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The value‐for money of preventing and managing periodontitis: Opportunities and challenges Periodontol. 2000 (IF 18.6) Pub Date : 2024-05-15 Madhuri Pattamatta, Iain Chapple, Stefan Listl
This article gives an overview of the societal and economic aspects of periodontitis and periodontal care. Despite its largely preventable nature, periodontitis is highly prevalent worldwide and imposes a substantial health and economic burden on individuals and society as a whole. The worldwide estimated direct treatment costs and productivity losses due to periodontitis (including for periodontitis‐related
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Oral microbiota of patients with phenylketonuria: A nation‐based cross‐sectional study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-05-15 Memduh Bingöl, Alessio Cardilli, Anne Carolin Bingöl, Ulrike Löber, Corinna Bang, Andre Franke, Theodosia Bartzela, Skadi Beblo, Eberhard Mönch, Simone Stolz, Arne S. Schaefer, Sofia Kirke Forslund, Gesa M. Richter
AimThe oral microenvironment contributes to microbial composition and immune equilibrium. It is considered to be influenced by dietary habits. Phenylketonuria (PKU) patients, who follow a lifelong low‐protein diet, exhibit higher prevalence of oral diseases such as periodontitis, offering a suitable model to explore the interplay between diet, oral microbiota and oral health.Materials and MethodsWe
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Peri‐implantitis and maxillary sinus membrane thickening: A retrospective cohort study Clin. Oral. Implants Res. (IF 4.3) Pub Date : 2024-05-15 Ramón Pons, María Giralt, José Nart, Beatriz de Tapia, Federico Hernández‐Alfaro, Alberto Monje
ObjectiveThe objective of this study is to investigate the association of peri‐implantitis (PI) and sinus membrane thickening and to assess the resolution of membrane thickening following intervention (implant removal or peri‐implantitis treatment) aimed at arresting PI.Materials and MethodsForty‐five patients with 61 implants in the posterior maxillary region were retrospectively included in the study
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Comparing the modified socket‐shield technique with the conventional immediate implantation technique in the anterior dentition: A 5‐year retrospective clinical study Clin. Oral. Implants Res. (IF 4.3) Pub Date : 2024-05-15 Xingfu Li, Xinhan Li, Yamei Xu, Gang Fu, Hong Huang
AimsThe aim of this retrospective clinical study was to compare the 5‐year radiological and clinical outcomes of patients undergoing immediate implantation with or without the modified socket‐shield technique.Materials and MethodsPatients who underwent anterior tooth replacement via the modified socket‐shield technique (MSST) or the conventional immediate implantation technique (CIIT) between 2016
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Ultrasound‐based jawbone surface quality evaluation after alveolar ridge preservation J. Periodontol. (IF 4.3) Pub Date : 2024-05-14 Amanda B. Rodriguez, Oliver D. Kripfgans, Kenneth M. Kozloff, Ankita Samal, Jae‐man Woo, Mostafa Shehabeldin, Hsun‐Liang Chan
BackgroundBone readiness for implant placement is typically evaluated by bone quality/density on 2‐dimensional radiographs and cone beam computed tomography at an arbitrary time between 3 and 6 months after tooth extraction and alveolar ridge preservation (ARP). The aim of this study is to investigate if high‐frequency ultrasound (US) can classify bone readiness in humans, using micro‐CT as a reference
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Peri‐implant diseases and systemic inflammation: A preliminary analysis from a cross‐sectional survey of patients with hypertension J. Periodontol. (IF 4.3) Pub Date : 2024-05-14 Marco Orlandi, Nicola Pranno, Vipul Patel, Piero Papi, Bianca Di Murro, Giorgio Pompa, Antonella Polimeni, Claudio Letizia, Jeanie Suvan, Francesco D'Aiuto
BackgroundThe aim of this study was to investigate the association between peri‐implant diseases and systemic inflammation assessed by serum C‐reactive protein (CRP) levels in a sample of patients with hypertension.MethodsA total of 151 participants with hypertension were included in a cross‐sectional study. The population was divided into six groups according to their peri‐implant and periodontal
