代表性学术论文: |
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Gao, J.; Liu, S.; Zhou, C.; Lara, D.; Zou, Y.*, Hai, Y.*, A pyridoxal 5’-phosphate-dependent Mannich Cyclase. Nature Catalysis 2023, 1-11. doi.org/10.1038/s41929-023-00963-y |
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Wang, H.‡; Zou, Y.‡; Li, M.; Tang, Z.; Wang, J.; Tian, Z., Strassner, N.; Yang, Q.; Zheng, Q.; Guo, Y.; Liu, W.; Pan, L.; Houk, K. N., A 2+2/4+2 Cyclase. Nature Chemistry 2023, 1-8. doi.org/10.1038/s41557-022-00918-z |
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Gao, L.‡; Zou, Y.‡; Liu, X.; Yang, J.; Du, X.; Wang, J.; Yu, X.; Fan, J.; Jiang, M.; Li, Y.; Houk, K. N.; Lei, X., Enzymatic control of endo- and exo-stereoselective Diels–Alder reactions with broad substrate scope. Nature Catalysis 2021, 4 (12), 1059-1069. |
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Zou, Y.*; Houk, K. N.*, J. Am. Chem. Soc. 2021, 143 (30), 11734-11740. “Mechanisms and Dynamics of Synthetic and Biosynthetic Formation of Delitschiapyrones: Solvent Control of Ambimodal Periselectivity” doi.org/10.1021/jacs.1c05293 |
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Basler, S.; Studer, S.; Zou, Y.; Mori, T.; Ota, Y.; Camus, A.; Bunzel, A.; Helgeson, R.; Houk, K. N.; Jiménez-Osés, G.; Hilvert, D. Nature Chemistry 2021, 13, 231-235. “Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold” |
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Zou, Y.; Yang, S.; Sanders, J. N.; Li, W.; Yu, P.; Wang, H.; Tang, Z.; Liu, W.; Houk, K.N. J. Am. Chem. Soc. 2020, 142, 20232-20239. “Computational Investigation of the Mechanism of Diels–Alderase PyrI4” doi.org/10.1021/jacs.0c10813 |
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Zou, Y.; Wong, J.; Houk, K. N. J. Am. Chem. Soc. 2020, 142, 38, 16403–16408. “Computational exploration of a redox-neutral organocatalytic Mitsunobu reaction” |
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Zou, Y.; Chen, S.; Houk, K. N. J. Am. Chem. Soc. 2019, 141, 12382-12387. “Origins of selective formation of 5-vinyl-2-methylene furans from oxyallyl/diene (3+2) cycloadditions with Pd(0) catalysis” doi.org/10.1021/jacs.9b05762 |
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Zou, Y.; Wang, X.; Sims, J.; Wang, B.; Pandey, P.; Welsh, C. L.; Stone, R. S.; Avery, M. A.; Doerksen, R. J.; Ferreira, D.; Anklin, C.; Valeriote, F. A.; Kelly, M.; Hamann, M. T. J. Am. Chem. Soc. 2019, 141, 4338-4344. “Computationally-assisted discovery and assignment of a highly strained and PANC-1 selective alkaloid from Alaska’s deep ocean” doi.org/10.1021/jacs.8b11403 |
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Zou, Y.; Li, X.; Yang, Y.; Berritt, S.; Melvin, J.; Gonzales, S.; Spafford, M.; Smith, A. B. J. Am. Chem. Soc. 2018, 140, 9502. “Total synthesis of (−)-nodulisporic acids D, C, and B: evolution of a unified synthetic strategy” doi.org/10.1021/jacs.8b04053 |
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Zou, Y.; Melvin, J. E.; Gonzales, S. S.; Spafford, M. J.; Smith, A. B. J. Am. Chem. Soc. 2015, 137, 7095. “Total synthesis of (−)-nodulisporic acid D”
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