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王涛 骨干专家     进组时间: 2020.03    离组时间: 2021.06

王涛, 中国农业科学院都市农业研究所植物与人类健康创新团队科研骨干。硕博期间着重化学精准定位修饰生物高分子,合成具有环境响应性的智能纳米生物材料,实现靶向药物递送和控释。主研了多项欧盟和德国的重点科研项目。于2016 年3 月作为引进人才到西南交通大学生物医学工程系,研究可降解纤维在肿瘤局部治疗、组织修复材料和生物传感方面的应用。于2020年3月加入中国农业科学院都市农业研究所植物与人类健康创新团队,研究功能植物成分的靶向递送与控释。以第一或通讯作者身份发表SCI论文10篇,平均影响因子大于6,其中在化学顶级期刊Chemical Science (IF: 9)上发表论文2篇。

教育经历:

2011/06-2014/12,德国乌尔姆大学,有机化学学院III,有机化学专业,博士,导师:Tanja Weil

2008/08-2011/05,新加坡国立大学,化学学院,化学专业,硕士,导师:Tanja Weil

2004/09-2008/06,四川大学,化学学院,化学专业,学士,导师:余孝其

科研与学术工作经历:

2020/03-至今,中国农业科学院都市农业研究所植物与人类健康创新团队,科研骨干

2016/03-2020/03,西南交通大学,材料科学与工程学院,材料学院生物医学工程系,材料先进技术教育部重点实验室,副教授

2014/12-2015/09,德国乌尔姆大学,有机化学学院III,博士后,合作导师:Tanja Weil

主要学术业绩

参加科研项目:

(1) 国家自然科学基金面上项目(31771034)、聚合物短纤维基微纳马达的运动特性及生物医学功能、2018/01-2021/12、60万、参与。

(2) Marie Sklodowska-Curie innovative training network (ITN), Horizon 2020, 2014-2018, 249216.48 欧元(约185.7万人民币),主研。

(3) German Research Foundation (DFG), SFB 1149, 2014-2018, 13800欧元(约102.8万人民币),主研。

(4) ERC Synergy grant, 2013-2019, 3576960 欧元(约2665.8万人民币),主研。

(5) DFG, WE 4396/1-1, 2011-2013, 125496 欧元(约93.5万人民币), 主研。 

研究成果

1.第一或通讯作者论文(#为第一作者,*为通讯作者)

(1) J. Wei, J. Lu, M. Chen, S. Xie, T. Wang*, X. Li*, 3D spheroids generated on carbon nanotube-functionalized fibrous scaffolds for drug metabolism and toxicity screening, Biomater. Sci. 8(1) (2020) 426-437.

(2) M.M. Zegota#, T. Wang#, C. Seidler, D.Y. Wah Ng, S.L. Kuan*, T. Weil*, “Tag and modify” protein conjugation with dynamic covalent chemistry, Bioconjugate Chem., 2018, 29 (8): 2665–2670. (IF : 4.49)

(3) X.M. Luo#, M.H. Chen#, Z.J. Chen a, S.Z. Xie, N. He, T. Wang*, X.H. Li*, An implantable depot capable of in situ generation of micelles to achieve controlled and targeted tumor chemotherapy, Acta Biomater., 2018, 67: 122-133. (IF : 6.38)

(4) L. Zhao#, T. Wang#, Q. Wu, Y. Liu, Z.J. Chen, X.H. Li*, Fluorescent strips of electrospun fibers for ratiometric sensing of serum heparin and urine trypsin, ACS Appl. Mater. Inter., 2017, 9(4): 3400-3410. (IF : 8.10)

(5) S. L. Kuan#, T. Wang#, T. Weil*, Site-selective disulfide modification of proteins: expanding diversity beyond the proteome, Chem. Eur. J., 2016, 22(48): 17112-17129. (IF : 5.16)

(6) T. Wang#, A. Riegger#, M. Lamla, S. Wiese, P. Oeckl, M. Otto, Y. Wu, S. Fischer, H. Barth, S. L. Kuan, T. Weil*, Water-soluble allyl sulfones for dual site-specific labelling of proteins and cyclic peptides, Chem. Sci. 2016, 7(5): 3234-3239. (IF : 9.03)

(7) T. Wang#, N. Zabarska#, Y. Wu, M. Lamla, S. Fischer, K. Monczak, D. Y. Ng*, S. Rau*, T. Weil*, Receptor selective ruthenium-somatostatin photosensitizer for cancer targeted photodynamic applications, Chem. Commun., 2015, 51 (63): 12552-12555. (IF : 6.29)

