(52)

Liu, S.; Yeh, C.; Reavill,   C.; Jones, B.; Zou, Y.; Hai, Y. Molecular and structural basis for   Cγ‐C bond formation by PLP‐dependent enzyme Fub7. Angew. Chem. Int. Ed. 2024,   e202317161.   doi.org/10.1002/ange.202317161

(51)

Qin, Z.-Y.; Gao, S.; Zou,   Y.; Liu, Z.; Wang, J. B.; Houk, K. N.; Arnold, F. H. Biocatalytic   Construction of Chiral Pyrrolidines and Indolines via Intramolecular C(sp3)–H   Amination. ACS Central Science 2023, 9, 2333-2338. doi.org/10.1021/acscentsci.3c00516

(50)

Gao, J.; Liu, S.; Zhou,   C.; Lara, D.; Zou, Y.*; Hai, Y.* A pyridoxal 5′-phosphate-dep­end­ent Mannich   cyclase. Nature Catalysis 2023, 1-11.

 doi.org/10.1038/s41929-023-00963-y

(49)

Yang, F.; Sang, M.; Lu, J.   R.; Zhao, H. M.; Zou, Y.; Wu, W.; Yu, Y.; Liu, Y. W.; Ma, W.; Zhang,   Y. Somalactams A–D: Anti‐inflammatory Macrolide Lactams with Unique Ring   Systems from an Arctic Actinomycete Strain. Angew. Chem. Int. Ed. 2023,   62, e202218085. doi.org/10.1002/ange.202218085

(48)

Martin-Somer, A.; Xue, X.-S.; Jamieson, C. S.; Zou, Y.; Houk, K.   N., Computational Design of a Tetrapericyclic Cycloaddition and the Nature of   Potential Energy Surfaces with Multiple Bifurcations. J. Am. Chem. Soc. 2023,   145 (7), 4221-4230. doi.org/10.1021/jacs.2c12871

(47)

Wang, H.‡;   Zou, Y.‡; Li, M.; Tang, Z.; Wang,   J.; Tian, Z., Strassner, N.; Yang, Q.; Zheng, Q.; Guo, Y.; Liu, W.; Pan, L.; Houk,   K. N., A 2+2/4+2 Cyclase. Nature Chemistry 2023, 1-8. doi.org/10.1038/s41557-022-00918-z

(46)

Schumacher, R. W.; Waters,   A. L.; Peng, J.; Schumacher, R. A.; Bateman, A.; Thiele, J.; Mitchell, A. J.;   Miller, S. G.; Goldberg, A.; Tripathi, S. K.; Agarwal, A. K.; Zou, Y.;   Choo, Y.-M.; Hamann, M. T., Structure and Antimicrobial Activity of Rare   Lactone Lipids from the Sooty Mold (Scorias spongiosa). J. Nat. Prod. 2022,   85 (5), 1436-1441.

doi.org/10.1021/acs.jnatprod.1c01012

(45)

Zhang, C.‡;   Zuo, H.‡;   Lee, G. Y.‡; Zou, Y.‡;   Dang, Q.-D.; Houk, K. N.; Niu, D., Halogen-bond-assisted radical activation of   glycosyl donors enables mild and stereoconvergent 1,2-cis-glycosylation. Nature   Chemistry 2022, 14 (6), 686-694.

doi.org/10.1038/s41557-022-00918-z

(44)

Li, B.; Guan, X.; Yang,   S.; Zou, Y.; Liu, W.; Houk, K. N., Mechanism of the Stereoselective   Catalysis of Diels–Alderase PyrE3 Involved in Pyrroindomycin Biosynthesis. J.   Am. Chem. Soc. 2022, 144 (11), 5099-5107. doi.org/10.1021/jacs.2c00015

(43)   

Gao, L.‡;   Zou, Y.‡; Liu, X.; Yang, J.; Du, X.;   Wang, J.; Yu, X.; Fan, J.; Jiang, M.; Li, Y.; Houk, K. N.; Lei, X., Enzymatic   control of endo- and exo-stereoselective Diels–Alder reactions with broad   substrate scope. Nature Catalysis 2021, 4 (12),   1059-1069.

doi.org/10.1038/s41929-021-00717-8

(42)   

