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Neuroanatomical substrates of depression in dementia with Lewy bodies and Alzheimer’s disease Geroscience (IF 5.6) Pub Date : 2024-05-15 Manon Querry, Anne Botzung, Benjamin Cretin, Catherine Demuynck, Candice Muller, Alix Ravier, Benoît Schorr, Mary Mondino, Léa Sanna, Paulo Loureiro de Sousa, Nathalie Philippi, Frédéric Blanc
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Clinical biomarker-based biological age predicts deaths in Brazilian adults: the ELSA-Brasil study Geroscience (IF 5.6) Pub Date : 2024-05-16 Amanda Viana Machado, Juliana Freitas de Mello e Silva, Enrico Antônio Colosimo, Belinda L. Needham, Chams Bicalho Maluf, Luana Giatti, Lidyane V. Camelo, Sandhi Maria Barreto
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Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin Geroscience (IF 5.6) Pub Date : 2024-05-16 Richard A. Miller, David E. Harrison, Gino A. Cortopassi, Ishmael Dehghan, Elizabeth Fernandez, Michael Garratt, John G. Geisler, Brett C. Ginsburg, Melissa L. Han, Catherine C. Kaczorowski, Navasuja Kumar, Scott F. Leiser, Marisa Lopez-Cruzan, Ginger Milne, James R. Mitchell, James F. Nelson, Peter C. Reifsnyder, Adam B. Salmon, Ron Korstanje, Nadia Rosenthal, Randy Strong
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Amyloid β accelerates age-related proteome-wide protein insolubility Geroscience (IF 5.6) Pub Date : 2024-05-16 Edward Anderton, Manish Chamoli, Dipa Bhaumik, Christina D. King, Xueshu Xie, Anna Foulger, Julie K. Andersen, Birgit Schilling, Gordon J. Lithgow
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Multi-night acoustic stimulation is associated with better sleep, amyloid dynamics, and memory in older adults with cognitive impairment Geroscience (IF 5.6) Pub Date : 2024-05-14 Céline J. Zeller, Marina Wunderlin, Korian Wicki, Charlotte E. Teunissen, Christoph Nissen, Marc A. Züst, Stefan Klöppel
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Reliable detection of stochastic epigenetic mutations and associations with cardiovascular aging Geroscience (IF 5.6) Pub Date : 2024-05-13 Yaroslav Markov, Morgan Levine, Albert T. Higgins-Chen
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Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer’s-like pathological dementia Geroscience (IF 5.6) Pub Date : 2024-05-11 Kumar Vaibhav, Mayuri Gulhane, Pankaj Ahluwalia, Manish Kumar, Meenakshi Ahluwalia, Ashiq M. Rafiq, Vibha Amble, Manuela G. Zabala, Jacob B. Miller, Liam Goldman, Ashis K. Mondal, Ferenc Deak, Ravindra Kolhe, Ali S. Arbab, Fernando L. Vale
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Genome integrity as a potential index of longevity in Ashkenazi Centenarian’s families Geroscience (IF 5.6) Pub Date : 2024-05-09 Mariana Andrawus, Gil Ben David, Ivana Terziyska, Lital Sharvit, Aviv Bergman, Nir Barzilai, Srilakshmi M. Raj, Diddahally R. Govindaraju, Gil Atzmon
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Intensive antihypertensive treatment does not lower cerebral blood flow or cause orthostatic hypotension in frail older adults Geroscience (IF 5.6) Pub Date : 2024-05-09 Ralf W. J. Weijs, Bente M. de Roos, Dick H. J. Thijssen, Jurgen A. H. R. Claassen
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The influence of immobility on muscle loss in older people with frailty and fragility fractures Geroscience (IF 5.6) Pub Date : 2024-05-10 Eleanor K. Lunt, Adam L. Gordon, Paul L. Greenhaff, John F. R. Gladman
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Abnormal EEG microstates in Alzheimer’s disease: predictors of β-amyloid deposition degree and disease classification Geroscience (IF 5.6) Pub Date : 2024-05-10 Yibing Yan, Manman Gao, Zhi Geng, Yue Wu, Guixian Xiao, Lu Wang, Xuerui Pang, Chaoyi Yang, Shanshan Zhou, Hongru Li, Panpan Hu, Xingqi Wu, Kai Wang