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Survival rate of teeth adjacent and nonadjacent to dental implants: A retrospective cohort study J. Periodontol. (IF 4.3) Pub Date : 2024-05-14 Hsuan‐Hung Chen, Guo‐Hao Lin, Richard T. Kao, Yu‐Ting Yeh
BackgroundThe aim of this retrospective study was to investigate the risk of tooth loss for teeth adjacent and nonadjacent to dental implants.MethodsA total of 787 patients with an average follow‐up of 57.1 months were examined to define the tooth loss, cumulative survival rate, and odds ratio (OR) for teeth adjacent versus nonadjacent to implants. A multivariate logistic regression was employed to
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Unveiling the oral-gut connection: chronic apical periodontitis accelerates atherosclerosis via gut microbiota dysbiosis and altered metabolites in apoE−/− Mice on a high-fat diet Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-05-13 Guowu Gan, Shihan Lin, Yufang Luo, Yu Zeng, Beibei Lu, Ren Zhang, Shuai Chen, Huaxiang Lei, Zhiyu Cai, Xiaojing Huang
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Human dental pulp stem cells mitigate the neuropathology and cognitive decline via AKT-GSK3β-Nrf2 pathways in Alzheimer’s disease Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-05-13 Wei Xiong, Ye Liu, Heng Zhou, Junyi Li, Shuili Jing, Cailei Jiang, Mei Li, Yan He, Qingsong Ye
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Polarized M2 macrophages induced by glycosylated nano‐hydroxyapatites activate bone regeneration in periodontitis therapy J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-05-13 Dan Qiao, Shuyu Cheng, Shiyuan Song, Wen Zhang, Bin Chen, Fuhua Yan, Yangheng Zhang
AimTo investigate the association between periodontal macrophage polarization states and the alveolar bone levels, and to assess whether glycosylated nano‐hydroxyapatites (GHANPs) could improve bone regeneration in periodontitis by inducing macrophage M2 polarization.Materials and MethodsThe change of macrophage polarization state in inflammatory periodontal tissues (with bone loss) was examined using
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A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-05-11 William Macalester, Asme Boussahel, Rafael O. Moreno-Tortolero, Mark R. Shannon, Nicola West, Darryl Hill, Adam Perriman
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Sinensetin protects against periodontitis through binding to Bach1 enhancing its ubiquitination degradation and improving oxidative stress Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-05-11 Zhiyao Yuan, Junjie Li, Fuyu Xiao, Yu Wu, Zhiting Zhang, Jiahong Shi, Jun Qian, Xudong Wu, Fuhua Yan
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m1A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signaling Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-05-10 Shujin Li, Tian Feng, Yuantong Liu, Qichao Yang, An Song, Shuo Wang, Jun Xie, Junjie Zhang, Bifeng Yuan, Zhijun Sun
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Systematic Review of Prognosis Models in Predicting Tooth Loss in Periodontitis J. Dent. Res. (IF 7.6) Pub Date : 2024-05-10 D.Y. Chow, J.R.H. Tay, G.G. Nascimento
This study reviews and appraises the methodological and reporting quality of prediction models for tooth loss in periodontitis patients, including the use of regression and machine learning models. Studies involving prediction modeling for tooth loss in periodontitis patients were screened. A search was performed in MEDLINE via PubMed, Embase, and CENTRAL up to 12 February 2022, with citation chasing
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Contemporary educational methods in periodontology J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-05-10 Philip M. Preshaw, Christoph A. Ramseier, Bruno G. Loos, Aušra Balčiūnaitė, Tin Crnić, Kevin Davey, Henrik Dommisch, Johanna B. Ettmayer, Anthony Roberts, E. Etienne Verheijck, Clemens Walter, Graziano Zappalà
AimThe 1st European Workshop on Periodontal Education in 2009 made recommendations regarding the scope of periodontal education at undergraduate (UG), postgraduate (PG) and continuing professional development (CPD) levels, defining competencies and learning outcomes that were instrumental at the time in helping to define periodontal teaching curricula. The 19th European Workshop on Periodontology and