Zou, Y.*;   Houk, K. N.*, J. Am. Chem. Soc. 2021, 143 (30), 11734-11740. “Mechanisms and Dynamics of Synthetic and   Biosynthetic Formation of Delitschiapyrones: Solvent Control of Ambimodal   Periselectivity” doi.org/10.1021/jacs.1c05293

(41)     

Deng, Y. ‡;   Zou, Y. ‡; Yang, C.-P. H.; Houk, K.   N.; Smith, A. B., J. Org. Chem. 2021, 86 (19),   13583-13597. “Total Syntheses of (+)-Peniciketals A-B and (−)-Diocollettines   A Exploiting a Photoisomerization/Cyclization Union Protocol”

doi.org/10.1021/acs.joc.1c01635

(40)       

Wan, L.-Q.‡; Zhang, X.‡; Zou, Y.‡; Shi, R.; Cao, J.-G.; Xu, S.-Y.; Deng, L.-F.; Zhou, L.; Gong, Y.; Shu,   X.; Lee, G. Y.; Ren, H.; Dai, L.; Qi, S.; Houk, K. N.; Niu, D., J. Am.   Chem. Soc. 2021, 143 (31), 11919-11926. “Nonenzymatic   Stereoselective S-Glycosylation of Polypeptides and Proteins” doi.org/10.1021/jacs.1c05156

(39)     

Anthony, S. M.‡; Tona, V.‡; Zou, Y.‡; Morrill, L. A.; Billingsley, J. M.; Lim, M.; Tang, Y.; Houk, K. N.;   Garg, N. K., J. Am. Chem. Soc. 2021, 143, 7471-7479. “Total   Synthesis of (−)-Strictosidine and Interception of Aryne Natural Product   Derivatives “Strictosidyne” and “Strictosamidyne” doi.org/10.1021/jacs.1c02004

(38)     

Basler, S.; Studer, S.; Zou, Y.; Mori, T.; Ota, Y.; Camus,   A.; Bunzel, A.; Helgeson, R.; Houk, K.  N.; Jiménez-Osés, G.; Hilvert, D. Nature   Chemistry 2021, 13, 231-235. “Efficient Lewis acid catalysis of an abiological reaction   in a de novo protein scaffold”

doi.org/10.1038/s41557-020-00628-4

(Highlighted on UCLA News Report and C&EN news)

(37)

Zou, Y.;   Yang, S.; Sanders, J. N.; Li, W.; Yu, P.; Wang, H.; Tang, Z.; Liu, W.; Houk,   K.N. J. Am. Chem. Soc. 2020, 142, 20232-20239. “Computational   Investigation of the Mechanism of Diels–Alderase PyrI4” doi.org/10.1021/jacs.0c10813

(36)

Yang, F.; Gao, Y.; Chang Y.; Zou,   Y.; Houk, K. N.; Lu, J.; He, J.; Tang, W.; Liao, H.; Han, H.; Lin, H. J.   Nat. Prod., 2020, 83, 3758-3763. “Aromatic ring substituted   aaptamine analogues as potential cytotoxic agents against extranodal natural killer/T-cell   lymphoma” doi.org/10.1021/acs.jnatprod.0c00769

(35)        

Liu, L.; Zou, Y.; Bhattacharya, A.; Zhang, D.;   Lang, S. Q.; Houk, K. N.; Devaraj, N. K. Nature Chemistry   2020, 12, 1029-1034. “Enzyme-free synthesis of natural   phospholipids in water” doi.org/10.1038/s41557-020-00559-0

(34)        

Zou, Y.; Wong, J.; Houk, K. N. J. Am. Chem. Soc. 2020,   142, 38, 16403–16408. “Computational exploration of a redox-neutral organocatalytic   Mitsunobu reaction”

doi.org/10.1021/jacs.0c07487

(33)        

Li, H.; Liang,   Y.-R.; Chen, S.-X.; Wang, W.-X.; Zou, Y.; Nuryyeva, S.; Houk, K. N.;   Xiong, J.; Hu, J.-F. J. Nat. Prod. 2020, 83, 2129-2144. “Amentotaxins   C–V, structurally diverse diterpenoids from the leaves and twigs of the vulnerable   conifer Amentotaxus argotaenia and their cytotoxic effects” doi.org/10.1021/acs.jnatprod.0c00064

