代表性论文：

1. Xin Wang, Mengjiao Zhang, Xiaolei Liu, Mingliang Lou, Gen Li, and Xiangbing Qi*, "Total Synthesis of Tetracyclic Spirooxindole Alkaloids via a Double Oxidative Rearrangement/Cyclization Cascade", Org. Lett. 2024, 26, 4, 824–828. doi.org/10.1021/acs.orglett.3c03938. 

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3. Mengxue Zeng, Kun Wang, Qingcui Wu, Jingjin Ding, Dan Xie, Xiangbing Qi, Feng Shao*, "Dissecting caspase-2-mediated cell death: from intrinsic PIDDosome activation to chemical modulation", Protein Cell, 2024, https://doi.org/10.1093/procel/pwae020.

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5. Mingliang Lou, Xiaolei Liu, Shoule Han, Songlin Bai and Xiangbing Qi*, "Total synthesis of (±)-3-demethoxyerythratidinone via Tf2O-promoted cascade reaction of enaminone", 2024, DOI: 10.1039/D3CC06270H       

6.          

7. Peihao, Chen, Jing Wang, Yan Wang, Yuze Sun, Qingcui WU, Xiangbing Qi*, "Total Synthesis of Tetrodotoxin and 9-epiTetrodotoxin", 2023, DOI:10.26434/chemrxiv-2023-76wll-v2 
   

    

8. Ye Zhang, Lei Zhang, Xiangbing Qi*, "Oxidative Coupling Approach to Sarpagine Alkaloids: Total Synthesis of (−)-Trinervine, Vellosimine, (+)-Normacusine B, and (−)-Alstomutinine C", Angew. Chem. Int. Ed., 2023, doi/abs/10.1002/anie.202304435  

9. Chao Yang, Songlin Bai, Qingcui Wu, Xiangbing Qi*,"Visible-light-induced Enantioselective Radical Cross-Coupling of C(sp3)–Borazirconocene", Chem, 2023, https://doi.org/10.1016/j.chempr.2023.04.006

10. 

11. Shoule Han, Mingliang Lou, Xiangbing Qi*, "Bioinspired Formal Synthesis of Pancracine via Selective Hydro­genation of an Indole Derivative",Synlett, 2023, DOI: 10.1055/a-2021-7944

12. Jun Yang, Peihao Chen, Yu Cao ,Sanduo Zheng, Xiangbing Qi* ,Hui Jiang*,"Chemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction", Cell Chemical Biology, DOI:https://doi.org/10.1016/j.chembiol.2023.02.002           

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14. Xiangbing Qi*, Wenhui Li*, “Unlocking the secrets to human NTCP structure” The Innovation, 10029

                     

15. Xiaolei Liu, Mingliang Lou, and Xiangbing Qi*, “Asymmetric Total Syntheses of Strychnos Alkaloids via Selective Fischer Indolization”, Journal of Organic Chemistry, 2022, 87 (8), 5199-5212

    

16. Yan Ma*, Yang Cao, Xiaocui Song, Yuanying Zhang, Jing Li, Yankai Wang, Xiaoqing Wu, and Xiangbing Qi, “ BAFinder: A software for  unknown bile acid identification using accurate mass LC-MS/MS in positive and negative modes”, Analytical Chemistry, 2022, 94 (16), 6242-6250

    
    

17. Daojiang Yan, Kunya Wang, Songlin Bai, Bingyu Liu, Jian Bai, Xiangbing Qi, Youcai Hu, “Flavin-Dependent Monooxygenase-Mediated 1,2-Oxazine Construction via Meisenheimer Rearrangement in the Biosynthesis of Paeciloxazine” J. Am. Chem. Soc., 2022, 144, 9, 4269-4276

    

18. Yue Liu, Songlin Bai, Yuanbo Du, Xiangbing Qi*, Hongyin Gao*, “Expeditious and Efficient ortho-Selective Trifluoromethane-sulfonylation of Arylhydroxylamines” Angew. Chem. Int. Ed., 2022, 61, e202115611

    

19. Gen Li, Mingliang Lou, Xiangbing Qi*, “A brief overview of classical natural product drug synthesis and bioactivity”, Organic Chemistry Frontiers, 2022, 9, 517-571

    