(8) T. Wang, Y. Wu, S. L. Kuan, O. Dumele, M. Lamla, D. Y. Ng, M. Arzt, J. Thomas, J. O. Mueller, C. Barner-Kowollik*, T. Weil*, A disulfide intercalator toolbox for the site-directed modification of polypeptides, Chem. Eur. J., 2015, 21(1): 228-238. (IF : 5.16)

(9) S. L. Kuan#*, T. Wang#, M. Raabe, W. Liu, M. Lamla, T. Weil*, Programming bioactive architectures with cyclic peptide amphiphiles, ChemPlusChem, 2015, 80(8): 1347-1353. (IF : 3.21)

(10) T. Wang, D. Y. Ng, Y. Wu, J. Thomas, T. TamTran, T. Weil*, Bis-sulfide bioconjugates for glutathione triggered tumor responsive drug release, Chem. Commun., 2014, 50(9): 1116-1118. (IF : 6.29)

(11) T. Wang#, A. Pfisterer#, S. L. Kuan, Y. Wu, O. Dumele, M. Lamla, K. Mullen, T. Weil*, Cross-conjugation of DNA, proteins and peptides via a pH switch, Chem. Sci., 2013, 4(4): 1889-1894. (IF : 9.03)

2.既非第一作者又非通讯作者论文

(1) L. Zhao, Z. Zhang, M. Chen, Y. Liu, T. Wang, X. Li*, Fluorescent fibrous mats assembled with self-propagating probes for visual sensing of hydrogen peroxide and choline, Analyst 144(18) (2019) 5624-5636.

(2) S.L. Kuan*, S. Fischer, S. Hafner, T. Wang, T. Syrovets, W. Liu, Y. Tokura, D.Y.W. Ng, A. Riegger, C. Förtsch, D. Jäger, T.F.E. Barth, T. Simmet*, H. Barth*, T. Weil*, Boosting antitumor drug efficacy with chemically engineered multidomain proteins, Adv. Sci., 2018, 5, 1701036. (IF : 12.44)

(3) S. Hafner, M. Raabe, Y. Wu, T. Wang, Z. Zuo, V. Rasche, T. Syrovets, T. Weil*, T. Simmet*, High-Contrast Magnetic Resonance Imaging and Efficient Delivery of an Albumin Nanotheranostic in Triple-Negative Breast Cancer Xenografts, Adv. Ther. 2(11) (2019) 1900084.

(4) Z. Chen, Z. Zhang, M. Chen, S. Xie, T. Wang, X. Li*, Synergistic antitumor efficacy of hybrid micelles with mitochondrial targeting and stimuli-responsive drug release behavior, J. Mater. Chem. B 7(9) (2019) 1415-1426.

(5) Z. Chen, T. Xia, Z. Zhang, S. Xie, T. Wang, X. Li*, Enzyme-powered Janus nanomotors launched from intratumoral depots to address drug delivery barriers, Chem. Eng. J. 375 (2019) 122109

(6) W. Liu, F. Boldt, Y. Tokura, T. Wang, B.K. Agrawalla, Y. Wu, T. Weil, Encoding function into polypeptide-oligonucleotide precision biopolymers, Chem. Commun. 54(83) (2018) 11797-11800.

(7) Z. Chen, W. Liu, L. Zhao, S. Xie, M. Chen, T. Wang, X. Li*, Acid-labile degradation of injectable fiber fragments to release bioreducible micelles for targeted cancer therapy, Biomacromolecules, 2018, 19(4): 1100-1110. (IF : 5.74)

(8) B. K. Agrawalla, T. Wang, A. Riegger, M. P. Domogalla, K. Steinbrink, T. Dorfler, X. Chen, F. Boldt, M. Lamla, J. Michaelis, S. L. Kuan*, T. Weil*, Chemoselective dual labeling of native and recombinant proteins, Bioconjugate Chem., 2018, 29 (1): 29-34. (IF : 4.49)

(9) N. He, Z.J. Chen, J. Yuan, L. Zhao, M.H. Chen, T. Wang,; X.H. Li*, Tumor pH-responsive release of drug-conjugated micelles from fiber fragments for intratumoral chemotherapy, ACS Appl. Mater. Inter., 2017, 9 (38): 32534-32544. (IF : 8.10)

(10) Y. Wu, T. Wang, D. Y. Ng, T. Weil*, Multifunctional polypeptide-PEO nanoreactors via the hydrophobic switch, Macromol. Rapid Commun., 2012, 33(17): 1474-1481. (IF : 4.44)