Fredrik Ryderheim, Jørgen Olesen, Thomas Kiørboe
Coevolution between predator and prey plays a central role in shaping the pelagic realm and may have significant implications for marine ecosystems and nutrient cycling dynamics. The siliceous diatom frustule is often assumed to have coevolved with the silica-lined teeth of copepods, but empirical evidence of how this relationship drives natural selection and evolution is still lacking. Here, we show
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Phylogenetic evidence clarifies the history of the extrusion of Indochina Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-19 Xiao-Qian Li, Huan-Wen Peng, Kun-Li Xiang, Xiao-Guo Xiang, Florian Jabbour, Rosa del C. Ortiz, Pamela S. Soltis, Douglas E. Soltis, Wei Wang
The southeastward extrusion of Indochina along the Ailao Shan–Red River shear zone (ARSZ) is one of two of the most prominent consequences of the India–Asia collision. This plate-scale extrusion has greatly changed Southeast Asian topography and drainage patterns and effected regional climate and biotic evolution. However, little is known about how Indochina was extruded toward the southeast over time
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Correction for Mehta et al., Neural auditory contrast enhancement in humans Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-16
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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Extended time, elevated expectations: The unappreciated downsides of pausing the tenure clock Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-16 Maria A. HollandKatharina MaiselCarolyn B. IbbersonLaura K. WileyDavid C. BurnettEmily M. MaceMary Williard EltingaDepartment of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556bFischell Department of Bioengineering, University of Maryland, College Park, MD 20742cDepartment of Microbiology, University of Tennessee, Knoxville, TN 37996dDepartment of Biomedical Informatics
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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Universal cold RNA phase transitions Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-16 Paolo RissoneAurélien SeverinoIsabel PastorFelix RitortaSmall Biosystems Lab, Condensed Matter Physics Department, Universitat de Barcelona, Barcelona 08028, SpainbInstitut de Nanociència i Nanotecnologia, Universitat de Barcelona, Barcelona 08028, Spain
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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Light regulates widespread plant alternative polyadenylation through the chloroplast Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-16 M. Guillermina KubaczkaMicaela A. Godoy HerzWei-Chun ChenDinghai ZhengEzequiel PetrilloBin TianAlberto R. KornblihttaUniversidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Fisiología, Biología Molecular y Celular and CONICET-UBA, Instituto de Fisiología, Biología Molecular y Neurociencias, Buenos Aires 1428, ArgentinabDepartment of Microbiology, Biochemistry and Molecular
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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Uncovering underlying physical principles and driving forces of cell differentiation and reprogramming from single-cell transcriptomics Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-16 Ligang ZhuSonglin YangKun ZhangHong WangXiaona FangJin WangaCollege of Physics, Jilin University, Changchun 130021, ChinabState Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, ChinacCollege of Chemistry, Northeast Normal University, Changchun 130024, ChinadCenter for Theoretical Interdisciplinary Sciences, Wenzhou
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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Adaptive evolution of carbapenem-resistant hypervirulent Klebsiella pneumoniae in the urinary tract of a single patient Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-16 Shikai Song, Shixin Yang, Ruicheng Zheng, Dandan Yin, Yue Cao, Yao Wang, Lu Qiao, Rina Bai, Shuge Wang, Wenjuan Yin, Yanjun Dong, Li Bai, Hui Yang, Jianzhong Shen, Congming Wu, Fupin Hu, Yang Wang
The emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) is a growing concern due to its high mortality and limited treatment options. Although hypermucoviscosity is crucial for CR-hvKp infection, the role of changes in bacterial mucoviscosity in the host colonization and persistence of CR-hvKp is not clearly defined. Herein, we observed a phenotypic switch of CR-hvKp from
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Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-16 Michalina HanzelKayla FernandoSusan E. MaloneyZachi HornShiaoching GongKärt MätlikJiajia ZhaoH. Amalia PasolliSøren HeisselJoseph D. DoughertyCourt HullMary E. HattenaLaboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065bNeurobiology Department, Duke University, Durham, NC 27710cDepartment of Psychiatry and the Intellectual and Developmental Disabilities Research
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-16 Kevin W. BollingerUte MühKarl L. OciusAlexis J. ApostolosMarcos M. PiresRichard F. HelmDavid L. PophamDavid S. WeissCraig D. EllermeieraDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242bDepartment of Chemistry, University of Virginia, Charlottesville, VA 22904cDepartment of Biochemistry, Virginia Tech, Blacksburg, VA 24061dDepartment of Biological
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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Sustainable H2O2 production via solution plasma catalysis Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-16 Shuang LiangQi WuChanghua WangRui WangDashuai LiYanmei XingDexin JinHe MaYichun LiuPeng ZhangXintong ZhangaKey Laboratory of Ultraviolet-Emitting Materials and Technology of Chinese Ministry of Education, Northeast Normal University, Changchun 130024, ChinabDepartment of Chemistry, Dalhousie University, Halifax B3H 4J3, Canada
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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A PIKfyve modulator combined with an integrated stress response inhibitor to treat lysosomal storage diseases Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-16 William C. HouLynée A. MasseyDerek RhoadesYin WuWen RenChiara FrankHerman S. OverkleeftJeffrey W. KellyaDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA 92122bDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92122cDepartment of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden 2333 CC, The Netherlands