20. Jie Chen, Nan Liu, Yinpin Huang, Yuanxun Wang, Yuxing Sun, Hong-Wei Wang*, Niu Huang*, Xiangbing Qi* and Xiaodong Wang* “Structure of PDE3A–SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells”, Nature Communications, 2021, 12:6204 | https://doi.org/10.1038/s41467-021-26546-8

    

21.     Zilin Li, Wang Liu, Jiaqi Fu, Sen Cheng, Yue Xu, Zhiqiang Wang, Xiaofan Liu, Xuyan Shi, Yaxin Liu, Xiangbing Qi, Xiaoyun Liu*, Jingjin Ding, Feng Shao* “Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11”, Nature, 2021,1-6.https://doi.org/10.1038/s41586-021-04020-1   
    

                

22. Xiaozhe Zhang, Na Li, Jun Zhang, Yanshen Zhang, Xiaoli Yang, Yifan Luo, Bobo Zhang, Zhixue Xu, Zhenhua Zhu, Xiuyan Yang, Yuan Yan, Biao Lin, Shen Wang, Da Chen, Caichao Ye, Yan Ding, Mingliang Lou, Qingcui Wu, Zhanfeng Hou, Keren Zhang, Ziming Liang, Anqi Wei, Bianbian Wang, Changhe Wang, Nan Jiang, Wenqing Zhang, Guozhi Xiao, Cong Ma, Yan Ren, Xiangbing Qi, Weiping Han, Chao Wang & Feng Rao, “5-IP7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis”, Nature Metabolism 2021, pages1400–1414
                                                                                                                                            
23. Yang Liu, Lei Zhang, Huan Yan, Zhiqiang Wang, Guoliang Sun, Xiao Song, Zhongmin Zhou, Bo Peng, Liwei Yan, Qingcui Wu, Wenhui Li*, and Xiangbing Qi* “Design of Dimeric Bile Acid Derivatives as Potent and Selective Human NTCP Inhibitors”, J. Med. Chem., 2021, 64 (20), 5973-6007.
      
24. Lu Lv, Peihao Chen, Longzhi Cao, Yamei Li, Zhi Zeng, Yue Cui, Qingcui Wu, Jiaojiao Li, Jian-Hua Wang, Meng-Qiu Dong, Xiangbing Qi* and Ting Han* “Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation”, eLife, Aug. 2020：https://elifesciences.org/articles/59994
        

25. Youwei Ai, Haibing He, Peihao Chen, Bo Yan, Wenbin Zhang, Zhangcheng Ding, Dianrong Li, Jie Chen, Yan Ma, Yang Cao, Jie Zhu, Jiaojiao Li, Jinjie Ou, Shan Du, Xiaodong Wang, Jianzhang Ma*, Shuanhu Gao* and Xiangbing Qi*, “An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity”, Nature Communication, 28 Jun. 2020: https://www.nature.com/articles/s41467-020-17052-4.pdf
    

                                                                    

26. Chao Yang, Yadong Gao, Songlin Bai, Chao Jiang* and Xiangbing Qi*, “Chemoselective Cross-coupling of gem-Borazirconocene Alkanes with Aryl Halides”, Journal of the American Chemical Society, 05 Jun. 2020: https://doi.org/10.1021/jacs.0c03821 
    

                                                   

27. Dapeng Ju, Wei Zhang, Jiawei Yan, Haijiao Zhao, Wei Li, Jiawen Wang, Meimei Liao, Zhancong Xu, Zhiqiang Wang, Guanshen Zhou, Long Mei, Nannan Hou, Shuhua Ying, Tao Cai, She Chen, Xiaowen Xie, Luhua Lai, Chao Tang, Noheon Park, Joseph S. Takahashi, Niu Huang, Xiangbing Qi* and Eric Erquan Zhang*, “Chemical perturbations reveal that RUVBL2 regulates the circadian phase in mammals”, Science Translational Medicine 06 May 2020: 12, Issue 542, eaba0769; DOI: 10.1126/scitranslmed.aba0769
    

     
    
    
28. Yadong Gao, Jianhua Li, Songlin Bai, Daoquan Tu, Chao Yang, Zhiwen Ye, Bingcheng Hu, Xiangbing Qi* and Chao Jiang*, “Direct Synthesis of Annulated Indoles through Palladium-Catalyzed Double Alkylations”Org. Chem. Front., 2020, DOI: 10.1039/D0QO00135J
      
