-
Hysterectomy Techniques and Outcomes for Benign Large Uteri: A Systematic Review. Obstet. Gynecol. (IF 7.2) Pub Date : 2024-05-15 Mamta M Mamik, Shunaha Kim-Fine, Linda Yang, Vidya Sharma, Rajiv Gala, Sarit Aschkenazi, David Sheyn, David Howard, Andrew J Walter, Bela Kudish, Ethan M Balk, Danielle D Antosh
To identify the optimal hysterectomy approach for large uteri in gynecologic surgery for benign indications from a perioperative morbidity standpoint.
-
Examining the association of hysterectomy with and without oophorectomy on cardiovascular disease and all‐cause, cardiovascular or cancer mortality: A systematic review and meta‐analysis BJOG An Int. J. Obstet. Gynaecol. (IF 5.8) Pub Date : 2024-05-15 Yuge Chen, Fengjuan Li, Lei Liang, Huiling Hua, Shizheng Liu, Zihe Yu, Qiuyu Chen, Shufeng Huang, Pei Qin
BackgroundThe associations between hysterectomy and cardiovascular disease (CVD) and mortality remains unlcear and a meta‐analysis with cohort studies is lacking.ObjectivesThis study aimed to conduct a systematic review and meta‐analysis of cohort studies to investigate the relationship between hysterectomy and CVD, coronary heart disease (CHD), stroke, heart failure, and all‐cause, cardiovascular
-
Self‐reported respiratory and gastrointestinal outcomes in children with isolated congenital diaphragmatic hernia: A prospective multicentre study BJOG An Int. J. Obstet. Gynaecol. (IF 5.8) Pub Date : 2024-05-15 Mary Patrice Eastwood, Lennart Van der Veeken, Luc Joyeux, Laura Salazar, Juan Otano, Rashmi d'Souza, Martin Sidler, Francesca Maria Russo, Jordi Prat, Paolo de Coppi, Eduard Gratacós, Jan Deprest
ObjectiveTo evaluate medium‐term self‐reported respiratory and gastrointestinal (GI) outcomes in children with congenital diaphragmatic hernia (CDH).DesignSelf‐reported respiratory and GI outcomes correlated with prenatal severity indicators.SettingProspective study at three fetal medicine units.PopulationFamilies of children prenatally diagnosed with isolated, left‐sided CDH surviving for >1 year
-
Investigation and Care of a Small-for-Gestational-Age Fetus and a Growth Restricted Fetus (Green-top Guideline No. 31) BJOG An Int. J. Obstet. Gynaecol. (IF 5.8) Pub Date : 2024-05-13 R. Katie Morris, Edward Johnstone, Christoph Lees, Victoria Morton, Gordon Smith
CONFLICT OF INTEREST STATEMENT RKM is the chair of the RCOG Scientific Advisory Committee, Deputy National Specialty Lead for Reproductive Health and Childbirth Clinical Research Network NIHR and President of the British Maternal Fetal Medicine Society. EJ received a NERC RESPIRE grant. CL is chief investigator of the TRUFFLE 2 study of moderate preterm fetal growth restriction and has received NIHR
-
Prophylactic Unfractionated Heparin in Antepartum Hospitalizations: A Randomized Controlled Trial. Obstet. Gynecol. (IF 7.2) Pub Date : 2024-05-14 Thalia Mok, Anissa V Nguyen, Lorna Kwan, Irving Steinberg, Cristianna Vallera, Neil S Silverman, Rashmi Rao
To assess the effect of gestational age-based dosing of unfractionated heparin (UFH) compared with standard dosing of UFH for thromboprophylaxis on an elevated serum activated partial thromboplastin time (aPTT) during prolonged antepartum hospitalizations.
