In Vivo Anti-inflammatory and Antiallergic Activity of Pure Naringenin, Naringenin Chalcone, and Quercetin in Mice,Journal of Natural Products

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In Vivo Anti-inflammatory and Antiallergic Activity of Pure Naringenin, Naringenin Chalcone, and Quercetin in Mice
Journal of Natural Products ( IF 3.3 ) Pub Date : 2019-01-28 00:00:00 , DOI: 10.1021/acs.jnatprod.8b00366
Elvira Escribano-Ferrer _{1,

2} , Josep Queralt Regué ₃ , Xavier Garcia-Sala ₁ , Antoni Boix Montañés ₁ , Rosa M. Lamuela-Raventos _{2,

4}

Affiliation

Flavonoids, found in almost all fruits and vegetables, belong to a class of plant secondary metabolites with a polyphenolic structure and have properties with health-improving potential. However, few experimental studies on the effects of flavonoids have been carried out in vivo after external application and using pure compounds. Aiming to fill this gap, in this study we tested the topical anti-inflammatory and antiallergic activity of three flavonoids of high purity, naringenin, naringenin chalcone, and quercetin, in mouse models. The topical anti-inflammatory effects were assessed against arachidonic acid- (AA) and tetradecanoylphorbol-13-acetate- (TPA) induced ear edema. The anti-inflammatory effect of naringenin against ear edema was noticeable at a 1% dose in the AA model and at half this dose in the TPA model. Quercetin (1.3%) did not exert any topical anti-inflammatory activity in the AA model, but its inhibitory effect in the TPA model was similar to that of naringenin (2%); in contrast, naringenin chalcone was more active against the AA-induced than TPA-induced inflammation. The flavonoid effect on IgE-mediated passive cutaneous anaphylaxis was also studied in mice, both intravenously and topically. Naringenin, naringenin chalcone, and quercetin all showed strong antiallergic activity after intravenous dosing (0.02%) and when applied topically (2%). The results of this study suggest that the flavonoids naringenin, naringenin chalcone, and quercetin may be useful alternatives for the topical treatment of inflammatory and allergic skin disorders.

中文翻译：

天然柚皮素，柚皮素查尔酮和槲皮素对小鼠的体内抗炎和抗过敏活性

类黄酮几乎存在于所有水果和蔬菜中，属于一类具有多酚结构的植物次生代谢产物，具有改善健康的潜力。然而，很少有关于黄酮类药物作用的实验研究在体内进行外用后并使用纯化合物。为了填补这一空白，在这项研究中，我们在小鼠模型中测试了三种高纯度黄酮，柚皮苷，柚皮苷查尔酮和槲皮素的局部抗炎和抗过敏活性。评估了抗花生四烯酸（AA）和十四烷酰phorbol-13-乙酸盐（TPA）引起的耳部水肿的局部抗炎作用。柚皮苷对耳部水肿的抗炎作用在AA模型中为1％，在TPA模型中为该剂量的一半。槲皮素（1.3％）在AA模型中未表现出任何局部抗炎活性，但其在TPA模型中的抑制作用与柚皮素（2％）相似。相反，柚皮素查尔酮比APA诱导的炎症更能抵抗AA诱导的炎症。还在小鼠中静脉内和局部研究了类黄酮对IgE介导的被动皮肤过敏反应的作用。静脉给药后（0.02％）和局部使用（2％）后，柚皮苷，柚皮苷查尔酮和槲皮素均显示出强大的抗过敏活性。这项研究的结果表明，类黄酮柚皮苷，柚皮苷查尔酮和槲皮素可能是局部治疗炎性和过敏性皮肤病的有用替代品。

更新日期：2019-01-28

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