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Young blood-mediated cerebromicrovascular rejuvenation through heterochronic parabiosis: enhancing blood-brain barrier integrity and capillarization in the aged mouse brain Geroscience (IF 5.6) Pub Date : 2024-05-10 Rafal Gulej, Ádám Nyúl-Tóth, Boglarka Csik, Roland Patai, Benjamin Petersen, Sharon Negri, Siva Sai Chandragiri, Santny Shanmugarama, Peter Mukli, Andriy Yabluchanskiy, Shannon Conley, Derek Huffman, Stefano Tarantini, Anna Csiszar, Zoltan Ungvari
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Association between physical fitness and executive functions in cognitively healthy female older adults: a cross-sectional study Geroscience (IF 5.6) Pub Date : 2024-05-09 Shirko Ahmadi, Isadora Quirion, Pierre Faivre, Pierre Philippe Wilson Registe, Myles W. O’Brien, Nick W. Bray, Olivier Dupuy, Martin Sénéchal, Mathieu Bélanger, Said Mekari
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Evaluating osteoporosis and bone quality in the aging spine: modern considerations for surgical management in the geriatric population Geroscience (IF 5.6) Pub Date : 2024-05-04 Miles Hudson, Jenna Meyer, Alexander Evans, Chandan Krishna, Zachary A. Smith, Joshua Bakhsheshian
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Hemodynamic gain index and risk of chronic kidney disease: A prospective cohort study of middle-aged and older men Geroscience (IF 5.6) Pub Date : 2024-05-06 Setor K. Kunutsor, Jari A. Laukkanen
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Age-related shifts in mental health determinants from a deprived area in the European Union: informing the national healthy aging program of Hungary Geroscience (IF 5.6) Pub Date : 2024-05-07 Nora Kovacs, Eva Biro, Peter Piko, Zoltan Ungvari, Roza Adany
Mental disorders are among the leading causes of disability worldwide, disproportionately affecting older people. This study aims to assess the mental health of elderly individuals living in a deprived region of Hungary, and to identify and estimate the weight of different determinants of mental health across different age groups. A cross-sectional study was conducted with randomly selected samples
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Sex-specific relationships of inflammatory biomarkers with blood pressure in older adults Geroscience (IF 5.6) Pub Date : 2024-05-08 Joanna Sulicka-Grodzicka, Barbara Wizner, Tomasz Zdrojewski, Małgorzata Mossakowska, Monika Puzianowska-Kuźnicka, Jerzy Chudek, Andrzej Więcek, Mariusz Korkosz, Elisabetta Caiazzo, Pasquale Maffia, Mateusz Siedlinski, Franz H. Messerli, Tomasz J. Guzik
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Cannabinoids and healthy ageing: the potential for extending healthspan and lifespan in preclinical models with an emphasis on Caenorhabditis elegans Geroscience (IF 5.6) Pub Date : 2024-05-02 Zhizhen Wang, Jonathon C. Arnold
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Using non-invasive behavioral and physiological data to measure biological age in wild baboons Geroscience (IF 5.6) Pub Date : 2024-05-02 Chelsea J. Weibel, Mauna R. Dasari, David A. Jansen, Laurence R. Gesquiere, Raphael S. Mututua, J. Kinyua Warutere, Long’ida I. Siodi, Susan C. Alberts, Jenny Tung, Elizabeth A. Archie
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Trends in prevalence, mortality, and risk factors of dementia among the oldest-old adults in the United States: the role of the obesity epidemic Geroscience (IF 5.6) Pub Date : 2024-05-02 Xueshan Cao, Minmin Wang, Mengge Zhou, Yuanqi Mi, Vince Fazekas-Pongor, David Major, Andrea Lehoczki, Yang Guo