(32)     

Low, Z. J.‡; Ma, G.-L.‡; Tran, H. T. ‡; Zou, Y.‡; Xiong, J.;   Pang, L.; Nuryyeva, S.; Ye, H.; Hu, J.-F.; Houk, K. N.; Liang, Z.-X. J.   Am. Chem. Soc. 2020, 142, 1673-1679. “Sungei­dines from a non-canonical   enediyne biosynthetic pathway” doi.org/10.1021/jacs.9b10086

(31)        

Liu, L.; Zou,   Y.; Bhattacharya, A.; Zhang, D.; Lang, S. Q.; Houk, K. N.; Devaraj, N. K.   bioRxiv 2019, 746156. “Enzyme-free synthesis of natural phospholipids   in water” doi.org/10.1101/746156

(30)        

Zou, Y.; Chen, S.; Houk, K. N. J. Am. Chem. Soc. 2019,   141, 12382-12387. “Origins of selective formation of 5-vinyl-2-methylene   furans from oxyallyl/diene (3+2) cycloadditions with Pd(0) catalysis” doi.org/10.1021/jacs.9b05762

(29)        

Zou, Y.; Xue, X.-S.; Deng, Y.; Smith, A. B.; Houk, K. N. Org.   Lett. 2019, 21, 5894-5897. “Factors controlling reactivity in   the hydrogen atom transfer and radical addition steps of a radical relay   cascade” doi.org/10.1021/acs.orglett.9b02023

(28)        

Xiong, J.; Meng, W.-J.; Zhang, H.-Y.; Zou, Y.; Wang, W.-X.; Wang, X.-Y.; Yang,   Q.-L.; Osman, E. E. A.; Hu, J.-F. Phytochemistry 2019, 162,   183-192. “Lycofargesiines A–F, further lycopodium alkaloids from the club   moss Huperzia fargesii”

doi.org/10.1016/j.phytochem.2019.03.015

(27)        

Deng, Y.; Nguyen, M. D.; Zou, Y.; Houk, K. N.;   Smith, A. B. Org. Lett. 2019, 21, 1708-1712. “Generation   of dithianyl and dioxolanyl radicals using photoredox catalysis: application   in the total synthesis of the danshenspiroketallactones via radical relay   chemistry” doi.org/10.1021/acs.orglett.9b00271

(26)        

Zou, Y.‡; Wang, X. ‡; Sims, J.;   Wang, B.; Pandey, P.; Welsh, C. L.; Stone, R. S.; Avery, M. A.; Doerksen, R.   J.; Ferreira, D.; Anklin, C.; Valeriote, F. A.; Kelly, M.; Hamann, M. T. J.   Am. Chem. Soc. 2019, 141, 4338-4344. “Computationally-assisted   discovery and assignment of a highly strained and PANC-1 selective alkaloid   from Alaska’s deep ocean” doi.org/10.1021/jacs.8b11403

(25)        

Tang, Y.; Li, N.; Zou,   Y.; Ai, Y.; Ma, G.-L.; Osman, E. E. A.; Xiong, J.; Li, J.; Jin, Z.-X.; Hu,   J.-F. Phytochemistry 2019, 160, 25-30. “LC-MS guided   isolation and dereplication of lycopodium alkaloids from Lycopodium cernuum   var. sikkimense of different geographical origins” doi.org/10.1016/j.phytochem.2019.01.006

(24)        

Zou, Y.; Li, X.; Yang, Y.; Berritt, S.; Melvin, J.; Gonzales,   S.; Spafford, M.; Smith, A. B. J. Am. Chem. Soc. 2018, 140, 9502. “Total synthesis of (−)-nodulisporic   acids D, C, and B: evolution of a unified synthetic strategy” doi.org/10.1021/jacs.8b04053

(23)        

Ai, Y.; Kozytska, M. V.; Zou, Y.; Khartulyari, A. S.; Maio, W.   A.; Smith, A. B. J. Org. Chem. 2018, 83, 6110. “Total synthesis   of the marine phosphomacrolide, (−)-enigmazole A, exploiting multicomponent type   I anion relay chemistry (ARC) in conjunction with a late-stage   Petasis–Ferrier union/rearrangement”

doi.org/10.1021/acs.joc.8b00899

(22)        