                                                                                                                                                                                                                                                                                       
29. Yadong Gao, Chao Yang, Songlin Bai, Xiaolei Liu, Qingcui Wu, Chao Jiang*, Xiangbing Qi*, “Visible-light-induced Nickel-catalyzed Cross-coupling with Alkylzirconocenes from Unactivated Alkenes” Chem, 2020, 6, 675-688.https://www.cell.com/chem/fulltext/S2451-9294(19)30557-1  
       
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
30. Ran Cao, Li Li, Zhengxin Ying, Zichen Cao, Yongfen Ma, Xiaoxu Mao, Jiaojiao Li, Xiangbing Qi, Zhiyuan Zhang, and Xiaodong Wang*.”A small molecule protects mitochondrial integrity by inhibiting mTOR activity” Proceedings of the National Academy of Sciences, Latest Articles. October 21, 2019.

31. Xiaofei Shen#, Lin Zhao#, Peihao Chen#, Yanqiu Gong, Dingdong Liu, Xia Zhang, Lunzhi Dai, Qingxiang Sun, Jizhong Lou, Zhong Jin, Baohua Zhang, Dawen Niu, Ceshi Chen, Xiangbing Qi, Da Jia* “A thiazole-derived oridonin analog exhibits antitumor activity by directly and allosterically inhibiting STAT3” DOI: 10.1074/jbc.RA119.009801 (# Equal Contribution)

32. Qiqi Chu, Changfu Yao, Xiangbing Qi, Barry Raymond Stripp, Nan Tang* “STK11 is required for the normal program of ciliated cell differentiation in airways” Cell Discovery (2019) 5:36, 1-16. DOI: https://doi.org/10.1038/s41421-019-0104-z

33. Dianrong Li, Jie Chen, Youwei Ai, Xiaoqiong Gu, Li Li, Di Che, Zhaodi Jiang, Lin Li, She Chen, Huanwei Huang, Jiawen Wang, Tao Cai, Yang Cao, Xiangbing Qi, Xiaodong Wang*, “Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover” Molecular Cell,2019, 1103. DOI: https://doi.org/10.1016/j.molcel.2019.06.040
    

                                             
                                           
         

34. Meiyi Zhou, Shao Jing, Cheng-Yang Wu, Le Shu, Weibing Dong, Yunxia Liu, Mengping Chen, R. Max Wynn, Jiqiu Wang, Ji Wang, Wen-Jun Gui, Xiangbing Qi, Aldons J. Lusis, Zhaoping Li, Weiqing Wang, Guang Ning, Xia Yang, David T. Chuang, Yibin Wang, Haipeng Sun*, “Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance” Diabetes 2019 Jun; db180927.

35. Lei Zhang, Ye Zhang, Wenting Li,  Xiangbing Qi*,  “Total Synthesis of (-)-Alstofolinine A through a Furan Oxidation/Rearrangement and Indole Nucleophilic Cyclization Cascade” Angew. Chem. Int. Ed. 2019, https://doi.org/10.1002/anie.201900156.
    
    

                                 

36. Hang Fu, Nan Liu, Qiang Dong, Chunxiao Ma, Jing Yang, Jun Xiong, Zhuqiang Zhang, Xiangbing Qi, Chang Huang & Bing Zhu*. “SENP6-mediated M18BP1 deSUMOylation regulates CENP-A centromeric localization” Cell Research 2019, 254-257

37. Yu Zhou, Yuanxun Wang, Pengfei Li, Xi-Ping Huang, Xiangbing Qi, Yunfei Du*, and Niu Huang*. “Exploring Halogen Bonds in 5-Hydroxytryptamine 2B Receptor–Ligand Interactions” ACS Med. Chem. Lett., 2018, 9 (10), pp 1019-1024.

38. Chao Wei, Xiao Han, Danwei Weng, Qiru Feng, Xiangbing Qi, Jin Li & Minmin Luo*. “Response dynamics of midbrain dopamine neurons and serotonin Interactions neurons to herxin, nicotine, cocxine, and MDMA” Cell Discovery, 4 : 60 (2018)  1019-1024

39. Aaron Nash, Xiangbing Qi, Pradip Maity, Kyle Owens, and Uttam K. Tambar*. “Development of the Vinylogous Pictet-Spengler Cyclization and Total Synthesis of (±)‐Lundurine A” Angew. Chem. Int. Ed., 2018, 57, 6888-6891.
       