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Associations between periodontitis and serum anti‐malondialdehyde–acetaldehyde antibody concentrations in rheumatoid arthritis: A case‐control study J. Periodontol. (IF 4.3) Pub Date : 2024-05-10 Joyce A. Lee, Ted R. Mikuls, Harlan R. Sayles, Geoffrey M. Thiele, Michael J. Duryee, Jeffrey B. Payne
BackgroundMalondialdehyde–acetaldehyde (MAA) adducts lead to generation of anti‐MAA autoantibodies and have been independently identified in inflamed periodontal and rheumatoid arthritis (RA) tissues. This study evaluates serum samples from RA cases and osteoarthritis (OA) controls to quantify associations between periodontal clinical measures, alveolar bone loss (ABL), and anti‐Porphyromonas gingivalis
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Mouse Models for Head and Neck Squamous Cell Carcinoma J. Dent. Res. (IF 7.6) Pub Date : 2024-05-09 J. Zhou, C. Liu, P. Amornphimoltham, S.C. Cheong, J.S. Gutkind, Q. Chen, Z. Wang
The prognosis and survival rate of head and neck squamous cell carcinoma (HNSCC) have remained unchanged for years, and the pathogenesis of HNSCC is still not fully understood, necessitating further research. An ideal animal model that accurately replicates the complex microenvironment of HNSCC is urgently needed. Among all the animal models for preclinical cancer research, tumor-bearing mouse models
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Harold C. Slavkin: A Transformative Leader of Our Times J. Dent. Res. (IF 7.6) Pub Date : 2024-05-09 D.V. Kleinman, M.C. Alfano, Y. Chai, R.N. D’Souza
Harold (Hal) C. Slavkin, DDS, the 22nd president of the American Association for Dental, Oral, and Craniofacial Research (1993 to 1994), died on December 22, 2023. During a career that spanned almost 6 decades, Hal distinguished himself as an international authority on craniofacial biology and an advocate for oral health equity. He served as dean of the University of Southern California’s dental school
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Fully automatic AI segmentation of oral surgery-related tissues based on cone beam computed tomography images Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-05-08 Yu Liu, Rui Xie, Lifeng Wang, Hongpeng Liu, Chen Liu, Yimin Zhao, Shizhu Bai, Wenyong Liu
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Phenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-05-08 Dexuan Zhuang, Shuangshuang Wang, Huiting Deng, Yuxin Shi, Chang Liu, Xue Leng, Qun Zhang, Fuxiang Bai, Bin Zheng, Jing Guo, Xunwei Wu
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Fissure Sealants or Fluoride Varnish? A Randomized Pragmatic Split-Mouth Trial J. Dent. Res. (IF 7.6) Pub Date : 2024-05-08 M.-M. Uhlen-Strand, L. Stangvaltaite-Mouhat, I. Mdala, I. Volden Klepaker, N.J. Wang, R. Skudutyte-Rysstad
This study aimed to compare the clinical effectiveness of resin-based fissure sealants (FS) and fluoride varnish (FV) in children at high caries risk. A practice-based split-mouth randomized clinical trial was conducted at 9 Public Dental Service (PDS) clinics in Norway. In total, 409 children age 6 to 10 y at high caries risk (d3mft > 0) meeting inclusion criteria were recruited by dentists and dental
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Neovascularization by DPSC-ECs in a Tube Model for Pulp Regeneration Study J. Dent. Res. (IF 7.6) Pub Date : 2024-05-08 Y. Zhang, J. Liu, I.J. de Souza Araujo, L. Bahammam, L.L. Munn, G.T.J. Huang
The process of neovascularization during cell-based pulp regeneration is difficult to study. Here we developed a tube model that simulates root canal space and allows direct visualization of the vascularization process in vitro. Endothelial-like cells (ECs) derived from guiding human dental pulp stem cells (DPSCs) into expressing endothelial cell markers CD144, vWF, VEGFR1, and VEGFR2 were used. Human
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ENAM Mutations Can Cause Hypomaturation Amelogenesis Imperfecta J. Dent. Res. (IF 7.6) Pub Date : 2024-05-08 Y.-L. Wang, H.-C. Lin, T. Liang, J.C.-Y. Lin, J.P. Simmer, J.C.-C. Hu, S.-K. Wang
Amelogenesis imperfecta (AI) is a diverse group of inherited diseases featured by various presentations of enamel malformations that are caused by disturbances at different stages of enamel formation. While hypoplastic AI suggests a thickness defect of enamel resulting from aberrations during the secretory stage of amelogenesis, hypomaturation AI indicates a deficiency of enamel mineralization and