Zou, Y.; Gutierrez, O.;   Sader, A. C.; Patel, N. D.; Fandrick, D. R.; Busacca, C. A.; Fandrick, K. R.;   Kozlowski, M.; Senanayake, C. H. Org. Lett. 2017, 19,   6064. “A computational investigation of the ligand-controlled Cu-catalyzed   site-selective propargylation and allenylation of carbonyl compounds”

doi.org/10.1021/acs.orglett.7b02845

(21)        

Zou, Y.; Smith, A. B. J   Antibiot 2017, 30, 94. “Total synthesis of architecturally   complex indole terpenoids: strategic and tactical evolution” doi.org/10.1038/ja.2017.94

– Special issue in honor of   Professor K. C. Nicolaou

(20)        

Tang, Y.; Xiong, J.; Zou, Y.; Wang, W.; Huang, C.; Zhang,   H.-Y.; Hu, J.-F. Phytochemistry 2017, 143, 1. “Annotinolide   F and lycoannotines A–I, further lycopodium alkaloids from Lycopodium   annotinum” doi.org/10.1016/j.phytochem.2017.07.003

(19)        

Hu, C.-L.; Xiong, J.; Gao, L.-X.;   Li, J.; Zeng, H.; Zou, Y.; Hu,   J.-F. RSC Advances 2016, 6, 60467. “Diterpenoids from the   shed trunk barks of the endangered plant Pinus dabeshanensis and their   PTP1B inhibitory effects” doi.org/10.1039/C6RA08986K

(18)        

Wang, L.-J.; Xiong, J.; Zou, Y.; Mei, Q.-B.; Wang, W.-X.; Hu,   J.-F. Phytochemistry Letters 2016, 18, 202. “Sesquiterpenoids   from the Chinese endangered plant Manglietia   aromatica” doi.org/10.1016/j.phytol.2016.10.018

(17)        

Tang, Y.; Xiong, J.; Zou, Y.; Zhang, H.-Y.; Hu, J.-F. Phytochemistry   2016, 131, 130. “Palhicerines A-F, lycopodium alkaloids   from the club moss Palhinhaea cernua”

doi.org/10.1016/j.phytochem.2016.08.010

(16)        

Xiong, J.; Hong, Z.-L.; Xu, P.; Zou, Y.; Yu, S.-B.; Yang, G.-X.; Hu,   J.-F. Organic & Biomolecular Chemistry 2016, 14, 4678.   “ent-Abietane diterpenoids with anti-neuroinflamm­atory activity from the   rare Chloranthaceae plant Chloranthus   ol dhamii” doi.org/10.1039/C6OB00731G

(15)    

Tang, Y.; Xiong, J.; Zou, Y.; Nay, B.; Wang, L.-J.; Hu,   J.-F. Chin. Chem. Lett. 2016, 27, 969. “Palcernuine,   the first [5/6/6/6]-cernuane-type alkaloid from Palhinhaea cernua f. sikkim­ensis” doi.org/10.1016/j.cclet.2016.02.014

(14)     

Xiong, L.; Zhou,   Q.-M.; Zou, Y.; Chen, M.-H.; Guo,   L.; Hu, G.-Y.; Liu, Z.-H.; Peng, C. Org. Lett. 2015. “Leonuketal, a   spiroketal diterpenoid from Leonurus japonicus”

doi.org/10.1021/acs.orglett.5b03227

(13)        

Ai, Y.; Kozytska,   M. V.; Zou, Y.; Khartulyari, A.   S.; Smith, A. B. J. Am. Chem. Soc. 2015, 137, 15426. “Total   synthesis of (−)-enigmazole A” doi.org/10.1021/jacs.5b11540

(Selected   by Synfacts, Carreira, E. M.; Westphal, M. Synfacts   2016, 12, 0117. “Synthesis of (–)-Enigmazole A” doi.org/10.1055/s-0035-1561117)

(This work has been included in the book Organophosphorus   Chemistry, Oxford University Press, 2017, authored by Professor John C.   Tebby)

(12)     

Zou, Y.;   Melvin, J. E.; Gonzales, S. S.; Spafford, M. J.; Smith, A. B. J. Am. Chem.   Soc. 2015, 137, 7095. “Total synthesis of (−)-nodulisporic acid   D”

doi.org/10.1021/jacs.5b04728

(Selected by D. F. Taber,Org. Chem. Highlights 2015, September 7.)