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Newer treatment paradigm improves outcomes in the most common neurosurgical disease of the elderly: a literature review of middle meningeal artery embolization for chronic subdural hematoma Geroscience (IF 5.6) Pub Date : 2024-05-01 Luca H. Debs, Samantha E. Walker, Scott Y. Rahimi
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Autopsy findings in cancer patients infected with SARS-CoV-2 show a milder presentation of COVID-19 compared to non-cancer patients Geroscience (IF 5.6) Pub Date : 2024-04-30 Éva Kocsmár, Ildikó Kocsmár, Flóra Elamin, Laura Pápai, Ákos Jakab, Tibor Várkonyi, Tibor Glasz, Gergely Rácz, Adrián Pesti, Krisztina Danics, András Kiss, Gergely Röst, Éva Belicza, Zsuzsa Schaff, Gábor Lotz
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Echocardiographic characterization of age- and sex-associated differences in cardiac function and morphometry in nonhuman primates Geroscience (IF 5.6) Pub Date : 2024-04-30 Maria Cristina Florio, Laura Fusini, Gloria Tamborini, Christopher Morrell, Alise McDonald, Michelle Walcott, Kenneth Ridley, Kelli L. Vaughan, Julie A. Mattison, Mauro Pepi, Edward G. Lakatta, Maurizio C. Capogrossi
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Increases in regional brain volume across two native South American male populations Geroscience (IF 5.6) Pub Date : 2024-04-29 Nikhil N. Chaudhari, Phoebe E. Imms, Nahian F. Chowdhury, Margaret Gatz, Benjamin C. Trumble, Wendy J. Mack, E. Meng Law, M. Linda Sutherland, James D. Sutherland, Christopher J. Rowan, L. Samuel Wann, Adel H. Allam, Randall C. Thompson, David E. Michalik, Michael Miyamoto, Guido Lombardi, Daniel K. Cummings, Edmond Seabright, Sarah Alami, Angela R. Garcia, Daniel E. Rodriguez, Raul Quispe Gutierrez
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Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches Geroscience (IF 5.6) Pub Date : 2024-04-26 Tihamer Molnar, Andrea Lehoczki, Monika Fekete, Reka Varnai, Laszlo Zavori, Szabina Erdo-Bonyar, Diana Simon, Tímea Berki, Peter Csecsei, Erzsebet Ezer
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Multimodal brain age prediction using machine learning: combining structural MRI and 5-HT2AR PET-derived features Geroscience (IF 5.6) Pub Date : 2024-04-26 Ruben P. Dörfel, Joan M. Arenas-Gomez, Claus Svarer, Melanie Ganz, Gitte M. Knudsen, Jonas E. Svensson, Pontus Plavén-Sigray
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Prognostic significance of a signature based on senescence-related genes in colorectal cancer Geroscience (IF 5.6) Pub Date : 2024-04-25 Zoltan Ungvari, Anna Ungvari, Giampaolo Bianchini, Balázs Győrffy
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Age-associated B cell infiltration in salivary glands represents a hallmark of Sjögren’s-like disease in aging mice Geroscience (IF 5.6) Pub Date : 2024-04-24 Harini Bagavant, Justyna Durslewicz, Marcelina Pyclik, Magdalena Makuch, Joanna A. Papinska, Umesh S. Deshmukh
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Sex-specific cardiovascular remodeling leads to a divergent sex-dependent development of heart failure in aged hypertensive rats Geroscience (IF 5.6) Pub Date : 2024-04-24 Árpád Kovács, Saltanat Zhazykbayeva, Melissa Herwig, Gábor Á. Fülöp, Tamás Csípő, Nikolett Oláh, Roua Hassoun, Heidi Budde, Hersh Osman, Mustafa Kaçmaz, Kornelia Jaquet, Dániel Priksz, Béla Juhász, Ibrahim Akin, Zoltán Papp, Wolfgang E. Schmidt, Andreas Mügge, Ibrahim El-Battrawy, Attila Tóth, Nazha Hamdani
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How does a fly die? Insights into ageing from the pathophysiology of Drosophila mortality Geroscience (IF 5.6) Pub Date : 2024-04-20 Eliano dos Santos, Helena M. Cochemé