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RNA Technology to Regenerate and Repair Alveolar Bone Defects J. Dent. Res. (IF 7.6) Pub Date : 2024-05-08 D. Su, S. Swearson, S. Eliason, K.G. Rice, B.A. Amendt
microRNA-200a ( miR-200a) targets multiple signaling pathways that are involved in osteogenic differentiation and bone development. However, its therapeutic function in osteogenesis and bone regeneration remains unknown. In this study, we use in vitro and in vivo models to investigate the molecular function of miR-200a overexpression and miR-200a inhibition using a plasmid-based miR inhibitor system
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Minimally invasive non‐surgical periodontal therapy of intrabony defects: A prospective multi‐centre cohort study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-05-07 Jaimini Mehta, Marco Montevecchi, Ruben Garcia‐Sanchez, Olanrewaju Onabolu, Antonio Liñares, Fernando Eriksson, Carlo Ghezzi, Camilla Donghi, Emily Ming‐Chieh Lu, Luigi Nibali
AimTo assess the potential benefits of minimally invasive non‐surgical therapy (MINST) in teeth with intrabony defects and to explore factors associated with the outcomes.Materials and MethodsA multi‐centre trial was conducted in 100 intrabony defects in periodontitis patients in private practice. Steps 1 and 2 periodontal therapy including MINST were provided. Clinical and radiographic data were analysed
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Three‐dimensional imaging analysis of CAD/CAM custom‐milled versus prefabricated allogeneic block remodelling at 6 months and long‐term follow‐up of dental implants: A retrospective cohort study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-05-07 Anna Seidel, Yago Leira, Pilar Batalla, Leticia Caneiro, Manfred Wichmann, Juan Blanco
AimThis retrospective cohort study aimed to volumetrically investigate the bone stability rate of prefabricated allogeneic bone blocks (PBB) and computer‐aided design (CAD)/computer‐aided manufacturing (CAM) custom‐milled allogeneic bone blocks (CCBB) for ridge augmentation.Materials and MethodsNineteen patients were treated with 20 allografts: 11 CCBB, 9 PBB; 10 in the maxilla and 10 in the mandible
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Change in clinical parameters after subgingival instrumentation for the treatment of periodontitis and timing of periodontal re‐evaluation: A systematic review and meta‐analysis J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-05-06 Lucrezia Paternò Holtzman, Nicola Alberto Valente, Gianluca Vittorini Orgeas, Luca Copes, Nicola Discepoli, Marco Clementini
AimTo evaluate the changes in periodontal parameters (reduction in probing pocket depth [PPD], gain in clinical attachment level [CAL] and reduction in full‐mouth bleeding on probing [BoP]) after subgingival instrumentation of periodontal pockets at different time points in systemically healthy patients suffering from periodontitis.Materials and MethodsFour databases were searched for RCTs that carried
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Dynamic analyses of a soft tissue–implant interface: Biological responses to immediate versus delayed dental implants J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-05-06 Fabiana Aellos, Joseph A. Grauer, Kasidy G. Harder, Julia S. Dworan, Giacomo Fabbri, Pedro L. Cuevas, Xue Yuan, Bo Liu, John B. Brunski, Jill A. Helms
AimTo qualitatively and quantitatively evaluate the formation and maturation of peri‐implant soft tissues around ‘immediate’ and ‘delayed’ implants.Materials and MethodsMiniaturized titanium implants were placed in either maxillary first molar (mxM1) fresh extraction sockets or healed mxM1 sites in mice. Peri‐implant soft tissues were evaluated at multiple timepoints to assess the molecular mechanisms
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Angiogenic potential in periodontal stem cells from upper and lower jaw: A pilot study J. Periodontol. (IF 4.3) Pub Date : 2024-05-06 Hanna Malyaran, Chloé Radermacher, Rogerio B. Craveiro, Mark P. Kühnel, Danny Jonigk, Michael Wolf, Sabine Neuss
BackgroundTeeth and supporting oral tissues are attractive and accessible sources of stem cells. Periodontal ligament stem cells (PDLSC) are readily isolated from extracted third molars, and exhibit the ability to self‐renew and differentiate into multiple mesodermal cell fates. Clinical experience suggests that the exact location of periodontal defects affects the oral bone remodeling and wound healing