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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Rtt105 stimulates Rad51-ssDNA assembly and orchestrates Rad51 and RPA actions to promote homologous recombination repair Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-15 Xuejie WangXiaocong ZhaoZhengshi YuTianai FanYunjing GuoJianqiang LiangYanyan WangJingfei ZhanGuifang ChenChun ZhouXinghua ZhangXiangpan LiXuefeng ChenaHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Department of Radiation Oncology, Renmin Hospital of Wuhan University, Frontier Science Center for Immunology and Metabolism, Wuhan University
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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Internal catalysis significantly promotes the bond exchange of covalent adaptable polyurethane networks Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-15 Hongfei HuangWei SunLijie SunLuzhi ZhangYang WangYouwei ZhangShijia GuZhengwei YouMeifang ZhuaState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Institute of Functional Materials, College of Materials Science and Engineering, Donghua University, Research Base of Textile Materials for Flexible Electronics and Biomedical Applications (China Textile Engineering Society), Shanghai
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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ATAD5 functions as a regulatory platform for Ub–PCNA deubiquitination Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-15 Eunjin RyuJuyeong YooMi-Sun KangNa Young HaYewon JangJinwoo KimYeongjae KimByung-Gyu KimShinseog KimKyungjae MyungSukhyun KangaCenter for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of KoreabDepartment of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of KoreacDepartment of Biomedical Engineering, Ulsan National Institute of
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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The importance of the location of the N-terminus in successful protein folding in vivo and in vitro Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-15 Natalie R. DallCarolina A. T. F. MendonçaHéctor L. Torres VeraSusan MarquseeaDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720bCalifornia Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720cDepartment of Chemistry, University of California, Berkeley, CA 94720
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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Local strain inhomogeneities during electrical triggering of a metal–insulator transition revealed by X-ray microscopy Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-15 Pavel SalevElliot KisielDayne SasakiBrandon GunnWei HeMingzhen FengJunjie LiNobumichi TamuraIshwor PoudyalZahirul IslamYayoi TakamuraAlex FranoIvan K. SchulleraDepartment of Physics and Astronomy, University of Denver, Denver, CO 80210bDepartment of Physics, University of California San Diego, La Jolla, CA 92093cX-ray Science Division, Argonne National Laboratory, Argonne, IL 60439dDepartment of Materials
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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Contribution of intraflagellar transport to compartmentalization and maintenance of the photoreceptor cell Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-15 Tylor R. LewisCarson M. CastilloNatalia V. KlementievaYing HsuYing HaoWilliam J. SpencerArlene V. DrackGregory J. PazourVadim Y. ArshavskyaDepartment of Ophthalmology, Duke University Medical Center, Durham, NC 27710bDepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA 52242cProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605dDepartment
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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DNA-DISK: Automated end-to-end data storage via enzymatic single-nucleotide DNA synthesis and sequencing on digital microfluidics Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-15 Kunjie LiXiaoyun LuJiaqi LiaoHeng ChenWei LinYuhan ZhaoDongbao TangCongyu LiZhenyang TianZhi ZhuHuifeng JiangJun SunHuimin ZhangChaoyong YangaKey Laboratory of Spectrochemical Analysis and Instrumentation, Ministry of Education, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Pen-Tung Sah Institute of Micro-Nano
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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Zika virus NS5 protein inhibits type I interferon signaling via CRL3 E3 ubiquitin ligase-mediated degradation of STAT2 Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-15 Wenlin RenChonglei FuYu ZhangXiaohui JuXi JiangJingwei SongMingli GongZhuoyang LiWenchun FanJun YaoQiang DingaCenter for Infection Biology, School of Medicine, Tsinghua University, Beijing 100084, ChinabState Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, McGovern Institute for Brain Research, School of Life Sciences, Tsinghua University, Beijing 100084, ChinacShanxi
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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Mechanism of gabapentinoid potentiation of opioid effects on cyclic AMP signaling in neuropathic pain Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-15 Anibal Garza-CarbajalAlexis BavencoffeJuan J. HerreraKayla N. JohnsonEdgar T. WaltersCarmen W. DessaueraDepartment of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030bDepartment of Diagnostic and Interventional Imaging, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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Disorder-to-order active site capping regulates the rate-limiting step of the inositol pathway Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-15 Toni K. TrägerFotis L. KyrilisFarzad HamdiChristian TütingMarie AlfesTommy HofmannCarla SchmidtPanagiotis L. KastritisaFaculty of Natural Sciences I, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, GermanybBiozentrum, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, GermanycInstitute of Chemical Biology, National Hellenic Research
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.
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Phosphorylation of Insig-2 mediates inhibition of fatty acid synthesis by polyunsaturated fatty acids Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-08-15 Jing TianJoseph L. GoldsteinShili LiMarc M. SchumacherMichael S. BrownaDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390
Proceedings of the National Academy of Sciences, Volume 121, Issue 34, August 2024.