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Repetitive element transcript accumulation is associated with inflammaging in humans Geroscience (IF 5.6) Pub Date : 2024-04-20 Meghan E. Smith, Devin Wahl, Alyssa N. Cavalier, Gabriella T. McWilliams, Matthew J. Rossman, Gregory R. Giordano, Angela D. Bryan, Douglas R. Seals, Thomas J. LaRocca
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Atherosclerotic burden and cerebral small vessel disease: exploring the link through microvascular aging and cerebral microhemorrhages Geroscience (IF 5.6) Pub Date : 2024-04-19 Anna Csiszar, Anna Ungvari, Roland Patai, Rafal Gulej, Andriy Yabluchanskiy, Zoltan Benyo, Illes Kovacs, Peter Sotonyi, Angelia C. Kirkpartrick, Calin I. Prodan, Eric M. Liotta, Xin A. Zhang, Peter Toth, Stefano Tarantini, Farzaneh A. Sorond, Zoltan Ungvari
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NASH triggers cardiometabolic HFpEF in aging mice Geroscience (IF 5.6) Pub Date : 2024-04-17 Dániel Kucsera, Mihály Ruppert, Nabil V. Sayour, Viktória E. Tóth, Tamás Kovács, Zsombor I. Hegedűs, Zsófia Onódi, Alexandra Fábián, Attila Kovács, Tamás Radovits, Béla Merkely, Pál Pacher, Péter Ferdinandy, Zoltán V. Varga
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The Gehan test identifies life-extending compounds overlooked by the log-rank test in the NIA Interventions Testing Program: Metformin, Enalapril, caffeic acid phenethyl ester, green tea extract, and 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride Geroscience (IF 5.6) Pub Date : 2024-04-17 Nisi Jiang, Jonathan Gelfond, Qianqian Liu, Randy Strong, James F. Nelson
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Differential mitochondrial bioenergetics and cellular resilience in astrocytes, hepatocytes, and fibroblasts from aging baboons Geroscience (IF 5.6) Pub Date : 2024-04-12 Daniel A. Adekunbi, Hillary F. Huber, Cun Li, Peter W. Nathanielsz, Laura A. Cox, Adam B. Salmon
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Sex differences in interacting genetic and functional connectivity biomarkers in Alzheimer’s disease Geroscience (IF 5.6) Pub Date : 2024-04-10 Jordan N. Williamson, Shirley A. James, Sean P. Mullen, Bradley P. Sutton, Tracey Wszalek, Beni Mulyana, Peter Mukli, Andriy Yabluchanskiy, Yuan Yang
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Spousal bereavement and its effects on later life physical and cognitive capability: the Tromsø study Geroscience (IF 5.6) Pub Date : 2024-04-09 Bjørn Heine Strand, Asta K. Håberg, Harpa Sif Eyjólfsdóttir, Almar Kok, Vegard Skirbekk, Oliver Huxhold, Gøril Kvamme Løset, Carin Lennartsson, Henrik Schirmer, Katharina Herlofson, Marijke Veenstra
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The association between blood biological age at rehabilitation admission and physical activity during rehabilitation in geriatric inpatients: RESORT Geroscience (IF 5.6) Pub Date : 2024-04-09 Jessica K. Lu, Lihuan Guan, Weilan Wang, Anna G. M. Rojer, Fedor Galkin, Jorming Goh, Andrea B. Maier
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Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans Geroscience (IF 5.6) Pub Date : 2024-04-08 Elizabeth M. L. Duxbury, Hanne Carlsson, Annabel Kimberley, Yvonne Ridge, Katie Johnson, Alexei A. Maklakov
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Yoga-based lifestyle intervention for healthy ageing in older adults: a two-armed, waitlist randomized controlled trial with multiple primary outcomes Geroscience (IF 5.6) Pub Date : 2024-04-07 Atmakur Snigdha, Vijaya Majumdar, N. K. Manjunath, Amrutha Jose
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The behavioural effect of short-term cognitive and physical intervention therapies in old dogs Geroscience (IF 5.6) Pub Date : 2024-04-03 Zsófia Bognár, Dóra Szabó, Borbála Turcsán, Enikő Kubinyi