-
TEX13B is essential for metabolic reprogramming during germ cell differentiation Hum. Reprod. (IF 6.1) Pub Date : 2024-05-14 Umesh Kumar, Digumarthi V S Sudhakar, Nithyapriya Kumar, Anurupa Moitra, Hanuman T Kale, Rajan Kumar Jha, Shivali Rawat, Geetika Verma, Nalini J Gupta, Mamata Deenadayal, Aarti Deenadayal Tolani, Swasti Raychaudhuri, P Chandra Shekar, Kumarasamy Thangaraj
STUDY QUESTION What is the functional significance of Tex13b in male germ cell development and differentiation? SUMMARY ANSWER Tex13b regulates male germ cell differentiation by metabolic reprogramming during spermatogenesis. WHAT IS KNOWN ALREADY Studies in mice and humans suggest that TEX13B is a transcription factor and is exclusively expressed in germ cells. STUDY DESIGN, SIZE, DURATION We sequenced
-
Rapamycin prevents cyclophosphamide-induced ovarian follicular loss and potentially inhibits tumour proliferation in a breast cancer xenograft mouse model Hum. Reprod. (IF 6.1) Pub Date : 2024-05-12 Yuji Tanaka, Tsukuru Amano, Akiko Nakamura, Fumi Yoshino, Akie Takebayashi, Akimasa Takahashi, Hiroyuki Yamanaka, Ayako Inatomi, Tetsuro Hanada, Yutaka Yoneoka, Shunichiro Tsuji, Takashi Murakami
STUDY QUESTION To what extent and via what mechanism does the concomitant administration of rapamycin (a follicle activation pathway inhibitor and antitumour agent) and cyclophosphamide (a highly toxic ovarian anticancer agent) prevent cyclophosphamide-induced ovarian reserve loss and inhibit tumour proliferation in a breast cancer xenograft mouse model? SUMMARY ANSWER Daily concomitant administration
-
Association between the length of in vitro embryo culture, mode of ART, and the initial endogenous hCG rise in ongoing singleton pregnancies Hum. Reprod. (IF 6.1) Pub Date : 2024-05-12 C Brockmeier, M B Borgstrøm, K Madsen, A Pinborg, N L Freiesleben, A Zedeler, M R Petersen, M L Grøndahl, P F Svendsen
STUDY QUESTION Is there an association between the length of in vitro culture, mode of ART and the initial endogenous hCG rise, in cycles with a foetal heartbeat after single embryo transfer (ET) and implantation? SUMMARY ANSWER Both the length of in vitro culture and the mode of ART have an impact on the initial endogenous rise in hCG in singleton pregnancies. WHAT IS KNOWN ALREADY Different factors
-
Müllerian anomalies and endometriosis as potential explanatory models for the retrograde menstruation/implantation and the embryonic remnants/celomic metaplasia pathogenic theories: a systematic review and meta-analysis Hum. Reprod. (IF 6.1) Pub Date : 2024-05-11 Paolo Vercellini, Noemi Salmeri, Edgardo Somigliana, Martina Piccini, Francesca Caprara, Paola Viganò, Sara De Matteis
STUDY QUESTION Does endometriosis prevalence differ in patients with obstructive Müllerian anomalies (OMA) versus those with nonobstructive Müllerian anomalies (NOMA), and in patients with NOMA versus those without Müllerian anomalies? SUMMARY ANSWER The quantitative synthesis of published data demonstrates a substantially increased prevalence of endometriosis in patients with OMA compared with those
-
Stillbirth mortality by Robson ten-group classification system: A cross-sectional registry of 80 663 births from 16 hospital in sub-Saharan Africa BJOG An Int. J. Obstet. Gynaecol. (IF 5.8) Pub Date : 2024-05-10 Claudia Hanson, Kristi Sidney Annerstedt, Maria Del Rosario Alsina, Muzdalifat Abeid, Hussein L. Kidanto, Helle Mölsted Alvesson, Andrea B. Pembe, Peter Waiswa, Jean-Paul Dossou, Effie Chipeta, Manuela Straneo, Lenka Benova
To assess stillbirth mortality by Robson ten-group classification and the usefulness of this approach for understanding trends.
-
Development and Validation of an Automated, Real-Time Predictive Model for Postpartum Hemorrhage. Obstet. Gynecol. (IF 7.2) Pub Date : 2024-05-10 Holly B Ende, Henry J Domenico, Aleksandra Polic, Amber Wesoloski, Lisa C Zuckerwise, Allison B Mccoy, Annastacia R Woytash, Ryan P Moore, Daniel W Byrne
To develop and validate a predictive model for postpartum hemorrhage that can be deployed in clinical care using automated, real-time electronic health record (EHR) data and to compare performance of the model with a nationally published risk prediction tool.
-
Effect of intraovarian platelet-rich plasma injection on IVF outcomes in women with poor ovarian response: the PROVA randomized controlled trial Hum. Reprod. (IF 6.1) Pub Date : 2024-05-10 Nola S Herlihy, Yigit Cakiroglu, Christine Whitehead, Andres Reig, Bulent Tiras, Richard T Scott, Emre Seli
STUDY QUESTION Does intraovarian platelet-rich plasma (PRP) injection increase the number of mature oocytes obtained after controlled ovarian stimulation (COS) in young women with poor ovarian response (POR) undergoing IVF? SUMMARY ANSWER Intraovarian PRP injection procedure does not improve mature oocyte yield after COS in women less than 38 years old with an established IVF history of POR. WHAT IS
