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Consciousness and sleep Neuron (IF 16.2) Pub Date : 2024-05-01 Giulio Tononi, Melanie Boly, Chiara Cirelli
Sleep is a universal, essential biological process. It is also an invaluable window on consciousness. It tells us that consciousness can be lost but also that it can be regained, in all its richness, when we are disconnected from the environment and unable to reflect. By considering the neurophysiological differences between dreaming and dreamless sleep, we can learn about the substrate of consciousness
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Taking consciousness for real: Increasing the ecological validity of the study of conscious vs. unconscious processes Neuron (IF 16.2) Pub Date : 2024-04-22 Liad Mudrik, Rony Hirschhorn, Uri Korisky
The study of consciousness has developed well-controlled, rigorous methods for manipulating and measuring consciousness. Yet, in the process, experimental paradigms grew farther away from everyday conscious and unconscious processes, which raises the concern of ecological validity. In this review, we suggest that the field can benefit from adopting a more ecological approach, akin to other fields of
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Modeling proprioception with task-driven neural network models Neuron (IF 16.2) Pub Date : 2024-04-12 Hansjörg Scherberger
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Building a science of human pleasure, meaning making, and flourishing Neuron (IF 16.2) Pub Date : 2024-04-11 Morten L. Kringelbach, Peter Vuust, Gustavo Deco
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Interferons: Invited guests at the brain’s gala banquet Neuron (IF 16.2) Pub Date : 2024-04-11 Mar Márquez-Ropero, Amanda Sierra
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Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin/β-catenin signaling Neuron (IF 16.2) Pub Date : 2024-04-09 Saptarshi Biswas, Sanjid Shahriar, Galina Bachay, Panos Arvanitis, Danny Jamoul, William J. Brunken, Dritan Agalliu
Interactions among neuronal, glial, and vascular components are crucial for retinal angiogenesis and blood-retinal barrier (BRB) maturation. Although synaptic dysfunction precedes vascular abnormalities in many retinal pathologies, how neuronal activity, specifically glutamatergic activity, regulates retinal angiogenesis and BRB maturation remains unclear. Using genetic studies in mice, single-cell
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Speak up & reach out: In defense of biomedical research Neuron (IF 16.2) Pub Date : 2024-04-09 Degan Mesler, Vicki Campbell
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Anesthesia and the neurobiology of consciousness Neuron (IF 16.2) Pub Date : 2024-04-04 George A. Mashour
In the 19 century, the discovery of general anesthesia revolutionized medical care. In the 21 century, anesthetics have become indispensable tools to study consciousness. Here, I review key aspects of the relationship between anesthesia and the neurobiology of consciousness, including interfaces of sleep and anesthetic mechanisms, anesthesia and primary sensory processing, the effects of anesthetics
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Astrocyte-secreted neurocan controls inhibitory synapse formation and function Neuron (IF 16.2) Pub Date : 2024-04-03 Dolores Irala, Shiyi Wang, Kristina Sakers, Leykashree Nagendren, Francesco Paolo Ulloa Severino, Dhanesh Sivadasan Bindu, Justin T. Savage, Cagla Eroglu
Astrocytes strongly promote the formation and maturation of synapses by secreted proteins. Several astrocyte-secreted synaptogenic proteins controlling excitatory synapse development were identified; however, those that induce inhibitory synaptogenesis remain elusive. Here, we identify neurocan as an astrocyte-secreted inhibitory synaptogenic protein. After secretion from astrocytes, neurocan is cleaved