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Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging Geroscience (IF 5.6) Pub Date : 2024-04-03 Naibedya Dutta, Joe A. Gerke, Sofia F. Odron, Joseph D. Morris, Adam Hruby, Juri Kim, Toni Castro Torres, Sarah J. Shemtov, Jacqueline G. Clarke, Michelle C. Chang, Hooriya Shaghasi, Marissa N. Ray, Maxim Averbukh, Sally Hoang, Maria Oorloff, Athena Alcala, Matthew Vega, Hemal H. Mehta, Max A. Thorwald, Phillip Crews, Marc Vermulst, Gilberto Garcia, Tyler A. Johnson, Ryo Higuchi-Sanabria
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DPP-4 inhibitors sitagliptin and PF-00734,200 mitigate dopaminergic neurodegeneration, neuroinflammation and behavioral impairment in the rat 6-OHDA model of Parkinson’s disease Geroscience (IF 5.6) Pub Date : 2024-04-02 Seong-Jin Yu, Yun Wang, Hui Shen, Eun-Kyung Bae, Yazhou Li, Kumar Sambamurti, Michael A. Tones, Margaret M. Zaleska, Barry J. Hoffer, Nigel H. Greig
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Genome-wide analysis of hepatic DNA methylation reveals impact of epigenetic aging on xenobiotic metabolism and transport genes in an aged mouse model Geroscience (IF 5.6) Pub Date : 2024-04-01 Sara Abudahab, Mohamad M. Kronfol, Mikhail G. Dozmorov, Thomas Campbell, Fay M. Jahr, Jasmine Nguyen, Ola AlAzzeh, Dalia Y. Al Saeedy, Ashley Victor, Sera Lee, Shravani Malay, Dana M. Lapato, Matthew S. Halquist, MaryPeace McRae, Laxmikant S. Deshpande, Patricia W. Slattum, Elvin T. Price, Joseph L. McClay
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Neurobehavioral dysfunction in a mouse model of Down syndrome: upregulation of cystathionine β-synthase, H2S overproduction, altered protein persulfidation, synaptic dysfunction, endoplasmic reticulum stress, and autophagy Geroscience (IF 5.6) Pub Date : 2024-04-01 Theodora Panagaki, Lucia Janickova, Dunja Petrovic, Karim Zuhra, Tamás Ditrói, Eszter P. Jurányi, Olivier Bremer, Kelly Ascenção, Thilo M. Philipp, Péter Nagy, Milos R. Filipovic, Csaba Szabo
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The duration of lithium use and biological ageing: telomere length, frailty, metabolomic age and all-cause mortality Geroscience (IF 5.6) Pub Date : 2024-03-28 Julian Mutz, Win Lee Edwin Wong, Timothy R. Powell, Allan H. Young, Gavin S. Dawe, Cathryn M. Lewis
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Combined aerobic and strength exercise training on biological ageing in Singaporean breast cancer patients: protocol for the Breast Cancer Exercise Intervention (BREXINT) Pilot Study Geroscience (IF 5.6) Pub Date : 2024-03-28 Patrick Henry Sebastian Sitjar, Si Ying Tan, Mabel Wong, Jingmei Li, Rufaihah Binte Abdul Jalil, Huizhen Aw, Elaine Hsuen Lim, Jorming Goh
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Sitagliptin elevates plasma and CSF incretin levels following oral administration to nonhuman primates: relevance for neurodegenerative disorders Geroscience (IF 5.6) Pub Date : 2024-03-27 Yazhou Li, Kelli L. Vaughan, Yun Wang, Seong-Jin Yu, Eun-Kyung Bae, Ian A. Tamargo, Katherine O. Kopp, David Tweedie, Cheng-Chuan Chiang, Keith T. Schmidt, Debomoy K. Lahiri, Michael A. Tones, Margaret M. Zaleska, Barry J. Hoffer, Julie A. Mattison, Nigel H. Greig
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A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic age Geroscience (IF 5.6) Pub Date : 2024-03-26 Kirsty C. McGee, Jack Sullivan, Jon Hazeldine, Lisa J. Schmunk, Daniel E. Martin-Herranz, Thomas Jackson, Janet M. Lord
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A loss of primary cilia by a reduction in mTOR signaling correlates with age-related deteriorations in condylar cartilage Geroscience (IF 5.6) Pub Date : 2024-03-25 Megumi Kitami, Masaru Kaku, Lay Thant, Takeyasu Maeda
