日本的乳制品消费和甲状腺癌的事件风险：宫城队列研究和 Ohsaki 队列研究的汇总分析,European Journal of Nutrition

当前位置： X-MOL 学术 › Eur. J. Nutr. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

日本的乳制品消费和甲状腺癌的事件风险：宫城队列研究和 Ohsaki 队列研究的汇总分析
European Journal of Nutrition ( IF 4.1 ) Pub Date : 2022-08-11 , DOI: 10.1007/s00394-022-02979-9
Marina Tanitame ₁ , Yumi Sugawara ₁ , Yukai Lu ₁ , Sanae Matsuyama ₁ , Seiki Kanemura ₂ , Akira Fukao ₃ , Ichiro Tsuji ₁

Affiliation

目的

乳制品消费对甲状腺癌的影响尚不清楚。本研究的目的是阐明乳制品消费与日本人甲状腺癌风险之间的关系。

方法

通过对日本宫城县居民的两项前瞻性研究进行汇总分析，研究了日本人乳制品消费与甲状腺癌风险之间的关联。对 1990 年宫城队列研究和 1994 年 Ohsaki 队列研究中登记的 64,340 名 40-79 岁男性和女性的数据进行了分析。使用自我管理的食物频率问卷在基线评估乳制品消费，并根据每天乳制品总消费量的重量（以克为单位）分为四分位数。

结果

在 1,075,018 人年的随访期间，有 190 例甲状腺癌病例（29 名男性和 161 名女性）。与最低四分位数相比，乳制品消费最高四分位数甲状腺癌发病率的风险比 (HR) 和 95% 置信区间 (CI) 男性为 0.83（95% CI 0.28–2.43，P趋势 = 0.823），男性为 0.67 (95% CIs 0.42–1.06, P -trend = 0.056) 女性。根据 BMI 进行分层后，观察到 BMI ≥ 25 kg/m ²的女性的风险降低（HR：0.37，95% CI 0.18–0.79，P趋势 = 0.010）。

结论

^{在 BMI ≥ 25 kg/m 2}的女性中，乳制品摄入量与患甲状腺癌的风险呈负相关。

"点击查看英文标题和摘要"

Dairy consumption and incident risk of thyroid cancer in Japan: a pooled analysis of the Miyagi Cohort Study and the Ohsaki Cohort Study

Purpose

The impact of dairy consumption on thyroid cancer is unclear. The purpose of this study was to elucidate the association between dairy consumption and the risk of thyroid cancer in Japanese people.

Methods

The association between dairy consumption and the risk of thyroid cancer in Japanese people was examined by conducting a pooled analysis of two prospective studies of residents in Miyagi Prefecture, Japan. Data from 64,340 men and women aged 40–79 years registered in the Miyagi Cohort Study in 1990 and in the Ohsaki Cohort Study in 1994 were analyzed. Dairy consumption was assessed at baseline using a self-administered food frequency questionnaire and was divided into quartiles based on the weight (in grams) of total dairy consumption per day.

Results

During 1,075,018 person-years of follow-up, there were 190 incident cases of thyroid cancer (29 men and 161 women). The hazard ratios (HRs) and 95% confidence intervals (CIs) for thyroid cancer incidence in the highest quartile of dairy consumption compared with the lowest quartile were 0.83 (95% CIs 0.28–2.43, P-trend = 0.823) for men and 0.67 (95% CIs 0.42–1.06, P-trend = 0.056) for women. After stratification for BMI, a decreased risk was observed in women with BMI ≥ 25 kg/m² (HRs: 0.37, 95% CIs 0.18–0.79, P-trend = 0.010).