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P-tau217 correlates with neurodegeneration in Alzheimer’s disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy Neuron (IF 16.2) Pub Date : 2024-03-20 Denghong Zhang, Wei Zhang, Chen Ming, Xuheng Gao, Huilong Yuan, Xiaojie Lin, Xinru Mao, Chunping Wang, Xiaoyi Guo, Ying Du, Lin Shao, Renzhi Yang, Zhihao Lin, Xilin Wu, Timothy Y. Huang, Zhanxiang Wang, Yun-wu Zhang, Huaxi Xu, Yingjun Zhao
Neuronal loss is the central issue in Alzheimer’s disease (AD), yet no treatment developed so far can halt AD-associated neurodegeneration. Here, we developed a monoclonal antibody (mAb2A7) against 217 site-phosphorylated human tau (p-tau217) and observed that p-tau217 levels positively correlated with brain atrophy and cognitive impairment in AD patients. Intranasal administration efficiently delivered
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Functional ultrasound imaging of the human spinal cord Neuron (IF 16.2) Pub Date : 2024-03-07 K.A. Agyeman, D.J. Lee, J. Russin, E.I. Kreydin, W. Choi, A. Abedi, Y.T. Lo, J. Cavaleri, K. Wu, V.R. Edgerton, C. Liu, V.N. Christopoulos
Utilizing the first in-human functional ultrasound imaging (fUSI) of the spinal cord, we demonstrate the integration of spinal functional responses to electrical stimulation. We record and characterize the hemodynamic responses of the spinal cord to a neuromodulatory intervention commonly used for treating pain and increasingly used for the restoration of sensorimotor and autonomic function. We found
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Cross-hemispheric communication: Insights on lateralized brain functions Neuron (IF 16.2) Pub Date : 2024-03-07 Sebastian Ocklenburg, Zengcai V. Guo
On the surface, the two hemispheres of vertebrate brains look almost perfectly symmetrical, but several motor, sensory, and cognitive systems show a deeply lateralized organization. Importantly, the two hemispheres are connected by various commissures, white matter tracts that cross the brain’s midline and enable cross-hemispheric communication. Cross-hemispheric communication has been suggested to
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Simultaneous, cortex-wide dynamics of up to 1 million neurons reveal unbounded scaling of dimensionality with neuron number Neuron (IF 16.2) Pub Date : 2024-03-06 Jason Manley, Sihao Lu, Kevin Barber, Jeffrey Demas, Hyewon Kim, David Meyer, Francisca Martínez Traub, Alipasha Vaziri
The brain’s remarkable properties arise from the collective activity of millions of neurons. Widespread application of dimensionality reduction to multi-neuron recordings implies that neural dynamics can be approximated by low-dimensional “latent” signals reflecting neural computations. However, can such low-dimensional representations truly explain the vast range of brain activity, and if not, what
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Multimodal sensory control of motor performance by glycinergic interneurons of the mouse spinal cord deep dorsal horn Neuron (IF 16.2) Pub Date : 2024-03-06 Mark A. Gradwell, Nofar Ozeri-Engelhard, Jaclyn T. Eisdorfer, Olivier D. Laflamme, Melissa Gonzalez, Aman Upadhyay, Laura Medlock, Tara Shrier, Komal R. Patel, Adin Aoki, Melissa Gandhi, Gloria Abbas-Zadeh, Olisemaka Oputa, Joshua K. Thackray, Matthew Ricci, Arlene George, Nusrath Yusuf, Jessica Keating, Zarghona Imtiaz, Simona A. Alomary, Manon Bohic, Michael Haas, Yurdiana Hernandez, Steven A. Prescott
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An integrative, multiscale view on neural theories of consciousness Neuron (IF 16.2) Pub Date : 2024-03-05 Johan F. Storm, P. Christiaan Klink, Jaan Aru, Walter Senn, Rainer Goebel, Andrea Pigorini, Pietro Avanzini, Wim Vanduffel, Pieter R. Roelfsema, Marcello Massimini, Matthew E. Larkum, Cyriel M.A. Pennartz