(Selected by Synfacts,   Carreira, E. M.; Fischer, S. Synfacts 2015, 11, 0796. “Synthesis   of (–)-Nodulisporic Acid D” doi.org/10.1055/s-0034-1381168)

(Included in the book “Organic   Synthesis: State of the Art, 2013-2015”)

(11)        

He, Y.-C.; Zou, Y.; Peng, C.; Liu, J.-L.; He, C.-J.;   Guo, L.; Xie, X.-F.; Xiong, L. Fitoterapia   2015, 100, 7. “Penthorin A and B,   two unusual 2,4′-epoxy-8,5′-neolignans from Penthorum chinese” doi.org/10.1016/j.fitote.2014.11.006

(10)    

Yang, F.#; Zou, Y. #; Wang, R.-P.; Hamann, M.; Zhang, H.-J.; Jiao,   W.-H.; Han, B.-N.; Song, S.-J.; Lin, H.-W. Marine Drugs 2014, 12,   4399. “Relative and absolute stereochemistry   of diacarperoxides: antimalarial norditerpene endoperoxides from marine   sponge Diacarnus megaspinorhabdosa” doi.org/10.3390/md12084399

(9)        

Albadry, M.; Zou,   Y.; Takahashi, Y.; Waters, A.; Hossein, M.; Tomioka, T.; Hamann, M. T. Planta   Med 2013, 79, PT2. “Progress toward the total synthesis of the   marine natural product karlotoxin 5” doi.org/10.1055/s-0033-1348824

(8)       

Oh, J.; Bowling, J. J.; Zou, Y.; Chittiboyina, A. G.; Doerksen, R. J.; Ferreira, D.;   Leininger, T. D.; Hamann, M. T. Biochimica et Biophysica Acta (BBA) -   General Subjects 2013, 1830, 4229. “Configurational assignments of conformationally restricted   bis-monoterpene hydroquinones: utility in exploration of endangered plants” doi.org/10.1016/j.bbagen.2013.04.029

(7)       

Zou, Y.; Hamann, M. T. Org. Lett. 2013, 15, 1516. “Atkamine:   a new pyrroloiminoquinone scaffold from the cold water Aleutian Islands Latrunculia sponge”

doi.org/10.1021/ol400294v

(Selected by ACS cross-journal organic chemistry virtual   issue “All Natural – the Renaissan­ce of Natural Products Chemistry” doi.org/10.1021/jo501288m)

(6)    

Belofsky, G.; Kolaczkowski, M.; Adams, E.; Schreiber,   J.; Eisenberg, V.; Coleman, C. M.; Zou,   Y.; Ferreira, D. J. Nat. Prod. 2013, 76, 915. “Fungal   ABC transporter-associated activity of isoflavonoids from   the root extract of Dalea formosa”

doi.org/10.1021/np4000763

(5)        

Wang, W.-X.; Zhu, J.-J.; Zou, Y.; Hong, Z.-L.; Liu, S.-T.; Li, M.; Huang, Y.; Xiong, J.; Zhao,   Y.; Yang, G.-X.; Xia, G.; Hu, J.-F. Tetrahedron Lett. 2013, 54,   2549. “Trichotomone,   a new cytotoxic dimeric abietane-derived diterpene from Clerodendrum trichotomum” doi.org/10.1016/j.tetlet.2013.03.048

(4)       

Wahba, A. E.; Fromentin, Y.; Zou, Y.; Hamann, M. T. Tetrahedron Lett. 2012, 53,   6329. “Acantholactone,   a new manzamine related alkaloid with an unprecedented d-lactone and e-lactam ring system” doi.org/10.1016/j.tetlet.2012.08.140

(3)       

Xu, Y.-J.; Foubert, K.; Dhooghe, L.; Lemière, F.;   Maregesi, S.; Coleman, C. M.; Zou, Y.;   Ferreira, D.; Apers, S.; Pieters, L. Phytochemistry 2012, 79,   121. “Rapid   isolation and identification of minor natural products by LC–MS, LC–SPE–NMR   and ECD: isoflavanones, biflavanones and bisdihydrocoumarins from Ormocarpum kirkii”

doi.org/10.1016/j.phytochem.2012.04.004

(2)   