-
Palmitic acid impairs human and mouse placental function by inhibiting trophoblast autophagy through induction of acyl-coenzyme A-binding protein (ACBP) upregulation Hum. Reprod. (IF 6.1) Pub Date : 2024-05-10 Yi Zhang, Ling-Ling Ruan, Ming-Rui Li, Lu Yao, Fang-Fang Li, You-Long Xie, Jing Tang, Qian Feng, Xiao-Yan Chen, Yu-Bin Ding, Li-Juan Fu
STUDY QUESTION Can exposure to palmitic acid (PA), a common saturated fatty acid, modulate autophagy in both human and mouse trophoblast cells through the regulation of acyl-coenzyme A-binding protein (ACBP)? SUMMARY ANSWER PA exposure before and during pregnancy impairs placental development through mechanisms involving placental autophagy and ACBP expression. WHAT IS KNOWN ALREADY High-fat diets
-
Trends in severe postpartum haemorrhage among nulliparous women with spontaneous onset of labour: A population‐based cohort study BJOG An Int. J. Obstet. Gynaecol. (IF 5.8) Pub Date : 2024-05-10 Camilla Tjønneland Mentzoni, Kari Klungsøyr, Hilde Marie Engjom
ObjectiveTo investigate the incidence of severe postpartum haemorrhage among nulliparous women with a spontaneous onset of labour at term from 2000 to 2020.DesignPopulation‐based cohort study.SettingNational, using the Medical Birth Registry of Norway.PopulationWomen (n = 330 244) who gave birth to their first singleton child in a cephalic presentation after a spontaneous onset of labour at term.M
-
Oral misoprostol alone, compared with oral misoprostol followed by oxytocin, in women induced for hypertension of pregnancy: A multicentre randomised trial BJOG An Int. J. Obstet. Gynaecol. (IF 5.8) Pub Date : 2024-05-10 Shuchita Mundle, Kate Lightly, Jill Durocher, Hillary Bracken, Moushmi Tadas, Seema Parvekar, Poonam Varma Shivkumar, Brian Faragher, Thomas Easterling, Simon Leigh, Mark Turner, Zarko Alfirevic, Beverly Winikoff, Andrew D. Weeks
ObjectiveTo assess whether, in those requiring continuing uterine stimulation after cervical ripening with oral misoprostol and membrane rupture, augmentation with low‐dose oral misoprostol is superior to intravenous oxytocin.DesignOpen‐label, superiority randomised trial.SettingGovernment hospitals in India.PopulationWomen who were induced for hypertensive disease in pregnancy and had undergone cervical
-
Phenotypes of maternal vascular malperfusion placental pathology and adverse pregnancy outcomes: A retrospective cohort study BJOG An Int. J. Obstet. Gynaecol. (IF 5.8) Pub Date : 2024-05-10 Rebecca L. Zur, Kelsey McLaughlin, Laura Aalto, Yidi Jiang, Ella Huszti, W. Tony Parks, John C. Kingdom
ObjectiveTo identify which components of maternal vascular malperfusion (MVM) pathology are associated with adverse pregnancy outcomes and to investigate the morphological phenotypes of MVM placental pathology and their relationship with distinct clinical presentations of pre‐eclampsia and/or fetal growth restriction (FGR).DesignRetrospective cohort study.SettingTertiary care hospital in Toronto, Canada
-
First-Trimester Ultrasound Screening in Routine Obstetric Practice. Obstet. Gynecol. (IF 7.2) Pub Date : 2024-05-09 Bryann Bromley, Lawrence D Platt
Technologic advances and ultrasonographer-physician experience in fetal imaging have led to significant improvements in our ability to distinguish between normal and abnormal fetal structural development in the latter part of the first trimester. As a critical component of pregnancy care, assessment of fetal anatomy at the end of the first trimester with a standardized imaging protocol should be offered
-
Long-Term Risk of Type 2 Diabetes After Preterm Delivery or Hypertensive Disorders of Pregnancy. Obstet. Gynecol. (IF 7.2) Pub Date : 2024-05-09 Casey Crump, Jan Sundquist, Kristina Sundquist
To examine long-term diabetes risk after preterm delivery or hypertensive disorders of pregnancy in a large population-based cohort.
-
Cannabidiol-Only Product Use in Pregnancy in the United States and Canada: Findings From the International Cannabis Policy Study. Obstet. Gynecol. (IF 7.2) Pub Date : 2024-05-09 Devika Bhatia, Sharonya Battula, Susan Mikulich-Gilbertson, Joseph Sakai, David Hammond
This study aimed to characterize pregnant individuals' use of cannabidiol (CBD). Data are from the International Cannabis Policy Study (2019-2021), a repeated cross-sectional survey of individuals aged 16-65 years in the United States and Canada (N=66,457 women, including 1,096 pregnant women). The primary analysis compared pregnant and nonpregnant women's CBD-only product use patterns and reasons
-
Metabolic imaging of human cumulus cells reveals associations with pregnancy and live birth Hum. Reprod. (IF 6.1) Pub Date : 2024-05-09 M Venturas, C Racowsky, D J Needleman