How is conscious experience related to material brain processes? A variety of theories aiming to answer this age-old question have emerged from the recent surge in consciousness research, and some are now hotly debated. Although most researchers have so far focused on the development and validation of their preferred theory in relative isolation, this article, written by a group of scientists representing
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Excitability mediates allocation of pre-configured ensembles to a hippocampal engram supporting contextual conditioned threat in mice Neuron (IF 16.2) Pub Date : 2024-03-05 Andrew J. Mocle, Adam I. Ramsaran, Alexander D. Jacob, Asim J. Rashid, Alessandro Luchetti, Lina M. Tran, Blake A. Richards, Paul W. Frankland, Sheena A. Josselyn
Little is understood about how engrams, sparse groups of neurons that store memories, are formed endogenously. Here, we combined calcium imaging, activity tagging, and optogenetics to examine the role of neuronal excitability and pre-existing functional connectivity on the allocation of mouse cornu ammonis area 1 (CA1) hippocampal neurons to an engram ensemble supporting a contextual threat memory
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Phasic/tonic glial GABA differentially transduce for olfactory adaptation and neuronal aging Neuron (IF 16.2) Pub Date : 2024-03-05 Hankui Cheng, Du Chen, Xiao Li, Umar Al-Sheikh, Duo Duan, Yuedan Fan, Linhui Zhu, Wanxin Zeng, Zhitao Hu, Xiajing Tong, Guohua Zhao, Yongming Zhang, Wenjuan Zou, Shumin Duan, Lijun Kang
Phasic (fast) and tonic (sustained) inhibition of γ-aminobutyric acid (GABA) are fundamental for regulating day-to-day activities, neuronal excitability, and plasticity. However, the mechanisms and physiological functions of glial GABA transductions remain poorly understood. Here, we report that the AMsh glia in exhibit both phasic and tonic GABAergic signaling, which distinctively regulate olfactory
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Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression Neuron (IF 16.2) Pub Date : 2024-03-04 Anthi C. Krontira, Cristiana Cruceanu, Leander Dony, Christina Kyrousi, Marie-Helen Link, Nils Rek, Dorothee Pöhlchen, Catarina Raimundo, Signe Penner-Goeke, Alicia Schowe, Darina Czamara, Marius Lahti-Pulkkinen, Sara Sammallahti, Elina Wolford, Kati Heinonen, Simone Roeh, Vincenza Sportelli, Barbara Wölfel, Maik Ködel, Susann Sauer, Monika Rex-Haffner, Katri Räikkönen, Marta Labeur, Silvia Cappello
Glucocorticoids are important for proper organ maturation, and their levels are tightly regulated during development. Here, we use human cerebral organoids and mice to study the cell-type-specific effects of glucocorticoids on neurogenesis. We show that glucocorticoids increase a specific type of basal progenitors (co-expressing PAX6 and EOMES) that has been shown to contribute to cortical expansion
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Sexually dimorphic control of affective state processing and empathic behaviors Neuron (IF 16.2) Pub Date : 2024-03-01 Shunchang Fang, Zhengyi Luo, Zicheng Wei, Yuxin Qin, Jieyan Zheng, Hongyang Zhang, Jianhua Jin, Jiali Li, Chenjian Miao, Shana Yang, Yonglin Li, Zirui Liang, Xiao-Dan Yu, Xiao Min Zhang, Wei Xiong, Hongying Zhu, Wen-Biao Gan, Lianyan Huang, Boxing Li
Recognizing the affective states of social counterparts and responding appropriately fosters successful social interactions. However, little is known about how the affective states are expressed and perceived and how they influence social decisions. Here, we show that male and female mice emit distinct olfactory cues after experiencing distress. These cues activate distinct neural circuits in the piriform
