To examine cross-sectional and longitudinal relationships of psychotropic medications with physical function after menopause. Analyses involved 4557 Women’s Health Initiative Long Life Study (WHI-LLS) participants (mean age at WHI enrollment (1993–1998): 62.8 years). Antidepressant, anxiolytic, and sedative/hypnotic medications were evaluated at WHI enrollment and 3-year follow-up visits. Performance-based physical function [Short Physical Performance Battery (SPPB)] was assessed at the 2012–2013 WHI-LLS visit. Self-reported physical function [RAND-36] was examined at WHI enrollment and the last available follow-up visit—an average of 22 [±2.8] (range: 12–27) years post-enrollment. Multivariable regression models controlled for socio-demographic, lifestyle, and health characteristics. Anxiolytics were not related to physical function. At WHI enrollment, antidepressant use was cross-sectionally related to worse self-reported physical function defined as a continuous (β = −6.27, 95% confidence interval [CI]: −8.48, −4.07) or as a categorical (< 78 vs. ≥ 78) (odds ratio [OR] = 2.10, 95% CI: 1.48, 2.98) outcome. Antidepressant use at WHI enrollment was also associated with worse performance-based physical function (SPPB) [< 10 vs. ≥ 10] (OR = 1.53, 95% CI: 1.05, 2.21) at the 2012–2013 WHI-LLS visit. Compared to non-users, those using sedative/hypnotics at WHI enrollment but not at the 3-year follow-up visit reported a faster decline in physical function between WHI enrollment and follow-up visits. Among postmenopausal women, antidepressant use was cross-sectionally related to worse self-reported physical function, and with worse performance-based physical function after > 20 years of follow-up. Complex relationships found for hypnotic/sedatives were unexpected and necessitate further investigation.

研究精神药物与绝经后身体功能的横断面和纵向关系。分析涉及 4557 名妇女健康倡议长寿研究 (WHI-LLS) 参与者（WHI 登记时的平均年龄 (1993-1998)：62.8 岁）。在 WHI 入组和 3 年随访时对抗抑郁药、抗焦虑药和镇静/催眠药物进行了评估。基于表现的身体机能 [短期身体表现电池 (SPPB)] 在 2012-2013 年 WHI-LLS 访问中进行了评估。在 WHI 入组和最后一次随访时对自我报告的身体功能 [RAND-36] 进行检查——平均入组后 22 [±2.8]（范围：12-27）年。控制社会人口、生活方式和健康特征的多变量回归模型。抗焦虑药与身体机能无关。在 WHI 入组时，抗抑郁药物的使用与自我报告的身体机能较差相关，定义为连续型（β = −6.27，95% 置信区间 [CI]：−8.48，−4.07）或分类型（< 78 vs ≥ 78)（比值比 [OR] = 2.10，95% CI：1.48，2.98）结果。在 2012-2013 年 WHI-LLS 访视中，WHI 入组时使用抗抑郁药物还与较差的基于表现的身体功能 (SPPB) [< 10 与 ≥ 10]（OR = 1.53，95% CI：1.05，2.21）相关。与非使用者相比，那些在 WHI 登记时使用镇静/安眠药但在 3 年随访时未使用镇静剂/安眠药的人报告称，在 WHI 登记和随访期间身体功能下降得更快。在绝经后女性中，抗抑郁药物的使用与自我报告的身体机能较差有关，并且在超过 20 年的随访后，基于表现的身体机能较差。催眠/镇静剂的复杂关系是出乎意料的，需要进一步调查。