STUDY QUESTION Can fluorescence lifetime imaging microscopy (FLIM) detect associations between the metabolic state of cumulus cell (CC) samples and the clinical outcome of the corresponding embryos? SUMMARY ANSWER FLIM can detect significant variations in the metabolism of CC associated with the corresponding embryos that resulted in a clinical pregnancy versus those that did not. WHAT IS KNOWN ALREADY
-
Assessment of reproductive outcomes of fresh versus cryopreserved ejaculated sperm samples—a retrospective analysis of 44 423 oocyte donation ICSI cycles Hum. Reprod. (IF 6.1) Pub Date : 2024-05-09 María Gil Juliá, Mauro Cozzolino, Ana Navarro-Gomezlechon, Irene Hervas, Laura Mossetti, Rosa María Pacheco-Rendón, Rocio Rivera-Egea, Nicolas Garrido
STUDY QUESTION Does the use of frozen sperm affect live birth rate (LBR) and cumulative LBR (CLBR) compared to fresh sperm samples in oocyte donation ICSI cycles? SUMMARY ANSWER Although there were slight decreases in pregnancy rates (PRs) and LBR, as well as CLBR per embryo replaced and per embryo transfer (ET), when frozen sperm samples were used compared to fresh ejaculates, their clinical impact
-
Pregnancy and obstetric outcomes after fertility-sparing management of endometrial cancer and atypical hyperplasia: a multicentre cohort study Hum. Reprod. (IF 6.1) Pub Date : 2024-05-09 Radostina Vasileva, Henri Wohrer, Victor Gaultier, Margot Bucau, Hélène Courcier, Selima Ben Miled, Clementine Gonthier, Martin Koskas
STUDY QUESTION What are the pregnancy and obstetric outcomes in women with atypical hyperplasia (AH) or early-stage endometrial cancer (EC) managed conservatively for fertility preservation? SUMMARY ANSWER The study found a live birth rate of 62% in patients with AH or EC after conservative treatment, with higher level of labour induction, caesarean section, and post-partum haemorrhage. WHAT IS KNOWN
-
Maternal suicide up to 1 year postpartum: Evidence or emotion‐based medicine? BJOG An Int. J. Obstet. Gynaecol. (IF 5.8) Pub Date : 2024-05-09 Alain Braillon
-
Perceived health status after mid‐urethral sling revision in 287 women from the VIGI‐MESH registry: A cross‐sectional study BJOG An Int. J. Obstet. Gynaecol. (IF 5.8) Pub Date : 2024-05-09 Hugo Camilli, Brigitte Fatton, Elise Gand, Sandrine Campagne‐Loiseau, Renaud De Tayrac, Laurent Wagner, Christian Saussine, Jérôme Rigaud, Thibault Thubert, Xavier Deffieux, Michel Cosson, Philippe Ferry, Grégoire Capon, Laure Panel, Emmanuel Chartier‐Kastler, Tristan Gauthier, Xavier Game, Cassandra Bouynat, Romane Bichon, Arnaud Fauconnier, Anne‐Cécile Pizzoferrato, Xavier Fritel
ObjectiveTo evaluate the health status and recovery of women after mid‐urethral sling (MUS) revision in response to complications.DesignCross‐sectional study using a questionnaire sent to women from a registry.SettingTwenty‐two French surgical centres.PopulationA total of 287 women from the VIGI‐MESH registry responded, having undergone MUS revision for complications.MethodsOur sample of women were
-
Menopausal hormonal therapy and cardiovascular health BJOG An Int. J. Obstet. Gynaecol. (IF 5.8) Pub Date : 2024-05-08 Sabthagi Sivathasan, Jacqueline Hui
-
Improving trustworthiness in research on women's health: Some suggestions from a reviewer's viewpoint BJOG An Int. J. Obstet. Gynaecol. (IF 5.8) Pub Date : 2024-05-08 Shigeki Matsubara
-
Accuracy of Antenatal Ultrasound in Predicting Large for Gestational Age Babies: Population Based Cohort Study Am. J. Obstet. Gynecol. (IF 9.8) Pub Date : 2024-05-07 Lauren J. EWINGTON PhD, Oliver HUGH MSc, Emily BUTLER BSc (Hons), Siobhan QUENBY MD FRCOG, Jason GARDOSI MD FRCOG
Pregnancies with large for gestational age fetuses are at increased risk of adverse maternal and neonatal outcomes. There is uncertainty about how to manage birth in such pregnancies. Current guidelines recommend a discussion with women of the pros and cons of options including expectant management, induction of labour and caesarean birth. For women to be able to make an informed decision about birth
-
Pipelle Endometrial Sampling With a Full Bladder Compared With Standard Care: A Randomized Controlled Trial. Obstet. Gynecol. (IF 7.2) Pub Date : 2024-05-06 Erwina Hashim, Jesrine Hong, Yin Ling Woo, Mukhri Hamdan, Peng Chiong Tan
To compare insertion failure rates for Pipelle endometrial sampling with a full bladder compared with the standard process (not taking into account bladder status) without cervical manipulation.
-
Health Care Utilization by Patients With Chronic Pelvic Pain. Obstet. Gynecol. (IF 7.2) Pub Date : 2024-05-02 Isabel Green, Morgan Briggs, Diana Encalada Soto, Kristin Cole, Jenna Wygant, Tatnai Burnett, Xuan Zhu, Innie Chen, Lindsey R Sangaralingam, Viengneesee Thao
To describe the patterns of health care utilization among patients with chronic pelvic pain.