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Age-related decline in cognitive flexibility and inadequate preparation: evidence from task-state network analysis Geroscience (IF 5.6) Pub Date : 2024-03-22 Haishuo Xia, Ting Li, Yongqing Hou, Zijin Liu, Antao Chen
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Relationship of psychotropic medication use with physical function among postmenopausal women Geroscience (IF 5.6) Pub Date : 2024-03-22 Hind A. Beydoun, May A. Beydoun, Edward Kwon, Brook T. Alemu, Alan B. Zonderman, Robert Brunner
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Longitudinal aortic strain, ventriculo-arterial coupling and fatty acid oxidation: novel insights into human cardiovascular aging Geroscience (IF 5.6) Pub Date : 2024-03-22 Hongzhou Zhang, Shuang Leng, Fei Gao, Jean-Paul Kovalik, Ru-San Tan, Hai Ning Wee, Kee Voon Chua, Jianhong Ching, Xiaodan Zhao, John Allen, Qinghua Wu, Tim Leiner, Liang Zhong, Angela S. Koh
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Impact of visceral adipose tissue on longevity and metabolic health: a comparative study of gene expression in perirenal and epididymal fat of Ames dwarf mice Geroscience (IF 5.6) Pub Date : 2024-03-22 Agnieszka Zaczek, Andrzej Lewiński, Małgorzata Karbownik-Lewińska, Andrea Lehoczki, Adam Gesing
Emerging research underscores the pivotal role of adipose tissue in regulating systemic aging processes, particularly when viewed through the lens of the endocrine hypotheses of aging. This study delves into the unique adipose characteristics in an important animal model of aging — the long-lived Ames dwarf (df/df) mice. Characterized by a Prop1df gene mutation, these mice exhibit a deficiency in growth
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Age-related effects on a hierarchical structure of canine cognition Geroscience (IF 5.6) Pub Date : 2024-03-21 Zsófia Bognár, Borbála Turcsán, Tamás Faragó, Dóra Szabó, Ivaylo Borislavov Iotchev, Enikő Kubinyi
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Neuroprotective treatment with the nitrone compound OKN-007 mitigates age-related muscle weakness in aging mice Geroscience (IF 5.6) Pub Date : 2024-03-21 Hongyang Xu, Katarzyna M. Piekarz, Jacob L. Brown, Shylesh Bhaskaran, Nataliya Smith, Rheal A. Towner, Holly Van Remmen
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Anti-cytomegalovirus antibody levels stratify human immune profiles across the lifespan Geroscience (IF 5.6) Pub Date : 2024-03-21 Makiko Watanabe, Lisa Davidson, Patricia Smith, Peter F. Castellucio, Mladen Jergovic, Jennifer L. Uhrlaub, Megan J. Smithey, Lori E. Fantry, Brett Dechambre, Rachel C. Wilson, Kenneth C. Knox, Jie Ren, Raymond P. Stowe, George Weinstock, Homer Twigg, Janko Ž. Nikolich
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Establishing healthy longevity clinics in publicly funded hospitals Geroscience (IF 5.6) Pub Date : 2024-03-21 Sara L. R. Bonnes, Tzipora Strauss, Allyson K. Palmer, Ryan T. Hurt, Louis Island, Abigail Goshen, Laureen Y. T. Wang, James L. Kirkland, Evelyne Bischof, Andrea B. Maier
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Detecting aortic valve stenosis based on the non-invasive blood pressure waveform—a proof of concept study Geroscience (IF 5.6) Pub Date : 2024-03-20 Eline Kho, Jimmy Schenk, Alexander P. J. Vlaar, Marije M. Vis, Marije Wijnberge, Lotte B. Stam, Martijn van Mourik, Harald T. Jorstad, Henning Hermanns, Berend E. Westerhof, Denise P. Veelo, Bjorn J. P. van der Ster
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Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells Geroscience (IF 5.6) Pub Date : 2024-03-20 Ambika Verma, Gohar Azhar, Pankaj Patyal, Wei Zhang, Xiaomin Zhang, Jeanne Y. Wei