Minichromosome maintenance 4 plays a key role in protecting against acute kidney injury by regulating tubular epithelial cells survival and regeneration,Journal of Advanced Research

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Minichromosome maintenance 4 plays a key role in protecting against acute kidney injury by regulating tubular epithelial cells survival and regeneration
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2025-03-17 , DOI: 10.1016/j.jare.2025.03.032
Jing Huang ₁ , Feng Liu ₁ , Zhi-Feng Xu ₁ , Hui-Ling Xiang ₁ , Qian Yuan ₁ , Chun Zhang ₁

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Minichromosome maintenance 4 (MCM4), a constituent of the MCM family, playing a pivotal role in DNA replication. Although MCM4 expression has been widely linked to various malignant tumors, its role in kidney diseases is not well-studied. This study primarily investigates the role and underlying mechanism of MCM4 in acute kidney injury (AKI).

中文翻译：

Minichromosome maintenance 4 通过调节肾小管上皮细胞的存活和再生，在预防急性肾损伤中起关键作用

Minichromosome maintenance 4 （MCM4）是 MCM 家族的一个组成部分，在 DNA 复制中起着关键作用。尽管 MCM4 表达与各种恶性肿瘤广泛相关，但其在肾脏疾病中的作用尚未得到充分研究。本研究主要探讨 MCM4 在急性肾损伤（AKI）中的作用和潜在机制。

更新日期：2025-03-17

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