                                                                                                                                                                                                                               
                                                                                                                                                               
       
40. Rui Lin, Qiru Feng, Peng Li, Ping Zhou, Ruiyu Wang, Zhe Liu, Zhiqiang Wang, Xiangbing Qi, Nan Tang, Feng Shao, Minmin Luo*, “A hybridization-chain-reaction-based method for amplifying immunosignals” Nature Methods, 2018 (4), 275          
         
41. Xuekai Zhang, Gang Lu, Meng Sun, Madhu Mahankali, Yanfei Ma, Mingming Zhang, Wangde Hua, Yuting Hu, Qingbing Wang, Jinghuo Chen, Gang He, Xiangbing Qi*, Weijun Shen*, Peng Liu*, Gong Chen*, “A general strategy for synthesis of cyclophane-braced peptide macrocycles via palladium-catalysed intramolecular sp 3 C− H arylation”, Nature Chemistry, 2018（10）, 540-548
42. Xueyan Ma, Peixue Li, Peihao Chen, Jinhui Li, Hongling Huang, Chao Wang, Wenjing Li, Jianping Ding, Yun Zhao, Fa-Xing Yu, Xiangbing Qi*, Lei Zhang*, “ Staurosporine targets the Hippo pathway to inhibit cell growth” Journal of Molecular Cell Biology, 2018, 10, 267-269
       
                                                                                                                                                                                                                      
       
43. Jingjing Fu, Yadong Gao, Xiangbing Qi*, Chao Jiang* “Synthesis of Polysubstituted Pyridines and Indoles by a Palladium-Catalyzed Catellani-type Alkylation-Alkenylation Sequence”  ChemistrySelect, 2018,10164      
44. Yanli Wang, Yuze Sun, Ran Cao, Dan Liu, Yuting Xie, Li Li, Xiangbing Qi*, Niu Huang*, “In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery” J. Med. Chem., 2017, 60 (20), pp 8552-8564
       
                                                                                                                                                                                                                               
                     
45. Shih-Chia Tso, Mingling Lou, Wen-Jun Gui, Cheng-Yang Wu, Jacinta L. Chuang, Lorraine K. Morlock, Noelle S. Williams, R. Max Wynn, Xiangbing Qi* and David T. Chuang* “Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-targeting Pyruvate Dehydrogenase Kinase Inhibitors” J. Med. Chem., 2017, 60 (3), 1142-1150.
       
                                                                                                                                                                                                                               
                                          