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Inflammation and tissue remodeling mediator expression during gingivitis: A comparison between experimental, naturally occurring gingivitis, and periodontal health J. Periodontol. (IF 4.3) Pub Date : 2024-05-06 Yung‐Ting Hsu, Ana M. Chang, Diane Daubert, Frank Roberts, Dandan Chen, Harsh M. Trivedi, Juliana Gomez, Rich P. Darveau
BackgroundThe aim of this study is to evaluate the immune regulation and tissue remodeling responses during experimental gingivitis (EG) and naturally occurring gingivitis (NG) to provide a comprehensive analysis of host responses. Gingival crevicular fluid (GCF) was obtained from 2 human studies conducted in university settings.MethodsThe EG study enrolling 26 volunteers provided controls for the
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Photobiomodulation of Gingival Cells Challenged with Viable Oral Microbes J. Dent. Res. (IF 7.6) Pub Date : 2024-05-03 J. Tanum, H.E. Kim, S.M. Lee, A. Kim, J. Korostoff, G. Hwang
The oral cavity, a unique ecosystem harboring diverse microorganisms, maintains health through a balanced microflora. Disruption may lead to disease, emphasizing the protective role of gingival epithelial cells (GECs) in preventing harm from pathogenic oral microbes. Shifting GECs’ response from proinflammatory to antimicrobial could be a novel strategy for periodontitis. Photobiomodulation therapy
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Are periodontitis and psoriasis associated? A pre‐clinical murine model J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-05-03 Crystal Marruganti, Carlo Gaeta, Chiara Falciani, Elisa Cinotti, Pietro Rubegni, Mario Alovisi, Nicola Scotti, Andrea Baldi, Cristiana Bellan, Chiara Defraia, Fabio Fiorino, Silvia Valensin, Erika Bellini, Antonella De Rosa, Francesco D'Aiuto, Simone Grandini
AimTo investigate the bidirectional influence between periodontitis and psoriasis, using the respective experimental models of ligature‐ and imiquimod‐induced diseases on murine models.Materials and MethodsThirty‐two C57/BL6J mice were randomly allocated to four experimental groups: control (P− Pso−), ligature‐induced periodontitis (P+ Pso−), imiquimod‐induced psoriasis (P− Pso+) and periodontitis
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Systemic antibiotics in the surgical treatment of peri‐implantitis: A randomized placebo‐controlled trial J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-05-03 Caroline Riben Grundström, Bodil Lund, Johan Kämpe, Georgios N. Belibasakis, Margareta Hultin
AimTo study the clinical, radiographic and microbiological outcomes after surgical treatment of peri‐implantitis, with or without adjunctive systemic antibiotics.Materials and MethodsEighty‐four patients (113 implants) with peri‐implantitis were randomized into three groups (A, amoxicillin and metronidazole; B, phenoxymethylpenicillin and metronidazole; or C, placebo). Treatment included resective
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The economic and societal impact of periodontal and peri‐implant diseases Periodontol. 2000 (IF 18.6) Pub Date : 2024-05-02 Muhammad H. A. Saleh, Debora R. Dias, Purnima Kumar
Periodontal and peri‐implant diseases result from a chronic inflammatory response to dysbiotic microbial communities and are characterized by inflammation in the soft tissue and the ensuing progressive destruction of supporting bone, resulting in tooth or implant loss. These diseases' high prevalence, multifactorial etiology, extensive treatment costs, and significant detriment to patients' quality‐of‐life
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Effects of minimally invasive non‐surgical therapy on C‐reactive protein, lipoprotein‐associated phospholipase A2, and clinical outcomes in periodontitis patients: A 1‐year randomized, controlled clinical trial J. Periodontol. (IF 4.3) Pub Date : 2024-05-02 Gaetano Isola, Paolo Pesce, Alessandro Polizzi, Antonino Lo Giudice, Marco Cicciù, Frank A. Scannapieco
BackgroundGrowing evidence suggests the type of periodontal treatment could differentially influence the reduction of key cardiovascular risk mediators in periodontitis patients. This randomized, controlled clinical trial compared the impact of minimally invasive non‐surgical therapy (MINST) with quadrant‐wise subgingival instrumentation (Q‐SI) on C‐reactive protein (CRP) together with lipoprotein‐associated
