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Meet the authors: Jordan B. Jastrab and Jonathan C. Kagan Cell Chem. Bio. (IF 8.6) Pub Date : 2024-05-16
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Meet the Authors: Harkamal S. Jhajj and Peter M. Tessier Cell Chem. Bio. (IF 8.6) Pub Date : 2024-05-16 Harkamal S. Jhajj, Peter M. Tessier
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Finding my leadership style Cell Chem. Bio. (IF 8.6) Pub Date : 2024-05-16 Helen Walden
In this Stories piece, Dr. Helen Walden—Professor and Head of the School of Molecular Biosciences at the University of Glasgow—shares how her past experiences and academic journey have shaped her leadership style.
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Voices: Challenges and opportunities in regulating the immune system Cell Chem. Bio. (IF 8.6) Pub Date : 2024-05-16 Yuezhou Chen, Fiachra Humphries, Ming O. Li, Thirumala-Devi Kanneganti, Dan Ye
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Sharks give a handle to potent anti-tumor multiparatopic antibodies inducing membrane depletion of PD-L1 Cell Chem. Bio. (IF 8.6) Pub Date : 2024-05-16 Gordana Wozniak-Knopp, Veronica Natale
Despite the immense clinical success of the antibody therapeutics that neutralize programmed death receptor ligand 1 (PD-L1) and thus resurrect T cell antitumor activity, the patient response rates remain low. In this issue of Cell Chemical Biology, Ludwig et al.1 reveal novel topologies of multiparatopic antibodies that mediate potent PD-L1 downregulation.
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Metabolism-inflammasome crosstalk shapes innate and adaptive immunity Cell Chem. Bio. (IF 8.6) Pub Date : 2024-05-16 Jun Wu, Xuan Sun, Peng Jiang
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Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity Cell Chem. Bio. (IF 8.6) Pub Date : 2024-05-16 Zhengxu Ren, Kun Wang, Yong Zhang, Hui Chen, Yiming Zhu, Hua Li, Jizhong Lou, Haopeng Wang, Chenqi Xu
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One-carbon unit supplementation fuels purine synthesis in tumor-infiltrating T cells and augments checkpoint blockade Cell Chem. Bio. (IF 8.6) Pub Date : 2024-05-16 Xincheng Xu, Zihong Chen, Caroline R. Bartman, Xi Xing, Kellen Olszewski, Joshua D. Rabinowitz
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Behavioral control through the direct, focal silencing of neuronal activity Cell Chem. Bio. (IF 8.6) Pub Date : 2024-05-09 Anna V. Elleman, Nikola Milicic, Damian J. Williams, Jane Simko, Christine J. Liu, Allison L. Haynes, David E. Ehrlich, Christopher D. Makinson, J. Du Bois
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Stimulating STING for cancer therapy: Taking the extracellular route Cell Chem. Bio. (IF 8.6) Pub Date : 2024-05-08 Lingyin Li
Ten years ago, the second messenger cGAMP was discovered as the activator of the anti-cancer STING pathway. The characterization of cGAMP’s paracrine action and dominant extracellular hydrolase ENPP1 cemented cGAMP as an intercellular immunotransmitter that coordinates the innate and adaptive immune systems to fight cancer. In this Perspective, I look back at a decade of discovery of extracellular
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Molecular glues for protein-protein interactions: Progressing toward a new dream Cell Chem. Bio. (IF 8.6) Pub Date : 2024-05-02 Markella Konstantinidou, Michelle R. Arkin
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Molecular glues and induced proximity: An evolution of tools and discovery Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-29 Stephanie Anne Robinson, Jennifer Anne Co, Steven Mark Banik
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Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1 Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-27 Seth D. Ludwig, Bunyarit Meksiriporn, Jiacheng Tan, Rakeeb Kureshi, Akhilesh Mishra, Kyle J. Kaeo, Angela Zhu, Georgia Stavrakis, Stephen J. Lee, David J. Schodt, Michael J. Wester, Dhiraj Kumar, Keith A. Lidke, Andrea L. Cox, Helen M. Dooley, Sridhar Nimmagadda, Jamie B. Spangler
