主要研究领域与方向
食品安全危害因子、疾病标志物增敏分析检测
1. 国家自然科学基金青年科学基金，2019.01-2021.12，主持
2. 安徽省重点研发计划项目，2020.01-2022.12，主持
3. 安徽省自然科学基金青年基金项目，2019.07-2021.06，主持
4. 中国博士后科学基金面上项目，2019.06-2021.01，主持
5. 国家重点实验室开放基金项目，2019.04-2021.03，主持（经费到校）
6. 合肥工业大学学术新人提升B计划，2019.04-2020.12，主持
7. 合肥工业大学学术新人提升A计划，2018.05-2019.12，主持（结题）
8. 合肥工业大学科研启动基金，2017.06-2020.06，主持
一、 期刊论文（通讯作者和第一作者）：
1. Wei Chen, Jun Teng, Li Yao, Jianguo Xu*, and Guodong Liu. Selection of specific DNA aptamers for hetero-sandwich based colorimetric determination of Campylobacter jejuni in food. Journal of Agricultural and Food Chemistry. 2020, 68, 31, 8455–8461
2. Wei Chen*, Lijun Yang, Chao Yan, Bangben Yao, Jian-feng Lu, Jianguo Xu*, and Guodong Liu*. Surface-confined building of Au@Pt-centered and multi-G-quadruplex/hemin wires-surrounded electroactive supernanostructures for ultrasensitive monitoring of morphine. ACS Sensors. 2020, 5, 8, 2644–2651
3. Prediction, evaluation, confirmation, and elimination of matrix effects for lateral flow test strip based rapid and on-site detection of aflatoxin B1 in tea. Wei Chen*, Fen Cai, Qian Wu, Yuhan Wu, Bangben Yao, and Jianguo Xu*. Food Chemistry. 2020, 328, 127081
4. Jie Wang, Shuhui Li, Jianguo Xu*, Yusheng Lu, Min Lin, Chaihung Wang, Chen Zhang, Guoxing Lin, Lee Jia*. Functionalized dumbbell probe-based cascading exponential amplification DNA machine enables amplified probing of microRNAs. Chemical Communications, 2020, 56, 1681-1684
5. Panzhu Qin, Li Yao, Jianguo Xu*, Guodong Liu, Wei Chen*. Smart engineering of a dual-DNA machine with a high signal-to-noise ratio for one-pot robust and sensitive miRNA signaling. Chemical Communications, 2019,55, 14367-14370
6. Jianguo Xu#, Chao Yan#, Xinxin Wang, Bangben Yao, Jianfeng Lu, Guodong Liu*, Wei Chen*. Ingenious design of DNA concatamers and G-quadruplex wires assisted assembly of multi-branched DNA nanoarchitectures for ultrasensitive biosensing of miRNA. Analytical Chemistry, 2019, 91: 9747-9753
7. Wei Chen, Chao Yan, Lin Cheng, Li Yao, Feng Xue, Jianguo Xu*. An ultrasensitive signal-on electrochemical aptasensor for ochratoxin A determination based on DNA controlled layer-by-layer assembly of dual gold nanoparticle conjugates, Biosensors and Bioelectronics, 2018,117: 845–851
8. Jianguo Xu, Zai-Sheng Wu*, Zhenmeng Wang, Jingqing Le, Tingting Zheng, Lee Jia*. Autonomous assembly of ordered metastable DNA nanoarchitecture and in situ visualizing of intracellular microRNAs, Biomaterials, 2017, 120: 57-65
9. Jianguo Xu, Zai-Sheng Wu*, Zhenmeng Wang, Hongling Li, Jingqing Le, and Lee Jia*, Two-wheel drive-based DNA nanomachine and its sensing potential for highly sensitive analysis of cancer-related gene, Biomaterials, 2016, 100: 110-117
10. Jianguo Xu, Hongling Li, Zai-Sheng Wu*, Jun Qian, Chang Xue, Lee Jia*. Double-stem hairpin probe and ultrasensitive colorimetric detection of cancer-related nucleic acids, Theranostics, 2016, 6: 318-327
11. Jianguo Xu, Zai-Sheng Wu*, Weiyu Shen, Jingqing Le, Tingting Zheng, Hongling Li, Lee Jia*. Programmable nanoassembly consisting of two hairpin-DNAs for p53 gene determination, Biosensors and Bioelectronics, 2017, 94: 626-631
12. Jianguo Xu, Zai-Sheng Wu*, Hongling Li, Zhenmeng Wang, Jingqing Le, Tingting Zheng, Lee Jia*. Dual-cyclical nucleic acid strand-displacement polymerization based signal amplification system for highly sensitive determination of p53 Gene, Biosensors and Bioelectronics, 2016, 86: 1024-1030
13. Jianguo Xu#, Jun Qian#, Hongling Li, Zai-Sheng Wu*, Weiyu Shen, Lee Jia*, Intelligent DNA machine for the ultrasensitive colorimetric detection of nucleic acids, Biosensors and Bioelectronics, 2016, 75: 41-47
14. Jianguo Xu, Haiyan Dong, Weiyu Shen, Sudan He, Hongling Li, Yusheng Lu, Zai-Sheng Wu*, Lee Jia*. New molecular beacon for p53 gene point mutation and significant potential in serving as the polymerization primer, Biosensors and Bioelectronics, 2015, 66: 504-511