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Salivary microbiome and MRP‐8/14 levels in children with gingivitis, healthy children, and their mothers J. Periodontol. (IF 4.3) Pub Date : 2024-05-02 Alice Blufstein, Natasa Pejcic, Kathrin Spettel, Bela Hausmann, David Seki, Tugba Ertekin, Julia Hinrichs‐Priller, Sarra Altner, Marion Nehr, Katrin Bekes, Athanasios Makristathis, Oleh Andrukhov
BackgroundGingivitis is the most common form of periodontal disease among children and adolescents and is associated with disrupted host–microbiome homeostasis. Family is an important factor influencing the prevalence of gingivitis. In the present study, we investigated the salivary microbiome, oral hygiene habits, and the salivary level of myeloid‐related protein (MRP)‐8/14 in children aged 7–12 years
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Treatment of peri‐implantitis with a flapless surgical access combined with implant surface decontamination and adjunctive systemic antibiotics: A retrospective case series study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-05-01 Ana Carrillo de Albornoz, Eduardo Montero, Andrea Alonso‐Español, Mariano Sanz, Ignacio Sanz‐Sánchez
AimTo evaluate the effectiveness of a flapless surgical approach in the treatment of peri‐implantitis and to explore the factors influencing its outcome.Materials and MethodsThe present retrospective study evaluated patients with at least one implant diagnosed with peri‐implantitis and treated with a flapless surgical access, with or without systemic antimicrobials, curettage and, when needed, prostheses
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An Acid-Responsive Iron-Based Nanocomposite for OSCC Treatment J. Dent. Res. (IF 7.6) Pub Date : 2024-04-30 X. Zhao, D. Leng, H. Wang, H. Jin, Y. Wu, Z. Qin, D. Wu, X. Wei
Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer, characterized by invasiveness, local lymph node metastasis, and poor prognosis. Traditional treatment and medications have limitations, making the specific inhibition of OSCC growth, invasion, and metastasis a challenge. The tumor microenvironment exhibits mildly acidity and high concentrations of H2O2, and its exploitation
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Efficacy and safety of a new heterologous fibrin biopolymer on socket bone healing after tooth extraction: An experimental pre‐clinical study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-04-30 Ana Carolina Cestari Bighetti, Tania Mary Cestari, Suelen Paini, Karina T. Pomini, Daniela Vieira Buchaim, Rafael Carneiro Ortiz, Rui Seabra Ferreira Júnior, Benedito Barraviera, Izabel R. F. R. Bullen, Gustavo Pompermaier Garlet, Rogério Leone Buchaim, Gerson F. de Assis
AimTo assess the efficacy of heterologous fibrin biopolymer (HFB) in promoting alveolar bone healing after tooth extraction in rats.Materials and MethodsThe upper right incisors of 48 Wistar rats were extracted. Toothless sockets were filled with HFB (HFBG, n = 24) or blood clot (BCG, n = 24). The tooth extraction sites were subjected to micro‐computed tomography (micro‐CT), histological, histomorphometric
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Enterococcus faecalis Extracellular Vesicles Promote Apical Periodontitis J. Dent. Res. (IF 7.6) Pub Date : 2024-04-29 R.Y. Ma, Z.L. Deng, Q.Y. Du, M.Q. Dai, Y.Y. Luo, Y.E. Liang, X.Z. Dai, S.M. Guo, W.H. Zhao
Enterococcus faecalis is an important contributor to the persistence of chronic apical periodontitis. However, the mechanism by which E. faecalis infection in the root canals and dentinal tubules affects periapical tissue remains unclear. Bacterial extracellular vesicles (EVs) act as natural carriers of microbe-associated molecular patterns (MAMPs) and have recently attracted considerable attention
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Artificial Intelligence in Orthodontics: Critical Review J. Dent. Res. (IF 7.6) Pub Date : 2024-04-29 N.F. Nordblom, M. Büttner, F. Schwendicke
With increasing digitalization in orthodontics, certain orthodontic manufacturing processes such as the fabrication of indirect bonding trays, aligner production, or wire bending can be automated. However, orthodontic treatment planning and evaluation remains a specialist’s task and responsibility. As the prediction of growth in orthodontic patients and response to orthodontic treatment is inherently
