Inflammasomes are a central component of innate immunity and play a vital role in regulating innate immune response. Activation of inflammasomes is also indispensable for adaptive immunity, modulating the development and response of adaptive immunity. Recently, increasing studies have shown that metabolic alterations and adaptations strongly influence and regulate the differentiation and function of the immune system. In this review, we will take a holistic view of how inflammasomes bridge innate and adaptive (especially T cell) immunity and how inflammasomes crosstalk with metabolic signals during the immune responses. And, special attention will be paid to the metabolic control of inflammasome-mediated interactions between innate and adaptive immunity in disease. Understanding the metabolic regulatory functions of inflammasomes would provide new insights into future research directions in this area and may help to identify potential targets for inflammasome-associated diseases and broaden therapeutic avenues.

炎症小体是先天免疫的核心组成部分，在调节先天免疫反应中发挥着至关重要的作用。炎症小体的激活对于适应性免疫也是不可或缺的，它调节适应性免疫的发展和反应。最近，越来越多的研究表明，代谢改变和适应强烈影响和调节免疫系统的分化和功能。在这篇综述中，我们将全面了解炎症小体如何桥接先天免疫和适应性（尤其是 T 细胞）免疫，以及炎症小体如何在免疫反应过程中与代谢信号相互作用。并且，将特别关注疾病中先天免疫和适应性免疫之间炎症体介导的相互作用的代谢控制。了解炎症小体的代谢调节功能将为该领域未来的研究方向提供新的见解，并可能有助于确定炎症小体相关疾病的潜在靶点并拓宽治疗途径。