-
Surgical Field Separation in Total Laparoscopic Hysterectomy. Obstet. Gynecol. (IF 7.2) Pub Date : 2024-05-02 Raanan Meyer, Clarissa Niino, Rebecca Schneyer, Kacey Hamilton, Matthew T Siedhoff, Kelly N Wright
We aimed to study whether separating the vaginal and abdominal surgical fields during total laparoscopic hysterectomy (TLH) is associated with surgical site infection rates. This was a retrospective cohort study of all patients who underwent TLH and any concomitant procedures with two minimally invasive gynecologic surgery subspecialists between January 2016 and May 2023. Among 680 included patients
-
Assessment of a Decade of Change in U.S. Assisted Reproductive Technology Cumulative Live-Birth Rates: 2004-2009 Compared With 2014-2020. Obstet. Gynecol. (IF 7.2) Pub Date : 2024-05-02 Sarah F Wang, David B Seifer
To assess the effects of demographic shifts, changes in contemporaneous clinical practices, and technologic innovation on assisted reproductive technology (ART) success rates by conducting an analysis of cumulative live-birth rates across different time periods, age groups, and infertility diagnoses.
-
Differences in medically assisted reproduction use by sexual identity and partnership: a prospective cohort of cisgender women Hum. Reprod. (IF 6.1) Pub Date : 2024-05-01 Kodiak R S Soled, Tabor Hoatson, Brent Monseur, Bethany Everett, Payal Chakraborty, Colleen A Reynolds, Aimee K Huang, Sarah McKetta, Sebastien Haneuse, Brittany M Charlton
STUDY QUESTION Does medically assisted reproduction (MAR) use among cisgender women differ among those with same-sex partners or lesbian/bisexual identities compared to peers with different-sex partners or heterosexual identities? SUMMARY ANSWER Women with same-sex partners or lesbian/bisexual identities are more likely to utilize any MAR but are no more likely to use ART (i.e. IVF, reciprocal IVF
-
Global, regional, and national burden of premenstrual syndrome, 1990–2019: an analysis based on the Global Burden of Disease Study 2019 Hum. Reprod. (IF 6.1) Pub Date : 2024-05-01 Xingyu Liu, Ruyuan Li, Shixuan Wang, Jinjin Zhang
STUDY QUESTION What is the burden of premenstrual syndrome (PMS) at the global, regional, and national levels across 21 regions and 204 countries and territories? SUMMARY ANSWER Over the past few decades, the global prevalent cases of PMS have grown significantly from 652.5 million in 1990 to 956.0 million in 2019, representing a 46.5% increase. WHAT IS KNOWN ALREADY PMS, which affects almost half
-
Parents’ disclosure to their donor-conceived children in the last 10 years and factors affecting disclosure: a narrative review Hum. Reprod. Update (IF 13.3) Pub Date : 2024-04-30 Michelle A Duff, Sonja Goedeke
BACKGROUND Disclosure of donor conception has been advocated in several jurisdictions in recent years, especially in those that practice identity-release donation. However, research on disclosure decisions has not been consolidated systematically in the last 10 years to review if parents are telling and what factors may be impacting their decisions. OBJECTIVE AND RATIONALE Are parents disclosing to
-
Chemicals in menstrual products: Biological plausibility should be combined with epidemiological evidence to define the magnitude of exposure BJOG An Int. J. Obstet. Gynaecol. (IF 5.8) Pub Date : 2024-04-30 Paolo Vercellini, Paola Viganò, Edgardo Somigliana, Sun‐Wei Guo
-
Burden and outcomes of postpartum haemorrhage in Nigerian referral‐level hospitals BJOG An Int. J. Obstet. Gynaecol. (IF 5.8) Pub Date : 2024-04-30 Tajudeen Adebayo, Ayodeji Adefemi, Idowu Adewumi, Opeyemi Akinajo, Bola Akinkunmi, David Awonuga, Olufemi Aworinde, Ekundayo Ayegbusi, Iyabode Dedeke, Iretiola Fajolu, Zainab Imam, Olusoji Jagun, Olumide Kuku, Ezra Ogundare, Timothy Oluwasola, Lawal Oyeneyin, Damilola Adebanjo‐Aina, Emmanuel Adenuga, Alaruru Adeyanju, Olufemi Akinsanya, Ibijoke Campbell, Bankole Kuti, Babatunde Olofinbiyi, Qasim Salau
ObjectiveTo determine the prevalence of primary postpartum haemorrhage (PPH), risk factors, and maternal and neonatal outcomes in a multicentre study across Nigeria.DesignA secondary data analysis using a cross‐sectional design.SettingReferral‐level hospitals (48 public and six private facilities).PopulationWomen admitted for birth between 1 September 2019 and 31 August 2020.MethodsData collected over
-
The mammalian sperm factor phospholipase C zeta is critical for early embryo division and pregnancy in humans and mice Hum. Reprod. (IF 6.1) Pub Date : 2024-04-27 Junaid Kashir, Bhavesh V Mistry, Mohamed A Rajab, Lujain BuSaleh, Raed Abu-Dawud, Hala A Ahmed, Sarah Alharbi, Michail Nomikos, Saad AlHassan, Serdar Coskun, Abdullah M Assiri