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Strategic approaches in oral squamous cell carcinoma diagnostics using liquid biopsy Periodontol. 2000 (IF 18.6) Pub Date : 2024-04-27 Denis F. Kinane, Joerg Gabert, George Xynopoulos, Esra Guzeldemir‐Akcakanat
Liquid biopsy is a noninvasive diagnostic technique used for monitoring cancer utilizing specific genetic biomarkers present in bodily fluids, such as blood, saliva, or urine. These analyses employ multiple biomolecular sources including circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and exosomes (that contain DNA fragments) to detect genetic biomarkers that can predict, disclose, and/or
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A Novel Mechanism of MSCs Responding to Occlusal Force for Bone Homeostasis J. Dent. Res. (IF 7.6) Pub Date : 2024-04-26 F. Wang, H. Wang, H. Zhang, B. Sun, Z. Wang
Alveolar bone, as tooth-supporting bone for mastication, is sensitive to occlusal force. However, the mechanism of alveolar bone loss after losing occlusal force remains unclear. Here, we performed single-cell RNA sequencing of nonhematopoietic (CD45–) cells in mouse alveolar bone after removing the occlusal force. Mesenchymal stromal cells (MSCs) and endothelial cell (EC) subsets were significantly
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Probing the salivary proteome for prognostic biomarkers in response to non‐surgical periodontal therapy J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-04-25 Angelika Silbereisen, Kai Bao, Witold Wolski, Paolo Nanni, Laura Kunz, Beral Afacan, Gülnur Emingil, Nagihan Bostanci
AimThis prospective study investigated the salivary proteome before and after periodontal therapy.Materials and MethodsTen systemically healthy, non‐smoking, stage III, grade C periodontitis patients underwent non‐surgical periodontal treatment. Full‐mouth periodontal parameters were measured, and saliva (n = 30) collected pre‐ (T0), and one (T1) and six (T6) months post‐treatment. The proteome was
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Domains, competences and learning outcomes for undergraduate education in periodontology J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-04-24 Elena Figuero, Mervi Gürsoy, Virginie Monnet‐Corti, Margarita Iniesta, Angeline Antezack, Ines Kapferer‐Seebacher, Christian Graetz, Yuval Vered, Andreas Stavropoulos, Asaf Wilensky, Peter Eickholz, Mariano Sanz
AimThis review is intended to adapt the current conceptual framework in dental education based on four domains to propose a set of competences, learning outcomes and methods of teaching, learning and assessment for undergraduate education in periodontology.ReviewBased on the current framework of competences and learning outcomes recommended by the Association for Dental Education in Europe (ADEE),
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Effects of intermittent fasting on periodontal inflammation and subgingival microbiota J. Periodontol. (IF 4.3) Pub Date : 2024-04-24 Ronaldo Lira‐Junior, Micheál Mac Aogáin, Eva Crncalo, Neda Rajamand Ekberg, Sanjay H. Chotirmall, Sven Pettersson, Anders Gustafsson, Kerstin Brismar, Nagihan Bostanci
BackgroundStudies on the impact of intermittent fasting on periodontal health are still scarce. Thus, this study evaluated the effects of long‐term intermittent fasting on periodontal health and the subgingival microbiota.MethodsThis pilot study was part of a nonrandomized controlled trial. Overweight/obese participants (n = 14) entered an intermittent fasting program, specifically the 5:2 diet, in
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Transcriptomic and cellular decoding of scaffolds-induced suture mesenchyme regeneration Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-04-23 Jiayi Wu, Feifei Li, Peng Yu, Changhao Yu, Chuyi Han, Yitian Wang, Fanyuan Yu, Ling Ye
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Impact of autologous platelet concentrates on the osseointegration of dental implants Periodontol. 2000 (IF 18.6) Pub Date : 2024-04-22 Sašo Ivanovski, Ryan S. B. Lee, Tulio Fernandez‐Medina, Nelson Pinto, Catherine Andrade, Marc Quirynen
Osseointegration is defined as the direct deposition of bone onto biomaterial devices, most commonly composed from titanium, for the purpose of anchoring dental prostheses. The use of autologous platelet concentrates (APC) has the potential to enhance this process by modifying the interface between the host and the surface of the titanium implant. The rationale is to modify the implant surface and
