个人简介

2001-2007-2007-2011 Assistant Professor, Department of Chemistry Associate Professor, Department of Chemistry 2011-present Professor, Department of Chemistry 2013-2017Associate Dean (T&L), Faculty of Science 2016-2016-present Interim Dean, Faculty of Science Associate Head, Department of Chemistry

研究领域

Organic chemistry

Research Areas Development of new organic synthetic methodology, asymmetric synthesis, total synthesis of natural products, bioactivity-directed isolation of natural products from Chinese medicinal herbs, and studies on their chemical biology and therapeutic applications, medicinal chemistry.

近期论文

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Intramolecular (4+3) Cycloadditions of Pyrroles and Application to the Synthesis of Class II Galbulimima Alkaloids. He, J.; Chen, Z.; Li, W.; Low, K.H.; Chiu, P.* Angew. Chem. Int. Ed. 2018, 57, 5253-5256. doi: 10.1002/anie.201711439 Synthesis and Applications of Unquaternized C-bound Boron Enolates. Ng., E. W. H.; Low, K.H.; Chiu, P.* J. Am. Chem. Soc. 2018, 140, 3537-3541. doi:10.1021/jacs.8b00614 Application of a Rhodium-catalyzed Cyclization Cycloaddition Cascade Strategy to the Total Synthesis of (-)-Curcumol. Zhang, X. X.;* Ko, R. Y. Y.; Xie, X. Q.; Qi, W. P.; Li, P. C.; Chiu, P.* Org. Chem. Front., 2018, 5, 1092-1095. doi: 10.1039/C7QO01150D Transannular [4+3] Cycloadditions of Macrocyclic Epoxy Ketones. Chan, D.; Chen, Y.; Low, K. H.; Chiu, P.* Chem.-Eur. J. 2018, 24, 2375-2378. doi: 10.1002/chem.201800019/full Abstract: Transannular [4+3] cycloadditions of dienophiles derived from macrocyclic epoxy ketones produce fused ring systems having central cycloheptane subunits. In some cases, base directly induced cycloisomerization of the epoxy ketones to yield the cycloadducts; in others, the epoxy ketones were transformed into their corresponding enolsilanes before undergoing cycloaddition. Enantiomerically-enriched tricyclic arrays are obtained from cycloadditions starting from optically pure epoxy ketones. An Approach to the Welwistatin Core via a Diazoketone Rearrangement–Ring Expansion Strategy. Lam. S. M.; Wong, W. T.; Chiu, P.* Org. Lett. 2017, 19, 4468–4471. DOI: 10.1021/acs.orglett.7b01988 Rearrangements of α-Diazo-β-Hydroxyketones for the Synthesis of Bicyclo[m.n.1]alkanones. Li, Z.; Lam, S. M.; Ip, I.; Wong, W. T.; Chiu, P.* Org. Lett. 2017, 19, 4464–4467. DOI: 10.1021/acs.orglett.7b01963 A Natural Product-like JAK2/STAT3 Inhibitor Induces Apoptosis of Malignant Melanoma Cells. Wu, K. J.; Huang J. M.; Zhong, H. J.; Dong Z. Z.; Liu, C.; Lu, J.-J.; Chen, X. P.; Chiu, P; Kwong, D. W.; Han, Q. B.; Ma, D. L.*; Leung, C. H.* PLoS One, 2017, 12(6) e0177123. DOI: 10.1371/journal.pone.0177123 Dearomative Intramolecular (4+3) Cycloadditions of Arenes with Epoxy and Aziridinyl Enolsilanes. Ling, J.; Lam, S.; Low, K.-H.; Chiu, P.* Angew. Chem., Int. Ed. 2017, 56, 8879–8882. DOI: 10.1002/anie.201704155 ​ Tetrandrine, an Activator of Autophagy, Induces Autophagic Cell Death via PKC-α Inhibition and mTOR-Dependent Mechanisms. Wong, V. K. W.; Zeng, W.; Chen J.; Yao, X. J.; Leung, E. L.; Wang Q. Q.; Chiu, P.*; Ko, B. C. B.*; Law, B. Y. K.* Front. Pharmacol. 2017, 8:351. DOI: 10.3389/fphar.2017.00351 3-Quinuclidinol. First Update. Y. Chen, Chiu, P.* In: Electronic Encyclopedia of Reagents for Organic Synthesis (e-EROS). John Wiley & Sons, 2016. "Goldilocks Effect" of Water in Lewis-Brønsted Acid and Base Catalysis. Barron, B. J.; Wong, W. T.; Chiu, P.; Hii, K. K.* ACS Catalysis. 2016, 6, 4189–4194. DOI: 10.1021/acscatal.6b00800 Epoxy and Aziridinyl Enolsilanes in Diastereoselective Inter- and Intramolecular Friedel–Crafts Alkylations. Ling, J.; Lam, S. K.; Lo, B.; Lam, S.; Wong, W. T.; Chen, G.; Sun, J.; Chiu, P.* Org. Chem. Front. 2016, 3, 457–461. DOI: 10.1039/C5QO00333D.This article is selected to be in the themed collection: Hot articles in Organic Chemistry Frontiers in 2016. Copper Hydride-Catalyzed Reductive Claisen Rearrangements. Wong, K. C.; Ng, E.; Wong, W. T.; Chiu, P.* Chem. – Eur. J. 2016, 22, 3709–3712. DOI: 10.1002/chem.201504870. This article is part of a Special Issue: Women in Chemistry. Formal Total Synthesis of (+)-Cortistatin A and J. Kuang, L.; Liu, L. L.; Chiu, P.* Chem. – Eur. J. 2015, 21, 14287–14291. DOI: 10.1002/chem.201502890. Selected as a Hot Paper by the Journal. Also highlighted in: Organic Chemistry Highlights: http://www.organic-chemistry.org/Highlights/2016/29August.shtm Further studies on sultones derived from carbene cyclization cycloaddition cascades. Groß, T.; Herrmann, T.; Shi, B.; Jäger, A.; Chiu, P.; Metz, P.* Tetrahedron, 2015, 71, 5925–5931. DOI: 10.1016/j.tet.2015.05.095 Concerted Ring-Opening and Cycloaddition of Chiral Epoxy Enolsilanes with Dienes. Krenske, E. H.*; Lam, S.; Ng, J. P. L.; Lo, B.; Lam, S. K.; Chiu, P.*; Houk, K. N.* Angew. Chem., Int. Ed. 2015, 54, 7422–7425. DOI: 10.1002/anie.201503003 Cycloaddition Reactions of Carbonyl Ylides Derived From Enones. Yu, Y.; Cornelissen, L.; Wong, W. T.; Chiu, P.* Synlett 2015, 26 (11), 1553–1556. DOI: 10.1055/s-0034-1379926. Invited Contribution to Special Issue dedicated to Prof. K. C. Vollhardt. Total Synthesis of (–)-Dolastatrienol. Leung, L. T.; Chiu, P.* Chem. – Asian J. 2015, 10, 1042–1049. DOI: 10.1002/asia.201403325. Selected as a VIP (Very Important Paper)