No Abstract
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Current advances in photocatalytic proximity labeling Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-24 Steve D. Knutson, Benito F. Buksh, Sean W. Huth, Danielle C. Morgan, David W.C. MacMillan
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Repurposing AS1411 for constructing ANM-PROTACs Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-23 Xuekun Fu, Jin Li, Xinxin Chen, Hongzhen Chen, Zhuqian Wang, Fang Qiu, Duoli Xie, Jie Huang, Siran Yue, Chunhao Cao, Yiying Liang, Aiping Lu, Chao Liang
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Facile generation of biepitopic antibodies with intrinsic agonism for activating tumor necrosis factor receptors Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-22 Harkamal S. Jhajj, John S. Schardt, Namir Khalasawi, Emily L. Yao, Timon S. Lwo, Na-Young Kwon, Ryen L. O’Meara, Alec A. Desai, Peter M. Tessier
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Meet the authors: Lori Emert-Sedlak and Tom Smithgall Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-18 Lori Emert-Sedlak, Tom Smithgall
In an interview with Samantha Nelson, a scientific editor of Cell Chemical Biology, the first and corresponding authors of the research article entitled “PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication” share insights on their paper and life as scientists.
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Meet the Authors: Christopher R. Mansfield and Emily R. Derbyshire Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-18 Christopher R. Mansfield, Emily R. Derbyshire
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Dual-action compounds unleash a one-two punch against tuberculosis Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-18 Wendy Le Mouëllic, Yannick Poquet, Olivier Neyrolles
In this issue of Cell Chemical Biology, Gries et al.1 employ an innovative screening approach to identify anti-tuberculosis compounds with dual modes of action: anti-virulence against the type VII secretion system ESX-1 and enhanced ethionamide efficacy. These compounds hold promise for developing multi-target tuberculosis drugs with potential clinical applications.
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METTL3: Melting the tumor microenvironment for improved immunotherapy Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-18 Longfei Gao, Lei Ding
The tumor microenvironment (TME) dictates the outcome of cancer immunotherapy. In this issue of Cell Chemical Biology, Yu et al.1 report that targeting Mettl3 leads to a more inflamed, “hot” TME and effective anti-PD-1 therapy. This study points to a new target in remodeling the TME for improved immunotherapy.
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SARS-CoV-2 resistance to monoclonal antibodies and small-molecule drugs Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-18 Sho Iketani, David D. Ho
Over four years have passed since the beginning of the COVID-19 pandemic. The scientific response has been rapid and effective, with many therapeutic monoclonal antibodies and small molecules developed for clinical use. However, given the ability for viruses to become resistant to antivirals, it is perhaps no surprise that the field has identified resistance to nearly all of these compounds. Here,
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Strategies of bacterial detection by inflammasomes Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-17 Jordan B. Jastrab, Jonathan C. Kagan
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Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-11 Andrew N. Dates, Daniel T.D. Jones, Jeffrey S. Smith, Meredith A. Skiba, Maria F. Rich, Maggie M. Burruss, Andrew C. Kruse, Stephen C. Blacklow