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The distance of insertion points from wound margins in interrupted and vertical mattress sutures influences the tensile load capacity: An in vitro experimental study Clin. Oral. Implants Res. (IF 4.3) Pub Date : 2024-04-22 Seungho Jeong, Won‐Ho Lee, Kyu‐Jin Hong, Franz Josef Strauss, Jung‐Seok Lee
AimTo determine the tensile load capacity (TLC) and the tearing characteristics for interrupted and vertical mattress sutures with different insertion points from the wound margin, and the effect of the bite size when using vertical mattress sutures.Materials and MethodsA total of 120 gingiva and lining mucosa samples obtained from pig jaws were divided into groups according to the suturing technique
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The role and impact of viruses on cancer development Periodontol. 2000 (IF 18.6) Pub Date : 2024-04-20 Adolfo Contreras, Sandra Amaya Sánchez, Carolina Rodríguez‐Medina, Javier Enrique Botero
This review focuses on three major aspects of oncoviruses' role in cancer development. To begin, we discuss their geographic distribution, revealing that seven oncoviruses cause 20% of all human cancers worldwide. Second, we investigate the primary carcinogenic mechanisms, looking at how these oncogenic viruses can induce cellular transformation, angiogenesis, and local and systemic inflammation. Finally
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The role of acquired host immunity in periodontal diseases Periodontol. 2000 (IF 18.6) Pub Date : 2024-04-20 Denis F. Kinane, David F. Lappin, Shauna Culshaw
The aim of this narrative review is to relate the contribution of European researchers to the complex topic of the host immune system in periodontal disease, focusing on acquired immunity. Other chapters in this volume will address the genetics and autoantibody responses and other forms of immunity to periodontal disease. While the contribution of European authors is the focus, global literature is
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Enhanced control of periodontitis by an artificial intelligence‐enabled multimodal‐sensing toothbrush and targeted mHealth micromessages: A randomized trial J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-04-17 Yuan Li, Xinyu Wu, Min Liu, Ke Deng, Annamaria Tullini, Xiao Zhang, Junyu Shi, Hongchang Lai, Maurizio S. Tonetti
AimTreatment of periodontitis, a chronic inflammatory disease driven by biofilm dysbiosis, remains challenging due to patients' poor performance and adherence to the necessary oral hygiene procedures. Novel, artificial intelligence‐enabled multimodal‐sensing toothbrushes (AI‐MST) can guide patients' oral hygiene practices in real‐time and transmit valuable data to clinicians, thus enabling effective
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Accuracy of template‐based guided dental implant placement—An in vitro comparison of different manufacturing methods Clin. Oral. Implants Res. (IF 4.3) Pub Date : 2024-04-17 Aura Sium‐Abel, Ludger Keilig, Istabrak Dörsam, Christoph Bourauel
ObjectivesThis study investigates effects of surgical guide manufacturing process on 3D transfer accuracy of planned dental implant position, using three production methods: additive 3D‐printed (3DF), subtractive milled (MF), and analog laboratory fabricated templates (LF).Material and MethodsImplant position for a single‐tooth gap (#26) planned digitally. 3DF and MF templates were designed digitally
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Inter and intra‐operator reliability of Lekholm and Zarb classification and proposal of a novel radiomic data‐driven clustering for qualitative assessment of edentulous alveolar ridges Clin. Oral. Implants Res. (IF 4.3) Pub Date : 2024-04-17 Giuseppe Troiano, Antonio Rapani, Francesco Fanelli, Federico Berton, Marino Caroprese, Teresa Lombardi, Khrystyna Zhurakivska, Claudio Stacchi
ObjectivesThe present study was conducted to evaluate the reproducibility of Lekholm and Zarb classification system (L&Z) for bone quality assessment of edentulous alveolar ridges and to investigate the potential of a data‐driven approach for bone quality classification.Materials and MethodsTwenty‐six expert clinicians were asked to classify 110 CBCT cross‐sections according to L&Z classification (T0)