A toxicologic and dermatologic review of 1-(2,4,4,5,5-pentamethyl-1-cyclopenten-1-yl)ethan-1-one when used as a fragrance ingredient is presented. 1-(2,4,4,5,5-Pentamethyl-1-cyclopenten-1-yl)ethan-1-one is a member of the fragrance structural group Alkyl Cyclic Ketones. These fragrances can be described as being composed of an alkyl, R1, and various substituted and bicyclic saturated or unsaturated cyclic hydrocarbons, R2, in which one of the rings may include up to 12 carbons. Alternatively, R2 may be a carbon bridge of C2-C4 carbon chain length between the ketone and cyclic hydrocarbon. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 1-(2,4,4,5,5-pentamethyl-1-cyclopenten-1-yl)ethan-1-one were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, phototoxicity, and photoallergy data. A safety assessment of the entire Alkyl Cyclic Ketones will be published simultaneously with this document; please refer to Belsito et al. (Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2013. A Toxicologic and Dermatologic Assessment of Alkyl Cyclic Ketones When Used as Fragrance Ingredients (submitted for publication)) for an overall assessment of the safe use of this material and all Alkyl Cyclic Ketones in fragrances.

中文翻译：

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1-（2,4,4,5,5-五甲基-1-环戊烯-1-基）乙-1-酮的香精材料综述。

提出了1-（2,4,4,5,5-五甲基-1-环戊烯-1-基）乙-1-酮用作香料成分的毒理学和皮肤病学综述。1-（2,4,4,5,5-五甲基-1-环戊烯-1-基）乙-1-酮是香料结构基团烷基环酮的成员。可以将这些香料描述为由烷基R1和各种取代的和双环的饱和或不饱和环状烃R2组成，其中一个环可包含多达12个碳。或者，R 2可以是在酮和环烃之间的C 2 -C 4碳链长度的碳桥。这篇评论包含与该单独的香料成分有关的所有可用毒理学和皮肤病学论文的详细摘要，并不旨在作为独立文档。1-（2,4,4,5，然后对5-戊甲基-1-环戊烯-1-基）乙-1-酮进行了评估，包括物理性质，急性毒性，皮肤刺激性，粘膜（眼）刺激性，皮肤致敏性，光毒性和光敏性数据。整个烷基环酮的安全性评估将与本文件同时发布；请参阅Belsito等。（Belsito，D.，Bickers，D.，Bruze，M.，Calow，P.，Dagli，M.，Fryer，AD，Greim，H.，Miyachi，Y.，Saurat，JH，Sipes，IG，2013。用作芳香成分的烷基环酮的毒理学和皮肤病学评估（提交出版）），用于总体评估该材料和香料中所有烷基环酮的安全使用。粘膜（眼睛）刺激，皮肤过敏，光毒性和光敏性数据。整个烷基环酮的安全性评估将与本文件同时发布；请参阅Belsito等。（Belsito，D.，Bickers，D.，Bruze，M.，Calow，P.，Dagli，M.，Fryer，AD，Greim，H.，Miyachi，Y.，Saurat，JH，Sipes，IG，2013。用作芳香成分的烷基环酮的毒理学和皮肤病学评估（提交出版）），用于总体评估该材料和香料中所有烷基环酮的安全使用。粘膜（眼睛）刺激，皮肤过敏，光毒性和光敏性数据。整个烷基环酮的安全性评估将与本文件同时发布；请参阅Belsito等。（Belsito，D.，Bickers，D.，Bruze，M.，Calow，P.，Dagli，M.，Fryer，AD，Greim，H.，Miyachi，Y.，Saurat，JH，Sipes，IG，2013。用作芳香成分的烷基环酮的毒理学和皮肤病学评估（提交出版）），用于总体评估该材料和香料中所有烷基环酮的安全使用。