STUDY QUESTION Are sperm phospholipase C zeta (PLCζ) profiles linked to the quality of embryogenesis and pregnancy? SUMMARY ANSWER Sperm PLCζ levels in both mouse and humans correlate with measures of ideal embryogenesis whereby minimal levels seem to be required to result in successful pregnancy. WHAT IS KNOWN ALREADY While causative factors underlying male infertility are multivariable, cases are
-
-
Definition of unexplained infertility and career choice of obstetrics and gynaecology for medical students BJOG An Int. J. Obstet. Gynaecol. (IF 5.8) Pub Date : 2024-04-26 Patrick Chien
Deputy Editor‐in‐Chief, Dr Patrick Chien, discusses his top articles from this issue in an audio podcast available at: https://soundcloud.com/bjog/June‐editorial‐2024
-
Regenerative Medicine in Gynecology. Obstet. Gynecol. (IF 7.2) Pub Date : 2024-04-25 Julia L Balough, Pamela Moalli
The female reproductive tract undergoes dynamic changes across the life span. Congenital abnormalities, life events, and medical interventions can negatively affect the structure and function of reproductive tract organs, resulting in lifelong sequelae. The objective of regenerative gynecology is to discover and promote endogenous mechanisms by which a healthy tissue maintains overall tissue integrity
-
Evaluation of Sleep in Pregnant Inpatients Compared With Outpatients. Obstet. Gynecol. (IF 7.2) Pub Date : 2024-04-25 Danielle M Panelli, Hayley E Miller, Samantha L Simpson, Janet Hurtado, Chi-Hung Shu, Ana C Boncompagni, Jane Chueh, Fiona Barwick, Brendan Carvalho, Pervez Sultan, Nima Aghaeepour, Maurice L Druzin
To evaluate whether antepartum hospitalization was associated with differences in sleep duration or disrupted sleep patterns.
-
Urine high‐risk human papillomavirus testing as an alternative to routine cervical screening: A comparative diagnostic accuracy study of two urine collection devices using a randomised study design trial BJOG An Int. J. Obstet. Gynaecol. (IF 5.8) Pub Date : 2024-04-25 Jennifer C. Davies, Alexandra Sargent, Elisabeth Pinggera, Suzanne Carter, Clare Gilham, Peter Sasieni, Emma J. Crosbie
ObjectiveTo evaluate the sensitivity of human papillomavirus (HPV) tested urine to detect high‐grade cervical precancer (cervical intraepithelial neoplasia grade 2+ [CIN2+]) using two urine collection devices.DesignRandomised controlled trial.SettingSt Mary's Hospital, Manchester, UK.PopulationColposcopy attendees with abnormal cervical screening; a total of 480 participants were randomised. Matched
-
Treatment methods for cervical intraepithelial neoplasia in England: A cost‐effectiveness analysis BJOG An Int. J. Obstet. Gynaecol. (IF 5.8) Pub Date : 2024-04-25 Michela Tinelli, Antonios Athanasiou, Areti Angeliki Veroniki, Orestis Efthimiou, Ilkka Kalliala, Sarah Bowden, Maria Paraskevaidi, Deirdre Lyons, Pierre Martin‐Hirsch, Phillip Bennett, Evangelos Paraskevaidis, Georgia Salanti, Maria Kyrgiou, Huseyin Naci
ObjectiveTo compare the cost‐effectiveness of different treatments for cervical intraepithelial neoplasia (CIN).DesignA cost‐effectiveness analysis based on data available in the literature and expert opinion.SettingEngland.PopulationWomen treated for CIN.MethodsWe developed a decision‐analytic model to simulate the clinical course of 1000 women who received local treatment for CIN and were followed
-
Planned oocyte cryopreservation: a systematic review and meta-regression analysis Hum. Reprod. Update (IF 13.3) Pub Date : 2024-04-24 Ayala Hirsch, Bruria Hirsh Raccah, Reut Rotem, Jordana H Hyman, Ido Ben-Ami, Avi Tsafrir
BACKGROUND Awareness of the age-related decline in fertility potential has increased the popularity of planned oocyte cryopreservation (POC). However, data regarding outcomes of POC, including rates of women returning to thaw oocytes, as well as pregnancy and live birth rates, are scarce and based mostly on small case series. OBJECTIVE AND RATIONALE POC was defined as cryopreservation exclusively for
-
Intrapartum electronic fetal heart rate monitoring to predict acidemia at birth with the use of deep learning Am. J. Obstet. Gynecol. (IF 9.8) Pub Date : 2024-04-24 Jennifer A. McCoy MD MSCE, Lisa D. Levine MD MSCE, Guangya Wan MS, Corey Chivers PhD, Joseph Teel MD, William G. La Cava PhD
Electronic fetal monitoring is used in most US hospital births but has significant limitations in achieving its intended goal of preventing intrapartum hypoxic-ischemic injury. Novel deep learning techniques can improve complex data processing and pattern recognition in medicine. This study aimed to apply deep learning approaches to develop and validate a model to predict fetal acidemia from electronic