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Transient cAMP production drives rapid and sustained spiking in brainstem parabrachial neurons to suppress feeding Neuron (IF 16.2) Pub Date : 2024-02-27 Jonnathan Singh Alvarado, Andrew Lutas, Joseph C. Madara, Jeremiah Isaac, Caroline Lommer, Crystian Massengill, Mark L. Andermann
Brief stimuli can trigger longer-lasting brain states. G-protein-coupled receptors (GPCRs) could help sustain such states by coupling slow-timescale molecular signals to neuronal excitability. Brainstem parabrachial nucleus glutamatergic (PBN) neurons regulate sustained brain states such as pain and express G-coupled GPCRs that increase cAMP signaling. We asked whether cAMP in PBN neurons directly
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Leptomeningeal collaterals regulate reperfusion in ischemic stroke and rescue the brain from futile recanalization Neuron (IF 16.2) Pub Date : 2024-02-26 Nadine Felizitas Binder, Mohamad El Amki, Chaim Glück, William Middleham, Anna Maria Reuss, Adrien Bertolo, Patrick Thurner, Thomas Deffieux, Chryso Lambride, Robert Epp, Hannah-Lea Handelsmann, Philipp Baumgartner, Cyrille Orset, Philipp Bethge, Zsolt Kulcsar, Adriano Aguzzi, Mickael Tanter, Franca Schmid, Denis Vivien, Matthias Tasso Wyss, Andreas Luft, Michael Weller, Bruno Weber, Susanne Wegener
Recanalization is the mainstay of ischemic stroke treatment. However, even with timely clot removal, many stroke patients recover poorly. Leptomeningeal collaterals (LMCs) are pial anastomotic vessels with yet-unknown functions. We applied laser speckle imaging, ultrafast ultrasound, and two-photon microscopy in a thrombin-based mouse model of stroke and fibrinolytic treatment to show that LMCs maintain
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Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD Neuron (IF 16.2) Pub Date : 2024-02-26 Chenyu Wang, Kimberly D. Derderian, Elizabeth Hamada, Xujia Zhou, Andrew D. Nelson, Henry Kyoung, Nadav Ahituv, Guy Bouvier, Kevin J. Bender
Children diagnosed with autism spectrum disorder (ASD) commonly present with sensory hypersensitivity or abnormally strong reactions to sensory stimuli. Such hypersensitivity can be overwhelming, causing high levels of distress that contribute markedly to the negative aspects of the disorder. Here, we identify a mechanism that underlies hypersensitivity in a sensorimotor reflex found to be altered
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Mechanisms of sex differences in Alzheimer’s disease Neuron (IF 16.2) Pub Date : 2024-02-22 Chloe Lopez-Lee, Eileen Ruth S. Torres, Gillian Carling, Li Gan
Alzheimer’s disease (AD) and the mechanisms underlying its etiology and progression are complex and multifactorial. The higher AD risk in women may serve as a clue to better understand these complicated processes. In this review, we examine aspects of AD that demonstrate sex-dependent effects and delve into the potential biological mechanisms responsible, compiling findings from advanced technologies
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Primate neocortex performs balanced sensory amplification Neuron (IF 16.2) Pub Date : 2024-02-21 Jagruti J. Pattadkal, Boris V. Zemelman, Ila Fiete, Nicholas J. Priebe
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Harnessing diversity to study Alzheimer’s disease: A new iPSC resource from the NIH CARD and ADNI Neuron (IF 16.2) Pub Date : 2024-02-21 Laurel A. Screven, Caroline B. Pantazis, Katherine M. Andersh, Samantha Hong, Dan Vitale, Erika Lara, Ray Yueh Ku, Peter Heutink, Jason Meyer, Kelley Faber, Kwangsik Nho, Andrew J. Saykin, Tatiana M. Foroud, Mike A. Nalls, Cornelis Blauwendraat, Andrew Singleton, Priyanka S. Narayan
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Driving valence-specific behavior through single-cell resolution control in the amygdala Neuron (IF 16.2) Pub Date : 2024-02-21 Leonardo Jared Ramirez Sanchez, Bo Li