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Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-08 Grennady Wirjanata, Jianqing Lin, Jerzy Michal Dziekan, Abbas El Sahili, Zara Chung, Seth Tjia, Nur Elyza Binte Zulkifli, Josephine Boentoro, Roy Tham, Lai Si Jia, Ka Diam Go, Han Yu, Anthony Partridge, David Olsen, Nayana Prabhu, Radoslaw M. Sobota, Pär Nordlund, Julien Lescar, Zbynek Bozdech
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A light-controlled phospholipase C for imaging of lipid dynamics and controlling neural plasticity Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-05
Abstract not available
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Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1 Cell Chem. Bio. (IF 8.6) Pub Date : 2024-03-27 Seth D. Ludwig, Bunyarit Meksiriporn, Jiacheng Tan, Rakeeb Kureshi, Akhilesh Mishra, Kyle J. Kaeo, Angela Zhu, Georgia Stavrakis, Stephen J. Lee, David. J. Schodt, Michael J. Wester, Dhiraj Kumar, Keith A. Lidke, Andrea L. Cox, Helen M. Dooley, Sridhar Nimmagadda, Jamie B. Spangler
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Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling Cell Chem. Bio. (IF 8.6) Pub Date : 2024-03-26
Abstract not available
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Chemical proteomics to study metabolism, a reductionist approach applied at the systems level Cell Chem. Bio. (IF 8.6) Pub Date : 2024-03-21 Md Yousuf Ali, Liron Bar-Peled
Cellular metabolism encompasses a complex array of interconnected biochemical pathways that are required for cellular homeostasis. When dysregulated, metabolism underlies multiple human pathologies. At the heart of metabolic networks are enzymes that have been historically studied through a reductionist lens, and more recently, using high throughput approaches including genomics and proteomics. Merging
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Identification of clickable HIV-1 capsid-targeting probes for viral replication inhibition Cell Chem. Bio. (IF 8.6) Pub Date : 2024-03-21 William M. McFadden, Mary C. Casey-Moore, Grant A.L. Bare, Karen A. Kirby, Xin Wen, Gencheng Li, Hua Wang, Ryan L. Slack, Alexa A. Snyder, Zachary C. Lorson, Isabella L. Kaufman, Maria E. Cilento, Philip R. Tedbury, Milan Gembicky, Arthur J. Olson, Bruce E. Torbett, K. Barry Sharpless, Stefan G. Sarafianos
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Bioorthogonal chemistry for biological insights Cell Chem. Bio. (IF 8.6) Pub Date : 2024-03-21 The Cell Chemical Biology editorial team
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Voices: Challenges and opportunities for bioorthogonal chemistry Cell Chem. Bio. (IF 8.6) Pub Date : 2024-03-21 Ku-Lung Hsu, Ben Schumann, Ellen Sletten, Ekaterina Vinogradova, Peng Zou
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Covalent hitchhikers guide proteins to the nucleus Cell Chem. Bio. (IF 8.6) Pub Date : 2024-03-21 Alexander F. Russell, Madeline F. Currie, Champak Chatterjee
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Combating the myth of “innate genius” in science Cell Chem. Bio. (IF 8.6) Pub Date : 2024-03-21 Sigrid Nachtergaele
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FLEX: genetically encodable enzymatic fluorescence signal amplification using engineered peroxidase Cell Chem. Bio. (IF 8.6) Pub Date : 2024-03-20 Nirmali Sharma, Minkyo Jung, Pratyush Kumar Mishra, Ji Young Mun, Hyun-Woo Rhee
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PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication Cell Chem. Bio. (IF 8.6) Pub Date : 2024-03-19 Lori A. Emert-Sedlak, Colin M. Tice, Haibin Shi, John J. Alvarado, Sherry T. Shu, Allen B. Reitz, Thomas E. Smithgall
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Chemical immunology: Recent advances in tool development and applications Cell Chem. Bio. (IF 8.6) Pub Date : 2024-03-18 Yujie Shi, Eleanor E. Bashian, Yingqin Hou, Peng Wu