-
Linzagolix therapy versus a placebo in patients with endometriosis-associated pain: a prospective, randomized, double-blind, Phase 3 study (EDELWEISS 3) Hum. Reprod. (IF 6.1) Pub Date : 2024-04-22 Jacques Donnez, Christian Becker, Hugh Taylor, Francisco Carmona Herrera, Olivier Donnez, Andrew Horne, Maciej Paszkowski, Felice Petraglia, Stefan P Renner, Amisha Patel, Mitra Boolell, Elke Bestel, Marie-Madeleine Dolmans
STUDY QUESTION Does linzagolix administered orally once daily for up to 3 months at a dose of 75 mg alone or 200 mg in combination with add-back therapy (ABT) (1.0 mg estradiol; 0.5 mg norethindrone acetate, also known as norethisterone acetate [NETA]) demonstrate better efficacy than placebo in the management of endometriosis-related dysmenorrhea and non-menstrual pelvic pain? SUMMARY ANSWER Combining
-
The long‐term impact of vaginal surgical mesh devices on pain clinic and psychological service referrals, anti‐inflammatory testing and pelvic scans in UK primary care: A cohort study with the Clinical Practice Research Datalink BJOG An Int. J. Obstet. Gynaecol. (IF 5.8) Pub Date : 2024-04-22 Emily McFadden, Carl Heneghan
ObjectiveTo examine long‐term complications in women with stress urinary incontinence (SUI) and pelvic organ prolapse (POP), with and without surgical mesh implants.DesignLongitudinal open cohort study from 1 April 2006 (or 1 April 2012) to 30 November 2018.SettingThe Clinical Practice Research Datalink (CPRD) Gold database, which is linked to Hospital Episodes Statistics (HES) inpatient data, the
-
Embryos don’t care if the sperm is there—intravaginal semen deposition does not increase pregnancy rates in in vitro fertilization Fertil. Steril. (IF 6.7) Pub Date : 2024-04-20 Sara C. Pierpoint M.D., Linnea R. Goodman M.D.
-
Implementation of perinatal quality collaborative statewide initiative improves obstetrical opioid use disorder care and outcomes Am. J. Obstet. Gynecol. (IF 9.8) Pub Date : 2024-04-19 Patricia A. Lee King PhD, SuYeon Lee PhD, Dan Weiss MPH, David Aaby MS, Tamela Milan-Alexander MPPA, Ann E.B. Borders MD MSc MPH
Maternal deaths resulting from opioid use disorder have been increasing across the United States. Opioid use disorder among pregnant persons is associated with adverse pregnancy outcomes, including preterm birth, along with racial disparities in optimal opioid use disorder care. This study aimed to evaluate whether the Illinois Perinatal Quality Collaborative implementation of the Mothers and Newborns
-
Preoperative prolapse phenotype is predictive of surgical outcome with minimally invasive sacrocolpopexy Am. J. Obstet. Gynecol. (IF 9.8) Pub Date : 2024-04-18 Jerry L. Lowder MD MSc, Peinan Zhao PhD, Megan S. Bradley MD, Lauren E. Giugale MD, Haonan Xu MS, Steven D. Abramowitch PhD, Philip V. Bayly PhD
The gold-standard treatment for advanced pelvic organ prolapse is sacrocolpopexy. However, the preoperative features of prolapse that predict optimal outcomes are unknown. This study aimed to develop a clinical prediction model that uses preoperative scores on the Pelvic Organ Prolapse Quantification examination to predict outcomes after minimally invasive sacrocolpopexy for stages 2, 3, and 4 uterovaginal
-
Obstetric Complications and Birth Outcomes After Antenatal Coronavirus Disease 2019 (COVID-19) Vaccination. Obstet. Gynecol. (IF 7.2) Pub Date : 2024-04-17 Kimberly K Vesco, Anna E Denoble, Heather S Lipkind, Elyse O Kharbanda, Malini B DeSilva, Matthew F Daley, Darios Getahun, Ousseny Zerbo, Allison L Naleway, Lisa Jackson, Joshua T B Williams, Thomas G Boyce, Candace C Fuller, Eric S Weintraub, Gabriela Vazquez-Benitez
To evaluate the association between antenatal messenger RNA (mRNA) coronavirus disease 2019 (COVID-19) vaccination and risk of adverse pregnancy outcomes.
-
Syphilis Treatment Among People Who Are Pregnant in Six U.S. States, 2018-2021. Obstet. Gynecol. (IF 7.2) Pub Date : 2024-04-17 Ayzsa Tannis, Kathryn Miele, Jeffrey M Carlson, Kevin P O'Callaghan, Kate R Woodworth, Breanne Anderson, Aisha Praag, Kourtney Pulliam, Nicole Coppola, Teri' Willabus, Deborah Mbotha, Dejene Abetew, Salvatore Currenti, Nicole D Longcore, Amanda Akosa, Dana Meaney-Delman, Van T Tong, Suzanne M Gilboa, Emily O Olsen
To describe syphilis treatment status and prenatal care among people with syphilis during pregnancy to identify missed opportunities for preventing congenital syphilis.