Yang, F.; Hamann, M. T.; Zou, Y.; Zhang, M.-Y.; Gong, X.-B.; Xiao, J.-R.; Chen, W.-S.;   Lin, H.-W. J. Nat. Prod. 2012, 75, 774. “Antimicrobial metabolites   from the paracel islands sponge Agelas mauritiana”   doi.org/10.1021/np2009016

(1)          

Wang, J.; Zhai, W.-Z.; Zou, Y.; Zhu, J.-J.; Xiong, J.; Zhao, Y.; Yang, G.-X.; Fan, H.;   Hamann, M. T.; Xia, G.; Hu, J.-F. Tetrahedron Lett. 2012, 53,   2654. “Eucalyptals   D and E, new cytotoxic phloroglucinols from the fruits of Eucalyptus globulus and assignment of absolute configuration” doi.org/10.1016/j.tetlet.2012.03.073

Academic Activities

2023

Seminar, “Discovery, Synthesis   and Biosynthesis of Bioactive Natural Products via the Combination of   Experimental and Computational Approaches”, School of Pharmacy, University of   Southern California

2022

Speaker, “Chemoenzymatic   Syntheses of Piperidine Alkaloids”, Houk Research Conference, UCLA

2022

Seminar, “Discovery,   Synthesis and Biosynthesis of Bioactive Natural Products”, Michigan State   University

2019

ACS Conference, San Diego, USA, poster section: Zou, Y.; Wang, X.; Sims, J.; Wang, B.; Pandey, P.; Welsh,   C.; Stone, R.; Avery, M.; Doerksen, R.; Ferreira, D.; Anklin, C.; Valeriote,   F. A.; Kelly, M.; Hamann, M. T. “Aleutianamine: architecturally-complex   pyrroloiminoquinone alkaloid with selective cytotoxicity toward pancreatic cancer   cell lines” (final paper number: ORGN 669)

2019    

ACS Conference,   San Diego, USA, poster section: Zou, Y.; Houk, K. N. “Change the enantioselectivity   of enzymes: Rational structural-modification of functional proteins catalyzing   Diels-Alder reactions with the reversed enantioselectivity” (final paper   number: ORGN 597)

2017

American Chemical Society (ACS),   Philadelphia local section, Young Chemist Committee (YCC) student poster   session: Zou, Y.; Yang, Y.; Smith A. B. “Indole diterpenoid total synthesis   study: construction of (−)-nodulisporic acid C”

2016

ACS Division of Organic Chemistry   Graduate Research Symposium presentation: Zou, Y. “Total synthesis of   (−)-nodulisporic acid D”

2015

44th National Organic Chemistry   Symposium, poster section: Zou, Y.; Melvin, J.; Gonzales, S.; Spafford, M.;   Smith, A. B. “Total synthesis of (−)-nodulisporic acid D”

2015

Invited seminar,   “The development and application of medicinal chemistry in the United   States”; School of Pharmacy, CDUTCM

2015

Invited seminar,   “The development of natural product chemistry in the United States”; School   of Pharmacy, Fudan University

Service

2016    

Reviewer: Organic Letters

2015    

Reviewer: Tetrahedron/Tetrahedron Letters

2015    

Council Member, World Federation of Chinese Medicine Societies (a World Health Organization member)

2014    

Reviewer: Natural Product Communications

2015    

Editorial Board Member: International   Journal of Pharmaceutical Sciences and Developmental Research

Awards and Certificates

2021

The Science Fund Program for Distinguished Young   Scholars (Overseas)

2016    

National   Scholarship for Self-Financed Outstanding Student

References

Prof. Amos B. Smith,   III     

(PhD advisor): smithab@sas.upenn.edu

Department of   Chemistry, University of Pennsylvania

Prof. Ken Houk                     

(Postdoc advisor):   houk@chem.ucla.edu

Department of Chemistry   & Biochemistry, UCLA

Prof. Neil Garg                      

(Dept. Chair and collaborator): neilgarg@chem.ucla.edu

Department of Chemistry   & Biochemistry, UCLA

Prof. Robert Doerksen          

(Computational mentor): rjd@olemiss.edu

School of Pharmacy, University   of Mississippi