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Tuned geometries of hippocampal representations meet the computational demands of social memory Neuron (IF 16.2) Pub Date : 2024-02-20 Lara M. Boyle, Lorenzo Posani, Sarah Irfan, Steven A. Siegelbaum, Stefano Fusi
Social memory consists of two processes: the detection of familiar compared with novel conspecifics and the detailed recollection of past social episodes. We investigated the neural bases for these processes using calcium imaging of dorsal CA2 hippocampal pyramidal neurons, known to be important for social memory, during social/spatial encounters with novel conspecifics and familiar littermates. Whereas
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Cell-type-specific expression of tRNAs in the brain regulates cellular homeostasis Neuron (IF 16.2) Pub Date : 2024-02-19 Mridu Kapur, Michael J. Molumby, Carlos Guzman, Sven Heinz, Susan L. Ackerman
Defects in tRNA biogenesis are associated with multiple neurological disorders, yet our understanding of these diseases has been hampered by an inability to determine tRNA expression in individual cell types within a complex tissue. Here, we developed a mouse model in which RNA polymerase III is conditionally epitope tagged in a Cre-dependent manner, allowing us to accurately profile tRNA expression
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Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons Neuron (IF 16.2) Pub Date : 2024-02-19 Ayako Kawatake-Kuno, Haiyan Li, Hiromichi Inaba, Momoka Hikosaka, Erina Ishimori, Takatoshi Ueki, Yury Garkun, Hirofumi Morishita, Shuh Narumiya, Naoya Oishi, Gen Ohtsuki, Toshiya Murai, Shusaku Uchida
Despite the rapid and sustained antidepressant effects of ketamine and its metabolites, their underlying cellular and molecular mechanisms are not fully understood. Here, we demonstrate that the sustained antidepressant-like behavioral effects of ()-hydroxynorketamine (HNK) in repeatedly stressed animal models involve neurobiological changes in the anterior paraventricular nucleus of the thalamus (aPVT)
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Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice Neuron (IF 16.2) Pub Date : 2024-02-15 Yazi D. Ke, Annika van Hummel, Carol Au, Gabriella Chan, Wei Siang Lee, Julia van der Hoven, Magdalena Przybyla, Yuanyuan Deng, Miheer Sabale, Nicolle Morey, Josefine Bertz, Astrid Feiten, Stefania Ippati, Claire H. Stevens, Shu Yang, Amadeus Gladbach, Nikolas K. Haass, Jillian J. Kril, Ian P. Blair, Fabien Delerue, Lars M. Ittner
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Episodic memory development: Bridging animal and human research Neuron (IF 16.2) Pub Date : 2024-02-14 Juraj Bevandić, Loïc J. Chareyron, Jocelyne Bachevalier, Francesca Cacucci, Lisa Genzel, Nora S. Newcombe, Faraneh Vargha-Khadem, H. Freyja Ólafsdóttir
Human episodic memory is not functionally evident until about 2 years of age and continues to develop into the school years. Behavioral studies have elucidated this developmental timeline and its constituent processes. In tandem, lesion and neurophysiological studies in non-human primates and rodents have identified key neural substrates and circuit mechanisms that may underlie episodic memory development
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ASICs mediate fast excitatory synaptic transmission for tactile discrimination Neuron (IF 16.2) Pub Date : 2024-02-14 Akihiro Yamada, Jennifer Ling, Ayaka I. Yamada, Hidemasa Furue, Jianguo G. Gu
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Cell-type-specific optogenetic fMRI on basal forebrain reveals functional network basis of behavioral preference Neuron (IF 16.2) Pub Date : 2024-02-14 Yijuan Zou, Chuanjun Tong, Wanling Peng, Yue Qiu, Jiangxue Li, Ying Xia, Mengchao Pei, Kaiwei Zhang, Weishuai Li, Min Xu, Zhifeng Liang