-
Is micronized vaginal progesterone effective for the prevention of preeclampsia in twin pregnancies? Am. J. Obstet. Gynecol. (IF 9.8) Pub Date : 2024-04-16 Odai Yaghi MBBS MD, Smriti Prasad MD, Holly Boorman MBBS, Erkan Kalafat MD, Asma Khalil MBBCH MD FRCOG
-
Drug-Induced Liver Injury in Pregnancy: The U.S. Drug-Induced Liver Injury Network Experience. Obstet. Gynecol. (IF 7.2) Pub Date : 2024-04-16 Umair Masood, Nicholas Venturini, Paola Nicoletti, Andrew Dellinger, David Kleiner, Herbert L Bonkovsky, Huiman Barnhart, Raj Vuppalanchi, Simona Rossi, Joseph A Odin, Tatyana Kushner
There are limited data on the causative agents and characteristics of drug-induced liver injury in pregnant individuals. Data from patients with drug-induced liver injury enrolled in the ongoing multicenter Drug-Induced Liver Injury Network between 2004 and 2022 and occurring during pregnancy or 6 months postpartum were reviewed and compared with cases of drug-induced liver injury in nonpregnant women
-
Neurologic Emergencies in Pregnancy. Obstet. Gynecol. (IF 7.2) Pub Date : 2024-04-16 Shaun R Wesley, G Edward Vates, Loralei L Thornburg
Neurologic emergencies in pregnancy require prompt evaluation and early, focused intervention to improve neurologic outcomes for the affected person and to avoid further injury. Neurologic events in pregnancy, although rare, present a time of extreme risk of permanent injury for the person who is pregnant. Therefore, obstetric clinicians should be well versed in the risk factors for potential neurologic
-
National Postpartum Permanent Contraception Practices and Perceived Barriers. Obstet. Gynecol. (IF 7.2) Pub Date : 2024-04-16 Ellen Murphy, Andrea Pelletier, Kathryn Fay, Deborah Bartz
Single institution-level studies have demonstrated low postpartum permanent contraception fulfillment rates after vaginal birth. To explore the national scope of the problem, we collected cross-sectional survey data from faculty at 109 U.S. academic medical centers to elicit perceptions about postpartum permanent contraception practices after vaginal birth, including barriers to and changes in practice
-
Pathophysiology and Clinical Implications of Ovarian Endometriomas. Obstet. Gynecol. (IF 7.2) Pub Date : 2024-04-16 Farr R Nezhat, Ann M Cathcart, Ceana H Nezhat, Camran R Nezhat
Ovarian endometriomas affect many patients with endometriosis and have significant effects on quality of life, fertility, and risk of malignancy. Endometriomas range from small (1-3 cm), densely fibrotic cysts to large (20 cm or greater) cysts with varying degrees of fibrosis. Endometriomas are hypothesized to form from endometriotic invasion or metaplasia of functional cysts or alternatively from
-
Classification and treatment of vaginal strictures at the donor-recipient anastomosis after uterus transplant Fertil. Steril. (IF 6.7) Pub Date : 2024-04-16 Liza Johannesson M.D. Ph.D., Leigh A. Humphries M.D., Paige M. Porrett M.D. Ph.D., Giuliano Testa M.D., Sophie Anderson, Jessica R. Walter M.D., Margaret Rush M.D., Cecile A. Ferrando M.D. M.P.H., Kathleen O’Neill M.D., Elliott G. Richards M.D. Ph.D.
To describe the incidence and management of vaginal stricture after uterus transplantation (UTx) in the US, to propose a grading system to classify stricture severity, and to identify risk factors for stricture formation. Prospective cohort study. University Hospital. Recipients undergoing UTx from 2016–2023 at Baylor University Medical Center in Dallas, Cleveland Clinic, the University of Pennsylvania
-
Laparoscopic removal of heterotopic cesarean scar pregnancy Fertil. Steril. (IF 6.7) Pub Date : 2024-04-16 Hakan Guraslan M.D., Ozlem K. Akgul M.D., Dogan E. Aydin M.D., Evrim E. Kovalak M.D., Nursen K. Aksoy M.D., Tugba O. Aydin M.D.
To present the laparoscopic management of heterotopic cesarean scar pregnancy and discuss other treatment options. Surgical video article. The Institutional Ethics Committee approved the video reproduction. Tertiary referral to a university hospital A 29-year-old woman with spontaneous heterotopic cesarean scar pregnancy presented for vaginal spotting. Ultrasound revealed two gestational sacs at 7
-
Surfing a shallow wave? Improving the scientific foundations for new contraceptive compounds targeting sperm in the human female reproductive tract Fertil. Steril. (IF 6.7) Pub Date : 2024-04-16 Steven A. Gellatly Ph.D., Michael L. Eisenberg M.D., Christopher L.R. Barratt Ph.D.