Lichen Usnea sp. is potential as a new natural medicine. This study report isolation of secondary metabolites from lichen Usnea sp. and α-glucosidase inhibitory, which is potential as an antidiabetic agent. Lichen powder was macerated using methanol, separated using column chromatography gravity and thin-layer chromatography. The crystalline was isolated and purified by the recrystallization process for obtaining pure compound. The isolated compound was determined using FTIR and NMR spectroscopy (¹H and ¹³C). The results showed that the isolated compound was yellow needle crystals. Based on the spectra data interpretation, it was obtained usnic acid compound with the molecular formula of C₁₈H₁₆O₇. The α-glucosidase inhibitory activity test showed that the usnic acid had activity in inhibiting the α-glucosidase enzyme with an IC₅₀ value of 106.78 µg/mL. The usnic acid from Usnea sp. has a very good impact on the source of natural compounds as an antidiabetic drug in the future.

地衣松萝sp。有潜力成为一种新的天然药物。本研究报告了从地衣松萝属植物中分离出次级代谢物。和 α-葡萄糖苷酶抑制剂，具有作为抗糖尿病药物的潜力。使用甲醇浸渍地衣粉末，使用柱色谱重力和薄层色谱分离。通过重结晶过程分离和纯化结晶以获得纯化合物。使用FTIR和NMR光谱( ¹ H和¹³ C)测定分离的化合物。结果表明，分离得到的化合物为黄色针状结晶。根据光谱数据解释，得到松萝酸化合物，分子式为C ₁₈ H ₁₆7 . _{_} α-葡萄糖苷酶抑制活性试验表明松萝酸具有抑制α-葡萄糖苷酶的活性，IC ₅₀值为106.78 μg/mL。松萝属的松萝酸。对未来作为抗糖尿病药物的天然化合物来源有很好的影响。