15. Jianguo Xu, Zai-Sheng Wu*, Weiyu Shen, Huo Xu, Hongling Li, Lee Jia*. Cascade DNA nanomachine and exponential amplification biosensing, Biosensors and Bioelectronics, 2015, 73: 19-25
16. Hongbo Li*, Mingbin Liu, Weihua Zhao, Jiamei Pu, Jianguo Xu*, Suqin Wang, Ruqin Yu*. Multi-channel collection of G-quadruplex transducers for amplified signaling of Pax-5 based on target-triggered split-to-intact remodeling of dual-G-rich duplex probe. Sensors & Actuators: B. Chemical, 2020, 311: 127913-127929
17. Xiaoming Ma, Shan He, Ying Zhang, Jianguo Xu*, Huifang Zhang, Zhen Wang, Jun Xue, Xun Li,* Wenbo Yu*. Xiaolin FanaSignal-off tuned signal-on (SF-T-SN) colorimetric immunoassay for amantadine using activity-metalmodulated peroxidase-mimicking nanozyme. Sensors & Actuators: B. Chemical, 2020, 311, 127933-127938
18. Xinxin Wang, Jianguo Xu*, Panzhu Qin, Chao Yan, Guodong Liu, Wei Chen*. Automated nanoassembly of poly-thymine embedded activatable molecular beacon for one-step quantification of the terminal deoxynucleotidyl transferase activity. Analytica Chimica Acta. 2021, 1141, 127-135
19. Jianguo Xu, Zai-Sheng Wu*, Yanru Chen, Tingting Zheng, Jingqing Le, Lee Jia*. Collapse of chain anadiplosis-structured DNA nanowires for highly sensitive colorimetric assay of nucleic acids, Analyst, 2017, 142: 613-620
20. Jianguo Xu#, Tingting Zheng#, Jingqing Le, Lee Jia*, Long-stem shaped multifunctional molecular beacon for highly sensitive nucleic acids determination via intramolecular and intermolecular interactions based strand displacement amplification, Analyst, 2017, 142: 4438–4445
21. Zhengrong Zhang, Shisheng Chen, Jianluan Ren, Fang Han, Xiaofeng Yu, Fang Tang, Feng Xue*, Wei Chen, Jielin Yang, Yuan Jiang, Hongmei Jiang, Bo Lv, Jianguo Xu*, Jianjun Dai. Facile construction of a Molecularly Imprinted Polymer based Electrochemical Sensor for the Detection of milk amyloid A. Microchimica Acta. 2020, 187, 642.
22. Li Yao, Yulin Li, Kewen Cheng, Daodong Pan, Jianguo Xu*, Wei Chen*,*Determination of 17β-estradiol by surface-enhanced Raman spectroscopy merged with hybridization chain reaction amplification on Au@Ag core-shell nanoparticles. Microchimica Acta, 2019, 186(2): 52.
23. Xiaoming Ma, Zhen Wang, Shan He, Jingyi Zhao, Xiaoqi Lai*, Jianguo Xu*. L-cysteine modified gold nanoparticles for tube-based fluorometric determination of mercury(II) ions. Microchimica Acta, 2019, 186(9): 632.
24. Jianguo Xu, Tingting Zheng, Jingqing Le, Lee Jia*, Stepwise nanoassembly of a single hairpin probe and its biosensing, Talanta, 2018, 187, 272-278
25. Panzhu Qin, Dongqing Qiao, Yan Gao, Li Yao, Jianfeng Lu, Jianguo Xu*, Wei Chen*. Self-signal-on fluorescent colorimetric protocol for rapid authentication of horsemeat adulterated beef samples with functional designed probes. International Journal of Food Science & Technology, 2019, 54(5): 1752-1759.
26. Panzhu Qin, Wei Qu, Jianguo Xu*, Dongqing Qiao, Li Yao, Feng Xue, Wei Chen*. A sensitive multiplex PCR protocol for simultaneous detection of chicken, duck, and pork in beef samples. Journal of food science and technology, 2019, 56(3): 1266-1274.
27. Wei Chen, Xinni Li, Qian Wu, Li Yao, Jianguo Xu*. Rapid and easy determination of morphine in chafing dish condiments with colloidal gold labeling based lateral flow strips. Food Science and Human Wellness, 2019, 8(1): 40-45.
28. Jianguo Xu*, Xinxin Wang, Chao Yan, Wei Chen*. A Polyamidoamine Dendrimer-Based Electrochemical Immunosensor for Label-Free Determination of Epithelial Cell Adhesion Molecule-Expressing Cancer Cells. Sensors, 2019, 19(8): 1879.
二、 专著：
1. Jianguo Xu, Li Yao, Lin Cheng, Chao Yan, and Wei Chen*. “Development of Aptamer-Based Electrochemical Methods.” Aptamers for Analytical Applications: Affinity Acquisition and Method Design, Willey publishing, 2018: 247-271.
2.《食品安全学》，郑州大学出版社，编委，2019年12月