Title: Synthesis of a Versatile 1H-indene-3-carboxylate Scaffold Enabled by Visible-Light Promoted Wolff Rearrangement of 1-Diazonaphthalen-2(1H)-ones

Chem. Commun., 2023, accepted, DOI: 10.1039/D3CC01093G

Authors: Xin Yue, Ying Zhou, Yan Zhang, Tengfei Meng, Yupei Zhao* and Wengang Guo*

Abstract: Herein, we developed a sequential visible-light-promoted Wolff rearrangement of 1-Diazonaphthalen-2(1H)-ones, followed by capturing the in situ generated ketene intermediates with virous alcohols, producing diverse 1H-indene-3-carboxylates in moderate to good yields under mild reaction conditions. The broad substrate scope, high functional group tolerance, and robust conditions make the resulting derivative a versatile platform for the synthesis of a plenty of bioactive molecules.

Congratulations to Yue Xin!