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Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome Cell Chem. Bio. (IF 8.6) Pub Date : 2024-03-15 Christopher R. Mansfield, Baiyi Quan, Michael E. Chirgwin, Benjamin Eduful, Philip F. Hughes, Gaëlle Neveu, Kayla Sylvester, Daniel H. Ryan, Björn F.C. Kafsack, Timothy A.J. Haystead, James W. Leahy, Michael C. Fitzgerald, Emily R. Derbyshire
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A proximity labeling-based orthogonal trap strategy identifies HDAC8 promotes cell motility by modulating cortactin acetylation Cell Chem. Bio. (IF 8.6) Pub Date : 2024-03-08 Yepei Huang, Guijin Zhai, Yun Fu, Yanan Li, Yong Zang, Yu Lin, Kai Zhang
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A sterol analog inhibits hedgehog pathway by blocking cholesterylation of smoothened Cell Chem. Bio. (IF 8.6) Pub Date : 2024-03-04 Yuan-Bin Liu, Li-Ming He, Ming Sun, Wen-Jun Luo, Zi-Cun Lin, Zhi-Ping Qiu, Yu-Liang Zhang, Ao Hu, Jie Luo, Wen-Wei Qiu, Bao-Liang Song
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Metabolic rewiring and communication in cancer immunity Cell Chem. Bio. (IF 8.6) Pub Date : 2024-02-29 Nicole M. Chapman, Hongbo Chi
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Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity Cell Chem. Bio. (IF 8.6) Pub Date : 2024-02-22 Emily Puumala, David Sychantha, Elizabeth Lach, Shawn Reeves, Sunna Nabeela, Meea Fogal, AkshatKumar Nigam, Jarrod W. Johnson, Alán Aspuru-Guzik, Rebecca S. Shapiro, Priya Uppuluri, Subha Kalyaanamoorthy, Jakob Magolan, Luke Whitesell, Nicole Robbins, Gerard D. Wright, Leah E. Cowen
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CYP7B1-mediated 25-hydroxycholesterol degradation maintains quiescence-activation balance and improves therapeutic potential of mesenchymal stem cells Cell Chem. Bio. (IF 8.6) Pub Date : 2024-02-20 Zhaoqiang Zhang, Zepeng Su, Zhikun Li, Jinteng Li, Wenhui Yu, Guiwen Ye, Jiajie Lin, Yunshu Che, Peitao Xu, Yipeng Zeng, Yanfeng Wu, Huiyong Shen, Zhongyu Xie
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All the mutations that are fit to die Cell Chem. Bio. (IF 8.6) Pub Date : 2024-02-15 Emma Gebauer, Markus A. Seeliger
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Cellular reprogramming by protein degradation: The next frontier in cancer immunotherapy Cell Chem. Bio. (IF 8.6) Pub Date : 2024-02-15 Erik Ehinger, Anjana Rao
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Meet the authors: Cydney N. Johnson, Shyra Wilde, Elaine Tuomanen, and Jason W. Rosch Cell Chem. Bio. (IF 8.6) Pub Date : 2024-02-15 Cydney N. Johnson, Shyra Wilde, Elaine Tuomanen, Jason W. Rosch
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When CDK4/6i meets GPX4i: Stop dividing to die iron hard Cell Chem. Bio. (IF 8.6) Pub Date : 2024-02-15 Deguang Liang, Xuejun Jiang
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Identification of differential biological activity and synergy between the PARP inhibitor rucaparib and its major metabolite Cell Chem. Bio. (IF 8.6) Pub Date : 2024-02-08 Huabin Hu, Carme Serra, Wenjie Zhang, Aurora Scrivo, Irene Fernández-Carasa, Antonella Consiglio, Alvaro Aytes, Miguel Angel Pujana, Amadeu Llebaria, Albert A. Antolin
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The cyclimids: Degron-inspired cereblon binders for targeted protein degradation Cell Chem. Bio. (IF 8.6) Pub Date : 2024-02-05 Saki Ichikawa, N. Connor Payne, Wenqing Xu, Chia-Fu Chang, Nandini Vallavoju, Spencer Frome, Hope A. Flaxman, Ralph Mazitschek, Christina M. Woo
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Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor Cell Chem. Bio. (IF 8.6) Pub Date : 2024-02-02 Ling-Yan Su, Yang Tian, Qiang Zheng, Yu Cao, Mengyu Yao, Shuangping Wang, Wen Xu, Chuyu Xi, Andrea Clocchiatti, Guangjun Nie, Hejiang Zhou