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Anterior cingulate cortex projections to the dorsal medial striatum underlie insomnia associated with chronic pain Neuron (IF 16.2) Pub Date : 2024-02-13 Ya-Dong Li, Yan-Jia Luo, Wei-Kun Su, Jing Ge, Andrew Crowther, Ze-Ka Chen, Lu Wang, Michael Lazarus, Zi-Long Liu, Wei-Min Qu, Zhi-Li Huang
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Epigenetic dysregulation in Alzheimer’s disease peripheral immunity Neuron (IF 16.2) Pub Date : 2024-02-09 Abhirami Ramakrishnan, Natalie Piehl, Brooke Simonton, Milan Parikh, Ziyang Zhang, Victoria Teregulova, Lynn van Olst, David Gate
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Data science opportunities of large language models for neuroscience and biomedicine Neuron (IF 16.2) Pub Date : 2024-02-09 Danilo Bzdok, Andrew Thieme, Oleksiy Levkovskyy, Paul Wren, Thomas Ray, Siva Reddy
Large language models (LLMs) are a new asset class in the machine-learning landscape. Here we offer a primer on defining properties of these modeling techniques. We then reflect on new modes of investigation in which LLMs can be used to reframe classic neuroscience questions to deliver fresh answers. We reason that LLMs have the potential to (1) enrich neuroscience datasets by adding valuable meta-information
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Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses Neuron (IF 16.2) Pub Date : 2024-02-07 Jinye Dai, Jason Aoto, Thomas C. Südhof
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The brain’s go-getter circuit: Anterior cingulate cortex to nucleus accumbens and its disruption by stress Neuron (IF 16.2) Pub Date : 2024-02-07 Simone Astori, Carmen Sandi
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Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons Neuron (IF 16.2) Pub Date : 2024-02-07 Juliet Goldsmith, Alban Ordureau, J. Wade Harper, Erika L.F. Holzbaur
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Does high-frequency stimulation of sensory axons break the causal link between pain relief and paresthesia? Neuron (IF 16.2) Pub Date : 2024-02-07 Evan R. Rogers, Scott F. Lempka, Marco Capogrosso
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Clearance of β-amyloid and synapses by the optogenetic depolarization of microglia is complement selective Neuron (IF 16.2) Pub Date : 2024-01-30 Zezhong Lv, Lixi Chen, Ping Chen, Huipai Peng, Yi Rong, Wei Hong, Qiang Zhou, Nan Li, Boxing Li, Rosa C. Paolicelli, Yang Zhan
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A role for the cerebellum in motor-triggered alleviation of anxiety Neuron (IF 16.2) Pub Date : 2024-01-31 Xiao-Yang Zhang, Wen-Xia Wu, Li-Ping Shen, Miao-Jin Ji, Peng-Fei Zhao, Lei Yu, Jun Yin, Shu-Tao Xie, Yun-Yong Xie, Yang-Xun Zhang, Hong-Zhao Li, Qi-Peng Zhang, Chao Yan, Fei Wang, Chris I. De Zeeuw, Jian-Jun Wang, Jing-Ning Zhu
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APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer’s disease pathology Neuron (IF 16.2) Pub Date : 2024-01-31 Augustine Chemparathy, Yann Le Guen, Sunny Chen, Eun-Gyung Lee, Lesley Leong, John E. Gorzynski, Tanner D. Jensen, Alexis Ferrasse, Guangxue Xu, Hong Xiang, Michael E. Belloy, Nandita Kasireddy, Andrés Peña-Tauber, Kennedy Williams, Ilaria Stewart, Lia Talozzi, Thomas S. Wingo, James J. Lah, Suman Jayadev, Chadwick M. Hales, Elaine Peskind, Daniel D. Child, Sigrun Roeber, C. Dirk Keene, Le Cong, Euan
The ε4 allele of apolipoprotein E () is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). Knockdown of ε4 may provide a therapeutic strategy for AD, but the effect of loss of function (LoF) on AD pathogenesis is unknown. We searched for LoF variants in a large cohort of controls and patients with AD and identified seven heterozygote carriers of LoF variants. Five carriers were