46. Yaling Wu, Dingbin Tang, Na Liu, Wei Xiong, Huanwei Huang, Yang Li, Zhixiong Ma,    Haijiao Zhao, Peihao Chen, Xiangbing Qi and Eric Erquan Zhang*. “Reciprocal Regulation between the Circadian Clock and Hypoxia Signaling at the Genome Level in Mammals”, Cell Metabolism, 2017, 25 (1), 73-85.
47. Shih-Chia Tso#, Xiangbing Qi#, Wen-Jun Gui, Cheng-Yang Wu, Jacinta L. Chuang, Ingrid Wernstedt-Asterholm, Lorraine K. Morlock, Kyle R. Owens, Philipp E. Scherer, Noelle S. Williams, Uttam K. Tambar, R. Max Wynn and David T. Chuang. “Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket”. J. Biol. Chem. 2014, 289, 4432-4443. (# Equal Contribution)
48. Shih-chia Tso#, Xiangbing Qi#, Wen-Jun Gui, Jacinta L. Chuang, Lorraine K. Morlock, Amy L. Wallace, Kamran Ahmed, Sunil Laxman, Philippe M. Campeau, Brendan H. Lee, Susan M. Hutson, Benjamin P. Tu, Noelle S. Williams, Uttam K. Tambar, R. Max Wynna, and David T. Chuang. , “Structure-based Design and Mechanisms of Allosteric Inhibitors for Mitochondrial Branched-chain α-Ketoacid Dehydrogenase Kinase.” Proc. Natl. Acad. Sci. U.S.A., 2013, 110, 9728-9733. (# Equal Contribution)
49. Yi Liu, Jun Liu*, Xiangbing Qi*, and Yuguo Du* “One-Pot Synthesis of 2,4-Disubstituted Thiazoline from β-Azido Disulfide and Carboxylic Acid” J. Org. Chem., 2012, 7108–7113
50. Feng Cai, Xiaotao Pu, Xiangbing Qi, Joseph. M. Ready. “Allenes in Asymmetric Catalysis: Asymmetric Addition of Boronic Acid to α-ketoesters Catalyzed by Allene-Containing Rhodium-Phosphine Catalyst”. J. Am. Chem. Soc., 2011, 133, 18066-18069.
51. Xiangbing Qi, Hongli Bao, Uttam K.Tambar. “Total Synthesis of (±)-Trigonoliimine C via Oxidative Rearrangement of an Unsymmetrical Bis-Tryptamine”, J. Am. Chem. Soc., 2011, 133, 10050-10053.
52. Hongli Bao, Xiangbing Qi, Uttam K. Tambar*. “Catalytic Enantioselective [2,3]-Rearrangements of Amine N-Oxides ”, J. Am. Chem. Soc., 2011, 133, 1206-1208.
53. Xiangbing Qi, Grant T. Rice, Manjinder S. Lall, Mark S. Plummer, M. Christina White* “Diversification of a β-lactam Pharmacophore via Allylic C–H Amination: Accelerating Effect of Lewis Acid co-catalyst”, Tetrahedron, 2010, 66, 4816-4826.
54. Xiaotao Pu, Xiangbing Qi, Joseph. M. Ready*. “Allenes in Asymmetric Catalysis: Asymmetric Ring Opening of meso-Epoxides Catalyzed by Allene-Containing Phosphine Oxides” J. Am. Chem. Soc., 2009, 131, 10364-10365.
55. Xiangbing Qi, Joseph. M. Ready*. “Synthesis of Cyclopentenones from Cyclopropanes and Silyl Ynol Ethers” Angew. Chem. Int. Ed. 2008, 47, 7068-7070.
56. Xiangbing Qi, Joseph. M. Ready*. “Copper-Promoted Cycloaddition of Diazocarbonyl Compounds with Copper Acetylides” Angew. Chem. Int. Ed. 2007, 46, 3242-3244.

专利：

       1.     Wenhui Li, Xiangbing Qi, Yang Liu, Zhiqiang Wang, Bo Peng, Lei Zhang，“Betulinic Acid Derivatives Inhibit Hepatitis B and D Virus and NTCP Transport”. In preparation.

        2.     Xiangbing Qi, Ting Han, Peihao Chen, Lu Lv, Yamei Li, Longzhi Cao, Qingcui Wu, Jiaojiao Li, “A molecular glue regulating CDK12-DDB1 interaction to trigger Cycl in K degradation” PCT/CN2020/095482

        3.    David T. Chuang, Shih-Chia Tso, Xiangbing Qi, Wen-Jun Gui, Cheng-Yang Wu, Jacinta L. Chuang, Uttam K. Tambar, R. Max Wynn “Inhibitors of mitochondrial pyruvate dehydrogenase kinase isoforms 1-4 and uses thereof” US20170001958A1

        4.    Wenhui Li, Xiangbing Qi, Huan Yan, Yang Liu, Zhiqiang Wang, Bo Peng, Lei Zhang, “Polymeric Bile Acid Derivatives Inhibit Hepatitis B and D Virus and NTCP Transport”. US20170266206A1

        5.    Niu Huang, Xiangbing Qi, Yanli Wang, Yuze Sun. “Kinase Inhibitors”, WO2017152842A1

        6.    Xiangbing Qi, Mingliang Lou, Enlong Wu, Peihao Chen, Qingcui Wu, “Dihydroxyphenyl Sulfonylisoindoline Derivatives”, WO2018095260A1

        7.    Erquan Zhang, Xiangbing Qi, Dapeng Ju, Haijiao Zhao, Long Mei, Zhiqiang Wang, Qingcui Wu, “Adenosine Analog and its use in Regulating the Circadian Clock”, WO2018133854A1

 

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