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Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer Cell Chem. Bio. (IF 8.6) Pub Date : 2024-02-01 Tinslee Dilday, Melissa Abt, Nicole Ramos-Solís, Neetu Dayal, Elizabeth Larocque, Adrian L. Oblak, Herman O. Sintim, Elizabeth S. Yeh
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Beyond antibiotic resistance: The whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria Cell Chem. Bio. (IF 8.6) Pub Date : 2024-01-23 Nicholas C. Poulton, Michael A. DeJesus, Vanisha Munsamy-Govender, Mariko Kanai, Cameron G. Roberts, Zachary A. Azadian, Barbara Bosch, Karl Matthew Lin, Shuqi Li, Jeremy M. Rock
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PARP trapping is governed by the PARP inhibitor dissociation rate constant Cell Chem. Bio. (IF 8.6) Pub Date : 2024-01-22 Angelica A. Gopal, Bianca Fernandez, Justin Delano, Ralph Weissleder, J. Matthew Dubach
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30th anniversary celebrations: Inspiring innovation in biology and medicine Cell Chem. Bio. (IF 8.6) Pub Date : 2024-01-18 T, h, e, , C, e, l, l, , C, h, e, m, i, c, a, l, , B, i, o, l, o, g, y, , e, d, i, t, o, r, i, a, l, , t, e, a, m
Abstract not available
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Cultivating creativity and belonging in science Cell Chem. Bio. (IF 8.6) Pub Date : 2024-01-18 M, e, g, a, n, , K, e, n
In this Stories piece, Megan Ken, a Fellow at The Scripps Research Institute, discusses the importance of inclusion, mentoring, and creativity to discovery and growth in science.
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30th anniversary of Cell Chemical Biology: A conversation with founding editors K.C. Nicolaou and Gregory Verdine Cell Chem. Bio. (IF 8.6) Pub Date : 2024-01-18 K.C. Nicolaou, Gregory L. Verdine
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Voices: Challenges and opportunities in RNA biology Cell Chem. Bio. (IF 8.6) Pub Date : 2024-01-18 Ling-Ling Chen, Nicholas T. Ingolia, Megan L. Insco, Jin Billy Li, Shalini Oberdoerffer, Kevin M. Weeks
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Mo’ m1A, mo’ problems Cell Chem. Bio. (IF 8.6) Pub Date : 2024-01-18 Linamarie Miller, James Shorter
CAG-repeat expansions underlie fatal neurodegenerative disorders. In a lodestar study published in a recent issue of Nature, Sun et al.1 identify a writer and eraser of N1-methyladenosine (m1A) modifications of CAG-repeat RNA. They establish that m1A modifications in CAG-repeat expanded RNA promote neurodegeneration and aberrant phase transitions of TDP-43. These findings suggest therapeutic strategies
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Bioorthogonal click labeling of an amber-free HIV-1 provirus for in-virus single molecule imaging Cell Chem. Bio. (IF 8.6) Pub Date : 2024-01-16 Yuanyun Ao, Jonathan R. Grover, Levi Gifford, Yang Han, Guohua Zhong, Revansiddha Katte, Wenwei Li, Rajanya Bhattacharjee, Baoshan Zhang, Stephanie Sauve, Wenyi Qin, Dibya Ghimire, Md Anzarul Haque, James Arthos, Mahmoud Moradi, Walther Mothes, Edward A. Lemke, Peter D. Kwong, Gregory B. Melikyan, Maolin Lu
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The interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond Cell Chem. Bio. (IF 8.6) Pub Date : 2024-01-11 Michael B. Geeson, Jeffrey C. Hsiao, Lydia P. Tsamouri, Daniel P. Ball, Daniel A. Bachovchin
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Regulation of bacterial gene expression by non-coding RNA: It is all about time! Cell Chem. Bio. (IF 8.6) Pub Date : 2024-01-10 Adrien Chauvier, Nils G. Walter
Commensal and pathogenic bacteria continuously evolve to survive in diverse ecological niches by efficiently coordinating gene expression levels in their ever-changing environments. Regulation through the RNA transcript itself offers a faster and more cost-effective way to adapt than protein-based mechanisms and can be leveraged for diagnostic or antimicrobial purposes. However, RNA can fold into numerous