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The mediodorsal thalamus in executive control Neuron (IF 16.2) Pub Date : 2024-01-30 Mathieu Wolff, Michael M. Halassa
Executive control, the ability to organize thoughts and action plans in real time, is a defining feature of higher cognition. Classical theories have emphasized cortical contributions to this process, but recent studies have reinvigorated interest in the role of the thalamus. Although it is well established that local thalamic damage diminishes cognitive capacity, such observations have been difficult
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The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish Neuron (IF 16.2) Pub Date : 2024-01-30 Margherita Zaupa, Nagarjuna Nagaraj, Anna Sylenko, Herwig Baier, Suphansa Sawamiphak, Alessandro Filosa
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Advances in structure-based drug design: The potential for precision therapeutics in psychiatric disorders Neuron (IF 16.2) Pub Date : 2024-01-29 Dongmei Cao, Pei Zhang, Sheng Wang
Over the years, the field of GPCR drug design has undergone a remarkable evolution, fueled by advancements in science and technology. This evolution has given rise to a diverse range of ideas and approaches in structure-based drug design, bolstering the versatility and strength of the GPCR drug design toolbox. This review encapsulates the iterative development process, navigating challenges and opportunities
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Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites Neuron (IF 16.2) Pub Date : 2024-01-29 Andrew D. Nelson, Amanda M. Catalfio, Julie P. Gupta, Lia Min, René N. Caballero-Florán, Kendall P. Dean, Carina C. Elvira, Kimberly D. Derderian, Henry Kyoung, Atehsa Sahagun, Stephan J. Sanders, Kevin J. Bender, Paul M. Jenkins
Dysfunction in sodium channels and their ankyrin scaffolding partners have both been implicated in neurodevelopmental disorders, including autism spectrum disorder (ASD). In particular, the genes , which encodes the sodium channel Na1.2, and , which encodes ankyrin-B, have strong ASD association. Recent studies indicate that ASD-associated haploinsufficiency in impairs dendritic excitability and synaptic
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Single-neuron projectomes of mouse paraventricular hypothalamic nucleus oxytocin neurons reveal mutually exclusive projection patterns Neuron (IF 16.2) Pub Date : 2024-01-29 Humingzhu Li, Tao Jiang, Sile An, Mingrui Xu, Lingfeng Gou, Biyu Ren, Xiaoxue Shi, Xiaofei Wang, Jun Yan, Jing Yuan, Xiaohong Xu, Qing-Feng Wu, Qingming Luo, Hui Gong, Wen-Jie Bian, Anan Li, Xiang Yu
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Glutamate inputs send prediction error of reward, but not negative value of aversive stimuli, to dopamine neurons Neuron (IF 16.2) Pub Date : 2024-01-25 Ryunosuke Amo, Naoshige Uchida, Mitsuko Watabe-Uchida
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Beyond hippocampus: Thalamic and prefrontal contributions to an evolving memory Neuron (IF 16.2) Pub Date : 2024-01-24 Nakul Yadav, Andrew Toader, Priya Rajasethupathy
The hippocampus has long been at the center of memory research, and rightfully so. However, with emerging technological capabilities, we can increasingly appreciate memory as a more dynamic and brain-wide process. In this perspective, our goal is to begin developing models to understand the gradual evolution, reorganization, and stabilization of memories across the brain after their initial formation
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Tranceformation: Digital dissemination of hypnosis Neuron (IF 16.2) Pub Date : 2024-01-22 David Spiegel
Hypnosis is an underutilized tool despite evidence of efficacy from randomized clinical trials. In this NeuroView, I discuss potential mechanisms in the context of brain networks and propose the use of app-based instruction in self-hypnosis.
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Phosphorylation of pyruvate dehydrogenase inversely associates with neuronal activity Neuron (IF 16.2) Pub Date : 2024-01-23 Dong Yang, Yu Wang, Tianbo Qi, Xi Zhang, Leyao Shen, Jingrui Ma, Zhengyuan Pang, Neeraj K. Lal, Daniel B. McClatchy, Saba Heydari Seradj, Verina H. Leung, Kristina Wang, Yi Xie, Filip S. Polli, Anton Maximov, Oscar Christian Gonzalez, Luis de Lecea, Hollis T. Cline, Vineet Augustine, John R. Yates III, Li Ye
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Direct neuronal reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle Neuron (IF 16.2) Pub Date : 2024-01-23 Giovanna Sonsalla, Ana Belen Malpartida, Therese Riedemann, Mirjana Gusic, Ejona Rusha, Giorgia Bulli, Sonia Najas, Aleks Janjic, Bob A. Hersbach, Pawel Smialowski, Micha Drukker, Wolfgang Enard, Jochen H.M. Prehn, Holger Prokisch, Magdalena Götz, Giacomo Masserdotti
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A septal-ventral tegmental area circuit drives exploratory behavior Neuron (IF 16.2) Pub Date : 2024-01-23 Petra Mocellin, Oliver Barnstedt, Kevin Luxem, Hiroshi Kaneko, Silvia Vieweg, Julia U. Henschke, Dennis Dalügge, Falko Fuhrmann, Anna Karpova, Janelle M.P. Pakan, Michael R. Kreutz, Sanja Mikulovic, Stefan Remy
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Apolipoprotein E secreted by astrocytes forms antiparallel dimers in discoidal lipoproteins Neuron (IF 16.2) Pub Date : 2024-01-23 Michael R. Strickland, Michael J. Rau, Brock Summers, Katherine Basore, John Wulf II, Hong Jiang, Yun Chen, Jason D. Ulrich, Gwendalyn J. Randolph, Rui Zhang, James A.J. Fitzpatrick, Anil G. Cashikar, David M. Holtzman
The Apolipoprotein E gene () is of great interest due to its role as a risk factor for late-onset Alzheimer’s disease. ApoE is secreted by astrocytes in the central nervous system in high-density lipoprotein (HDL)-like lipoproteins. Structural models of lipidated ApoE of high resolution could aid in a mechanistic understanding of how ApoE functions in health and disease. Using monoclonal Fab and F(ab′)
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Amygdala-hippocampus somatostatin interneuron beta-synchrony underlies a cross-species biomarker of emotional state Neuron (IF 16.2) Pub Date : 2024-01-23 Adam D. Jackson, Joshua L. Cohen, Aarron J. Phensy, Edward F. Chang, Heather E. Dawes, Vikaas S. Sohal
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Mapping of multiple neurotransmitter receptor subtypes and distinct protein complexes to the connectome Neuron (IF 16.2) Pub Date : 2024-01-22 Piero Sanfilippo, Alexander J. Kim, Anuradha Bhukel, Juyoun Yoo, Pegah S. Mirshahidi, Vijaya Pandey, Harry Bevir, Ashley Yuen, Parmis S. Mirshahidi, Peiyi Guo, Hong-Sheng Li, James A. Wohlschlegel, Yoshinori Aso, S. Lawrence Zipursky
Neurons express various combinations of neurotransmitter receptor (NR) subunits and receive inputs from multiple neuron types expressing different neurotransmitters. Localizing NR subunits to specific synaptic inputs has been challenging. Here, we use epitope-tagged endogenous NR subunits, expansion light-sheet microscopy, and electron microscopy (EM) connectomics to molecularly characterize synapses
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Neuronal ensembles: Building blocks of neural circuits Neuron (IF 16.2) Pub Date : 2024-01-22 Rafael Yuste, Rosa Cossart, Emre Yaksi
Neuronal ensembles, defined as groups of neurons displaying recurring patterns of coordinated activity, represent an intermediate functional level between individual neurons and brain areas. Novel methods to measure and optically manipulate the activity of neuronal populations have provided evidence of ensembles in the neocortex and hippocampus. Ensembles can be activated intrinsically or in response